{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:18:30Z","timestamp":1788607110439,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.jdermsci.2020.06.007","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T11:32:52Z","timestamp":1592998372000},"page":"100-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["TGF-\u03b23 suppresses melanogenesis in human melanocytes cocultured with UV-irradiated neighboring cells and human skin"],"prefix":"10.1016","volume":"99","author":[{"given":"Hye-Rim","family":"Moon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Min","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngsup","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Eun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2020.06.007_bib0005","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1038\/jid.2010.5","article-title":"Regulation of human skin pigmentation in situ by repetitive UV exposure: molecular characterization of responses to UVA and\/or UVB","volume":"130","author":"Choi","year":"2010","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0010","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature05660","article-title":"Melanocyte biology and skin pigmentation","volume":"445","author":"Lin","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0015","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/bjd.15651","article-title":"Paracrine regulation of melanogenesis","volume":"178","author":"Yuan","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0020","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1046\/j.1523-1747.2001.01290.x","article-title":"The paracrine role of stem cell factor\/c-kit signaling in the activation of human melanocytes in ultraviolet-B-induced pigmentation","volume":"116","author":"Hachiya","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0025","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/j.0022-202X.2004.22503.x","article-title":"The epidermal stem cell factor is over-expressed in lentigo senilis: implication for the mechanism of hyperpigmentation","volume":"122","author":"Hattori","year":"2004","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0030","doi-asserted-by":"crossref","first-page":"24675","DOI":"10.1016\/S0021-9258(18)35817-4","article-title":"Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes","volume":"267","author":"Imokawa","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0035","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1046\/j.1523-1747.2001.01296.x","article-title":"The role of the epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilis","volume":"116","author":"Kadono","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0040","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jdermsci.2013.03.012","article-title":"Effects of fibroblast-derived factors on the proliferation and differentiation of human melanocytes in culture","volume":"71","author":"Hirobe","year":"2013","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0045","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jdermsci.2017.06.018","article-title":"Precise role of dermal fibroblasts on melanocyte pigmentation","volume":"88","author":"Wang","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0050","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/pcmr.12234","article-title":"Factors secreted by irradiated aged fibroblasts induce solar lentigo in pigmented reconstructed epidermis","volume":"27","author":"Salducci","year":"2014","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114182","article-title":"Key regulatory role of dermal fibroblasts in pigmentation as demonstrated using a reconstructed skin model: impact of photo-aging","volume":"9","author":"Duval","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0060","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.3390\/ijms19051475","article-title":"Silencing stem cell factor gene in fibroblasts to regulate paracrine factor productions and enhance c-Kit expression in melanocytes on melanogenesis","volume":"19","author":"Li","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0065","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.devcel.2008.11.009","article-title":"TGF-beta targets PAX3 to control melanocyte differentiation","volume":"15","author":"Moustakas","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0070","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s11033-008-9304-6","article-title":"Regulation of melanin synthesis by the TGF-beta family in B16 melanoma cells","volume":"36","author":"Murakami","year":"2009","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0075","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1074\/jbc.272.7.3967","article-title":"Transforming growth factor-beta1 inhibits basal melanogenesis in B16\/F10 mouse melanoma cells by increasing the rate of degradation of tyrosinase and tyrosinase-related protein-1","volume":"272","author":"Martinez-Esparza","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0080","first-page":"1482","article-title":"Transforming growth factor-beta1 decreases melanin synthesis via delayed extracellular signal-regulated kinase activation","volume":"36","author":"Kim","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0085","doi-asserted-by":"crossref","first-page":"17996","DOI":"10.1074\/jbc.M112.358341","article-title":"Expression of microphthalmia-associated transcription factor (MITF), which is critical for melanoma progression, is inhibited by both transcription factor GLI2 and transforming growth factor-\u03b2","volume":"287","author":"Pierrat","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"Pt 3","key":"10.1016\/j.jdermsci.2020.06.007_bib0090","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1242\/jcs.108.3.985","article-title":"Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring","volume":"108","author":"Shah","year":"1995","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0095","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jdermsci.2015.02.012","article-title":"Transforming growth factor-beta (TGF-beta) signaling in healthy human fetal skin: a descriptive study","volume":"78","author":"Walraven","year":"2015","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0100","doi-asserted-by":"crossref","first-page":"8490","DOI":"10.1074\/jbc.RA118.005763","article-title":"Transforming