{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:50:21Z","timestamp":1790038221520,"version":"4.0.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"European Research Council under the European Union's Seventh Framework Programme","award":["FP\/2007-2013"],"award-info":[{"award-number":["FP\/2007-2013"]}]},{"name":"ERC Grant","award":["320737"],"award-info":[{"award-number":["320737"]}]}],"content-domain":{"domain":["clinicalkey.jp","jdsjournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.jdermsci.2018.07.002","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:43:21Z","timestamp":1531269801000},"page":"97-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Phenotypic and lipidomic characterization of primary human epidermal keratinocytes exposed to simulated solar UV radiation"],"prefix":"10.1016","volume":"92","author":[{"given":"N\u00faria","family":"Dalmau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Andrieu-Abadie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rom\u00e0","family":"Tauler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Bedia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jdermsci.2018.07.002_bib0005","first-page":"1231","article-title":"Ultraviolet A radiation-induced expression of human genes: molecular and photobiological mechanisms","volume":"378","author":"Grether-Beck","year":"1997","journal-title":"Biol. Chem."},{"issue":"4","key":"10.1016\/j.jdermsci.2018.07.002_bib0010","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1751-1097.1984.tb04622.x","article-title":"Transmission of human epidermis and stratum corneum as a function of thickness in the ultraviolet and visible wavelengths","volume":"40","author":"Bruls","year":"1984","journal-title":"Photochem. Photobiol."},{"issue":"6","key":"10.1016\/j.jdermsci.2018.07.002_bib0015","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1751-1097.1989.tb02907.x","article-title":"Wavelength dependence of histological, physical, and visible changes in chronically UV-irradiated hairless mouse skin","volume":"50","author":"Bissett","year":"1989","journal-title":"Photochem. Photobiol."},{"issue":"6","key":"10.1016\/j.jdermsci.2018.07.002_bib0020","first-page":"515","article-title":"Mechanisms involved in ultraviolet light-induced immunosuppression","volume":"13","author":"Aubin","year":"2003","journal-title":"Eur. J. Dermatol."},{"issue":"2","key":"10.1016\/j.jdermsci.2018.07.002_bib0025","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1152\/physrev.1997.77.2.397","article-title":"The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation","volume":"77","author":"Eckert","year":"1997","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.jdermsci.2018.07.002_bib0030","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1684\/ejd.2014.2452","article-title":"Calcium--a central regulator of keratinocyte differentiation in health and disease","volume":"24","author":"Elsholz","year":"2014","journal-title":"Eur. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2018.07.002_bib0035","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ejpb.2016.12.017","article-title":"Increased permeability of reconstructed human epidermis from UVB-irradiated keratinocytes","volume":"116","author":"L\u00f6wenau","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"12","key":"10.1016\/j.jdermsci.2018.07.002_bib0040","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1600-0625.2008.00786.x","article-title":"The skin: an indispensable barrier","volume":"17","author":"Proksch","year":"2008","journal-title":"Exp. Dermatol."},{"issue":"20","key":"10.1016\/j.jdermsci.2018.07.002_bib0045","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1038\/sj.onc.1207430","article-title":"Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin","volume":"23","author":"Dai","year":"2004","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.jdermsci.2018.07.002_bib0050","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0887-2333(02)00024-3","article-title":"Ultraviolet B radiation induces activation of neutral and acidic sphingomyelinases and ceramide generation in cultured normal human keratinocytes","volume":"16","author":"Magnoni","year":"2002","journal-title":"Toxicol. In Vitro"},{"issue":"8","key":"10.1016\/j.jdermsci.2018.07.002_bib0055","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1111\/j.1600-0625.2009.01000.x","article-title":"Lipidome of narrow-band ultraviolet B irradiated keratinocytes shows apoptotic hallmarks","volume":"19","author":"Reich","year":"2010","journal-title":"Exp. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2018.07.002_bib0060","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1562\/2004-05-14-RA-167R1.1","article-title":"Standard Ultraviolet Daylight for Nonextreme Exposure Conditions","volume":"81","author":"Christiaens","year":"2005","journal-title":"Photochem. Photobiol."