{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:46:28Z","timestamp":1767703588739},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24650233"],"award-info":[{"award-number":["24650233"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jdsjournal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.jdermsci.2015.10.002","type":"journal-article","created":{"date-parts":[[2015,10,18]],"date-time":"2015-10-18T14:29:12Z","timestamp":1445178552000},"page":"203-211","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["l-tyrosine induces melanocyte differentiation in novel pink-eyed dilution castaneus mouse mutant showing age-related pigmentation"],"prefix":"10.1016","volume":"80","author":[{"given":"Tomohisa","family":"Hirobe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2015.10.002_bib0005","series-title":"The Coat Colors of Mice","author":"Silvers","year":"1979"},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0010","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1034\/j.1600-0749.2003.00067.x","article-title":"The color loci of mice\u2014a genetic century","volume":"16","author":"Bennett","year":"2003","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0015","series-title":"A Model Genetic Network","article-title":"The colors of mice","author":"Lamoreux","year":"2010"},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0020","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1755-148X.2011.00845.x","article-title":"How are proliferation and differentiation of melanocytes regulated?","volume":"24","author":"Hirobe","year":"2011","journal-title":"Pigm. Cell Melan. Res."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0025","doi-asserted-by":"crossref","first-page":"D881","DOI":"10.1093\/nar\/gkr974","article-title":"The Mouse Genome Database Group. The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse","volume":"40","author":"Eppig","year":"2012","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0030","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/jez.1402500310","article-title":"Levels of tyrosinase and its mRNA in coat-color mutants of C57BL\/10J congenic mice: genic substitution at the agouti, brown, albino, dilute, and pink-eyed dilution loci","volume":"250","author":"Tamate","year":"1989","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0035","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/1523-1747.ep12320792","article-title":"Chemical characterization of hair melanins in various coat-color mutants of mice","volume":"105","author":"Ozeki","year":"1995","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0040","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1091\/mbc.02-02-0022.","article-title":"Pink-eyed dilution protein controls the processing of tyrosinase","volume":"13","author":"Chen","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0045","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/jez.10051","article-title":"Effects of genic substitution at the pink-eyed dilution locus on the proliferation and differentiation of mouse epidermal melanocytes in vivo and in vitro","volume":"292","author":"Hirobe","year":"2002","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0050","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/jcp.10085","article-title":"Stimulation of the proliferation and differentiation of mouse pink-eyed dilution epidermal melanocytes by excess tyrosine in serum-free primary culture","volume":"191","author":"Hirobe","year":"2002","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0055","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1034\/j.1600-0749.2002.02007.x","article-title":"The etiology of oculocutaneous albinism (OCA) type II: the pink protein modulates the processing and transport of tyrosinase","volume":"15","author":"Toyofuku","year":"2002","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0060","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/361072a0","article-title":"A gene for the mouse pink-eyed dilution locus and for human type II oculocutaneous albinism","volume":"361","author":"Rinchik","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0065","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/pcmr.12167","article-title":"Increasing the complexity: new genes and new types of albinism","volume":"27","author":"Montoliu","year":"2014","journal-title":"Pigm. Cell Melan. Res."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0070","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1126\/science.257.5073.1121","article-title":"The mouse pink-eyed dilution gene: association with human Prader\u2013Willi and Angelman syndromes","volume":"257","author":"Gardner","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0075","doi-asserted-by":"crossref","first-page":"12071","DOI":"10.1073\/pnas.91.25.12071","article-title":"Identification of a melanosomal membrane protein encoded by the pink-eyed dilution (type II oculocutaneous albinism) gene","volume":"91","author":"Rosemblat","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0080","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1600-0749.1995.tb00668.x","article-title":"Melanosomal tyrosine transport in normal and pink-eyed dilution murine melanocytes","volume":"8","author":"Gahl","year":"1995","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0085","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1046\/j.1523-1747.2000.00108.x","article-title":"Aberrant pH of melanosomes in pink-eyed dilution (p) mutant melanocytes","volume":"115","author":"Puri","year":"2000","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0090","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1091\/mbc.E08-07-0710","article-title":"Localization to mature melanosomes by virtue of cytoplasmic dileucine motifs is required for human OCA2 function","volume":"20","author":"Sitaram","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0095","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1046\/j.1600-0749.2003.00091.x","article-title":"Changes in the proliferation and differentiation of neonatal mouse pink-eyed dilution melanocytes in the presence of excess tyrosine","volume":"16","author":"Hirobe","year":"2003","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0100","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1600-0749.2007.00370.x","article-title":"High levels of melanin-related metabolites in plasma from pink-eyed dilution mice","volume":"20","author":"Wakamatsu","year":"2007","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0105","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2108\/zsj.25.1057","article-title":"Mitochondria are more numerous and smaller in pink-eyed dilution melanoblasts than in wild-type melanocytes in the neonatal mouse epidermis","volume":"25","author":"Hirobe","year":"2008","journal-title":"Zool. Sci."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0110","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2108\/zsj.29.725","article-title":"Reduced proliferative and differentiative activity of mouse pink-eyed dilution melanoblasts is related to apoptosis","volume":"29","author":"Hirobe","year":"2012","journal-title":"Zool. Sci."