{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:36:53Z","timestamp":1775687813148,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01ZX1312A"],"award-info":[{"award-number":["01ZX1312A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jdsjournal.com","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.jdermsci.2017.12.018","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T19:06:37Z","timestamp":1515697597000},"page":"68-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Increased levels of lipocalin 2 in palmoplantar pustular psoriasis"],"prefix":"10.1016","volume":"90","author":[{"given":"Kerstin","family":"Wolk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Frambach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnd","family":"Jacobi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"Wilsmann-Theis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Phillipp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Witte-H\u00e4ndel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Wenzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rotraut","family":"M\u00f6ssner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Sabat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jdermsci.2017.12.018_bib0005","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3109\/09546631003636817","article-title":"Pustulosis palmoplantaris is a disease distinct from psoriasis","volume":"22","author":"de Waal","year":"2011","journal-title":"J. Dermatolog. Treat."},{"issue":"1","key":"10.1016\/j.jdermsci.2017.12.018_bib0010","doi-asserted-by":"crossref","first-page":"e006450","DOI":"10.1136\/bmjopen-2014-006450","article-title":"Epidemiology of psoriasis and palmoplantar pustulosis: a nationwide study using the Japanese national claims database","volume":"5","author":"Kubota","year":"2015","journal-title":"BMJ Open"},{"issue":"1","key":"10.1016\/j.jdermsci.2017.12.018_bib0015","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/jdv.13846","article-title":"What do we know about palmoplantar pustulosis?","volume":"31","author":"Misiak-Galazka","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"4","key":"10.1016\/j.jdermsci.2017.12.018_bib0020","doi-asserted-by":"crossref","DOI":"10.5070\/D3234034627","article-title":"Palmoplantar pustulosis \u2013 a cross-sectional analysis in Germany","volume":"23","author":"Wilsmann-Theis","year":"2017","journal-title":"Dermatol. Online J."},{"issue":"9","key":"10.1016\/j.jdermsci.2017.12.018_bib0025","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1111\/jdv.12545","article-title":"Palmoplantar pustulosis \u2013 a retrospective review of comorbid conditions","volume":"29","author":"Becher","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"3","key":"10.1016\/j.jdermsci.2017.12.018_bib0030","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1046\/j.1365-2133.1998.02113.x","article-title":"Palmoplantar pustulosis: a clinical and immunohistological study","volume":"138","author":"Eriksson","year":"1998","journal-title":"Br. J. Dermatol."},{"issue":"8","key":"10.1016\/j.jdermsci.2017.12.018_bib0035","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1038\/jid.2010.87","article-title":"Acrosyringium is the main site of the vesicle\/pustule formation in palmoplantar pustulosis","volume":"130","author":"Murakami","year":"2010","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2017.12.018_bib0040","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1046\/j.1523-1747.2003.12094.x","article-title":"Genetic analysis of PSORS1 distinguishes guttate psoriasis and palmoplantar pustulosis","volume":"120","author":"Asumalahti","year":"2003","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.jdermsci.2017.12.018_bib0045","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1468-3083.2007.02344.x","article-title":"Palmoplantar pustulosis should not be considered as a variant of psoriasis","volume":"22","author":"Ammoury","year":"2008","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"2","key":"10.1016\/j.jdermsci.2017.12.018_bib0050","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1365-2133.2006.07675.x","article-title":"A classification of psoriasis vulgaris according to phenotype","volume":"156","author":"Griffiths","year":"2007","journal-title":"Br. J. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2017.12.018_bib0055","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jaad.2014.04.063","article-title":"Palmoplantar psoriasis is associated with greater impairment of health-related quality of life compared with moderate to severe plaque psoriasis","volume":"71","author":"Chung","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"issue":"2","key":"10.1016\/j.jdermsci.2017.12.018_bib0060","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1067\/S0190-9622(03)01479-8","article-title":"Patients with palmoplantar psoriasis have more physical disability and discomfort than patients with other forms of psoriasis: implications for clinical practice","volume":"49","author":"Pettey","year":"2003","journal-title":"J. Am. Acad. Dermatol."