{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:50:29Z","timestamp":1781538629734,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jdsjournal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.jdermsci.2015.07.010","type":"journal-article","created":{"date-parts":[[2015,7,26]],"date-time":"2015-07-26T15:02:30Z","timestamp":1437922950000},"page":"142-149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Effects of rhododendrol and its metabolic products on melanocytic cell growth"],"prefix":"10.1016","volume":"80","author":[{"given":"Masae","family":"Okura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasue","family":"Ishii-Osai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoko","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Sumikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Wakamatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shosuke","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2015.07.010_bib0170","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1046\/j.1523-1747.1998.00178.x","article-title":"Supranuclear melanin caps reduce ultraviolet induced DNA photoproducts in human epidermis","volume":"110","author":"Kobayashi","year":"1998","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0175","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1586\/edm.10.70","article-title":"Update on the regulation of mammalian melanocyte function and skin pigmentation","volume":"6","author":"Kondo","year":"2011","journal-title":"Expert Rev. Dermatol."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0180","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/j.1460-2075.1992.tb05082.x","article-title":"Second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautamerase","volume":"11","author":"Tsukamoto","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0185","doi-asserted-by":"crossref","first-page":"5818","DOI":"10.1002\/j.1460-2075.1994.tb06925.x","article-title":"Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis","volume":"13","author":"Kobayashi","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0190","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1751-1097.2007.00238.x","article-title":"Chemistry of mixed melanogenesis \u2013 pivotal roles of dopaquinone","volume":"84","author":"Ito","year":"2008","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0195","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/1523-1747.ep12285496","article-title":"Effects of melanin-induced free radicals on the isolated rat peritoneal mast cells","volume":"86","author":"Ranadive","year":"1986","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0200","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1751-1097.2007.00242.x","article-title":"Increased melanogenesis is a risk factor for oxidative DNA damage \u2013 study on cultured melanocytes and atypical nevus cells","volume":"84","author":"Smit","year":"2008","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0205","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/pcmr.12262","article-title":"Pheomelanin-induced oxidative stress: bright and dark chemistry bridging red hair phenotype and melanoma","volume":"27","author":"Napolitano","year":"2014","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0210","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.3390\/ijms11062566","article-title":"Quasi-drugs developed in Japan for the prevention or treatment of hyperpigmentation disorders","volume":"11","author":"Ando","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0215","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/00043764-198806000-00014","article-title":"Occupational vitiligo due to unsuspected presence of phenolic antioxidant byproducts in commercial bulk rubber","volume":"30","author":"O\u2019Malley","year":"1988","journal-title":"J. Occup. Med."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0220","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1600-0536.1990.tb01525.x","article-title":"Contact depigmentation from free para-tertiary-butylphenol in bindi adhesive","volume":"22","author":"Bajaj","year":"1990","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0225","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1600-0749.2004.00130.x","article-title":"On the etiology of contact\/occupational vitiligo","volume":"17","author":"Boissy","year":"2004","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0230","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1046\/j.1523-1747.2000.00836.x","article-title":"The cytotoxicity and apoptosis induced by 4-tertiary butylphenol in human melanocytes are independent of tyrosinase activity","volume":"114","author":"Yang","year":"2000","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0235","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/jid.2009.214","article-title":"Monobenzyl ether of hydroquinone and 4-tertiary butyl phenol activate markedly different physiological responses in melanocytes: relevance to skin depigmentation","volume":"130","author":"Hariharan","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0240","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/1346-8138.12744","article-title":"Guide for medical professionals (i.e. dermatologists) for the management of rhododenol-induced leukoderma","volume":"42","author":"Nishigori","year":"2015","journal-title":"J. Dermatol."