{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:00:36Z","timestamp":1775484036620,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jdermsci.2020.11.001","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T17:30:32Z","timestamp":1604597432000},"page":"40-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ethanol consumption synergistically increases ultraviolet radiation induced skin damage and immune dysfunction"],"prefix":"10.1016","volume":"101","author":[{"given":"Rhonda M.","family":"Brand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Mark","family":"Stottlemyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa C.","family":"Paglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cara Donahue","family":"Carey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Louis D.","family":"Falo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2020.11.001_bib0005","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3389\/fphar.2018.00920","article-title":"Targeting mitochondrial oxidative stress to mitigate UV-induced skin damage","volume":"9","author":"Brand","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.jdermsci.2020.11.001_bib0010","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/phpp.12494","article-title":"Relationship between sun safety behaviours and modifiable lifestyle cancer risk factors and vitamin D levels","volume":"35","author":"Kalia","year":"2019","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"issue":"4","key":"10.1016\/j.jdermsci.2020.11.001_bib0015","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2310\/7750.2014.EDIT18.4","article-title":"A cocktail for skin cancer: why alcohol and sun exposure do not mix","volume":"18","author":"Rivers","year":"2014","journal-title":"J. Cutan. Med. Surg."},{"issue":"4","key":"10.1016\/j.jdermsci.2020.11.001_bib0020","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jaad.2006.04.033","article-title":"Alcohol consumption and self-reported sunburn: a cross-sectional, population-based survey","volume":"55","author":"Mukamal","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2020.11.001_bib0025","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jaad.2006.05.029","article-title":"The epidemiology of sunburn in the US population in 2003","volume":"55","author":"Brown","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jdermsci.2020.11.001_bib0030","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ypmed.2014.02.018","article-title":"The association between demographic and behavioral characteristics and sunburn among U.S. adults - National Health Interview Survey, 2010","volume":"63","author":"Holman","year":"2014","journal-title":"Prev. Med."},{"issue":"8","key":"10.1016\/j.jdermsci.2020.11.001_bib0035","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1001\/archderm.139.8.1003","article-title":"The economic impact of acute sunburn","volume":"139","author":"Warthan","year":"2003","journal-title":"Arch. Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2020.11.001_bib0040","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000343908","article-title":"Alcohol consumption decreases the protection efficiency of the antioxidant network and increases the risk of sunburn in human skin","volume":"26","author":"Darvin","year":"2013","journal-title":"Skin Pharmacol. Physiol."},{"issue":"1","key":"10.1016\/j.jdermsci.2020.11.001_bib0045","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1610-0387.2008.06793.x","article-title":"Sun protection by red wine?","volume":"7","author":"Moehrle","year":"2009","journal-title":"J. der Deutschen Dermatologischen Gesellschaft"},{"issue":"3","key":"10.1016\/j.jdermsci.2020.11.001_bib0050","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/bjd.15790","article-title":"Evidence for an association between alcohol intake and an increased risk of nonmelanoma skin cancer","volume":"177","author":"Rota","year":"2017","journal-title":"Br. J. Dermatol."},{"issue":"6","key":"10.1016\/j.jdermsci.2020.11.001_bib0055","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/j.fct.2008.01.034","article-title":"Chronic ethanol ingestion alters xenobiotic absorption through the skin: potential role of oxidative stress","volume":"46","author":"Brand","year":"2008","journal-title":"Food Chem. Toxicol."},{"issue":"7","key":"10.1016\/j.jdermsci.2020.11.001_bib0060","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1111\/j.1530-0277.2008.00699.x","article-title":"Effects of chronic ethanol feeding on murine dendritic cell numbers, turnover rate, and dendropoiesis","volume":"32","author":"Edsen-Moore","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"12","key":"10.1016\/j.jdermsci.2020.11.001_bib0065","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1111\/acer.12201","article-title":"Mechanisms by which chronic ethanol feeding impairs the migratory capacity of cutaneous dendritic cells","volume":"37","author":"Parlet","year":"2013","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"2","key":"10.1016\/j.jdermsci.2020.11.001_bib0070","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1530-0277.2006.00307.x","article-title":"Effects of acute ethanol exposure on the early inflammatory response after excisional injury","volume":"31","author":"Fitzgerald","year":"2007","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"4","key":"10.1016\/j.jdermsci.2020.11.001_bib0075","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1189\/jlb.4A0214-092R","article-title":"Chronic ethanol feeding increases the severity of Staphylococcus aureus skin infections by altering local host defenses","volume":"97","author":"Parlet","year":"2015","journal-title":"J. Leukoc. Biol."