{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:54:10Z","timestamp":1790553250466,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.jdermsci.2020.08.011","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T03:36:53Z","timestamp":1598672213000},"page":"58-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["TLR3 augments glucocorticoid-synthetic enzymes expression in epidermal keratinocytes; Implications of glucocorticoid metabolism in rosacea epidermis"],"prefix":"10.1016","volume":"100","author":[{"given":"Ryoko","family":"Shimada-Omori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenshi","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saaya","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setsuya","family":"Aiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2020.08.011_bib0005","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3389\/fnins.2016.00547","article-title":"ACTH action on StAR biology","volume":"10","author":"Clark","year":"2016","journal-title":"Front. Neurosci."},{"issue":"4854","key":"10.1016\/j.jdermsci.2020.08.011_bib0010","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.3283939","article-title":"The steroid and thyroid hormone receptor superfamily","volume":"240","author":"Evans","year":"1988","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.jdermsci.2020.08.011_bib0015","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jaci.2013.09.007","article-title":"The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease","volume":"132","author":"Oakley","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"issue":"8","key":"10.1016\/j.jdermsci.2020.08.011_bib0020","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nm1616","article-title":"Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea","volume":"13","author":"Yamasaki","year":"2007","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.jdermsci.2020.08.011_bib0025","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/jid.2010.351","article-title":"TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes","volume":"131","author":"Yamasaki","year":"2011","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.jdermsci.2020.08.011_bib0030","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jdermsci.2009.04.007","article-title":"The molecular pathology of rosacea","volume":"55","author":"Yamasaki","year":"2009","journal-title":"J. Dermatol. Sci."},{"issue":"1","key":"10.1016\/j.jdermsci.2020.08.011_bib0035","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/jidsymp.2011.4","article-title":"Rosacea as a disease of cathelicidins and skin innate immunity","volume":"15","author":"Yamasaki","year":"2011","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"issue":"7","key":"10.1016\/j.jdermsci.2020.08.011_bib0040","first-page":"2746","article-title":"ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin","volume":"81","author":"Slominski","year":"1996","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"6","key":"10.1016\/j.jdermsci.2020.08.011_bib0045","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1002\/jcb.23081","article-title":"Keratinocytes synthesize and activate cortisol","volume":"112","author":"Cirillo","year":"2011","journal-title":"J. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.jdermsci.2020.08.011_bib0050","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/pcmr.12703","article-title":"Toll-like receptors 2 and 3 enhance melanogenesis and melanosome transport in human melanocytes","volume":"31","author":"Koike","year":"2018","journal-title":"Pigment Cell Melanoma Res."},{"issue":"2","key":"10.1016\/j.jdermsci.2020.08.011_bib0055","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1016\/j.jid.2017.06.021","article-title":"The potential of muse cells for regenerative medicine of skin: procedures to reconstitute skin with muse cell-derived keratinocytes, fibroblasts, and melanocytes","volume":"137","author":"Yamauchi","year":"2017","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.jdermsci.2020.08.011_bib0060","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jdermsci.2017.03.001","article-title":"A quantitative analysis of multilineage-differentiating stress-enduring (Muse) cells in human adipose tissue and efficacy of melanocytes induction","volume":"86","author":"Yamauchi","year":"2017","journal-title":"J. Dermatol. Sci."},{"issue":"10","key":"10.1016\/j.jdermsci.2020.08.011_bib0065","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1038\/jid.2013.172","article-title":"Functional melanocytes are readily reprogrammable from multilineage-differentiating stress-enduring (muse) cells, distinct stem cells in human fibroblasts","volume":"133","author":"Tsuchiyama","year":"2013","journal-title":"J. Invest. Dermatol."},{"issue":"10","key":"10.1016\/j.jdermsci.2020.08.011_bib0070","doi-asserted-by":"crossref","first-page":"5140","DOI":"10.4049\/jimmunol.1302574","article-title":"Alarmin function of cathelicidin antimicrobial peptide LL37 through IL-36gamma induction in human epidermal keratinocytes","volume":"193","author":"Li","year":"2014","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.jdermsci.2020.08.011_bib0075","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1038\/jid.2013.163","article-title":"In vivo imaging demonstrates ATP release from murine keratinocytes and its involvement in cutaneous inflammation after tape stripping","volume":"133","author":"Takahashi","year":"2013","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.jdermsci.2020.08.011_bib0080","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jdermsci.2019.04.005","article-title":"Toll-like receptor 2 utilizes RAB11A for melanosome transfer from melanocytes to keratinocytes","volume":"94","author":"Koike","year":"2019","journal-title":"J. Dermatol. Sci."},{"issue":"2","key":"10.1016\/j.jdermsci.2020.08.011_bib0085","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jdermsci.2019.04.004","article-title":"TRIF and MAVS signaling pathways regulate RAB27A induction and melanosome transfer by TLR3 signaling in human epidermal melanocytes","volume":"94","author":"Koike","year":"2019","journal-title":"J. Dermatol. Sci."