{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T03:31:28Z","timestamp":1764646288788,"version":"build-2065373602"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Future Core Research Institute of LG Household and Health Care, Ltd"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jdermsci.2020.11.006","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T11:34:54Z","timestamp":1605526494000},"page":"101-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Exogenous pyruvate alleviates UV-induced hyperpigmentation via restraining dendrite outgrowth and Rac1 GTPase activity"],"prefix":"10.1016","volume":"101","author":[{"given":"Seon-Guk","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Heon","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oun Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nae-Gyu","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jdermsci.2020.11.006_bib0005","doi-asserted-by":"crossref","first-page":"12222","DOI":"10.3390\/ijms140612222","article-title":"UV radiation and the skin","volume":"14","author":"D\u2019Orazio","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.jdermsci.2020.11.006_bib0010","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1600-0854.2006.00425.x","article-title":"The quest for the mechanism of melanin transfer","volume":"7","author":"Van Den Bossche","year":"2006","journal-title":"Traffic"},{"issue":"3","key":"10.1016\/j.jdermsci.2020.11.006_bib0015","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1001\/archderm.1967.01610030083015","article-title":"The evolution of concepts of melanin biology","volume":"96","author":"Fitzpatrick","year":"1967","journal-title":"Arch. Dermatol."},{"issue":"6","key":"10.1016\/j.jdermsci.2020.11.006_bib0020","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/1523-1747.ep12325522","article-title":"Endothelin-1 of keratinocyte origin is a mediator of melanocyte dendricity","volume":"105","author":"Hara","year":"1995","journal-title":"J. Invest. Dermatol."},{"issue":"5","key":"10.1016\/j.jdermsci.2020.11.006_bib0025","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1034\/j.1600-0749.2002.02056.x","article-title":"Rac and rho: the story behind melanocyte dendrite formation","volume":"15","author":"Scott","year":"2002","journal-title":"Pigment Cell Res."},{"issue":"2","key":"10.1016\/j.jdermsci.2020.11.006_bib0030","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0092-8674(04)00003-0","article-title":"Rho and Rac take center stage","volume":"116","author":"Burridge","year":"2004","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.jdermsci.2020.11.006_bib0035","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0092-8674(92)90163-7","article-title":"The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors","volume":"70","author":"Ridley","year":"1992","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.jdermsci.2020.11.006_bib0040","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1002\/j.1460-2075.1994.tb06550.x","article-title":"Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase","volume":"13","author":"Ridley","year":"1994","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.jdermsci.2020.11.006_bib0045","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0092-8674(92)90164-8","article-title":"The small GTP-binding protein rac regulates growth factor-induced membrane ruffling","volume":"70","author":"Ridley","year":"1992","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.jdermsci.2020.11.006_bib0050","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1128\/MCB.15.4.1942","article-title":"The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts","volume":"15","author":"Kozma","year":"1995","journal-title":"Mol. Cell. Biol."},{"issue":"5","key":"10.1016\/j.jdermsci.2020.11.006_bib0055","doi-asserted-by":"crossref","first-page":"858","DOI":"10.3892\/mco.2013.145","article-title":"Narrow-band UVB radiation promotes dendrite formation by activating Rac1 in B16 melanoma cells","volume":"1","author":"Wang","year":"2013","journal-title":"Mol. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.jdermsci.2020.11.006_bib0060","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.bbagen.2006.01.003","article-title":"Centaureidin promotes dendrite retraction of melanocytes by activating Rho","volume":"1760","author":"Ito","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.jdermsci.2020.11.006_bib0065","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jdermsci.2005.12.015","article-title":"Effects of methylophiopogonanone B on melanosome transfer and dendrite retraction","volume":"42","author":"Ito","year":"2006","journal-title":"J. Dermatol. Sci."},{"issue":"1","key":"10.1016\/j.jdermsci.2020.11.006_bib0070","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00000658-199607000-00015","article-title":"Lactic acidosis during sepsis is related to increased pyruvate production, not deficits in tissue oxygen availability","volume":"224","author":"Gore","year":"1996","journal-title":"Ann. Surg."},{"issue":"2","key":"10.1016\/j.jdermsci.2020.11.006_bib0075","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1016\/j.jss.2009.12.005","article-title":"Protection by pyruvate infusion in a rat model of severe intestinal ischemia-reperfusion injury","volume":"167","author":"Petrat","year":"2011","journal-title":"J. Surg. Res."