{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:01:30Z","timestamp":1767902490822,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jdermsci.2019.07.007","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T11:28:14Z","timestamp":1563967694000},"page":"99-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Thimerosal induces skin pseudo-allergic reaction via Mas-related G-protein coupled receptor B2"],"prefix":"10.1016","volume":"95","author":[{"given":"Bin","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delu","family":"Che","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Langchong","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songmei","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2019.07.007_bib0005","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/bjd.14167","article-title":"Prevalence of contact allergy in the general population in different European regions","volume":"174","author":"Diepgen","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0010","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1067\/mjd.2001.113473","article-title":"Thimerosal in the detection of clinically relevant allergic contact reactions","volume":"45","author":"Suneja","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0015","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1590\/abd1806-4841.20142645","article-title":"Thimerosal: current sources of contact in Brazil","volume":"89","author":"Rocha","year":"2014","journal-title":"An. Bras. Derm. Sifilogr."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0020","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/jocd.12359","article-title":"Patch testing in patients with suspected cosmetic dermatitis: a retrospective study","volume":"17","author":"Garg","year":"2018","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0025","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/jocd.12078","article-title":"Contact sensitization to cosmetic series of allergens in a general population in Beijing","volume":"13","author":"Zhao","year":"2014","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0030","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1346-8138.2012.01551.x","article-title":"Multicenter study of preservative sensitivity in patients with suspected cosmetic contact dermatitis in Korea","volume":"39","author":"Lee","year":"2012","journal-title":"J. Dermatol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0035","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.0105-1873.2004.00334.x","article-title":"Allergic and non-allergic periorbital dermatitis: patch test results of the Information Network of the Departments of Dermatology during a 5-year period","volume":"51","author":"Herbst","year":"2004","journal-title":"Contact Derm."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0040","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jaad.2003.11.069","article-title":"Prevalence and relevance of contact dermatitis allergens: a meta-analysis of 15 years of published T.R.U.E. Test data","volume":"51","author":"Krob","year":"2004","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0045","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1600-0536.2011.01963.x","article-title":"Contact allergy and allergic contact dermatitis in children\u2014a review of current data","volume":"65","author":"Simonsen","year":"2011","journal-title":"Contact Derm."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0050","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1001\/archderm.136.2.272","article-title":"North American Contact Dermatitis Group patch-test results, 1996\u20131998","volume":"136","author":"Marks","year":"2000","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/ajcd.2002.31366","article-title":"Thimerosal: contact (non)allergen of the year","volume":"13","author":"Belsito","year":"2002","journal-title":"Am. J. Contact Dermat."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0060","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nri2018","article-title":"Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data","volume":"7","author":"Bischoff","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0065","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.jaci.2014.05.004","article-title":"Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria","volume":"134","author":"Fujisawa","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0070","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature14022","article-title":"Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions","volume":"519","author":"Mcneil","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0075","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jaci.2016.04.051","article-title":"Roles of Mas-related G protein\u2013coupled receptor X2 on mast cell\u2013mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases","volume":"138","author":"Subramanian","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0080","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/all.13301","article-title":"Allergic Fc\u03b5RI- and pseudo-allergic MRGPRX2-triggered mast cell activation routes are independent and inversely regulated by SCF","volume":"73","author":"Babina","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2018.03027","article-title":"Mas-related G protein-coupled receptor-X2 (MRGPRX2) in drug hypersensitivity reactions","volume":"9","author":"Porebski","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0090","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cellimm.2018.08.005","article-title":"Mivacurium induce mast cell activation and pseudo-allergic reactions via MAS-related G protein coupled receptor-X2","volume":"332","author":"Che","year":"2018","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0095","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1002\/eji.201746951","article-title":"Typical antimicrobials induce mast cell degranulation and anaphylactoid reactions via MRGPRX2 and its murine homologue MRGPRB2","volume":"47","author":"Zhang","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0100","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0002-9440(10)62055-X","article-title":"Mast cell-deficient W-sash c-kit mutant Kit W-sh mice as a model for investigating mast cell biology in vivo","volume":"167","author":"Grimbaldeston","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0105","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/toxsci\/kfg126","article-title":"Thimerosal induces DNA breaks, caspase-3 activation, membrane damage, and cell death in cultured human neurons and fibroblasts","volume":"74","author":"Baskin","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0110","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.immuni.2011.03.028","article-title":"Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens","volume":"34","author":"Dudeck","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0115","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nri3150","article-title":"Early immune events in the induction of allergic contact dermatitis","volume":"12","author":"Kaplan","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0120","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/jid.2012.284","article-title":"Update of immune events in the murine contact hypersensitivity model: toward the understanding of allergic contact dermatitis","volume":"133","author":"Honda","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0125","doi-asserted-by":"crossref","first-page":"11628","DOI":"10.1038\/s41598-018-29965-8","article-title":"MRGPRX2-mediated mast cell response to drugs used in perioperative procedures and anaesthesia","volume":"8","author":"Navin\u00e9s-ferrer","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0130","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000453265","article-title":"Classification of drug hypersensitivity into allergic, p-i, and pseudo-allergic forms","volume":"171","author":"Pichler","year":"2017","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0135","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.bbrc.2006.08.177","article-title":"Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptors","volume":"349","author":"Tatemoto","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0140","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/imr.12629","article-title":"Non-IgE mediated mast cell activation","volume":"282","author":"Redegeld","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0145","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.4049\/jimmunol.173.6.4197","article-title":"IL-8 is a key chemokine regulating neutrophil recruitment in a new mouse model of shigella-induced colitis","volume":"173","author":"Singer","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-2094-7-20","article-title":"Mercury induces inflammatory mediator release from human mast cells","volume":"7","author":"Kempuraj","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0155","first-page":"399","article-title":"Patch testing with thimerosal in a Canadian center: an 11-year experience","volume":"91","author":"Freiman","year":"2003","journal-title":"Am. J. Contact Dermat."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0160","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12016-018-8705-0","article-title":"Contact dermatitis to medications and skin products","volume":"56","author":"Nguyen","year":"2018","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0165","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1525-1470.2008.00769.x","article-title":"Clinically relevant patch test reactions in children\u2014a United States based study","volume":"25","author":"Jacob","year":"2008","journal-title":"Pediatr. Dermatol."},{"key":"10.1016\/j.jdermsci.2019.07.007_bib0170","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s11882-014-0421-0","article-title":"Allergic contact dermatitis in children: review of the past decade","volume":"14","author":"Admani","year":"2014","journal-title":"Curr. Allergy Asthma Rep."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181119302361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181119302361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:49:30Z","timestamp":1760330970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181119302361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0923181119302361"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2019.07.007","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thimerosal induces skin pseudo-allergic reaction via Mas-related G-protein coupled receptor B2","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2019.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}