{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:46:05Z","timestamp":1793256365581,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.jdermsci.2021.07.003","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T11:15:03Z","timestamp":1625570103000},"page":"93-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["H3K27Ac modification and gene expression in psoriasis"],"prefix":"10.1016","volume":"103","author":[{"given":"Moamen","family":"Masalha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iddo Z.","family":"Ben-Dov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Ram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Meningher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Jacob-Hirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riad","family":"Kassem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yechezkel","family":"Sidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror","family":"Avni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7130","key":"10.1016\/j.jdermsci.2021.07.003_bib0005","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/nature05663","article-title":"Pathogenesis and therapy of psoriasis","volume":"445","author":"Lowes","year":"2007","journal-title":"Nature"},{"issue":"17","key":"10.1016\/j.jdermsci.2021.07.003_bib0010","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1093\/hmg\/10.17.1793","article-title":"Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies","volume":"10","author":"Bowcock","year":"2001","journal-title":"Hum. Mol. Genet."},{"issue":"4","key":"10.1016\/j.jdermsci.2021.07.003_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010247","article-title":"Evaluation of the psoriasis transcriptome across different studies by gene set enrichment analysis (GSEA)","volume":"5","author":"Suarez-Farinas","year":"2010","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.jdermsci.2021.07.003_bib0020","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1073\/pnas.0909344107","article-title":"Histone modification levels are predictive for gene expression","volume":"107","author":"Karlic","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"50","key":"10.1016\/j.jdermsci.2021.07.003_bib0025","doi-asserted-by":"crossref","first-page":"21931","DOI":"10.1073\/pnas.1016071107","article-title":"Histone H3K27ac separates active from poised enhancers and predicts developmental state","volume":"107","author":"Creyghton","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.jdermsci.2021.07.003_bib0030","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.cell.2013.09.053","article-title":"Super-enhancers in the control of cell identity and disease","volume":"155","author":"Hnisz","year":"2013","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.jdermsci.2021.07.003_bib0035","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.jdermsci.2021.07.003_bib0040","series-title":"DiffBind: Differential Binding Analysis of ChIP-Seq Peak Data, Bioconductor","author":"Stark","year":"2011"},{"issue":"5","key":"10.1016\/j.jdermsci.2021.07.003_bib0045","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.1630","article-title":"GREAT improves functional interpretation of cis-regulatory regions","volume":"28","author":"McLean","year":"2010","journal-title":"Nat. Biotechnol."},{"issue":"12","key":"10.1016\/j.jdermsci.2021.07.003_bib0050","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1038\/nprot.2013.150","article-title":"Target analysis by integration of transcriptome and ChIP-seq data with BETA","volume":"8","author":"Wang","year":"2013","journal-title":"Nat. Protoc."},{"issue":"9","key":"10.1016\/j.jdermsci.2021.07.003_bib0055","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1101\/gr.136184.111","article-title":"ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia","volume":"22","author":"Landt","year":"2012","journal-title":"Genome Res."},{"issue":"1-2","key":"10.1016\/j.jdermsci.2021.07.003_bib0060","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s11010-011-1036-6","article-title":"IL-17 receptor and its functional significance in psoriatic arthritis","volume":"359","author":"Raychaudhuri","year":"2012","journal-title":"Mol. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.jdermsci.2021.07.003_bib0065","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1365-2133.2008.08902.x","article-title":"Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin","volume":"160","author":"Johansen","year":"2009","journal-title":"Br. J. Dermatol."},{"issue":"5","key":"10.1016\/j.jdermsci.2021.07.003_bib0070","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1177\/002215540305100513","article-title":"S100 protein subcellular localization during epidermal differentiation and psoriasis","volume":"51","author":"Broome","year":"2003","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.jdermsci.2021.07.003_bib0075","series-title":"DiffBind: Differential Binding Analysis of ChIP-Seq Peak Data","author":"Stark R","year":"2011"},{"issue":"9","key":"10.1016\/j.jdermsci.2021.07.003_bib0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044274","article-title":"Meta-analysis derived (MAD) transcriptome of psoriasis defines the \"core\" pathogenesis of disease","volume":"7","author":"Tian","year":"2012","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.jdermsci.2021.07.003_bib0085","doi-asserted-by":"crossref","first-page":"e268","DOI":"10.1038\/emm.2016.97","article-title":"Integrated computational approach to the analysis of RNA-seq data reveals new transcriptional regulators of psoriasis","volume":"48","author":"Zolotarenko","year":"2016","journal-title":"Exp. Mol. Med."},{"issue":"6","key":"10.1016\/j.jdermsci.2021.07.003_bib0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020916","article-title":"MiRNA expression in psoriatic skin: reciprocal regulation of hsa-miR-99a and IGF-1R","volume":"6","author":"Lerman","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jdermsci.2021.07.003_bib0095","doi-asserted-by":"crossref","first-page":"e610","DOI":"10.1371\/journal.pone.0000610","article-title":"MicroRNAs: Novel Regulators Involved in the Pathogenesis of Psoriasis?","volume":"2","author":"Sonkoly","year":"2007","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jdermsci.2021.07.003_bib0100","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/j.1365-2133.2011.10497.x","article-title":"microRNA-mediated keratinocyte hyperproliferation in psoriasis vulgaris","volume":"165","author":"Ichihara","year":"2011","journal-title":"Br. J. Dermatol."