{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:00:48Z","timestamp":1770825648065,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Hangzhou Science and Technology Development Project","award":["20140733Q19"],"award-info":[{"award-number":["20140733Q19"]}]},{"name":"Zhejiang Public Welfare Technology Research & Social Development Project","award":["2016C33206"],"award-info":[{"award-number":["2016C33206"]}]},{"name":"Medical and Health Science and Technology Project of Zhejiang Province","award":["2014KYB200"],"award-info":[{"award-number":["2014KYB200"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jdsjournal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.jdermsci.2016.07.006","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T03:37:02Z","timestamp":1468553822000},"page":"40-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["The changes of gene expression profiling between segmental vitiligo, generalized vitiligo and healthy individual"],"prefix":"10.1016","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6206-8073","authenticated-orcid":false,"given":"Ping","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiqiong","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiongyan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuli","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weisong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2016.07.006_bib0005","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1034\/j.1600-0749.2003.00032.x","article-title":"Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families","volume":"16","author":"Alkhateeb","year":"2003","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0010","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1365-4632.2009.03770.x","article-title":"Case detection rates of vitiligo by gender and age","volume":"48","author":"Kyriakis","year":"2009","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0015","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2174\/138920010791526105","article-title":"Vitiligo: pathogenetic hypotheses and targets for current therapies","volume":"11","author":"Guerra","year":"2010","journal-title":"Curr. Drug Metab."},{"issue":"Suppl","key":"10.1016\/j.jdermsci.2016.07.006_bib0020","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaut.2005.10.001","article-title":"Physiopathology and genetics of vitiligo","volume":"25","author":"Passeron","year":"2005","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0025","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1111\/j.1755-148X.2012.00997.x","article-title":"Revised classification\/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference","volume":"25","author":"Ezzedine","year":"2012","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0030","first-page":"160","article-title":"Clinical practice. Vitiligo","volume":"360","author":"Taieb","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0035","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1600-0749.2006.00333.x","article-title":"A review and a new hypothesis for non-immunological pathogenetic mechanisms in vitiligo","volume":"19","author":"Dell\u2fffanna","year":"2006","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0040","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1087-0024.2004.00825.x","article-title":"Autoimmune aspects of depigmentation in vitiligo","volume":"9","author":"Le Poole","year":"2004","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0045","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/sj.jid.5700001","article-title":"Cytotoxic T cells","volume":"126","author":"Andersen","year":"2006","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0050","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1600-0749.2005.00244.x","article-title":"Melanocyte-specific, cytotoxic T cell responses in vitiligo: the effective variant of melanoma immunity?","volume":"18","author":"Garbelli","year":"2005","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0055","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.4049\/jimmunol.177.5.3055","article-title":"CD4T cell-dependent autoimmunity against a melanocyte neoantigen induces spontaneous vitiligo and depends upon Fas-Fas ligand interactions","volume":"177","author":"Lambe","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0060","first-page":"1219","article-title":"Presence of T cells and macrophages in inflammatory vitiligo skin parallels melanocyte disappearance","volume":"148","author":"Le Poole","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0065","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/labinvest.3780138","article-title":"Local immune response in skin of generalized vitiligo patients. Destruction of melanocytes is associated with the prominent presence of CLA+ T cells at the perilesional site","volume":"80","author":"van den Wijngaard","year":"2000","journal-title":"Lab. Invest."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0070","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1038\/jid.2009.32","article-title":"Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients","volume":"129","author":"van den Boorn","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0075","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jaad.2008.09.048","article-title":"The role of helper and regulatory T cells in the pathogenesis of vitiligo","volume":"60","author":"Basak","year":"2009","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0080","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1084\/jem.188.6.1203","article-title":"High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo","volume":"188","author":"Ogg","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0085","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1046\/j.1523-1747.2003.12413.x","article-title":"Cytotoxic T lymphocyte reactivity to gp100, MelanA\/MART-1, and tyrosinase, in HLA-A2-positive vitiligo patients","volume":"121","author":"Mandelcorn-Monson","year":"2003","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0090","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1046\/j.1523-1747.2001.01408.x","article-title":"Specific cytotoxic T lymphocyte responses against Melan-A\/MART1, tyrosinase and gp100 in vitiligo by the use of major histocompatibility complex\/peptide tetramers: the role of cellular immunity in the etiopathogenesis of vitiligo","volume":"117","author":"Palermo","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0095","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1600-0749.2007.00384.x","article-title":"The genetics of generalized vitiligo and associated autoimmune diseases","volume":"20","author":"Spritz","year":"2007","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0100","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1056\/NEJMoa061592","article-title":"NALP1 in vitiligo-associated multiple autoimmune disease","volume":"356","author":"Jin","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0105","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1038\/sj.jid.5700953","article-title":"Genetic variations in NALP1 are associated with generalized vitiligo in a Romanian population","volume":"127","author":"Jin","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0110","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1600-0749.2007.00393.x","article-title":"NALP1 and the inflammasomes: challenging our perception of vitiligo