{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:03:19Z","timestamp":1790132599313,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25461682"],"award-info":[{"award-number":["25461682"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jdsjournal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.jdermsci.2016.05.015","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T17:52:18Z","timestamp":1464285138000},"page":"167-173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Tumor-associated macrophages in skin: How to treat their heterogeneity and plasticity"],"prefix":"10.1016","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-5833","authenticated-orcid":false,"given":"Taku","family":"Fujimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Kakizaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadanori","family":"Furudate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Kambayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setsuya","family":"Aiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2016.05.015_bib0005","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.immuni.2014.06.010","article-title":"Tumor-associated macrophages: from mechanisms to therapy","volume":"41","author":"Noy","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0010","doi-asserted-by":"crossref","first-page":"279ra41","DOI":"10.1126\/scitranslmed.aaa4691","article-title":"Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma","volume":"7","author":"Hu-Lieskovan","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0015","doi-asserted-by":"crossref","first-page":"e1047584","DOI":"10.1080\/2162402X.2015.1047584","article-title":"Immunomodulatory effect of peritumoral administration of interferon-beta on melanoma through tumor-associated macrophages","volume":"4","author":"Kakizaki","year":"2015","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0020","doi-asserted-by":"crossref","DOI":"10.1097\/DSS.0000000000000371","article-title":"Density and polarization states of tumor-associated macrophages in human cutaneous squamous cell carcinomas arising in solid organ transplant recipients","author":"Cyrus","year":"2016","journal-title":"Dermatol. Surg."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdermsci.2016.04.013","article-title":"Cutaneous squamous cell carcinomas with markers of increased metastatic risk are associated with elevated numbers of neutrophils and\/or granulocytic myeloid derived suppressor cells","author":"Seddon","year":"2016","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0030","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1038\/jid.2015.199","article-title":"The possible interaction between receptor activator of nuclear factor kappa-B ligand (RANKL) expressed by extramammary Paget cells and its ligand on dermal macrophages","volume":"135","author":"Kambayashi","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0035","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1038\/jid.2015.209","article-title":"Receptor activator of nuclear factor kappa-B ligand (RANKL) promotes the production of CCL17 from RANK+ M2 macrophages","volume":"135","author":"Fujimura","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0040","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/exd.12873","article-title":"The possible interaction between periostin expressed by cancer stroma and tumor-associated macrophages in developing mycosis fungoides","volume":"25","author":"Furudate","year":"2016","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0045","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jdermsci.2012.07.007","article-title":"Association of the numbers of CD163(+) cells in lesional skin and serum levels of soluble CD163 with disease progression of cutaneous T cell lymphoma","volume":"68","author":"Sugaya","year":"2012","journal-title":"J. Dermatol. Sci."},{"issue":"Pt B","key":"10.1016\/j.jdermsci.2016.05.015_bib0050","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.addr.2015.11.009","article-title":"Tumor-associated macrophages: potential therapeutic targets for anti-cancer therapy","volume":"99","author":"Komohara","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0055","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.imbio.2014.10.001","article-title":"Myeloid cells in cancer-related inflammation","volume":"220","author":"Caronni","year":"2015","journal-title":"Immunobiology"},{"issue":"7203","key":"10.1016\/j.jdermsci.2016.05.015_bib0060","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0065","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1101\/gad.1874010","article-title":"IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion","volume":"24","author":"Gocheva","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0070","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1023\/A:1020399802795","article-title":"The macrophage growth factor CSF-1 in mammary gland development and tumor progression","volume":"7","author":"Lin","year":"2002","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0075","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/jid.2011.9","article-title":"Tumor-associated macrophages in the cutaneous SCC microenvironment are heterogeneously activated","volume":"131","author":"Pettersen","year":"2011","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdermsci.2016.05.004","article-title":"Tumor-associated M2 macrophages in mycosis fungoides acquire immunomodulatory function by interferon alpha and interferon gamma","author":"Furudate","year":"2016","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0085","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0090","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1038\/jid.2014.206","article-title":"Depletion of M2-like tumor-associated macrophages delays cutaneous T-cell lymphoma development in vivo","volume":"134","author":"Wu","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0095","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1182\/blood-2006-06-031856","article-title":"L-arginine availability reglates T-lymphocyte cell-cycle progression","volume":"109","author":"Rodriguez","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jdermsci.2010.05.001","article-title":"Myeloid derived suppressor cells and their role in tolerance induction in cancer","volume":"59","author":"Fujimura","year":"2010","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0105","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1158\/0008-5472.CAN-14-3590","article-title":"CCL5-mediated th2 immune polarization promotes metastasis in luminal breast cancer","volume":"75","author":"Zhang","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0110","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.4049\/jimmunol.1004175","article-title":"Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells","volume":"187","author":"Getts","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0115","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/jid.2011.416","article-title":"Regulatory T cells (Treg) stimulate B7-H1 expression in myeloid derived suppressor cells (MDSC) in ret melanomas","volume":"132","author":"Fujimura","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0120","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/path.3989","article-title":"Vascular endothelial growth factor-induced skin carcinogenesis depends on recruitment and alternative activation of macrophages","volume":"227","author":"Linde","year":"2012","journal-title":"J. Pathol."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0125","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nm1609","article-title":"Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer","volume":"13","author":"Nagaraj","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0130","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1600-0625.2008.00779.x","article-title":"Immune modulation by melanoma-derived factors","volume":"17","author":"Ilkovitch","year":"2008","journal-title":"Exp. Dermatol."