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0115","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1538\/expanim.44.347","article-title":"A new spontaneous allele at the pink-eyed dilution (p) locus discovered in Mus musculus castaneus","volume":"44","author":"Tsuji","year":"1995","journal-title":"Exp. Anim."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0120","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1538\/expanim.14-0101","article-title":"Development of a novel pink-eyed dilution mouse model showing progressive darkening of the eyes and coat hair with aging","volume":"64","author":"Ishikawa","year":"2015","journal-title":"Exp. Anim."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0125","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/gtc.12117","article-title":"Insertion of long interspersed element-1 in the Mitf gene is associated with altered neurobehavior of the black-eyed white Mitfmi\u2212bw mouse","volume":"19","author":"Takeda","year":"2014","journal-title":"Genes Cells"},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0130","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/ng.185","article-title":"A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse","volume":"40","author":"Pielberg","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0135","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev-animal-031412-103659","article-title":"Genetics of pigmentation in dogs and cats","volume":"1","author":"Kaelin","year":"2013","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0140","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0092-8674(85)80017-9","article-title":"Greying with age in mice: relation to expression of murine leukemia viruses","volume":"41","author":"Morse","year":"1985","journal-title":"Cell"},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0145","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1126\/science.1099593","article-title":"Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche","volume":"307","author":"Nishimura","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0150","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1034\/j.1600-0749.2002.02035.x","article-title":"Changes in the proliferative activity of epidermal melanocytes in serum-free primary culture during the development of ultraviolet radiation B-induced pigmented spots in hairless mice","volume":"15","author":"Furuya","year":"2002","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0155","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0749.2004.00198.x","article-title":"Role of keratinocyte-derived factors involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes","volume":"18","author":"Hirobe","year":"2005","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0160","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1755-148X.2012.01032.x","article-title":"Adam10 haploinsufficiency causes freckle-like macules in Hairless mice","volume":"25","author":"Tharmarajah","year":"2012","journal-title":"Pigm. Cell Melan. Res."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0165","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1034\/j.1600-0749.2003.00037.x","article-title":"A chemist\u2019s view of melanogenesis","volume":"16","author":"Ito","year":"2003","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0170","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1755-148X.2011.00898.x","article-title":"l-tyrosine and l-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions","volume":"25","author":"Slominski","year":"2012","journal-title":"Pigm. Cell Melan. Res."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0175","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1600-0749.2003.00126.x","article-title":"Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders","volume":"17","author":"Imokawa","year":"2004","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0180","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1600-0749.1997.tb00488.x","article-title":"The role of endothelin-1 in epidermal hyperpigmentation and signaling mechanisms of mitogenesis and melanogenesis","volume":"10","author":"Imokawa","year":"1997","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0185","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1242\/dev.125.15.2915","article-title":"Transgene expression of steel factor in the basal layer of epidermis promotes survival, proliferation, differentiation and migration of melanocyte precursors","volume":"125","author":"Kunisada","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0190","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0925-4773(00)00308-7","article-title":"Keratinocyte expression of transgenic hepatocyte growth factor affects melanocyte development, leading to dermal melanocytosis","volume":"94","author":"Kunisada","year":"2000","journal-title":"Mech. Dev."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0195","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1006\/excr.1997.3901","article-title":"Melanosomal defects in melanocytes from mice lacking expression of the pink-eyed dilution gene: correction by culture in the presence of excess tyrosine","volume":"239","author":"Rosemblat","year":"1998","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0200","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/1523-1747.ep12285621","article-title":"Complementation of hypopigmentation in p-mutant (pink-eyed dilution) mouse melanocytes by normal human P cDNA, and defective complementation by OCA2 mutant sequences","volume":"108","author":"Sviderskaya","year":"1997","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0205","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/exer.1993.1128","article-title":"Postnatal ocular expression of tyrosinase and related proteins: disruption by the pink-eyed unstable (pun) mutation","volume":"57","author":"Chiu","year":"1993","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.jdermsci.2015.10.002_bib0210","series-title":"The Pigmentary System Physiology and Pathophysiology","first-page":"59","article-title":"Extracutaneous melanocytes","author":"Boissy","year":"1998"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181115300542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181115300542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T13:48:01Z","timestamp":1653313681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181115300542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0923181115300542"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2015.10.002","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"l-tyrosine induces melanocyte differentiation in novel pink-eyed dilution castaneus mouse mutant showing age-related pigmentation","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2015.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}