},{"issue":"5","key":"10.1016\/j.jdermsci.2020.11.006_bib0080","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/SHK.0b013e3181cc02b3","article-title":"Hypertonic sodium pyruvate solution is more effective than Ringer\u2019s ethyl pyruvate in the treatment of hemorrhagic shock","volume":"33","author":"Sharma","year":"2010","journal-title":"Shock"},{"issue":"1","key":"10.1016\/j.jdermsci.2020.11.006_bib0085","first-page":"60","article-title":"Pyruvic acid\/ethyl pyruvate inhibits melanogenesis in B16F10 melanoma cells through PI3K\/AKT","volume":"24","author":"Zhou","year":"2019","journal-title":"GSK3beta, and ROS-ERK signaling pathways"},{"issue":"44","key":"10.1016\/j.jdermsci.2020.11.006_bib0090","doi-asserted-by":"crossref","first-page":"28959","DOI":"10.1074\/jbc.273.44.28959","article-title":"Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter","volume":"273","author":"Lin","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"Suppl 2","key":"10.1016\/j.jdermsci.2020.11.006_bib0095","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1034\/j.1600-0625.12.s2.7.x","article-title":"The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells","volume":"12","author":"Usuki","year":"2003","journal-title":"Exp. Dermatol."},{"issue":"Pt 5","key":"10.1016\/j.jdermsci.2020.11.006_bib0100","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1042\/BST0330891","article-title":"Rho GTPases and the control of cell behaviour","volume":"33","author":"Hall","year":"2005","journal-title":"Biochem. Soc. Trans."},{"issue":"5","key":"10.1016\/j.jdermsci.2020.11.006_bib0105","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/sj.jid.5701177","article-title":"Downregulation of melanin synthesis by haginin A and its application to in vivo lightening model","volume":"128","author":"Kim","year":"2008","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2020.11.006_bib0110","doi-asserted-by":"crossref","first-page":"8772","DOI":"10.3390\/ijms16048772","article-title":"Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression","volume":"16","author":"Kim","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jdermsci.2020.11.006_bib0115","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1034\/j.1600-0749.2001.140205.x","article-title":"Possible involvement of ERK 1\/2 in UVA-induced melanogenesis in cultured normal human epidermal melanocytes","volume":"14","author":"Yanase","year":"2001","journal-title":"Pigment Cell Res."},{"issue":"2","key":"10.1016\/j.jdermsci.2020.11.006_bib0120","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jdermsci.2010.08.006","article-title":"MKK6 increases the melanocyte dendricity through the regulation of Rho family GTPases","volume":"60","author":"Kim","year":"2010","journal-title":"J. Dermatol. Sci."},{"issue":"11","key":"10.1016\/j.jdermsci.2020.11.006_bib0125","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/S0960-9822(96)00749-X","article-title":"Phosphatidylinositol 3-kinase signals activate a selective subset of Rac\/Rho-dependent effector pathways","volume":"6","author":"Reif","year":"1996","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.jdermsci.2020.11.006_bib0130","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1128\/MCB.20.1.158-172.2000","article-title":"Phosphatidylinositol 3-kinase, Cdc42, and Rac1 act downstream of Ras in integrin-dependent neurite outgrowth in N1E-115 neuroblastoma cells","volume":"20","author":"Sarner","year":"2000","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.jdermsci.2020.11.006_bib0135","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1046\/j.1523-1747.1998.00276.x","article-title":"Rac1 mediates dendrite formation in response to melanocyte stimulating hormone and ultraviolet light in a murine melanoma model","volume":"111","author":"Scott","year":"1998","journal-title":"J. Invest. Dermatol."},{"issue":"5443","key":"10.1016\/j.jdermsci.2020.11.006_bib0140","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1126\/science.286.5443.1358","article-title":"Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms","volume":"286","author":"Bonni","year":"1999","journal-title":"Science"},{"issue":"5467","key":"10.1016\/j.jdermsci.2020.11.006_bib0145","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1126\/science.288.5467.870","article-title":"Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway","volume":"288","author":"Tournier","year":"2000","journal-title":"Science"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181120303558?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181120303558?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:50:36Z","timestamp":1760331036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181120303558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S0923181120303558"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2020.11.006","relation":{},"ISSN":["0923-1811"],"issn-type":[{"type":"print","value":"0923-1811"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exogenous pyruvate alleviates UV-induced hyperpigmentation via restraining dendrite outgrowth and Rac1 GTPase activity","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2020.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}