},{"issue":"12","key":"10.1016\/j.jdermsci.2018.07.002_bib0065","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.0906-6705.2004.00221.x","article-title":"Narrow-band ultraviolet-B stimulates proliferation and migration of cultured melanocytes","volume":"13","author":"Wu","year":"2004","journal-title":"Exp. Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2018.07.002_bib0070","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s00403-005-0567-7","article-title":"An accumulation of glucosylceramide in the stratum corneum due to attenuated activity of beta-glucocerebrosidase is associated with the early phase of UVB-induced alteration in cutaneous barrier function","volume":"297","author":"Takagi","year":"2005","journal-title":"Arch. Dermatol. Res."},{"issue":"1","key":"10.1016\/j.jdermsci.2018.07.002_bib0075","first-page":"193","article-title":"Ultraviolet exposure of melanoma cells induces fibroblast activation protein-alpha in fibroblasts: implications for melanoma invasion","volume":"39","author":"Waster","year":"2011","journal-title":"Int. J. Oncol."},{"issue":"12","key":"10.1016\/j.jdermsci.2018.07.002_bib0080","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1039\/C5MB00413F","article-title":"Epithelial-to-mesenchymal transition involves triacylglycerol accumulation in DU145 prostate cancer cells","volume":"11","author":"Dalmau","year":"2015","journal-title":"Mol. Biosyst."},{"issue":"4","key":"10.1016\/j.jdermsci.2018.07.002_bib0085","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1021\/ac050980b","article-title":"Second-order peak detection for multicomponent high-resolution LC\/MS data","volume":"78","author":"Stolt","year":"2006","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.jdermsci.2018.07.002_bib0090","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0169-7439(95)00047-X","article-title":"Multivariate curve resolution applied to second order data","volume":"30","author":"Tauler","year":"1995","journal-title":"Chemom. Intell. Lab. Syst."},{"issue":"14","key":"10.1016\/j.jdermsci.2018.07.002_bib0095","doi-asserted-by":"crossref","first-page":"7675","DOI":"10.1021\/acs.analchem.7b01648","article-title":"Untargeted comprehensive two-dimensional liquid chromatography coupled with high-resolution mass spectrometry analysis of rice metabolome using multivariate curve resolution","volume":"89","author":"Navarro-Reig","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jdermsci.2018.07.002_bib0100","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.aca.2017.04.049","article-title":"Knowledge integration strategies for untargeted metabolomics based on MCR-ALS analysis of CE-MS and LC-MS data","volume":"978","author":"Ortiz-Villanueva","year":"2017","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jdermsci.2018.07.002_bib0105","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.envpol.2016.11.010","article-title":"Assessment of chlorpyrifos toxic effects in zebrafish (Danio rerio) metabolism","volume":"220","author":"G\u00f3mez-Canela","year":"2017","journal-title":"Environ. Pollut."},{"issue":"21","key":"10.1016\/j.jdermsci.2018.07.002_bib0110","doi-asserted-by":"crossref","first-page":"5829","DOI":"10.1007\/s00216-016-9695-5","article-title":"Assessment of the effects of As(III) treatment on cyanobacteria lipidomic profiles by LC-MS and MCR-ALS","volume":"408","author":"Marques","year":"2016","journal-title":"Anal. Bioanal.Chem."},{"key":"10.1016\/j.jdermsci.2018.07.002_bib0115","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.trac.2016.07.004","article-title":"Data analysis strategies for targeted and untargeted LC-MS metabolomic studies: Overview and workflow","volume":"82","author":"Gorrochategui","year":"2016","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.jdermsci.2018.07.002_bib0120","first-page":"9","article-title":"Multivariate curve resolution applied to second order data","author":"Tauler","year":"1995","journal-title":"Chemom. Intell. Lab. Syst."},{"issue":"1-2","key":"10.1016\/j.jdermsci.2018.07.002_bib0125","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.chroma.2005.04.089","article-title":"Solving liquid chromatography mass spectrometry coelution problems in the analysis of environmental samples by multivariate curve resolution","volume":"1096","author":"Pere-Trepat","year":"2005","journal-title":"J. Chromatogr. A"},{"issue":"29","key":"10.1016\/j.jdermsci.2018.07.002_bib0130","doi-asserted-by":"crossref","first-page":"8835","DOI":"10.1007\/s00216-015-9042-2","article-title":"Evaluation of changes induced in rice metabolome by Cd and Cu exposure using LC-MS with XCMS and MCR-ALS data analysis strategies","volume":"407","author":"Navarro-Reig","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jdermsci.2018.07.002_bib0135","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s11306-014-0689-z","article-title":"Chemometric evaluation of Saccharomyces cerevisiae metabolic profiles using LC-MS","volume":"11","author":"Farres","year":"2015","journal-title":"Metabolomics"},{"key":"10.1016\/j.jdermsci.2018.07.002_bib0140","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.envres.2015.03.014","article-title":"Phenotypic malignant changes and untargeted lipidomic analysis of long-term exposed prostate cancer cells to endocrine disruptors","volume":"140","author":"Bedia","year":"2015","journal-title":"Environ. Res."