},{"issue":"8","key":"10.1016\/j.jdermsci.2020.08.011_bib0090","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/nm.2861","article-title":"Ultraviolet radiation damages self noncoding RNA and is detected by TLR3","volume":"18","author":"Bernard","year":"2012","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.jdermsci.2020.08.011_bib0095","doi-asserted-by":"crossref","first-page":"10265","DOI":"10.1074\/jbc.M110.188268","article-title":"Cortisol synthesis in epidermis is induced by IL-1 and tissue injury","volume":"286","author":"Vukelic","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.jdermsci.2020.08.011_bib0100","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/exd.12682","article-title":"UVB induces epidermal 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo","volume":"24","author":"Tiganescu","year":"2015","journal-title":"Exp. Dermatol."},{"issue":"3","key":"10.1016\/j.jdermsci.2020.08.011_bib0105","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/bjd.12096","article-title":"Ultraviolet radiation regulates cortisol activity in a waveband-dependent manner in human skin ex vivo","volume":"168","author":"Skobowiat","year":"2013","journal-title":"Br. J. Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2020.08.011_bib0110","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/jid.2010.257","article-title":"Localization, age- and site-dependent expression, and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in skin","volume":"131","author":"Tiganescu","year":"2011","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2020.08.011_bib0115","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jsbmb.2014.11.010","article-title":"Novel activities of CYP11A1 and their potential physiological significance","volume":"151","author":"Slominski","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.jdermsci.2020.08.011_bib0120","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4103\/0019-5154.77547","article-title":"Steroid-induced rosacea: a clinical study of 200 patients","volume":"56","author":"Bhat","year":"2011","journal-title":"Indian J. Dermatol."},{"issue":"10","key":"10.1016\/j.jdermsci.2020.08.011_bib0125","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/j.jid.2019.02.036","article-title":"Abnormal glucocorticoid synthesis in the lesional skin of Erythematotelangiectatic Rosacea","volume":"139","author":"Hong","year":"2019","journal-title":"J. Invest. Dermatol."},{"issue":"10","key":"10.1016\/j.jdermsci.2020.08.011_bib0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026632","article-title":"LL37 and cationic peptides enhance TLR3 signaling by viral double-stranded RNAs","volume":"6","author":"Lai","year":"2011","journal-title":"PloS one"},{"issue":"12","key":"10.1016\/j.jdermsci.2020.08.011_bib0135","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.1074\/jbc.M112.440883","article-title":"The human antimicrobial peptide LL-37, but not the mouse ortholog, mCRAMP, can stimulate signaling by poly(I:C) through a FPRL1-dependent pathway","volume":"288","author":"Singh","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.jdermsci.2020.08.011_bib0140","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1177\/0022034515589289","article-title":"Necrosis-induced TLR3 activation promotes TLR2 expression in gingival cells","volume":"94","author":"Mori","year":"2015","journal-title":"J. Dent. Res."},{"issue":"2","key":"10.1016\/j.jdermsci.2020.08.011_bib0145","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cellimm.2011.10.019","article-title":"Overlapping and distinct roles of GRK5 in TLR2-, and TLR3-induced inflammatory response in vivo","volume":"272","author":"Packiriswamy","year":"2012","journal-title":"Cell Immunol."},{"issue":"2","key":"10.1016\/j.jdermsci.2020.08.011_bib0150","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/jid.2008.237","article-title":"Glucocorticoids enhance Toll-like receptor 2 expression in human keratinocytes stimulated with propionibacterium acnes or proinflammatory cytokines","volume":"129","author":"Shibata","year":"2009","journal-title":"J. Invest. Dermatol."},{"issue":"9","key":"10.1016\/j.jdermsci.2020.08.011_bib0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025039","article-title":"11beta-Hydroxysteroid dehydrogenase-1 is a novel regulator of skin homeostasis and a candidate target for promoting tissue repair","volume":"6","author":"Terao","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jdermsci.2020.08.011_bib0160","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/jid.2014.354","article-title":"Toll-like receptor 3 activation is required for normal skin barrier repair following UV damage","volume":"135","author":"Borkowski","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2020.08.011_bib0165","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.semcdb.2016.08.014","article-title":"The toll-like receptor 3 pathway in homeostasis, responses to injury and wound repair","volume":"61","author":"Ramnath","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"issue":"8","key":"10.1016\/j.jdermsci.2020.08.011_bib0170","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1038\/jid.2013.39","article-title":"Activation of TLR3 in keratinocytes increases expression of genes involved in formation of the epidermis, lipid accumulation, and epidermal organelles","volume":"133","author":"Borkowski","year":"2013","journal-title":"J. Invest. Dermatol."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092318112030267X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092318112030267X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:50:16Z","timestamp":1760331016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092318112030267X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S092318112030267X"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2020.08.011","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TLR3 augments glucocorticoid-synthetic enzymes expression in epidermal keratinocytes; Implications of glucocorticoid metabolism in rosacea epidermis","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2020.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}