growth factor\u2013\u03b2 (TGF-\u03b2)\u2013induced up-regulation of TGF-\u03b2 receptors at the cell surface amplifies the TGF-\u03b2 response","volume":"294","author":"Duan","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0105","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1600-0749.1998.tb00735.x","article-title":"Does alpha-MSH have a role in regulating skin pigmentation in humans?","volume":"11","author":"Thody","year":"1998","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0110","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1749-6632.1999.tb08679.x","article-title":"alpha-MSH and the regulation of melanocyte function","volume":"885","author":"Thody","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0128678","article-title":"UVB stimulates the expression of endothelin B receptor in human melanocytes via a sequential activation of the p38\/MSK1\/CREB\/MITF pathway which can Be interrupted by a French maritime pine bark extract through a direct inactivation of MSK1","volume":"10","author":"Tagashira","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0120","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/jid.2014.423","article-title":"Substance P stimulates endothelin 1 secretion via endothelin-converting enzyme 1 and promotes melanogenesis in human melanocytes","volume":"135","author":"Park","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0125","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/php.12400","article-title":"Nobiletin, a polymethoxy flavonoid, reduced endothelin-1 plus SCF-induced pigmentation in human melanocytes","volume":"91","author":"Kim","year":"2015","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0130","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-\u03b2 signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0135","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00403-015-1543-5","article-title":"Melanogenesis inhibition of \u03b2-lapachone, a natural product from Tabebuia avellanedae, with effective in vivo lightening potency","volume":"307","author":"Kim","year":"2015","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0140","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0733-8635(03)00085-8","article-title":"Skin cancer and photoaging in ethnic skin","volume":"21","author":"Halder","year":"2003","journal-title":"Dermatol. Clin."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0145","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1034\/j.1600-0749.2001.140205.x","article-title":"Possible involvement of ERK 1\/2 in UVA\u2010induced melanogenesis in cultured normal human epidermal melanocytes","volume":"14","author":"Yanase","year":"2001","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0150","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0898-6568(02)00024-4","article-title":"Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes","volume":"14","author":"Kim","year":"2002","journal-title":"Cell. Signal."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0155","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1242\/jcs.00366","article-title":"Sphingosine-1-phosphate decreases melanin synthesis via sustained ERK activation and subsequent MITF degradation","volume":"116","author":"Kim","year":"2003","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0160","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/34681","article-title":"MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes","volume":"391","author":"Hemesath","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0165","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1101\/gad.14.3.301","article-title":"c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi","volume":"14","author":"Wu","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0170","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/jid.2012.241","article-title":"TGFbeta1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity","volume":"133","author":"Mohammed","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0175","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1200\/JCO.2005.02.047","article-title":"Role of transforming growth factor Beta in human cancer","volume":"23","author":"Elliott","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0180","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1248\/bpb.31.606","article-title":"Whitening effect of adipose-derived stem cells: a critical role of TGF-beta 1","volume":"31","author":"Kim","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0185","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/pcmr.12355","article-title":"Increased circulating Th17 cells and elevated serum levels of TGF\u2010beta and IL\u201021 are correlated with human non\u2010segmental vitiligo development","volume":"28","author":"Zhou","year":"2015","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0190","doi-asserted-by":"crossref","first-page":"5737","DOI":"10.1021\/bi500647d","article-title":"Biological activity differences between TGF-\u03b21 and TGF-\u03b23 correlate with differences in the rigidity and arrangement of their component monomers","volume":"53","author":"Huang","year":"2014","journal-title":"Biochemistry"},{"key":"10.1016\/j.jdermsci.2020.06.007_bib0195","doi-asserted-by":"crossref","first-page":"S100","DOI":"10.1111\/1523-1747.ep12540786","article-title":"Involucrin and other markers of keratinocyte terminal differentiation","volume":"81","author":"Watt","year":"1983","journal-title":"J. Invest. Dermatol."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092318112030205X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092318112030205X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:50:31Z","timestamp":1760331031000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092318112030205X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S092318112030205X"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2020.06.007","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TGF-\u03b23 suppresses melanogenesis in human melanocytes cocultured with UV-irradiated neighboring cells and human skin","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2020.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}