},{"issue":"Pt B","key":"10.1016\/j.jdermsci.2018.07.002_bib0145","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.envpol.2016.11.010","article-title":"Assessment of chlorpyrifos toxic effects in zebrafish (Danio rerio) metabolism","volume":"220","author":"Gomez-Canela","year":"2017","journal-title":"Environ. Pollut."},{"issue":"14","key":"10.1016\/j.jdermsci.2018.07.002_bib0150","doi-asserted-by":"crossref","first-page":"7675","DOI":"10.1021\/acs.analchem.7b01648","article-title":"Untargeted comprehensive two-dimensional liquid chromatography coupled with high-resolution mass spectrometry analysis of rice metabolome using multivariate curve resolution","volume":"89","author":"Navarro-Reig","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jdermsci.2018.07.002_bib0155","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.aca.2017.04.049","article-title":"Knowledge integration strategies for untargeted metabolomics based on MCR-ALS analysis of CE-MS and LC-MS data","volume":"978","author":"Ortiz-Villanueva","year":"2017","journal-title":"Anal. Chim. Acta"},{"issue":"21","key":"10.1016\/j.jdermsci.2018.07.002_bib0160","doi-asserted-by":"crossref","first-page":"5829","DOI":"10.1007\/s00216-016-9695-5","article-title":"Assessment of the effects of As(III) treatment on cyanobacteria lipidomic profiles by LC-MS and MCR-ALS","volume":"408","author":"Marques","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"issue":"22","key":"10.1016\/j.jdermsci.2018.07.002_bib0165","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1021\/ac00046a015","article-title":"Self-modeling mixture analysis of second-derivative near-infrared spectral data using the simplisma approach","volume":"64","author":"Windig","year":"1992","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jdermsci.2018.07.002_bib0170","first-page":"473","volume":"vol. 2","author":"Tauler","year":"2010"},{"issue":"Database issue","key":"10.1016\/j.jdermsci.2018.07.002_bib0175","first-page":"D801","article-title":"HMDB 3.0\u2014the human metabolome database in 2013","volume":"41","author":"Wishart","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.jdermsci.2018.07.002_bib0180","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0005-2795(75)90109-9","article-title":"Comparison of the predicted and observed secondary structure of T4 phage lysozyme","volume":"405","author":"Matthews","year":"1975","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.jdermsci.2018.07.002_bib0185","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0169-7439(01)00155-1","article-title":"PLS-regression: a basic tool of chemometrics","volume":"58","author":"Wold","year":"2001","journal-title":"Chemom. Intell. Lab. Syst."},{"issue":"3","key":"10.1016\/j.jdermsci.2018.07.002_bib0190","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1039\/C4AN00801D","article-title":"Potential use of multivariate curve resolution for the analysis of mass spectrometry images","volume":"140","author":"Jaumot","year":"2015","journal-title":"Analyst"},{"key":"10.1016\/j.jdermsci.2018.07.002_bib0195","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jsbmb.2016.05.015","article-title":"Lipid deregulation in UV irradiated skin cells: Role of 25-hydroxycholesterol in keratinocyte differentiation during photoaging","volume":"169","author":"Olivier","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.jdermsci.2018.07.002_bib0200","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1083\/jcb.201203134","article-title":"miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration","volume":"199","author":"Amelio","year":"2012","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.jdermsci.2018.07.002_bib0205","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.0022-202X.2004.22723.x","article-title":"Regulation of involucrin gene expression","volume":"123","author":"Eckert","year":"2004","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.jdermsci.2018.07.002_bib0210","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1600-0625.2010.01157.x","article-title":"Autophagy in human keratinocytes: an early step of the differentiation?","volume":"20","author":"Aymard","year":"2011","journal-title":"Exp. Dermatol."