{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:27:05Z","timestamp":1764174425740},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","jdsjournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.jdermsci.2017.11.011","type":"journal-article","created":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T05:00:13Z","timestamp":1512190813000},"page":"241-247","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Activation of PKB\/Akt and p44\/42 by mechanical stretch utilizes desmosomal structures and the keratin filament"],"prefix":"10.1016","volume":"89","author":[{"given":"Stefan","family":"Kippenberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Kleemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Meissner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Steinhorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutta","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos C.","family":"Zouboulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadja","family":"Z\u00f6ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5317","key":"10.1016\/j.jdermsci.2017.11.011_bib0005","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1126\/science.276.5317.1425","article-title":"Geometric control of cell life and death","volume":"276","author":"Chen","year":"1997","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.jdermsci.2017.11.011_bib0010","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1074\/jbc.M409590200","article-title":"Mechanical stretch stimulates protein kinase B\/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor","volume":"280","author":"Kippenberger","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.jdermsci.2017.11.011_bib0015","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/BF00505641","article-title":"A new model of epidermal differentiation: induction by mechanical stimulation","volume":"282","author":"Gormar","year":"1990","journal-title":"Arch. Dermatol. Res."},{"issue":"3","key":"10.1016\/j.jdermsci.2017.11.011_bib0020","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1046\/j.1523-1747.2000.00915.x","article-title":"Signaling of mechanical stretch in human keratinocytes via MAP kinases","volume":"114","author":"Kippenberger","year":"2000","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2017.11.011_bib0025","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/(SICI)1097-4652(199710)173:1<64::AID-JCP8>3.0.CO;2-H","article-title":"Effect of strain on human keratinocytes in vitro","volume":"173","author":"Takei","year":"1997","journal-title":"J. Cell Physiol."},{"issue":"2\u20133","key":"10.1016\/j.jdermsci.2017.11.011_bib0030","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pbiomolbio.2008.02.005","article-title":"Tensegrity-based mechanosensing from macro to micro","volume":"97","author":"Ingber","year":"2008","journal-title":"Prog. Biophys. Mol. Biol."},{"issue":"5","key":"10.1016\/j.jdermsci.2017.11.011_bib0035","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.0906-6705.2006.00425.x","article-title":"Activation of Akt by mechanical stretching in human epidermal keratinocytes","volume":"15","author":"Yano","year":"2006","journal-title":"Exp. Dermatol."},{"issue":"Pt 14","key":"10.1016\/j.jdermsci.2017.11.011_bib0040","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1113\/jphysiol.2011.207829","article-title":"Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes","volume":"589","author":"Mihara","year":"2011","journal-title":"J. Physiol."},{"issue":"5","key":"10.1016\/j.jdermsci.2017.11.011_bib0045","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.devcel.2004.08.021","article-title":"Activation of a signaling cascade by cytoskeleton stretch","volume":"7","author":"Tamada","year":"2004","journal-title":"Dev. Cell"},{"issue":"4","key":"10.1016\/j.jdermsci.2017.11.011_bib0050","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1096\/fj.12-215632","article-title":"Effects of keratin phosphorylation on the mechanical properties of keratin filaments in living cells","volume":"27","author":"Fois","year":"2013","journal-title":"FASEB J."},{"issue":"11","key":"10.1016\/j.jdermsci.2017.11.011_bib0055","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1038\/sj.jid.5701015","article-title":"Desmosomes: new perspectives on a classic","volume":"127","author":"Green","year":"2007","journal-title":"J. Invest. Dermatol."},{"issue":"5","key":"10.1016\/j.jdermsci.2017.11.011_bib0060","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.0022-202X.2005.23714.x","article-title":"In vitro keratinocyte dissociation assay for evaluation of the pathogenicity of anti-desmoglein 3 IgG autoantibodies in pemphigus vulgaris","volume":"124","author":"Ishii","year":"2005","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2017.11.011_bib0065","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.4049\/jimmunol.170.4.2170","article-title":"Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3","volume":"170","author":"Tsunoda","year":"2003","journal-title":"J. Immunol."},{"issue":"Pt 21","key":"10.1016\/j.jdermsci.2017.11.011_bib0070","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1242\/jcs.00096","article-title":"Induction of rapid and reversible cytokeratin filament network remodeling by inhibition of tyrosine phosphatases","volume":"115","author":"Strnad","year":"2002","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.jdermsci.2017.11.011_bib0075","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1046\/j.1523-1747.2003.12038.x","article-title":"Light-induced resistance of the keratin network to the filament-disrupting tyrosine phosphatase inhibitor orthovanadate","volume":"120","author":"Strnad","year":"2003","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2017.11.011_bib0080","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s004030100217","article-title":"Serum factors regulate the expression of the proliferation-related genes alpha5 integrin and keratin 1, but not keratin 10, in HaCaT keratinocytes","volume":"293","author":"Pivarcsi","year":"2001","journal-title":"Arch. Dermatol. Res."