and vitiligo-related autoimmune disorders","volume":"20","author":"Taieb","year":"2007","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0115","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1034\/j.1600-0749.2001.140608.x","article-title":"\u2fffVIT1\u2fff, a novel gene associated with vitiligo","volume":"14","author":"Le Poole","year":"2001","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0120","first-page":"673","article-title":"VIT1\/FBXO11 knockdown induces morphological alterations and apoptosis in B10BR mouse melanocytes","volume":"23","author":"Li","year":"2009","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0125","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1038\/sj.jid.5701233","article-title":"PTPN22 is genetically associated with risk of generalized vitiligo, but CTLA4 is not","volume":"128","author":"LaBerge","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0130","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1038\/jid.2009.143","article-title":"Genetic polymorphisms of glutathione S-transferase and risk of vitiligo in the Chinese population","volume":"129","author":"Liu","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0135","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1080\/000155500300012918","article-title":"Increased basic fibroblast growth factor levels in serum and blister fluid from patients with vitiligo","volume":"80","author":"Ozdemir","year":"2000","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0140","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1111\/j.1365-4632.2006.02744.x","article-title":"Increased tumor necrosis factor alpha (TNF-alpha) and interleukin 1 alpha (IL1-alpha) levels in the lesional skin of patients with nonsegmental vitiligo","volume":"45","author":"Birol","year":"2006","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0145","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1600-0625.2007.00666_2.x","article-title":"Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else?","volume":"17","author":"Schallreuter","year":"2008","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0150","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-0749.2006.00355.x","article-title":"The definition and assessment of vitiligo: a consensus report of the Vitiligo European Task Force","volume":"20","author":"Taieb","year":"2007","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0155","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0160","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0165","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/bioinformatics\/bth078","article-title":"Open source clustering software","volume":"20","author":"de Hoon","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0170","doi-asserted-by":"crossref","first-page":"14863","DOI":"10.1073\/pnas.95.25.14863","article-title":"Cluster analysis and display of genome-wide expression patterns","volume":"95","author":"Eisen","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0175","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0185","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1038\/nprot.2007.324","article-title":"Integration of biological networks and gene expression data using Cytoscape","volume":"2","author":"Cline","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0190","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","article-title":"ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks","volume":"25","author":"Bindea","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0195","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1034\/j.1600-0749.2003.00023.x","article-title":"Evidence for an autoimmune pathogenesis of vitiligo","volume":"16","author":"Ongenae","year":"2003","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0200","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1111\/j.1600-0625.2009.01039.x","article-title":"Association of UVRAG polymorphisms with susceptibility to non-segmental vitiligo in a Korean sample","volume":"19","author":"Jeong","year":"2010","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0205","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.4161\/auto.21212","article-title":"Autophagy in immunity: implications in etiology of autoimmune\/autoinflammatory diseases","volume":"8","author":"Zhou","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0210","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1046\/j.0022-202x.2001.01459.x","article-title":"Mitochondrial impairment in peripheral blood mononuclear cells during the active phase of vitiligo","volume":"117","author":"Dell\u2fffAnna","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0215","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcp.22027","article-title":"Membrane lipid defects are responsible for the generation of reactive oxygen species in peripheral blood mononuclear cells from vitiligo patients","volume":"223","author":"Dell\u2fffAnna","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0220","first-page":"849","article-title":"Keratinocyte dysfunction in vitiligo epidermis: cytokine microenvironment and correlation to keratinocyte apoptosis","volume":"24","author":"Moretti","year":"2009","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0225","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/j.1365-2133.2004.06136.x","article-title":"Keratinocytes in the depigmented epidermis of vitiligo are more vulnerable to trauma (suction) than keratinocytes in the normally pigmented epidermis, resulting in their apoptosis","volume":"151","author":"Lee","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0230","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/1523-1747.ep12500086","article-title":"Extracellular granular material and degeneration of keratinocytes in the normally pigmented epidermis of patients with vitiligo","volume":"79","author":"Moellmann","year":"1982","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0235","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1600-0749.2007.00385.x","article-title":"Keratinocyte cultures from involved skin in vitiligo patients show an impaired in vitro behaviour","volume":"20","author":"Bondanza","year":"2007","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0240","doi-asserted-by":"crossref","first-page":"223ra223","DOI":"10.1126\/scitranslmed.3007811","article-title":"CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo","volume":"6","author":"Rashighi","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jdermsci.2016.07.006_bib0245","first-page":"567","article-title":"Genetics of pigment cells: lessons from the tyrosinase gene family","volume":"21","author":"Murisier","year":"2006","journal-title":"Histol. Histopathol."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181116301530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181116301530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T07:11:27Z","timestamp":1718694687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181116301530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0923181116301530"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2016.07.006","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The changes of gene expression profiling between segmental vitiligo, generalized vitiligo and healthy individual","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2016.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}