},{"issue":"21","key":"10.1016\/j.jdermsci.2017.12.018_bib0065","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.1158\/1078-0432.CCR-14-0707","article-title":"Deficient cutaneous antibacterial competence in cutaneous T-cell lymphomas: role of Th2-mediated biased Th17 function","volume":"20","author":"Wolk","year":"2014","journal-title":"Clin. Cancer Res."},{"issue":"204","key":"10.1016\/j.jdermsci.2017.12.018_bib0070","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006245","article-title":"IL-29 is produced by T(H)17 cells and mediates the cutaneous antiviral competence in psoriasis","volume":"5","author":"Wolk","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"4","key":"10.1016\/j.jdermsci.2017.12.018_bib0075","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00109-015-1367-y","article-title":"Interleukin-29 induces epithelial production of CXCR3A ligands and T-cell infiltration","volume":"94","author":"Witte","year":"2016","journal-title":"J. Mol. Med. (Berl.)"},{"issue":"5","key":"10.1016\/j.jdermsci.2017.12.018_bib0080","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/sj.gene.6364104","article-title":"Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart","volume":"5","author":"Weiss","year":"2004","journal-title":"Genes Immun."},{"issue":"8","key":"10.1016\/j.jdermsci.2017.12.018_bib0085","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3109\/1354750X.2015.1123354","article-title":"The potential of lipocalin-2\/NGAL as biomarker for inflammatory and metabolic diseases","volume":"20","author":"Abella","year":"2015","journal-title":"Biomarkers"},{"issue":"1","key":"10.1016\/j.jdermsci.2017.12.018_bib0090","first-page":"129","article-title":"The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer","volume":"1826","author":"Chakraborty","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.jdermsci.2017.12.018_bib0095","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/bjd.15424","article-title":"Lipocalin-2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa\/hidradenitis suppurativa","volume":"177","author":"Wolk","year":"2017","journal-title":"Br. J. Dermatol."},{"issue":"2","key":"10.1016\/j.jdermsci.2017.12.018_bib0100","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.immuni.2004.07.007","article-title":"IL-22 increases the innate immunity of tissues","volume":"21","author":"Wolk","year":"2004","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.jdermsci.2017.12.018_bib0105","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/eji.200535503","article-title":"IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis","volume":"36","author":"Wolk","year":"2006","journal-title":"Eur. J. Immunol."},{"issue":"3","key":"10.1016\/j.jdermsci.2017.12.018_bib0110","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s11154-016-9381-0","article-title":"Adipokines in psoriasis: an important link between skin inflammation and metabolic alterations","volume":"17","author":"Wolk","year":"2016","journal-title":"Rev. Endocr. Metab. Disord."},{"issue":"6","key":"10.1016\/j.jdermsci.2017.12.018_bib0115","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s00105-016-3812-4","article-title":"Systemic treatments for psoriasis and psoriatic arthritis","volume":"67","author":"Philipp","year":"2016","journal-title":"Hautarzt"},{"issue":"4","key":"10.1016\/j.jdermsci.2017.12.018_bib0120","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s40257-016-0191-7","article-title":"Palmoplantar psoriasis and palmoplantar pustulosis: current treatment and future prospects","volume":"17","author":"Raposo","year":"2016","journal-title":"Am. J. Clin. Dermatol."},{"issue":"10","key":"10.1016\/j.jdermsci.2017.12.018_bib0125","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1111\/jdv.12272","article-title":"Increased expression of IL-17A and limited involvement of IL-23 in patients with palmo-plantar (PP) pustular psoriasis or PP pustulosis; results from a randomised controlled trial","volume":"28","author":"Bissonnette","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"3","key":"10.1016\/j.jdermsci.2017.12.018_bib0130","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1182\/blood.V83.3.799.799","article-title":"Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils","volume":"83","author":"Kjeldsen","year":"1994","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.jdermsci.2017.12.018_bib0135","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/bjd.15424","article-title":"Lipocalin-2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa\/hidradenitis suppurativa","volume":"177","author":"Wolk","year":"2017","journal-title":"Br. J. Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2017.12.018_bib0140","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jdermsci.2016.09.019","article-title":"Palmoplantar pustular psoriasis (PPPP) is characterized by activation of the IL-17A pathway","volume":"85","author":"Bissonnette","year":"2017","journal-title":"J. Dermatol. Sci."