},{"issue":"1","key":"10.1016\/j.jdermsci.2017.11.011_bib0085","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1046\/j.1365-2133.2003.05493.x","article-title":"Generation and characterization of epidermolysis bullosa simplex cell lines: scratch assays show faster migration with disruptive keratin mutations","volume":"149","author":"Morley","year":"2003","journal-title":"Br. J. Dermatol."},{"issue":"Pt 22","key":"10.1016\/j.jdermsci.2017.11.011_bib0090","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1242\/jcs.01407","article-title":"Mechanical stress induces profound remodelling of keratin filaments and cell junctions in epidermolysis bullosa simplex keratinocytes","volume":"117","author":"Russell","year":"2004","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.jdermsci.2017.11.011_bib0095","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/jid.2012.256","article-title":"Keratins mediate localization of hemidesmosomes and repress cell motility","volume":"133","author":"Seltmann","year":"2013","journal-title":"J. Invest. Dermatol."},{"issue":"6","key":"10.1016\/j.jdermsci.2017.11.011_bib0100","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1046\/j.1523-1747.1999.00771.x","article-title":"Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95)","volume":"113","author":"Zouboulis","year":"1999","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2017.11.011_bib0105","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000396287","article-title":"Effect of chemical modification of keratinocytes and collagen in keratinocyte-collagen interactions","volume":"10","author":"Karasek","year":"1980","journal-title":"Curr. Probl. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2017.11.011_bib0110","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1083\/jcb.113.4.881","article-title":"Endocytosis of junctional cadherins in bovine kidney epithelial (MDBK) cells cultured in low Ca2+ ion medium","volume":"113","author":"Kartenbeck","year":"1991","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.jdermsci.2017.11.011_bib0115","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000210927","article-title":"Culture of human sebocytes and markers of sebocytic differentiation in vitro","volume":"4","author":"Zouboulis","year":"1991","journal-title":"Skin Pharmacol."},{"issue":"2","key":"10.1016\/j.jdermsci.2017.11.011_bib0120","doi-asserted-by":"crossref","first-page":"a000125","DOI":"10.1101\/cshperspect.a000125","article-title":"Intercellular junction assembly, dynamics, and homeostasis","volume":"2","author":"Green","year":"2010","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"3","key":"10.1016\/j.jdermsci.2017.11.011_bib0125","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/jid.2009.327","article-title":"ERK involvement in resistance to apoptosis in keratinocytes with mutant keratin","volume":"130","author":"Russell","year":"2010","journal-title":"J. Invest. Dermatol."},{"issue":"10","key":"10.1016\/j.jdermsci.2017.11.011_bib0130","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1016\/j.yexcr.2007.04.023","article-title":"Intermediate filaments and stress","volume":"313","author":"Pekny","year":"2007","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.jdermsci.2017.11.011_bib0135","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1083\/jcb.200906094","article-title":"Keratins regulate protein biosynthesis through localization of GLUT1 and \u22123 upstream of AMP kinase and Raptor","volume":"187","author":"Vijayaraj","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jdermsci.2017.11.011_bib0140","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/bs.mie.2015.08.019","article-title":"Functional analysis of keratin-associated proteins in intestinal epithelia: heat-shock protein chaperoning and kinase rescue","volume":"569","author":"Mashukova","year":"2016","journal-title":"Methods Enzymol."},{"issue":"Pt 7","key":"10.1016\/j.jdermsci.2017.11.011_bib0145","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1242\/jcs.097139","article-title":"Deletion of K1\/K10 does not impair epidermal stratification but affects desmosomal structure and nuclear integrity","volume":"125","author":"Wallace","year":"2012","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.jdermsci.2017.11.011_bib0150","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1593\/neo.05469","article-title":"Lowering of tumor interstitial fluid pressure reduces tumor cell proliferation in a xenograft tumor model","volume":"8","author":"Hofmann","year":"2006","journal-title":"Neoplasia (New York N.Y.)"},{"issue":"10","key":"10.1016\/j.jdermsci.2017.11.011_bib0155","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1016\/j.jbiomech.2006.10.039","article-title":"Long-term lowering of tumour interstitial fluid pressure reduces Ki-67 expression","volume":"40","author":"Hofmann","year":"2007","journal-title":"J. Biomech."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181117309830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181117309830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T14:07:07Z","timestamp":1535206027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181117309830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S0923181117309830"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2017.11.011","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of PKB\/Akt and p44\/42 by mechanical stretch utilizes desmosomal structures and the keratin filament","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2017.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}