{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:12:23Z","timestamp":1760346743117},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Health, Labour, and Welfare of Japan"}],"content-domain":{"domain":["clinicalkey.jp","jdsjournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.jdermsci.2018.09.005","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T05:04:37Z","timestamp":1537419877000},"page":"207-214","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Progranulin overproduction due to constitutively activated c-Abl\/PKC-\u03b4\/Fli1 pathway contributes to the resistance of dermal fibroblasts to the anti-fibrotic effect of tumor necrosis factor-\u03b1 in localized scleroderma"],"prefix":"10.1016","volume":"92","author":[{"given":"Takuya","family":"Miyagawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Ichimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Hirabayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Saigusa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaname","family":"Akamata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Yoshizaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihide","family":"Asano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2018.09.005_bib0005","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","article-title":"Classification criteria for systemic sclerosis: an American college of rheumatology\/European league against rheumatism collaborative initiative","volume":"72","author":"van den Hoogen","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0010","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jaad.2010.05.045","article-title":"Update on morphea: part I. Epidemiology, clinical presentation, and pathogenesis","volume":"64","author":"Fett","year":"2011","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0015","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00281-015-0505-5","article-title":"Vasculopathy in scleroderma","volume":"37","author":"Asano","year":"2015","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0020","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1111\/jdv.12280","article-title":"Histological features of localized scleroderma\u2019 en coup de sabre\u2019: a study of 16 cases","volume":"28","author":"Taniguchi","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0025","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.jdermsci.2017.12.005","article-title":"Systemic sclerosis complicated with localized scleroderma-like lesions induced by Kobner phenomenon","volume":"89","author":"Saigusa","year":"2018","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0030","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1002\/art.11129","article-title":"Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha","volume":"48","author":"Chizzolini","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0035","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1126\/science.1199214","article-title":"The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice","volume":"332","author":"Tang","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0040","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nm816","article-title":"Progranulin is a mediator of the wound response","volume":"9","author":"He","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0045","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1002\/art.39312","article-title":"Progranulin overproduction due to Fli-1 deficiency contributes to the resistance of dermal fibroblasts to tumor necrosis factor in systemic sclerosis","volume":"67","author":"Ichimura","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0050","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.biocel.2015.06.004","article-title":"Epigenetic suppression of Fli1, a potential predisposing factor in the pathogenesis of systemic sclerosis","volume":"67","author":"Asano","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0055","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1002\/art.21948","article-title":"Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts","volume":"54","author":"Wang","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0060","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1111\/j.1365-2133.2012.11055.x","article-title":"Constitutive activation of c-Abl\/protein kinase C-\u03b4\/Fli1 pathway in dermal fibroblasts derived from patients with localized scleroderma","volume":"167","author":"Noda","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0065","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/01.bor.0000245727.40630.c3","article-title":"Localized scleroderma","volume":"18","author":"Laxer","year":"2006","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0070","doi-asserted-by":"crossref","first-page":"34672","DOI":"10.1074\/jbc.M703907200","article-title":"Transforming growth factor-beta regulates DNA binding activity of transcription factor Fli1 by p300\/CREB-binding protein-associated factor-dependent acetylation","volume":"282","author":"Asano","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0075","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.2353\/ajpath.2008.071049","article-title":"CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma","volume":"172","author":"Yoshizaki","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0080","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00403-013-1431-9","article-title":"Fli1 deficiency contributes to the suppression of endothelial CXCL5 expression in systemic sclerosis","volume":"306","author":"Ichimura","year":"2014","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0085","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0002-9440(10)63215-4","article-title":"Increased expression levels of integrin alphavbeta5 on scleroderma fibroblasts","volume":"164","author":"Asano","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0090","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1128\/MCB.01320-08","article-title":"Phosphorylation of Fli1 at threonine 312 by protein kinase C delta promotes its interaction with p300\/CREB-binding protein-associated factor and subsequent acetylation in response to transforming growth factor beta","volume":"29","author":"Asano","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0095","doi-asserted-by":"crossref","first-page":"5841","DOI":"10.1016\/S0021-9258(18)60642-8","article-title":"Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts","volume":"263","author":"Solis-Herruzo","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0100","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI114866","article-title":"Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels","volume":"86","author":"K\u00e4h\u00e4ri","year":"1990","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0105","doi-asserted-by":"crossref","first-page":"30226","DOI":"10.1074\/jbc.M005310200","article-title":"Tumor necrosis factor-alpha inhibits transforming growth factor-beta \/Smad signaling in human dermal fibroblasts via AP-1 activation","volume":"275","author":"Verrecchia","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0110","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.4049\/jimmunol.171.7.3855","article-title":"Antagonistic effects of TNF-alpha on TGF-beta signaling through down-regulation of TGF-beta receptor type II in human dermal fibroblasts","volume":"171","author":"Yamane","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0115","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1038\/sj.jid.5700331","article-title":"Involvement of alphavbeta5 integrin in the establishment of autocrine TGF-beta signaling in dermal fibroblasts derived from localized scleroderma","volume":"126","author":"Asano","year":"2006","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0120","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1136\/ard.2010.143974","article-title":"Imatinib mesylate (Gleevec) in the treatment of diffuse cutaneous systemic sclerosis: results of a 1-year, phase IIa, single-arm, open-label clinical trial","volume":"70","author":"Spiera","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0125","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1083\/jcb.201603079","article-title":"EphA2 is a functional receptor for the growth factor progranulin","volume":"215","author":"Neill","year":"2016","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0130","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.neuron.2010.09.034","article-title":"Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin","volume":"68","author":"Hu","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0135","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1038\/jid.2010.120","article-title":"Epithelial cells promote fibroblast activation via IL-1alpha in systemic sclerosis","volume":"130","author":"Aden","year":"2010","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0140","first-page":"5","article-title":"Expression of NLRP3 inflammasome, cytokines and vascular mediators in the skin of systemic sclerosis patients","volume":"17","author":"Mart\u00ednez-God\u00ednez","year":"2015","journal-title":"Isr. Med. Assoc. J."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0145","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000071783","article-title":"Serum levels of tumor necrosis factor and interleukin-13 are elevated in patients with localized scleroderma","volume":"207","author":"Hasegawa","year":"2003","journal-title":"Dermatology"},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0150","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3109\/s10165-011-0550-4","article-title":"Morphea associated with the use of adalimumab: a case report and review of the literature","volume":"22","author":"Ramirez","year":"2012","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0155","first-page":"400","article-title":"Morphea, an unusual side effect of anti-TNF-alpha treatment","author":"Mattozzi","year":"2010","journal-title":"Eur. J. Dermatol. France"},{"key":"10.1016\/j.jdermsci.2018.09.005_bib0160","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/j.1365-2133.2011.10243.x","article-title":"A case of taxane-induced scleroderma: a different expression profile of Fli1 proteins in dermal fibroblasts and microvascular endothelial cells compared with systemic sclerosis","volume":"164","author":"Takahashi","year":"2011","journal-title":"Br. J. Dermatol."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181118303694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181118303694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:11:33Z","timestamp":1662077493000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181118303694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0923181118303694"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2018.09.005","relation":{},"ISSN":["0923-1811"],"issn-type":[{"type":"print","value":"0923-1811"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progranulin overproduction due to constitutively activated c-Abl\/PKC-\u03b4\/Fli1 pathway contributes to the resistance of dermal fibroblasts to the anti-fibrotic effect of tumor necrosis factor-\u03b1 in localized scleroderma","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2018.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}