{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:37:13Z","timestamp":1791211033978,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009539","name":"Council for Science and Technology Policy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009539","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.jdermsci.2013.01.002","type":"journal-article","created":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T19:00:24Z","timestamp":1359658824000},"page":"12-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":139,"title":["Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice"],"prefix":"10.1016","volume":"70","author":[{"given":"Tomoko","family":"Sugawara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Akashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzo","family":"Hisatsune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoyuki","family":"Sugai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Furuse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2013.01.002_bib0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/emm.1999.2","article-title":"Bricks and mortar of the epidermal barrier","volume":"31","author":"Nemes","year":"1999","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0010","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nrm1619","article-title":"The cornified envelope: a model of cell death in the skin","volume":"6","author":"Candi","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0015","first-page":"313","article-title":"Transglutaminases in skin epidermis","volume":"15","author":"Hitomi","year":"2005","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0020","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1006\/jmbi.1993.1369","article-title":"The mechanism of interaction of filaggrin with intermediate filaments. The ionic zipper hypothesis","volume":"232","author":"Mack","year":"1993","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0025","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1242\/jcs.033969","article-title":"Filaggrin in the frontline: role in skin barrier function and disease","volume":"122","author":"Sandilands","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0030","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.tibs.2009.08.001","article-title":"The emerging roles of serine protease cascades in the epidermis","volume":"34","author":"Ovaere","year":"2009","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0035","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1046\/j.1523-1747.2003.12359.x","article-title":"Barrier function of the skin: \u201cla raison d\u2019etre\u201d of the epidermis","volume":"121","author":"Madison","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0040","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1194\/jlr.R700013-JLR200","article-title":"Thematic review series: skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis","volume":"48","author":"Feingold","year":"2007","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0045","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1172\/JCI116374","article-title":"Processing of epidermal glucosylceramides is required for optimal mammalian cutaneous permeability barrier function","volume":"91","author":"Holleran","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0050","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/S0022-2275(20)32369-5","article-title":"Epidermal sphingomyelins are precursors for selected stratum corneum ceramides","volume":"41","author":"Uchida","year":"2000","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0055","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000029827","article-title":"Epidermal enzymes: their role in homeostasis and their relationships with dermatoses","volume":"11","author":"Redoules","year":"1998","journal-title":"Skin Pharmacol Appl Skin Physiol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0060","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1600-0625.2008.00786.x","article-title":"The skin: an indispensable barrier","volume":"17","author":"Proksch","year":"2008","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0065","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1083\/jcb.17.2.375","article-title":"Junctional complexes in various epithelia","volume":"17","author":"Farquhar","year":"1963","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0070","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.tcb.2006.02.006","article-title":"Claudins in occluding junctions of humans and flies","volume":"16","author":"Furuse","year":"2006","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0075","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.physiol.68.040104.131404","article-title":"Claudins and epithelial paracellular transport","volume":"68","author":"Van Itallie","year":"2006","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0080","doi-asserted-by":"crossref","first-page":"F867","DOI":"10.1152\/ajprenal.90264.2008","article-title":"Biology of claudins","volume":"295","author":"Angelow","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0085","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1078\/0171-9335-00244","article-title":"Organization and formation of the tight junction system in human epidermis and cultured keratinocytes","volume":"81","author":"Brandner","year":"2002","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0090","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1083\/jcb.200110122","article-title":"Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice","volume":"156","author":"Furuse","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0095","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1600-0625.2006.00539.x","article-title":"Tight junction proteins in keratinocytes: localization and contribution to barrier function","volume":"16","author":"Yuki","year":"2007","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0100","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bbrc.2009.02.005","article-title":"Regulation of tight junction permeability by sodium caprate in human keratinocytes and reconstructed epidermis","volume":"381","author":"Kurasawa","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0105","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.ejcb.2010.07.010","article-title":"Tight junctions form a barrier in human epidermis","volume":"89","author":"Kirschner","year":"2010","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0110","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1053\/j.gastro.2004.07.022","article-title":"Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease","volume":"127","author":"Hadj-Rabia","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0115","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/humu.20333","article-title":"Confirmation of the origin of NISCH syndrome","volume":"27","author":"Feldmeyer","year":"2006","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0120","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jaci.2010.10.018","article-title":"Tight junction defects in patients with atopic dermatitis","volume":"127","author":"De Benedetto","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0125","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.2353\/ajpath.2009.080973","article-title":"Alteration of tight junction proteins is an early event in psoriasis: putative involvement of proinflammatory cytokines","volume":"175","author":"Kirschner","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0130","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1046\/j.1365-2958.2000.02169.x","article-title":"Phage conversion of exfoliative toxin A production in Staphylococcus