},{"issue":"3","key":"10.1016\/j.jdermsci.2020.11.001_bib0080","doi-asserted-by":"crossref","DOI":"10.3390\/biom7030061","article-title":"Alcohol and cancer: mechanisms and therapies","volume":"7","author":"Ratna","year":"2017","journal-title":"Biomolecules"},{"issue":"7","key":"10.1016\/j.jdermsci.2020.11.001_bib0085","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.jid.2018.11.034","article-title":"Acute ethanol exposure augments low-dose UVB-mediated systemic immunosuppression via enhanced production of platelet-activating factor receptor agonists","volume":"139","author":"Travers","year":"2019","journal-title":"J. Invest. Dermatol."},{"issue":"11","key":"10.1016\/j.jdermsci.2020.11.001_bib0090","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/j.jid.2018.04.039","article-title":"Enhanced platelet-activating factor synthesis facilitates acute and delayed effects of ethanol-intoxicated thermal burn injury","volume":"138","author":"Harrison","year":"2018","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2020.11.001_bib0095","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.3390\/biom5043009","article-title":"Skin immunization obviates alcohol-related immune dysfunction","volume":"5","author":"Brand","year":"2015","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.jdermsci.2020.11.001_bib0100","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1530-0277.1996.tb01055.x","article-title":"Development and characterization of a binge drinking model in mice for evaluation of the immunological effects of ethanol","volume":"20","author":"Carson","year":"1996","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"7 Pt 1","key":"10.1016\/j.jdermsci.2020.11.001_bib0105","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1158\/1078-0432.CCR-05-2672","article-title":"Prevention of ultraviolet radiation-induced immunosuppression by (-)-epigallocatechin-3-gallate in mice is mediated through interleukin 12-dependent DNA repair","volume":"12","author":"Meeran","year":"2006","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.jdermsci.2020.11.001_bib0110","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1084\/jem.20041212","article-title":"Prevention of UV radiation\u2013induced immunosuppression by IL-12 is dependent on DNA repair","volume":"201","author":"Schwarz","year":"2005","journal-title":"J. Exp. Med."},{"issue":"11","key":"10.1016\/j.jdermsci.2020.11.001_bib0115","doi-asserted-by":"crossref","first-page":"7006","DOI":"10.4049\/jimmunol.178.11.7006","article-title":"In vivo signaling through the neurokinin 1 receptor favors transgene expression by Langerhans cells and promotes the generation of Th1- and Tc1-biased immune responses","volume":"178","author":"Mathers","year":"2007","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.jdermsci.2020.11.001_bib0120","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.jid.2016.09.033","article-title":"A topical mitochondria-targeted redox cycling nitroxide mitigates oxidative stress induced skin damage","volume":"137","author":"Brand","year":"2017","journal-title":"J. Invest. Dermatol."},{"issue":"5","key":"10.1016\/j.jdermsci.2020.11.001_bib0125","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1034\/j.1600-0749.2001.140505.x","article-title":"Variation in melanin content and composition in type V and VI photoexposed and photoprotected human skin: the dominant role of DHI","volume":"14","author":"Alaluf","year":"2001","journal-title":"Pigment Cell Res."},{"issue":"8","key":"10.1016\/j.jdermsci.2020.11.001_bib0130","first-page":"1221","article-title":"Early alteration in leukocyte populations and Th1\/Th2 function in ethanol-consuming mice","volume":"25","author":"Starkenburg","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"1","key":"10.1016\/j.jdermsci.2020.11.001_bib0135","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jdermsci.2007.11.008","article-title":"Topical treatment with (-)-epigallocatechin-3-gallate and genistein after a single UV exposure can reduce skin damage","volume":"50","author":"Brand","year":"2008","journal-title":"J. Dermatol. Sci."},{"issue":"10","key":"10.1016\/j.jdermsci.2020.11.001_bib0140","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/exd.12012","article-title":"Pigment-independent cAMP-mediated epidermal thickening protects against cutaneous UV injury by keratinocyte proliferation","volume":"21","author":"Scott","year":"2012","journal-title":"Exp. Dermatol."},{"issue":"5","key":"10.1016\/j.jdermsci.2020.11.001_bib0145","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/jid.2009.329","article-title":"Agents that reverse UV-induced immune suppression and photocarcinogenesis affect DNA repair","volume":"130","author":"Sreevidya","year":"2010","journal-title":"J. Invest. Dermatol."},{"issue":"12","key":"10.1016\/j.jdermsci.2020.11.001_bib0150","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1038\/sj.jid.5701001","article-title":"Narrow-band UVB induces more carcinogenic skin tumors than broad-band UVB through the formation of cyclobutane pyrimidine dimer","volume":"127","author":"Kunisada","year":"2007","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.jdermsci.2020.11.001_bib0155","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/phpp.12021","article-title":"Photoimmunosuppression: a brief overview","volume":"29","author":"Gibbs","year":"2013","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"issue":"3","key":"10.1016\/j.jdermsci.2020.11.001_bib0160","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1158\/1940-6207.CAPR-12-0320","article-title":"Bioactive grape proanthocyanidins enhance immune reactivity in UV-irradiated skin through functional activation of dendritic cells in mice","volume":"6","author":"Vaid","year":"2013","journal-title":"Cancer Prev. Res. (Phila)"},{"issue":"2","key":"10.1016\/j.jdermsci.2020.11.001_bib0165","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1158\/1940-6207.CAPR-09-0044","article-title":"Green tea polyphenols prevent UV-induced immunosuppression by rapid repair of DNA damage and enhancement of nucleotide excision repair genes","volume":"3","author":"Katiyar","year":"2010","journal-title":"Cancer Prev. Res. (Phila)"},{"issue":"1","key":"10.1016\/j.jdermsci.2020.11.001_bib0170","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/jid.2012.234","article-title":"Reflections