{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:55:28Z","timestamp":1791291328127,"version":"4.3.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.jdermsci.2014.08.007","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T14:31:37Z","timestamp":1409063497000},"page":"132-138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Mutation analysis of the IL36RN gene in Chinese patients with generalized pustular psoriasis with\/without psoriasis vulgaris"],"prefix":"10.1016","volume":"76","author":[{"given":"Xiuyan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2019an","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongqi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Futang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2014.08.007_bib0005","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1038\/jid.2013.230","article-title":"The majority of generalized pustular psoriasis without psoriasis vulgaris is caused by deficiency of interleukin-36 receptor antagonist","volume":"133","author":"Sugiura","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0010","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1038\/jid.2013.267","article-title":"Prevalent and rare mutations in IL-36RN gene in Chinese patients with generalized pustular psoriasis and psoriasis vulgaris","volume":"133","author":"Li","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0015","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1056\/NEJMoa1013068","article-title":"Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis","volume":"365","author":"Marrakchi","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0020","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/humu.22203","article-title":"Mutation analysis of the IL-36RN gene in 14 Japanese patients with generalized pustular psoriasis","volume":"34","author":"Farooq","year":"2012","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0025","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/1346-8138.12227","article-title":"Novel IL36RN mutation in a Japanese case of early onset generalized pustular psoriasis","volume":"40","author":"Kanazawa","year":"2013","journal-title":"J Dermatol"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0030","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1038\/jid.2013.214","article-title":"Mutations in IL36RN in patients with generalized pustular psoriasis","volume":"133","author":"K\u00f6rber","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0035","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.ajhg.2011.07.022","article-title":"Mutations in IL36RN\/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis","volume":"89","author":"Onoufriadis","year":"2011","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0040","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/jid.2012.490","article-title":"Rare pathogenic variants in IL36RN underlie a spectrum of psoriasis-associated pustular phenotypes","volume":"133","author":"Setta-Kaffetzi","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0045","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1365-2133.2012.10953.x","article-title":"A novel IL-36RN\/IL1F5 homozygous nonsense mutation, p.Arg10X, in a Japanese patient with adult-onset generalized pustular psoriasis","volume":"167","author":"Sugiura","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0050","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/jid.2013.285","article-title":"Loss of IL36RN function does not confer susceptibility to psoriasis vulgaris","volume":"134","author":"Berki","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0055","doi-asserted-by":"crossref","first-page":"13677","DOI":"10.1074\/jbc.M400117200","article-title":"Interleukin (IL)-1F6 IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs","volume":"279","author":"Towne","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0060","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/ni1110-973","article-title":"IL-1 family nomenclature","volume":"11","author":"Dinarello","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0065","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nri2691","article-title":"The IL-1 family: regulators of immunity","volume":"10","author":"Sims","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0070","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1084\/jem.20070157","article-title":"Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation","volume":"204","author":"Blumberg","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0075","doi-asserted-by":"crossref","first-page":"4354","DOI":"10.4049\/jimmunol.1000313","article-title":"IL-1RL2 and its ligands contribute to the cytokine network in psoriasis","volume":"185","author":"Blumberg","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0080","doi-asserted-by":"crossref","first-page":"66","DOI":"10.7326\/0003-4819-153-1-201007060-00030","article-title":"Successful treatment of generalized pustular psoriasis with the interleukin-1-receptor antagonist anakinra: lack of correlation with IL1RN mutations","volume":"153","author":"Viguier","year":"2010","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0085","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/bjd.12548","article-title":"Successful therapy with anakinra in a patient with generalized pustular psoriasis carrying IL36RN mutations","volume":"170","author":"H\u00fcffmeier","year":"2014","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0090","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/ng.694","article-title":"A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1","volume":"42","author":"Strange","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0095","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.4049\/jimmunol.1003162","article-title":"IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression","volume":"186","author":"Johnston","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.jdermsci.2014.08.007_bib0100","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1038\/jid.2011.234","article-title":"Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis","volume":"131","author":"Carrier","year":"2011","journal-title":"J Invest Dermatol"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181114001923?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181114001923?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T05:00:23Z","timestamp":1538283623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181114001923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0923181114001923"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2014.08.007","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mutation analysis of the IL36RN gene in Chinese patients with generalized pustular psoriasis with\/without psoriasis vulgaris","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2014.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}