{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T08:46:55Z","timestamp":1745916415275},"reference-count":10,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["16K10149"],"award-info":[{"award-number":["16K10149"]}]}],"content-domain":{"domain":["clinicalkey.jp","jdsjournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.jdermsci.2018.01.011","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T17:42:29Z","timestamp":1517506949000},"page":"211-213","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Diversity of circulating tumor cells in peripheral blood: Detection of heterogeneous BRAF mutations in a patient with advanced melanoma by single-cell analysis"],"prefix":"10.1016","volume":"90","author":[{"given":"Yukiko","family":"Kiniwa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asuka","family":"Mikoshiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuhei","family":"Okuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2018.01.011_bib0005","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1056\/NEJMoa1103782","article-title":"Brim- Study Group, improved survival with vemurafenib in melanoma with BRAF V600E mutation","volume":"364","author":"Chapman","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jdermsci.2018.01.011_bib0010","doi-asserted-by":"crossref","first-page":"742-e1","DOI":"10.1016\/j.cell.2017.01.026","article-title":"SnapShot: circulating tumor cells","volume":"168","author":"Dive","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jdermsci.2018.01.011_bib0015","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1038\/jid.2008.30","article-title":"Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma","volume":"128","author":"Houben","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2018.01.011_bib0020","doi-asserted-by":"crossref","first-page":"e0130418","DOI":"10.1371\/journal.pone.0130418","article-title":"High-density dielectrophoretic microwell array for detection, capture, and single-cell analysis of rare tumor cells in peripheral blood","volume":"10","author":"Morimoto","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jdermsci.2018.01.011_bib0025","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1038\/jid.2015.127","article-title":"Circulating melanoma cell subpopulations: their heterogeneity and differential responses to treatment","volume":"135","author":"Gray","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2018.01.011_bib0030","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.clinbiochem.2014.12.007","article-title":"Detection of BRAF-V600E and V600K in melanoma circulating tumour cells by droplet digital PCR","volume":"48","author":"Reid","year":"2015","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.jdermsci.2018.01.011_bib0035","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/pcmr.12450","article-title":"Clinicopathological characteristics associated with BRAF(K601E) and BRAF(L597) mutations in melanoma","volume":"29","author":"Voskoboynik","year":"2016","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.jdermsci.2018.01.011_bib0040","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1158\/2159-8290.CD-12-0097","article-title":"BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors","volume":"2","author":"Dahlman","year":"2012","journal-title":"Cancer Discov."},{"key":"10.1016\/j.jdermsci.2018.01.011_bib0045","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40164-017-0067-4","article-title":"Metastatic BRAF K601E-mutated melanoma reaches complete response to MEK inhibitor trametinib administered for over 36 months","volume":"6","author":"Marconcini","year":"2017","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.jdermsci.2018.01.011_bib0050","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/molehr\/gag051","article-title":"Detailed investigation of factors influencing amplification efficiency and allele drop-out in single cell PCR: implications for preimplantation genetic diagnosis","volume":"9","author":"Piyamongkol","year":"2003","journal-title":"Mol. Hum. Reprod."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181118300768?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181118300768?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T13:55:00Z","timestamp":1535118900000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181118300768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0923181118300768"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2018.01.011","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diversity of circulating tumor cells in peripheral blood: Detection of heterogeneous BRAF mutations in a patient with advanced melanoma by single-cell analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2018.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}