{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:20:54Z","timestamp":1793380854990,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Chinese National Natural Science Foundation to H.N.","award":["81373993"],"award-info":[{"award-number":["81373993"]}]},{"name":"Chinese National Natural Science Foundation to H.N.","award":["81673634"],"award-info":[{"award-number":["81673634"]}]},{"name":"Innovation and entrepreneurship training of Jinan University to H.N.","award":["201610559016"],"award-info":[{"award-number":["201610559016"]}]},{"name":"Climbing project of Guangzhou province to H.N.","award":["PDJH2016B0062"],"award-info":[{"award-number":["PDJH2016B0062"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.jdermsci.2018.04.009","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T23:41:56Z","timestamp":1527810116000},"page":"134-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Anti-pruritic and anti-inflammatory effects of oxymatrine in a mouse model of allergic contact dermatitis"],"prefix":"10.1016","volume":"91","author":[{"given":"Xiaoyun","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaihe","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Paranjpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lintao","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2018.04.009_bib0005","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrn1950","article-title":"The neurobiology of itch","volume":"7","author":"Ikoma","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0010","first-page":"1631","article-title":"Studies of effective constituent and compatibility mechanism of prescription of Sophorae Flavesentis Radix","volume":"11","author":"Peng","year":"2008","journal-title":"Chin. Herbal Med."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0015","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrn1950","article-title":"The neurobiology of itch","volume":"7","author":"Ikoma","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0020","doi-asserted-by":"crossref","first-page":"532","DOI":"10.2340\/00015555-1572","article-title":"Incidence and determinants of chronic pruritus: a population-based cohort study","volume":"93","author":"Matterne","year":"2013","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0025","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/09546630410027337","article-title":"Over-the-counter topical antipruritic agents are commonly recommended by office-based physicians: an analysis of US practice patterns","volume":"15","author":"Duque","year":"2004","journal-title":"J. Dermatol. Treat."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0030","unstructured":"YZ Z. Sophora lotion of Sophora lotion in the treatment of allergic contact dermatitis Guide of China Medicine 10: 308, 2012."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0035","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.neulet.2014.03.062","article-title":"Enhanced scratching elicited by a pruritogen and an algogen in a mouse model of contact hypersensitivity","volume":"579","author":"Fu","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0040","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1600-0625.2011.01367.x","article-title":"Mouse models of acute: chemical itch and pain in humans","volume":"20","author":"Lamotte","year":"2011","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0045","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.4049\/jimmunol.179.8.5071","article-title":"The importance of myeloid-derived suppressor cells in the regulation of autoimmune effector cells by a chronic contact eczema","volume":"179","author":"Marhaba","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0050","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000250380","article-title":"Contact allergy as a therapeutic tool for alopecia areata: application of squaric acid dibutylester","volume":"161","author":"Happle","year":"1980","journal-title":"Dermatologica"},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0055","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1006\/taap.2002.9469","article-title":"Insights into the quantitative relationship between sensitization and challenge for allergic contact dermatitis reactions","volume":"183","author":"Scott","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0060","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2310\/6620.2008.07110","article-title":"Determination of in vivo dose response and allergen-specific T cells in subjects contact-sensitized to squaric acid dibutyl ester","volume":"19","author":"Camouse","year":"2008","journal-title":"Dermatitis"},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0065","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/brain\/awu007","article-title":"Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain","volume":"137","author":"Qu","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0070","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.pain.2008.08.002","article-title":"Behavioral differentiation between itch and pain in mouse","volume":"139","author":"Shimada","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0075","doi-asserted-by":"crossref","DOI":"10.1038\/jid.2008.139","article-title":"Patients with chronic mucocutaneous candidiasis exhibit reduced production of Th17-associated cytokines IL-17 and IL-22","volume":"128","author":"Eyerich","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0080","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.jaci.2009.04.003","article-title":"de Waal Malefyt R: Development and function of TH17 cells in health and disease","volume":"123","author":"Louten","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0085","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nature06764","article-title":"Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome","volume":"452","author":"Milner","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0090","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/eji.200839102","article-title":"IL-17\/Th17 in anti-fungal immunity: what's new?","volume":"39","author":"Zelante","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0095","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/jid.2008.295","article-title":"Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling","volume":"129","author":"Zheng","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0100","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/ni1084","article-title":"Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice","volume":"5","author":"Dillon","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0105","first-page":"37","article-title":"Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity","volume":"7","author":"Schwarz","year":"1996","journal-title":"Immunol. Today"},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0110","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0887-2333(00)00030-8","article-title":"Investigation of induced changes in interleukin 1 beta mRNA expression by cultured human dendritic cells as an in vitro approach to skin sensitization testing","volume":"14","author":"Pichowki","year":"2000","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0115","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/cei.12671","article-title":"Langerhans cell-like dendritic cells stimulated with an adjuvant direct the development of Th1 and Th2 cells in vivo","volume":"182","author":"Matsui","year":"2015","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0120","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cyto.2015.05.010","article-title":"T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production","volume":"75","author":"Zhu","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0125","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1440-0960.2007.00409.x","article-title":"Irritant contact dermatitis: a review","volume":"49","author":"Slodownik","year":"2008","journal-title":"Australas. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0130","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jaci.2007.09.015","article-title":"Signal transducer and activator of transcription 1 decoy oligodeoxynucleotide suppression of contact hypersensitivity","volume":"121","author":"Wagner","year":"2008","journal-title":"J. Allergy Clin. Immun."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0135","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cellimm.2009.03.004","article-title":"Induction of Foxp3+ regulatory T cells with histone deacetylase inhibitors","volume":"257","author":"Lucas","year":"2009","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0140","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0145","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature04754","article-title":"Transforming growth factor-\u03b2 induces development of the TH17 lineage","author":"Mangan","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jdermsci.2018.04.009_bib0150","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.immuni.2006.01.001","article-title":"TGF-\u03b2 in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells","volume":"24","author":"Veldhoen","year":"2006","journal-title":"Immunity"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181118301658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181118301658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:49:40Z","timestamp":1760330980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181118301658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S0923181118301658"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2018.04.009","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-pruritic and anti-inflammatory effects of oxymatrine in a mouse model of allergic contact dermatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2018.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V. on behalf of Japanese Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}