{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:46:03Z","timestamp":1789847163387,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372915"],"award-info":[{"award-number":["81372915"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402259"],"award-info":[{"award-number":["81402259"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Natural Science Foundation","award":["7163234"],"award-info":[{"award-number":["7163234"]}]}],"content-domain":{"domain":["clinicalkey.jp","jdsjournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.jdermsci.2017.11.019","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T13:32:37Z","timestamp":1515072757000},"page":"60-67","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["PAK1 overexpression promotes cell proliferation in cutaneous T cell lymphoma via suppression of PUMA and p21"],"prefix":"10.1016","volume":"90","author":[{"given":"Yimeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jdermsci.2017.11.019_bib0005","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/CCO.0000000000000161","article-title":"Recent advances in primary cutaneous T-cell lymphoma","volume":"27","author":"DeSimone","year":"2015","journal-title":"Curr. Opin. Oncol."},{"issue":"13","key":"10.1016\/j.jdermsci.2017.11.019_bib0010","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1182\/blood-2013-05-504308","article-title":"PLCG1 mutations in cutaneous T-cell lymphomas","volume":"123","author":"Vaque","year":"2014","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.jdermsci.2017.11.019_bib0015","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1172\/JCI24826","article-title":"Immunopathogenesis and therapy of cutaneous T cell lymphoma","volume":"115","author":"Kim","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jdermsci.2017.11.019_bib0020","article-title":"Cutaneous lymphomas","author":"Klemke","year":"2013","journal-title":"J. Dtsch. Dermatol. Ges."},{"issue":"6","key":"10.1016\/j.jdermsci.2017.11.019_bib0025","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/leu.2015.9","article-title":"BIN1 tumor suppressor regulates Fas\/Fas ligand-mediated apoptosis through c-FLIP in cutaneous T-cell lymphoma","volume":"29","author":"Esmailzadeh","year":"2015","journal-title":"Leukemia"},{"key":"10.1016\/j.jdermsci.2017.11.019_bib0030","doi-asserted-by":"crossref","DOI":"10.3322\/caac.21357","article-title":"2016 US lymphoid malignancy statistics by world health organization subtypes","author":"Teras","year":"2016","journal-title":"CA. Cancer J. Clin."},{"key":"10.1016\/j.jdermsci.2017.11.019_bib0035","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.8829.1","article-title":"An overview of cutaneous T cell lymphomas","volume":"5","author":"Bagherani","year":"2016","journal-title":"F1000Res"},{"issue":"19","key":"10.1016\/j.jdermsci.2017.11.019_bib0040","doi-asserted-by":"crossref","first-page":"27422","DOI":"10.18632\/oncotarget.8320","article-title":"p21-activated kinase 1 (PAK1) expression correlates with prognosis in solid tumors: a systematic review and meta-analysis","volume":"7","author":"Fang","year":"2016","journal-title":"Oncotarget"},{"issue":"36","key":"10.1016\/j.jdermsci.2017.11.019_bib0045","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1038\/onc.2008.131","article-title":"P21-activated kinase is required for mitotic progression and regulates Plk1","volume":"27","author":"Maroto","year":"2008","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.jdermsci.2017.11.019_bib0050","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/MIB.0000000000000281","article-title":"Overexpression of PAK1 promotes cell survival in inflammatory bowel diseases and colitis-associated cancer","volume":"21","author":"Khare","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jdermsci.2017.11.019_bib0055","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1186\/1471-2407-14-650","article-title":"Reduced expression of p21-activated protein kinase 1 correlates with poor histological differentiation in pancreatic cancer","volume":"14","author":"Han","year":"2014","journal-title":"BMC Cancer"},{"issue":"20","key":"10.1016\/j.jdermsci.2017.11.019_bib0060","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1038\/sj.onc.1209309","article-title":"PAK1 hyperactivation is sufficient for mammary gland tumor formation","volume":"25","author":"Wang","year":"2006","journal-title":"Oncogene"},{"issue":"17","key":"10.1016\/j.jdermsci.2017.11.019_bib0065","doi-asserted-by":"crossref","first-page":"7177","DOI":"10.1073\/pnas.1103350108","article-title":"Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells","volume":"108","author":"Ong","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.jdermsci.2017.11.019_bib0070","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4161\/cl.21882","article-title":"PAK signaling in cancer","volume":"2","author":"Ye","year":"2012","journal-title":"Cell. Logist."