{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:42:46Z","timestamp":1790775766992,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.jdermsci.2019.06.001","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T23:46:21Z","timestamp":1560901581000},"page":"2-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Protective and pathogenic roles of resident memory T cells in human skin disorders"],"prefix":"10.1016","volume":"95","author":[{"given":"Rei","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jdermsci.2019.06.001_bib0005","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ni.2744","article-title":"The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin","volume":"14","author":"Mackay","year":"2013","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.jdermsci.2019.06.001_bib0010","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/ni.1718","article-title":"Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus","volume":"10","author":"Gebhardt","year":"2009","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.jdermsci.2019.06.001_bib0015","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.cell.2014.10.026","article-title":"Spatial map of human T cell compartmentalization and maintenance over decades of life","volume":"159","author":"Thome","year":"2014","journal-title":"Cell"},{"issue":"7388","key":"10.1016\/j.jdermsci.2019.06.001_bib0020","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nature10851","article-title":"Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity","volume":"483","author":"Jiang","year":"2012","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jdermsci.2019.06.001_bib0025","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nm.2078","article-title":"Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity","volume":"16","author":"Liu","year":"2010","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.jdermsci.2019.06.001_bib0030","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/eji.1830220402","article-title":"Tissue-specific migration pathways by phenotypically distinct subpopulations of memory T cells","volume":"22","author":"Mackay","year":"1992","journal-title":"Eur. J. Immunol."},{"issue":"3","key":"10.1016\/j.jdermsci.2019.06.001_bib0035","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.4049\/jimmunol.166.3.1813","article-title":"Activated antigen-specific CD8+ T cells persist in the lungs following recovery from respiratory virus infections","volume":"166","author":"Hogan","year":"2001","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.jdermsci.2019.06.001_bib0040","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.immuni.2014.03.007","article-title":"Oral infection drives a distinct population of intestinal resident memory CD8(+) T cells with enhanced protective function","volume":"40","author":"Sheridan","year":"2014","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.jdermsci.2019.06.001_bib0045","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.4049\/jimmunol.1402256","article-title":"Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention","volume":"194","author":"Mackay","year":"2015","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.jdermsci.2019.06.001_bib0050","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/ni.2745","article-title":"Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells","volume":"14","author":"Skon","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jdermsci.2019.06.001_bib0055","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-94-017-9153-3_7","article-title":"Integrin alphaEbeta7: molecular features and functional significance in the immune system","volume":"819","author":"Hadley","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"issue":"279","key":"10.1016\/j.jdermsci.2019.06.001_bib0060","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3010302","article-title":"Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells","volume":"7","author":"Watanabe","year":"2015","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.jdermsci.2019.06.001_bib0065","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.immuni.2017.01.009","article-title":"CD49a expression defines tissue-resident CD8(+) t cells poised for cytotoxic function in human skin","volume":"46","author":"Cheuk","year":"2017","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.jdermsci.2019.06.001_bib0070","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.4049\/jimmunol.1701377","article-title":"CCR8 expression defines tissue-resident memory T cells in human skin","volume":"200","author":"McCully","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2019.06.001_bib0075","article-title":"Staged development of long lived TCRalphabeta Th17 resident memory T cell population to Candida albicans after skin infection","author":"Park","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"issue":"7450","key":"10.1016\/j.jdermsci.2019.06.001_bib0080","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/nature12110","article-title":"Immune surveillance by CD8alphaalpha+ skin-resident T cells in human herpes virus infection","volume":"497","author":"Zhu","year":"2013","journal-title":"Nature"},{"issue":"6205","key":"10.1016\/j.jdermsci.2019.06.001_bib0085","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.1257530","article-title":"T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells","volume":"346","author":"Iijima","year":"2014","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.jdermsci.2019.06.001_bib0090","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/mi.2017.96","article-title":"Detection of HIV-1-specific gastrointestinal tissue resident CD8(+) T-cells in chronic infection","volume":"11","author":"Kiniry","year":"2018","journal-title":"Mucosal Immunol."