on the field of photoimmunology","volume":"133","author":"Kripke","year":"2013","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.jdermsci.2020.11.001_bib0175","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/jid.2011.405","article-title":"The immunologic revolution: photoimmunology","volume":"132","author":"Ullrich","year":"2012","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2020.11.001_bib0180","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4049\/jimmunol.181.1.217","article-title":"Cis-urocanic acid initiates gene transcription in primary human keratinocytes","volume":"181","author":"Kaneko","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2020.11.001_bib0185","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.plipres.2016.03.004","article-title":"Understanding the connection between platelet-activating factor, a UV-induced lipid mediator of inflammation, immune suppression and skin cancer","volume":"63","author":"Damiani","year":"2016","journal-title":"Prog. Lipid Res."},{"issue":"29","key":"10.1016\/j.jdermsci.2020.11.001_bib0190","doi-asserted-by":"crossref","first-page":"22211","DOI":"10.1074\/jbc.M110.119982","article-title":"Chronic alcohol exposure increases circulating bioactive oxidized phospholipids","volume":"285","author":"Yang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jdermsci.2020.11.001_bib0195","series-title":"Handb Exp Pharmacol","doi-asserted-by":"crossref","DOI":"10.1007\/164_2019_218","article-title":"Platelet-activating factor as an effector for environmental stressors","author":"Travers","year":"2019"},{"issue":"2\u20133","key":"10.1016\/j.jdermsci.2020.11.001_bib0200","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1011-1344(01)00248-2","article-title":"Green tea polyphenols: DNA photodamage and photoimmunology","volume":"65","author":"Katiyar","year":"2001","journal-title":"J. Photochem. Photobiol. B"},{"issue":"7","key":"10.1016\/j.jdermsci.2020.11.001_bib0205","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1038\/jid.2010.59","article-title":"UVR-induced regulatory T cells switch antigen-presenting cells from a stimulatory to a regulatory phenotype","volume":"130","author":"Schwarz","year":"2010","journal-title":"J. Invest. Dermatol."},{"issue":"12","key":"10.1016\/j.jdermsci.2020.11.001_bib0210","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1111\/acer.12201","article-title":"Mechanisms by which chronic ethanol feeding impairs the migratory capacity of cutaneous dendritic cells","volume":"37","author":"Parlet","year":"2013","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"5","key":"10.1016\/j.jdermsci.2020.11.001_bib0215","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1111\/acer.12358","article-title":"Chronic ethanol feeding induces subset loss and hyporesponsiveness in skin t cells","volume":"38","author":"Parlet","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"4","key":"10.1016\/j.jdermsci.2020.11.001_bib0220","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1530-0277.2007.00614.x","article-title":"Chronic ethanol consumption decreases murine Langerhans cell numbers and delays migration of Langerhans cells as well as dermal dendritic cells","volume":"32","author":"Ness","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"2","key":"10.1016\/j.jdermsci.2020.11.001_bib0225","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/toxsci\/kfl010","article-title":"A single oral dose of ethanol can alter transdermal absorption of topically applied chemicals in rats","volume":"92","author":"Brand","year":"2006","journal-title":"Toxicol. Sci."},{"issue":"10","key":"10.1016\/j.jdermsci.2020.11.001_bib0230","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1158\/1055-9965.EPI-18-0243","article-title":"An epidemiological review of diet and cutaneous malignant melanoma","volume":"27","author":"Yang","year":"2018","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"12","key":"10.1016\/j.jdermsci.2020.11.001_bib0235","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1158\/1055-9965.EPI-16-0303","article-title":"Alcohol intake and risk of incident melanoma: a pooled analysis of three prospective studies in the United States","volume":"25","author":"Rivera","year":"2016","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"1","key":"10.1016\/j.jdermsci.2020.11.001_bib0240","first-page":"1","article-title":"Alcohol consumption and risk of melanoma and non-melanoma skin cancer in the Women\u2019s Health Initiative","volume":"25","author":"Kubo","year":"2014","journal-title":"Cancer Causes Control"},{"issue":"3","key":"10.1016\/j.jdermsci.2020.11.001_bib0245","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/bjd.15647","article-title":"Alcohol intake and risk of nonmelanoma skin cancer: a systematic review and dose-response meta-analysis","volume":"177","author":"Yen","year":"2017","journal-title":"Br. J. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2020.11.001_bib0250","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/01635581.2016.1158296","article-title":"Alcohol intake is associated with increased risk of squamous cell carcinoma of the skin: three US prospective cohort studies","volume":"68","author":"Siiskonen","year":"2016","journal-title":"Nutr. Cancer"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181120303509?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181120303509?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:51:25Z","timestamp":1760331085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181120303509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S0923181120303509"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2020.11.001","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ethanol consumption synergistically increases ultraviolet radiation induced skin damage and immune dysfunction","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2020.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}