},{"issue":"1","key":"10.1016\/j.jdermsci.2017.12.018_bib0145","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrd4176","article-title":"Therapeutic opportunities of the IL-22-IL-22R1 system","volume":"13","author":"Sabat","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.jdermsci.2017.12.018_bib0150","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1056\/NEJMcp1014163","article-title":"Clinical practice. hidradenitis suppurativa","volume":"366","author":"Jemec","year":"2012","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.jdermsci.2017.12.018_bib0155","doi-asserted-by":"crossref","first-page":"e31810","DOI":"10.1371\/journal.pone.0031810","article-title":"Increased prevalence of metabolic syndrome in patients with acne inversa","volume":"7","author":"Sabat","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jdermsci.2017.12.018_bib0160","doi-asserted-by":"crossref","first-page":"4097574","DOI":"10.1155\/2016\/4097574","article-title":"MMP8 is increased in lesions and blood of acne inversa patients: a potential link to skin destruction and metabolic alterations","volume":"2016","author":"Tsaousi","year":"2016","journal-title":"Mediators Inflamm."},{"issue":"5 Suppl. 1","key":"10.1016\/j.jdermsci.2017.12.018_bib0165","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/j.jaad.2015.07.047","article-title":"New insights into the diagnosis of hidradenitis suppurativa: clinical presentations and phenotypes","volume":"73","author":"van der Zee","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"issue":"3","key":"10.1016\/j.jdermsci.2017.12.018_bib0170","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00403-013-1414-x","article-title":"Estimation of tissue and serum lipocalin-2 in psoriasis vulgaris and its relation to metabolic syndrome","volume":"306","author":"El-Hadidi","year":"2014","journal-title":"Arch. Dermatol. Res."},{"issue":"10","key":"10.1016\/j.jdermsci.2017.12.018_bib0175","doi-asserted-by":"crossref","first-page":"7420","DOI":"10.4049\/jimmunol.181.10.7420","article-title":"Low expression of the IL-23\/Th17 pathway in atopic dermatitis compared to psoriasis","volume":"181","author":"Guttman-Yassky","year":"2008","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.jdermsci.2017.12.018_bib0180","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1034\/j.1600-0625.2002.110611.x","article-title":"Neutrophil gelatinase-associated lipocalin is a marker for dysregulated keratinocyte differentiation in human skin","volume":"11","author":"Mallbris","year":"2002","journal-title":"Exp. Dermatol."},{"issue":"7","key":"10.1016\/j.jdermsci.2017.12.018_bib0185","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.jid.2016.03.002","article-title":"Increased lipocalin-2 contributes to the pathogenesis of psoriasis by modulating neutrophil chemotaxis and cytokine secretion","volume":"136","author":"Shao","year":"2016","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.jdermsci.2017.12.018_bib0190","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1365-2230.2011.04265.x","article-title":"Serum lipocalin-2 levels are increased in patients with psoriasis","volume":"37","author":"Kamata","year":"2012","journal-title":"Clin. Exp. Dermatol."},{"issue":"2","key":"10.1016\/j.jdermsci.2017.12.018_bib0195","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00403-012-1306-5","article-title":"Circulating levels of lipocalin-2 and retinol-binding protein-4 are increased in psoriatic patients and correlated with baseline PASI","volume":"305","author":"Romani","year":"2013","journal-title":"Arch. Dermatol. Res."},{"issue":"9","key":"10.1016\/j.jdermsci.2017.12.018_bib0200","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.4049\/jimmunol.1202411","article-title":"Impaired neutrophil function in 24p3 null mice contributes to enhanced susceptibility to bacterial infections","volume":"190","author":"Liu","year":"2013","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.jdermsci.2017.12.018_bib0205","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1002\/eji.201142351","article-title":"Lipocalin-2 ameliorates granulocyte functionality","volume":"42","author":"Schroll","year":"2012","journal-title":"Eur. J. Immunol."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181118300033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181118300033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T13:40:40Z","timestamp":1656855640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181118300033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0923181118300033"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2017.12.018","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased levels of lipocalin 2 in palmoplantar pustular psoriasis","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2017.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}