},{"issue":"12","key":"10.1016\/j.jdermsci.2019.06.001_bib0095","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aam6970","article-title":"Resident memory CD8(+) T cells in the upper respiratory tract prevent pulmonary influenza virus infection","volume":"2","author":"Pizzolla","year":"2017","journal-title":"Sci. Immunol."},{"issue":"1","key":"10.1016\/j.jdermsci.2019.06.001_bib0100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jdermsci.2014.07.010","article-title":"The panoply of alphabetaT cells in the skin","volume":"76","author":"Nomura","year":"2014","journal-title":"J. Dermatol. Sci."},{"issue":"3","key":"10.1016\/j.jdermsci.2019.06.001_bib0105","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0091-6749(03)01624-5","article-title":"IFN-gamma-producing effector CD8+ T cells and IL-10-producing regulatory CD4+ T cells in fixed drug eruption","volume":"112","author":"Teraki","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.jdermsci.2019.06.001_bib0110","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/S0002-9440(10)64410-0","article-title":"Direct evidence for interferon-gamma production by effector-memory-type intraepidermal T cells residing at an effector site of immunopathology in fixed drug eruption","volume":"161","author":"Mizukawa","year":"2002","journal-title":"Am. J. Pathol."},{"issue":"10","key":"10.1016\/j.jdermsci.2019.06.001_bib0115","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1001\/archderm.1989.01670220067010","article-title":"Fixed drug eruption. Expression of epidermal keratinocyte intercellular adhesion molecule-1 (ICAM-1)","volume":"125","author":"Shiohara","year":"1989","journal-title":"Arch. Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2019.06.001_bib0120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000078583","article-title":"Successful desensitization to fixed drug eruption: the presence of CD25+CD4+ T cells in the epidermis of fixed drug eruption lesions may be involved in the induction of desensitization","volume":"209","author":"Teraki","year":"2004","journal-title":"Dermatology"},{"issue":"7","key":"10.1016\/j.jdermsci.2019.06.001_bib0125","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.4049\/jimmunol.1302313","article-title":"Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasis","volume":"192","author":"Cheuk","year":"2014","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.jdermsci.2019.06.001_bib0130","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/1523-1747.ep12335758","article-title":"T-lymphocyte dependence of psoriatic pathology in human psoriatic skin grafted to SCID mice","volume":"109","author":"Gilhar","year":"1997","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2019.06.001_bib0135","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0002-9440(10)65109-7","article-title":"Injection of pre-psoriatic skin with CD4+ T cells induces psoriasis","volume":"155","author":"Nickoloff","year":"1999","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.jdermsci.2019.06.001_bib0140","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1084\/jem.20031482","article-title":"Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha","volume":"199","author":"Boyman","year":"2004","journal-title":"J. Exp. Med."},{"issue":"7","key":"10.1016\/j.jdermsci.2019.06.001_bib0145","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nm1605","article-title":"Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis","volume":"13","author":"Conrad","year":"2007","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.jdermsci.2019.06.001_bib0150","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jaci.2015.10.046","article-title":"Targeting CD8(+) T cells prevents psoriasis development","volume":"138","author":"Di Meglio","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6 Suppl","key":"10.1016\/j.jdermsci.2019.06.001_bib0155","doi-asserted-by":"crossref","first-page":"135S","DOI":"10.1111\/1523-1747.ep12876121","article-title":"Role of growth factors, cytokines, and their receptors in the pathogenesis of psoriasis","volume":"94","author":"Krueger","year":"1990","journal-title":"J. Invest. Dermatol."},{"issue":"23","key":"10.1016\/j.jdermsci.2019.06.001_bib0160","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1001\/jama.290.23.3073","article-title":"Efalizumab for patients with moderate to severe plaque psoriasis: a randomized controlled trial","volume":"290","author":"Gordon","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jdermsci.2019.06.001_bib0165","article-title":"A skewed pool of resident T cells triggers psoriasis-associated tissue responses in never-lesional skin from patients with psoriasis","author":"Gallais Serezal","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jdermsci.2019.06.001_bib0170","doi-asserted-by":"crossref","DOI":"10.1111\/bjd.17748","article-title":"CD8 resident memory T cells with IL-17A-producing potential are accumulated in disease-naive non-lesional sites of psoriasis possibly in correlation with disease duration","author":"Vo","year":"2019","journal-title":"Br. J. Dermatol."