},{"issue":"5","key":"10.1016\/j.jdermsci.2018.07.002_bib0215","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1034\/j.1600-0781.2002.02755.x","article-title":"Acute effects of UVB radiation on the proliferation and differentiation of keratinocytes","volume":"18","author":"Lee","year":"2002","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"issue":"1","key":"10.1016\/j.jdermsci.2018.07.002_bib0220","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.0022-202X.2004.22723.x","article-title":"Regulation of Involucrin Gene Expression","volume":"123","author":"Eckert","year":"2004","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2018.07.002_bib0225","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3109\/01913123.2012.756568","article-title":"Short-term exposure to UV-A, UV-B, and UV-C irradiation induces alteration in cytoskeleton and autophagy in human keratinocytes","volume":"37","author":"Misovic","year":"2013","journal-title":"Ultrastruct. Pathol."},{"issue":"11","key":"10.1016\/j.jdermsci.2018.07.002_bib0230","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1194\/jlr.M800158-JLR200","article-title":"2-Hydroxy-ceramide synthesis by ceramide synthase family: enzymatic basis for the preference of FA chain length","volume":"49","author":"Mizutani","year":"2008","journal-title":"J. Lipid Res."},{"issue":"6","key":"10.1016\/j.jdermsci.2018.07.002_bib0235","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.biochi.2009.04.001","article-title":"Ceramide biosynthesis in keratinocyte and its role in skin function","volume":"91","author":"Mizutani","year":"2009","journal-title":"Biochimie"},{"issue":"6","key":"10.1016\/j.jdermsci.2018.07.002_bib0240","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/1523-1747.ep12476124","article-title":"Influence of UV Irradiation on the Composition of Human Stratum Corneum Lipids","volume":"96","author":"Wefers","year":"1990","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2018.07.002_bib0245","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4196\/kjpp.2008.12.1.31","article-title":"Lysophosphatidylcholine Increases Ca Current via Activation of Protein Kinase C in Rabbit Portal Vein Smooth Muscle Cells","volume":"12","author":"Jung","year":"2008","journal-title":"Korean J. Physiol. Pharmacol."},{"issue":"6","key":"10.1016\/j.jdermsci.2018.07.002_bib0250","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1080\/00015550410016930","article-title":"Lysophosphatidylcholine induces keratinocyte differentiation and upregulation of AP-1- and NF-kappaB DNA-binding activity","volume":"84","author":"Ryborg","year":"2004","journal-title":"Acta Derm. Venereol."},{"issue":"2","key":"10.1016\/j.jdermsci.2018.07.002_bib0255","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.abb.2011.01.014","article-title":"Aquaporin-3 in keratinocytes and skin: its role and interaction with phospholipase D2","volume":"508","author":"Qin","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"issue":"9","key":"10.1016\/j.jdermsci.2018.07.002_bib0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107119","article-title":"Distinct Effects of Different Phosphatidylglycerol Species on Mouse Keratinocyte Proliferation","volume":"9","author":"Xie","year":"2014","journal-title":"PLOS One"},{"issue":"Pt 2","key":"10.1016\/j.jdermsci.2018.07.002_bib0265","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1042\/bj3050471","article-title":"Ultraviolet radiation stimulates a biphasic pattern of 1,2-diacylglycerol formation in cultured human melanocytes and keratinocytes by activation of phospholipases C and D","volume":"305","author":"Carsberg","year":"1995","journal-title":"Biochem. J"},{"issue":"2","key":"10.1016\/j.jdermsci.2018.07.002_bib0270","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/1523-1747.ep12650445","article-title":"Ultraviolet light irradiation increases cellular diacylglycerol and induces translocation of diacylglycerol kinase in murine keratinocytes","volume":"99","author":"Punnonen","year":"1992","journal-title":"J. Invest. Dermatol."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181118302767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181118302767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T13:36:50Z","timestamp":1604583410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181118302767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0923181118302767"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2018.07.002","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phenotypic and lipidomic characterization of primary human epidermal keratinocytes exposed to simulated solar UV radiation","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2018.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}