},{"issue":"7355","key":"10.1016\/j.jdermsci.2016.05.015_bib0135","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature10138","article-title":"CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis","volume":"475","author":"Qian","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0140","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1158\/1078-0432.CCR-15-0204","article-title":"CCL2 and CCL5 are novel therapeutic targets for estrogen-dependent breast cancer","volume":"21","author":"Svensson","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0145","doi-asserted-by":"crossref","first-page":"843","DOI":"10.2217\/imt.15.52","article-title":"Regulatory T cells in cancer; can they be controlled","volume":"7","author":"Adeegbe","year":"2015","journal-title":"Immunotherapy"},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0150","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/CMR.0000000000000045","article-title":"Melanoma brain metastasis globally reconfigures chemokine and cytokine profiles in patient cerebrospinal fluid","volume":"24","author":"Lok","year":"2014","journal-title":"Melanoma Res."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0155","doi-asserted-by":"crossref","DOI":"10.1111\/exd.12949","article-title":"Receptor activator of nuclear factor kappa-B ligand (RANKL)\/RANK signaling promotes cancer-related inflammation through M2 macrophages","author":"Fujimura","year":"2016","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0160","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1158\/0008-5472.CAN-14-3590","article-title":"CCL5-Mediated th2 immune polarization promotes metastasis in luminal breast cancer","volume":"75","author":"Zhang","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0165","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1200\/JCO.2014.60.3969","article-title":"Phase II investigator-initiated study of brentuximab vedotin in mycosis fungoides and S\u00e9zary syndrome with variable CD30 expression level: a multi-Institution collaborative project","volume":"33","author":"Kim","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0170","doi-asserted-by":"crossref","first-page":"600","DOI":"10.2340\/00015555-2016","article-title":"Comparison of CD163+ macrophagess and CD206+ cells in the lesional skin of CD30+ lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma","author":"Kakizaki","year":"2015","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0175","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.ajpath.2011.05.040","article-title":"Up-regulation of the chemokine CCL18 by macrophages is a potential immunomodulatory pathway in cutaneous T-cell lymphoma","volume":"179","author":"G\u00fcnther","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0180","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1158\/1078-0432.CCR-14-3322","article-title":"The use of transcriptional profiling to improve personalized diagnosis and management of cutaneous T-cell lymphoma (CTCL)","volume":"21","author":"Litvinov","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0185","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jaad.2011.09.002","article-title":"Merkel cell carcinoma induces lymphatic microvessel formation","volume":"67","author":"Werchau","year":"2012","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0190","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0092-8674(02)00754-7","article-title":"Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-Ligand","volume":"109","author":"Heissig","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0195","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1038\/onc.2013.184","article-title":"Osteopontin signaling upregulates cyclooxygenase-2 expression in tumor-associated macrophages leading to enhanced angiogenesis and melanoma growth via \u03b19\u03b21 integrin","volume":"33","author":"Kale","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0200","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/1479-5876-9-177","article-title":"Tumour macrophages as potential targets of bisphosphonates","volume":"9","author":"Rogers","year":"2011","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0205","doi-asserted-by":"crossref","first-page":"11438","DOI":"10.1158\/0008-5472.CAN-07-1882","article-title":"Colombo MP. Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid derived suppressor cell expansion and macrophage infiltration in tumor stroma","volume":"67","author":"Melani","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0210","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1158\/0008-5472.CAN-12-2731","article-title":"Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses","volume":"73","author":"Mitchem","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0215","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.4049\/jimmunol.1202781","article-title":"Antitumor effect of paclitaxel is mediated by inhibition of myeloid-derived suppressor cells and chronic inflammation in the spontaneous melanoma model","volume":"190","author":"Sevko","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0220","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nm.2999","article-title":"Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth","volume":"19","author":"Bruchard","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0225","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.1158\/1078-0432.CCR-10-0733","article-title":"A novel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers","volume":"16","author":"Kodumudi","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0230","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jdermsci.2011.02.002","article-title":"A synthetic NOD2 agonist, muramyl dipeptide (MDP)-Lys (L18) and IFN-b synergistically induce dendritic cell maturation with augmented IL-12 production and suppress melanoma growth","volume":"62","author":"Fujimura","year":"2011","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0235","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jdermsci.2014.11.010","article-title":"Real-time imaging of interaction between macrophages and lymphatic vessels in an in vitro model to study inflammatory resolution","volume":"77","author":"Matsumoto-Okazaki","year":"2015","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0240","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/1346-8138.12346","article-title":"Japanese Skin Cancer Society \u2013 Lymphoma Study Group. current therapy of choice for cutaneous lymphomas: complementary to the Japanese Dermatological Association\/Japanese Skin Cancer Society guidelines","volume":"41","author":"Iwatsuki","year":"2014","journal-title":"J. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0245","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1158\/0008-5472.CAN-15-1737","article-title":"A Breakthrough: macrophage-directed cancer immunotherapy","volume":"76","author":"Mills","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.jdermsci.2016.05.015_bib0250","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jdermsci.2014.01.006","article-title":"Metastatic melanoma cell lines do not secrete IL-1\u03b2 but promote IL-1\u03b2 production from macrophages","volume":"74","author":"Gehrke","year":"2014","journal-title":"J. Dermatol. Sci."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181116301025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181116301025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T19:07:17Z","timestamp":1567969637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181116301025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0923181116301025"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2016.05.015","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor-associated macrophages in skin: How to treat their heterogeneity and plasticity","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2016.05.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}