},{"issue":"8","key":"10.1016\/j.jdermsci.2019.06.001_bib0175","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1016\/j.jid.2018.02.030","article-title":"Resident t cells in resolved psoriasis steer tissue responses that stratify clinical outcome","volume":"138","author":"Gallais Serezal","year":"2018","journal-title":"J. Invest. Dermatol."},{"issue":"11","key":"10.1016\/j.jdermsci.2019.06.001_bib0180","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1172\/JCI93396","article-title":"Clinically resolved psoriatic lesions contain psoriasis-specific IL-17-producing alphabeta T cell clones","volume":"127","author":"Matos","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jdermsci.2019.06.001_bib0185","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.1038\/ncomms6621","article-title":"The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis","volume":"5","author":"Lande","year":"2014","journal-title":"Nat. Commun."},{"issue":"13","key":"10.1016\/j.jdermsci.2019.06.001_bib0190","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1084\/jem.20151093","article-title":"Melanocyte antigen triggers autoimmunity in human psoriasis","volume":"212","author":"Arakawa","year":"2015","journal-title":"J. Exp. Med."},{"issue":"9","key":"10.1016\/j.jdermsci.2019.06.001_bib0195","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1038\/jid.2009.32","article-title":"Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients","volume":"129","author":"van den Boorn","year":"2009","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.jdermsci.2019.06.001_bib0200","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jid.2017.08.038","article-title":"Vitiligo skin is imprinted with resident memory CD8 t cells expressing CXCR3","volume":"138","author":"Boniface","year":"2018","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.jdermsci.2019.06.001_bib0205","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jdermsci.2015.02.001","article-title":"Biochemical, cytological, and immunological mechanisms of rhododendrol-induced leukoderma","volume":"77","author":"Tokura","year":"2015","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2019.06.001_bib0210","article-title":"Resident memory and recirculating memory t cells cooperate to maintain disease in a mouse model of vitiligo","author":"Richmond","year":"2018","journal-title":"J. Invest. Dermatol."},{"issue":"11","key":"10.1016\/j.jdermsci.2019.06.001_bib0215","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/nm.3962","article-title":"Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma","volume":"21","author":"Adachi","year":"2015","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.jdermsci.2019.06.001_bib0220","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aam6346","article-title":"Resident memory T cells in the skin mediate durable immunity to melanoma","volume":"2","author":"Malik","year":"2017","journal-title":"Sci. Immunol."},{"issue":"117","key":"10.1016\/j.jdermsci.2019.06.001_bib0225","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003008","article-title":"Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients","volume":"4","author":"Clark","year":"2012","journal-title":"Sci. Transl. Med."},{"issue":"7","key":"10.1016\/j.jdermsci.2019.06.001_bib0230","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1001\/jamadermatol.2013.10099","article-title":"Alemtuzumab therapy for leukemic cutaneous T-cell lymphoma: diffuse erythema as a positive predictor of complete remission","volume":"150","author":"Watanabe","year":"2014","journal-title":"JAMA Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2019.06.001_bib0235","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jdermsci.2013.12.003","article-title":"CCR7 expression correlates with subcutaneous involvement in mycosis fungoides skin lesions and promotes migration of mycosis fungoides cells (MyLa) through mTOR activation","volume":"74","author":"Hu","year":"2014","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2019.06.001_bib0240","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.3389\/fimmu.2018.02076","article-title":"Tumor resident memory t cells: new players in immune surveillance and therapy","volume":"9","author":"Dumauthioz","year":"2018","journal-title":"Front. Immunol."},{"issue":"21","key":"10.1016\/j.jdermsci.2019.06.001_bib0245","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.88955","article-title":"Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cells","volume":"1","author":"Boddupalli","year":"2016","journal-title":"JCI Insight"},{"issue":"6","key":"10.1016\/j.jdermsci.2019.06.001_bib0250","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.125476","article-title":"Skin cancer precursor immunotherapy for squamous cell carcinoma prevention","volume":"4","author":"Rosenberg","year":"2019","journal-title":"JCI Insight"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181119301471?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181119301471?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:49:26Z","timestamp":1760330966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181119301471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0923181119301471"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2019.06.001","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective and pathogenic roles of resident memory T cells in human skin disorders","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2019.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}