aureus","volume":"38","author":"Yamaguchi","year":"2000","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0135","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1242\/dev.125.8.1541","article-title":"Patterned acquisition of skin barrier function during development","volume":"125","author":"Hardman","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0140","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1083\/jcb.200501038","article-title":"The epidermal barrier function is dependent on the serine protease CAP1\/Prss8","volume":"170","author":"Leyvraz","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0145","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.1523-1747.2003.12006.x","article-title":"Characteristics of the epidermis and stratum corneum of hairless mice with experimentally induced diabetes mellitus","volume":"120","author":"Sakai","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0150","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can J Biochem Physiol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0155","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1046\/j.1523-1747.2003.12365.x","article-title":"pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity\/cohesion","volume":"121","author":"Hachem","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0160","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.4049\/jimmunol.1100058","article-title":"Activation of TLR2 enhances tight junction barrier in epidermal keratinocytes","volume":"187","author":"Yuki","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0165","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/81385","article-title":"Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1","volume":"6","author":"Amagai","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0170","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jdermsci.2010.07.010","article-title":"Removal of amino-terminal extracellular domains of desmoglein 1 by staphylococcal exfoliative toxin is sufficient to initiate epidermal blister formation","volume":"59","author":"Nishifuji","year":"2010","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0175","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2165\/00128071-200506040-00002","article-title":"Role of ceramides in barrier function of healthy and diseased skin","volume":"6","author":"Choi","year":"2005","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0180","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S0022-2275(20)40772-2","article-title":"Beta-glucocerebrosidase activity in murine epidermis: characterization and localization in relation to differentiation","volume":"33","author":"Holleran","year":"1992","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0185","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0022-2275(20)32121-0","article-title":"Beta-glucocerebrosidase activity in mammalian stratum corneum","volume":"40","author":"Takagi","year":"1999","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0190","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/jid.2011.393","article-title":"One remarkable molecule: filaggrin","volume":"132","author":"Brown","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0195","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ng1743","article-title":"Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris","volume":"38","author":"Smith","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0200","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.2353\/ajpath.2010.090957","article-title":"Flaky tail mouse denotes human atopic dermatitis in the steady state and by topical application with Dermatophagoides pteronyssinus extract","volume":"176","author":"Moniaga","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0205","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1046\/j.0022-202x.2001.01493.x","article-title":"Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytes","volume":"117","author":"Pummi","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0210","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/1523-1747.ep12292052","article-title":"Intercellular spaces of the human epidermis as demonstrated with lanthanum","volume":"57","author":"Hashimoto","year":"1971","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0215","doi-asserted-by":"crossref","first-page":"e31641","DOI":"10.1371\/journal.pone.0031641","article-title":"Lamellar granule secretion starts before the establishment of tight junction barrier for paracellular tracers in mammalian epidermis","volume":"7","author":"Ishida-Yamamoto","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0220","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1084\/jem.20091527","article-title":"External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers","volume":"206","author":"Kubo","year":"2009","journal-title":"J Exp Med"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0225","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/1523-1747.ep12470233","article-title":"Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin?","volume":"96","author":"Imokawa","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0230","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0925-4439(93)90135-N","article-title":"Ceramide composition of the psoriatic scale","volume":"1182","author":"Motta","year":"1993","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0235","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1365-2133.1994.tb08452.x","article-title":"Quantification of stratum corneum ceramides and lipid envelope ceramides in the hereditary ichthyoses","volume":"131","author":"Paige","year":"1994","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0240","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1038\/jid.2010.161","article-title":"Changes in the ceramide profile of atopic dermatitis patients","volume":"130","author":"Ishikawa","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0245","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0022-2275(20)34214-0","article-title":"Role of ceramide 1 in the molecular organization of the stratum corneum lipids","volume":"39","author":"Bouwstra","year":"1998","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0250","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1172\/JCI117160","article-title":"Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease","volume":"93","author":"Holleran","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0255","doi-asserted-by":"crossref","first-page":"5456","DOI":"10.1016\/j.febslet.2006.08.039","article-title":"Epidermal sphingolipids: metabolism, function, and roles in skin disorders","volume":"580","author":"Holleran","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0260","doi-asserted-by":"crossref","first-page":"27512","DOI":"10.1074\/jbc.M603559200","article-title":"Mouse homologue of skin-specific retroviral-like aspartic protease involved in wrinkle formation","volume":"281","author":"Matsui","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jdermsci.2013.01.002_bib0265","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.jaci.2012.01.068","article-title":"Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice","volume":"129","author":"Kawasaki","year":"2012","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181113000121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181113000121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:47:44Z","timestamp":1760330864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181113000121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0923181113000121"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2013.01.002","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717990735.793473224","asserted-by":"object"}]},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2013.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}