{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:21:29Z","timestamp":1787505689534,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy, Korea","doi-asserted-by":"crossref","award":["2017-10063396"],"award-info":[{"award-number":["2017-10063396"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","jdsjournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.jdermsci.2017.11.004","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T23:47:22Z","timestamp":1511221642000},"page":"165-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["A novel anti-melanogenic agent, KDZ-001, inhibits tyrosinase enzymatic activity"],"prefix":"10.1016","volume":"89","author":[{"given":"Kyu-Seok","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Yoon","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jooyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ri","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Soon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geum Ran","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Sil","family":"Chae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hee","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Seop","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Ae","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2017.11.004_bib0005","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0076-6879(04)78005-2","article-title":"Quinone chemistry and melanogenesis","volume":"378","author":"Land","year":"2004","journal-title":"Methods Enzymol."},{"issue":"1","key":"10.1016\/j.jdermsci.2017.11.004_bib0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1600-0749.2005.00288.x","article-title":"Tyrosinase maturation through the mammalian secretory pathway: bringing color to life","volume":"19","author":"Wang","year":"2006","journal-title":"Pigm. Cell Res."},{"issue":"2","key":"10.1016\/j.jdermsci.2017.11.004_bib0015","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1046\/j.1523-1747.1999.00653.x","article-title":"The role of melanin in the induction of oxidative DNA base damage by ultraviolet A irradiation of DNA or melanoma cells","volume":"113","author":"Kvam","year":"1999","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.jdermsci.2017.11.004_bib0020","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0190-9622(79)70018-1","article-title":"Photoprotection by melanin\u2014a comparison of black and Caucasian skin","volume":"1","author":"Kaidbey","year":"1979","journal-title":"J. Am. Acad. Dermatol."},{"issue":"2","key":"10.1016\/j.jdermsci.2017.11.004_bib0025","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1600-0625.1999.tb00365.x","article-title":"What's the use of generating melanin?","volume":"8","author":"Wood","year":"1999","journal-title":"Exp. Dermatol."},{"issue":"3","key":"10.1016\/j.jdermsci.2017.11.004_bib0030","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1034\/j.1600-0749.2001.140303.x","article-title":"Redox regulation in human melanocytes and melanoma","volume":"14","author":"Meyskens","year":"2001","journal-title":"Pigm. Cell Res."},{"issue":"12","key":"10.1016\/j.jdermsci.2017.11.004_bib0035","doi-asserted-by":"crossref","first-page":"5326","DOI":"10.3390\/ijms10125326","article-title":"The hunt for natural skin whitening agents","volume":"10","author":"Smit","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jdermsci.2017.11.004_bib0040","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1242\/dev.124.12.2377","article-title":"Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor","volume":"124","author":"Opdecamp","year":"1997","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.jdermsci.2017.11.004_bib0045","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1083\/jcb.142.3.827","article-title":"Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes","volume":"142","author":"Bertolotto","year":"1998","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.jdermsci.2017.11.004_bib0050","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1128\/MCB.18.2.694","article-title":"Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia","volume":"18","author":"Bertolotto","year":"1998","journal-title":"Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.jdermsci.2017.11.004_bib0055","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1034\/j.1600-0749.2000.130404.x","article-title":"MITF: a stream flowing for pigment cells","volume":"13","author":"Tachibana","year":"2000","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.jdermsci.2017.11.004_bib0060","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.1038\/skinbio.2011.4","article-title":"Determination of melanin synthetic pathways","volume":"131","author":"Hearing","year":"2011","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2017.11.004_bib0065","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0167-4889(98)00176-1","article-title":"Effects of lithium on pigmentation in the embryonic zebrafish (Brachydanio rerio)","volume":"1449","author":"Jin","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.jdermsci.2017.11.004_bib0070","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s004270000125","article-title":"Tyrosinase gene expression in zebrafish embryos","volume":"211","author":"Camp","year":"2001","journal-title":"Dev. Genes Evol."