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0245","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1016\/j.bmc.2014.02.048","article-title":"Tyrosinase: the four oxidation states of the active site and their relevance to enzymatic activation, oxidation and inactivation","volume":"22","author":"Ramsden","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0250","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/pcmr.12269","article-title":"Rhododendrol, a depigmentation-inducing phenolic compound, exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism","volume":"27","author":"Sasaki","year":"2014","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0255","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jdermsci.2014.07.001","article-title":"Depigmentation caused by application of the active brightening material, rhododendrol, is related to tyrosinase activity at a certain threshold","volume":"76","author":"Kasamatsu","year":"2014","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0260","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/pcmr.12275","article-title":"Tyrosinase-catalyzed oxidation of rhododendrol produces 2-methychromane-6,7-dione, the putative ultimate toxic metabolite: implications for melanocyte toxicity","volume":"27","author":"Ito","year":"2014","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0265","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/pcmr.12300","article-title":"Human tyrosinase is able to oxidize both enantiomers of rhododendrol","volume":"27","author":"Ito","year":"2014","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0270","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/pcmr.12363","article-title":"Tyrosinase-catalyzed metabolism of rhododendrol (RD) in B16 melanoma cells: production of RD-pheomelanin and covalent binding with thiol proteins","volume":"28","author":"Ito","year":"2015","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0275","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jdermsci.2012.04.009","article-title":"N-propionyl-4-S-cysteaminylphenol induces apoptosis in B16F1 cells and mediates tumor-specific T-cell immune responses in a mouse melanoma model","volume":"67","author":"Ishii-Osai","year":"2012","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0280","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1539\/joh.40.118","article-title":"Occupational leukoderma in workers engaged in 4-(p-hydroxyphenyl)-2-butanone manufacturing","volume":"40","author":"Fukuda","year":"1998","journal-title":"J. Occup. Health"},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0285","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1248\/bpb.29.1970","article-title":"Melanogenesis inhibitory and free radicalscavenging activities of diarylheptanoids and other phenolic compounds from the bark of Acer nikoense","volume":"29","author":"Akazawa","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0290","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jdermsci.2015.01.006","article-title":"4-(4-Hydroroxyphenyl)-2-butanol (rhododendrol) activates the autophagy-lysosome pathway in melanocytes: insights into the mechanisms of rhododendrol-induced leukoderma","volume":"77","author":"Yang","year":"2015","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0295","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1600-0749.1988.tb00138.x","article-title":"Initial mushroom tyrosinase-catalyzed oxidation product of 4-hydroxyanisole is 4-methoxy-ortho-benzoquinone","volume":"1","author":"Naish","year":"1988","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0300","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1021\/tx900018q","article-title":"A reactive ortho-quinone generated by tyrosinase-catalyzed oxidation of the skin depigmentation agent monobenzene: self coupling and thiol-conjugation reactions and possible implications for melanocyte toxicity","volume":"22","author":"Manini","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0305","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/jid.2011.16","article-title":"Skin-depigmenting agent monobenzon induces potent T-cell autoimmunity toward pigmented cells by tyrosinase haptenation and melanosome autophagy","volume":"131","author":"van den Boorn","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0310","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1038\/jid.2009.39","article-title":"N-propionyl-cysteaminylphenol-magnetite conjugate (NPrCAP\/M) is a nanoparticle for the targeted growth suppression of melanoma cells","volume":"129","author":"Sato","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0315","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1016\/S0026-895X(25)13536-0","article-title":"Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro","volume":"14","author":"Graham","year":"1978","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0320","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jdermsci.2015.02.014","article-title":"Possible involvement of CCR4+CD8+ T cells and elevated plasma CCL22 and CCL17 in patients with rhododenol-induced leukoderma","volume":"77","author":"Nishioka","year":"2015","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0325","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jdermsci.2015.01.002","article-title":"An immune pathological and ultrastructural skin analysis for rhododenol-induced leukoderma patients","volume":"77","author":"Tanemura","year":"2015","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2015.07.010_bib0330","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.bcp.2012.06.015","article-title":"Mechanism of putative neo-antigen formation from N-propionyl-4-S-cysteaminylphenol, a tyrosinese substrate, in melanoma models","volume":"84","author":"Ito","year":"2012","journal-title":"Biochem. Pharmacol."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181115300293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181115300293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T18:18:39Z","timestamp":1748542719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181115300293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0923181115300293"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2015.07.010","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of rhododendrol and its metabolic products on melanocytic cell growth","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2015.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}