},{"issue":"9","key":"10.1016\/j.jdermsci.2017.11.019_bib0075","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1182\/blood-2014-12-618801","article-title":"PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome","volume":"126","author":"Pandolfi","year":"2015","journal-title":"Blood"},{"issue":"51","key":"10.1016\/j.jdermsci.2017.11.019_bib0080","doi-asserted-by":"crossref","first-page":"14745","DOI":"10.1073\/pnas.1618582114","article-title":"Growth hormone-releasing hormone receptor antagonists inhibit human gastric cancer through downregulation of PAK1-STAT3\/NF-kappaB signaling","volume":"113","author":"Gan","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.jdermsci.2017.11.019_bib0085","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1182\/blood-2002-08-2434","article-title":"Amplification and overexpression of JUNB is associated with primary cutaneous T-cell lymphomas","volume":"101","author":"Mao","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jdermsci.2017.11.019_bib0090","doi-asserted-by":"crossref","first-page":"22814","DOI":"10.1038\/srep22814","article-title":"Effects of acute intra-abdominal hypertension on multiple intestinal barrier functions in rats","volume":"6","author":"Leng","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jdermsci.2017.11.019_bib0095","series-title":"Guide for the Care and Use of Laboratory Animals","author":"R. National Research Council Institute for Laboratory Animal","year":"1996"},{"issue":"8","key":"10.1016\/j.jdermsci.2017.11.019_bib0100","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1089\/dna.2017.3650","article-title":"Gene expression profile of peripheral blood mononuclear cells in response to intracerebral hemorrhage","volume":"36","author":"Sang","year":"2017","journal-title":"DNA Cell Biol."},{"issue":"12","key":"10.1016\/j.jdermsci.2017.11.019_bib0105","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.18632\/oncotarget.2031","article-title":"Thymocyte selection-associated high mobility group box gene (TOX) is aberrantly over-expressed in mycosis fungoides and correlates with poor prognosis","volume":"5","author":"Huang","year":"2014","journal-title":"Oncotarget"},{"issue":"7","key":"10.1016\/j.jdermsci.2017.11.019_bib0110","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.jid.2017.02.980","article-title":"BCL11B-mediated epigenetic repression is a crucial target for histone deacetylase inhibitors in cutaneous T-cell lymphoma","volume":"137","author":"Fu","year":"2017","journal-title":"J. Invest. Dermatol."},{"issue":"8","key":"10.1016\/j.jdermsci.2017.11.019_bib0115","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/1346-8138.12160","article-title":"Aberrant expression of BCL11B in mycosis fungoides and its potential role in interferon-induced apoptosis","volume":"40","author":"Gu","year":"2013","journal-title":"J. Dermatol."},{"issue":"5","key":"10.1016\/j.jdermsci.2017.11.019_bib0120","first-page":"2457","article-title":"MicroRNA-199a-3p inhibits tumorigenesis of hepatocellular carcinoma cells by targeting ZHX1\/PUMA signal","volume":"9","author":"Guan","year":"2017","journal-title":"Am. J. Transl. Res."},{"issue":"6","key":"10.1016\/j.jdermsci.2017.11.019_bib0125","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/bjh.14155","article-title":"Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1)","volume":"174","author":"Delbridge","year":"2016","journal-title":"Br. J. Haematol."},{"issue":"7","key":"10.1016\/j.jdermsci.2017.11.019_bib0130","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/cdd.2015.50","article-title":"The BCL-2 protein family, BH3-mimetics and cancer therapy","volume":"22","author":"Delbridge","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jdermsci.2017.11.019_bib0135","doi-asserted-by":"crossref","first-page":"e235","DOI":"10.1038\/cddis.2011.116","article-title":"Novel tumor suppressive function of Smad4 in serum starvation-induced cell death through PAK1-PUMA pathway","volume":"2","author":"Lee","year":"2011","journal-title":"Cell. Death. Dis."},{"issue":"14","key":"10.1016\/j.jdermsci.2017.11.019_bib0140","doi-asserted-by":"crossref","first-page":"23690","DOI":"10.18632\/oncotarget.15783","article-title":"Anti-cancer effect of novel PAK1 inhibitor via induction of PUMA-mediated cell death and p21-mediated cell cycle arrest","volume":"8","author":"Woo","year":"2017","journal-title":"Oncotarget"},{"issue":"22","key":"10.1016\/j.jdermsci.2017.11.019_bib0145","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1182\/blood-2013-10-534693","article-title":"SATB1 overexpression promotes malignant T-cell proliferation in cutaneous CD30+ lymphoproliferative disease by repressing p21","volume":"123","author":"Wang","year":"2014","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.jdermsci.2017.11.019_bib0150","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/j.0022-202X.2005.23925.x","article-title":"Selective induction of apoptosis by histone deacetylase inhibitor SAHA in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action","volume":"125","author":"Zhang","year":"2005","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2017.11.019_bib0155","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/sj.jid.5700968","article-title":"Effects of topically applied acitretin in reconstructed human epidermis and the rhino mouse","volume":"128","author":"Hsia","year":"2008","journal-title":"J. Invest. Dermatol."},{"issue":"22","key":"10.1016\/j.jdermsci.2017.11.019_bib0160","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.4161\/15384101.2014.962957","article-title":"C\/EBPalpha regulates CRL4(Cdt2)-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1\/S checkpoint","volume":"13","author":"Hall","year":"2014","journal-title":"ABBV Cell Cycle"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181118300021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181118300021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T06:38:12Z","timestamp":1565332692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181118300021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0923181118300021"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2017.11.019","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PAK1 overexpression promotes cell proliferation in cutaneous T cell lymphoma via suppression of PUMA and p21","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2017.11.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}