},{"issue":"17","key":"10.1016\/j.jdermsci.2017.11.004_bib0075","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1242\/dev.126.17.3757","article-title":"Nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate","volume":"126","author":"Lister","year":"1999","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.jdermsci.2017.11.004_bib0080","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1600-0749.2007.00365.x","article-title":"Zebrafish as a new model for phenotype-based screening of melanogenic regulatory compounds","volume":"20","author":"Choi","year":"2007","journal-title":"Pigm. Cell Res."},{"issue":"10","key":"10.1016\/j.jdermsci.2017.11.004_bib0085","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrd4627","article-title":"Zebrafish as tools for drug discovery","volume":"14","author":"MacRae","year":"2015","journal-title":"Nat. Rev. Drug. Discov."},{"issue":"3","key":"10.1016\/j.jdermsci.2017.11.004_bib0090","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/jid.2009.280","article-title":"Impact of NAD (P) H: quinone oxidoreductase-1 on pigmentation","volume":"130","author":"Choi","year":"2010","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2017.11.004_bib0095","series-title":"The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish (Danio Rerio)","author":"Westerfield","year":"2000"},{"key":"10.1016\/j.jdermsci.2017.11.004_bib0100","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/bioinformatics\/bti770","article-title":"The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling","volume":"22","author":"Arnold","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jdermsci.2017.11.004_bib0105","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/bioinformatics\/btq662","article-title":"Toward the estimation of the absolute quality of individual protein structure models","volume":"27","author":"Benkert","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jdermsci.2017.11.004_bib0110","doi-asserted-by":"crossref","first-page":"W252","DOI":"10.1093\/nar\/gku340","article-title":"SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information","volume":"42","author":"Biasini","year":"2014","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.jdermsci.2017.11.004_bib0115","doi-asserted-by":"crossref","first-page":"D214","DOI":"10.1093\/nar\/gkq1020","article-title":"The UniProt consortium, ongoing and future developments at the universal protein resource","volume":"39","year":"2011","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.jdermsci.2017.11.004_bib0120","doi-asserted-by":"crossref","first-page":"12965","DOI":"10.1073\/pnas.97.24.12965","article-title":"Small molecule developmental screens reveal the logic and timing of vertebrate development","volume":"97","author":"Peterson","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.jdermsci.2017.11.004_bib0125","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.biochi.2010.11.014","article-title":"Interaction of sesamol (3, 4-methylenedioxyphenol) with tyrosinase and its effect on melanin synthesis","volume":"93","author":"Kumar","year":"2011","journal-title":"Biochimie"},{"issue":"5","key":"10.1016\/j.jdermsci.2017.11.004_bib0130","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/1523-1747.ep12560926","article-title":"Specific incorporation of 4-S-cysteinylphenol into human melanoma cells","volume":"90","author":"Nakamura","year":"1988","journal-title":"J. Invest. Dermatol."},{"issue":"7","key":"10.1016\/j.jdermsci.2017.11.004_bib0135","doi-asserted-by":"crossref","first-page":"e1000544","DOI":"10.1371\/journal.pgen.1000544","article-title":"Defects in ErbB-dependent establishment of adult melanocyte stem cells reveal independent origins for embryonic and regeneration melanocytes","volume":"5","author":"Hultman","year":"2009","journal-title":"PLoS Genet."},{"issue":"8","key":"10.1016\/j.jdermsci.2017.11.004_bib0140","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/exd.12195","article-title":"Novel inhibitory effect of the antidiabetic drug voglibose on melanogenesis","volume":"22","author":"Bin","year":"2013","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jdermsci.2017.11.004_bib0145","series-title":"Enzymatic Browning and Its Prevention","first-page":"64","article-title":"Tyrosinase: molecular and active-site structure","author":"Lerch","year":"1995"},{"issue":"6","key":"10.1016\/j.jdermsci.2017.11.004_bib0150","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1034\/j.1600-0749.2001.140603.x","article-title":"Tyrp1 and oculocutaneous albinism type 3","volume":"14","author":"Sarangarajan","year":"2001","journal-title":"Pigm. Cell Res."},{"issue":"5","key":"10.1016\/j.jdermsci.2017.11.004_bib0155","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1600-0749.1992.tb00547.x","article-title":"Functional properties of cloned melanogenic proteins","volume":"5","author":"Hearing","year":"1992","journal-title":"Pigm. Cell Res."},{"issue":"48","key":"10.1016\/j.jdermsci.2017.11.004_bib0160","doi-asserted-by":"crossref","first-page":"31801","DOI":"10.1074\/jbc.273.48.31801","article-title":"Tyrosinase stabilization by Tyrp1 (the brown locus protein)","volume":"273","author":"Kobayashi","year":"1998","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181117309775?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181117309775?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T15:09:07Z","timestamp":1659884947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181117309775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S0923181117309775"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2017.11.004","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel anti-melanogenic agent, KDZ-001, inhibits tyrosinase enzymatic activity","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2017.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}