},{"issue":"20","key":"10.1016\/j.jdermsci.2021.07.003_bib0105","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1093\/hmg\/ddr331","article-title":"Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome","volume":"20","author":"Joyce","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.jdermsci.2021.07.003_bib0110","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jdermsci.2010.03.004","article-title":"MicroRNAs and potential target interactions in psoriasis","volume":"58","author":"Zibert","year":"2010","journal-title":"J. Dermatol. Sci."},{"issue":"1","key":"10.1016\/j.jdermsci.2021.07.003_bib0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.jdermsci.2021.07.003_bib0120","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.2353\/ajpath.2009.080973","article-title":"Alteration of tight junction proteins is an early event in psoriasis: putative involvement of proinflammatory cytokines","volume":"175","author":"Kirschner","year":"2009","journal-title":"Am. J. Pathol."},{"issue":"3 Pt 1","key":"10.1016\/j.jdermsci.2021.07.003_bib0125","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/jid.2011.348","article-title":"A subset of methylated CpG sites differentiate psoriatic from normal skin","volume":"132","author":"Roberson","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.07.003_bib0130","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jaut.2013.01.001","article-title":"Whole-genome DNA methylation in skin lesions from patients with psoriasis vulgaris","volume":"41","author":"Zhang","year":"2013","journal-title":"J. Autoimmun."},{"issue":"4","key":"10.1016\/j.jdermsci.2021.07.003_bib0135","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.jid.2015.12.029","article-title":"Epigenome-wide association analysis identified nine skin DNA methylation loci for psoriasis","volume":"136","author":"Zhou","year":"2016","journal-title":"J. Invest. Dermatol."},{"issue":"6","key":"10.1016\/j.jdermsci.2021.07.003_bib0140","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.jid.2019.10.016","article-title":"Loss of the epigenetic mark 5-hmC in psoriasis: implications for epidermal stem cell dysregulation","volume":"140","author":"Li","year":"2020","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2021.07.003_bib0145","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41576-018-0089-8","article-title":"Chromatin accessibility and the regulatory epigenome","volume":"20","author":"Klemm","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jdermsci.2021.07.003_bib0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jid.2020.12.031","article-title":"ATAC-seq analysis reveals a widespread increase in chromatin accessibility in psoriasis","author":"Tang","year":"2021","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.07.003_bib0155","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev.biochem.77.062706.153223","article-title":"The biology of chromatin remodeling complexes","volume":"78","author":"Clapier","year":"2009","journal-title":"Annu. Rev. Biochem."},{"issue":"4","key":"10.1016\/j.jdermsci.2021.07.003_bib0160","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrg2957","article-title":"Enhancer function: new insights into the regulation of tissue-specific gene expression","volume":"12","author":"Ong","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jdermsci.2021.07.003_bib0165","doi-asserted-by":"crossref","DOI":"10.1101\/gr.220079.116","article-title":"Relationship between histone modifications and transcription factor binding is protein family specific","author":"Xin","year":"2018","journal-title":"Genome Res."},{"issue":"1","key":"10.1016\/j.jdermsci.2021.07.003_bib0170","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nm1162","article-title":"Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model","volume":"11","author":"Sano","year":"2005","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.jdermsci.2021.07.003_bib0175","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1096\/fasebj.13.3.495","article-title":"Psoriatic keratinocytes show reduced IRF-1 and STAT-1alpha activation in response to gamma-IFN","volume":"13","author":"Jackson","year":"1999","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.jdermsci.2021.07.003_bib0180","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/path.1263","article-title":"Psoriatic lesional skin exhibits an aberrant expression pattern of interferon regulatory factor-2 (IRF-2)","volume":"199","author":"van der Fits","year":"2003","journal-title":"J. Pathol."},{"issue":"1","key":"10.1016\/j.jdermsci.2021.07.003_bib0185","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/1346-8138.12000","article-title":"Transcriptional regulatory network for psoriasis","volume":"40","author":"Lu","year":"2013","journal-title":"J. Dermatol."},{"issue":"12","key":"10.1016\/j.jdermsci.2021.07.003_bib0190","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1172\/JCI77138","article-title":"A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia","volume":"124","author":"Gordon","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jdermsci.2021.07.003_bib0195","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/B978-0-12-386499-4.00002-1","article-title":"Grainy head and its target genes in epithelial morphogenesis and wound healing","volume":"98","author":"Wang","year":"2012","journal-title":"Curr. Top. Dev. Biol."},{"issue":"6","key":"10.1016\/j.jdermsci.2021.07.003_bib0200","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/emboj.2008.24","article-title":"Perturbed desmosomal cadherin expression in grainy head-like 1-null mice","volume":"27","author":"Wilanowski","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.jdermsci.2021.07.003_bib0205","doi-asserted-by":"crossref","first-page":"e450","DOI":"10.1038\/cddis.2012.190","article-title":"Grainyhead-like 2 (GRHL2) inhibits keratinocyte differentiation through epigenetic mechanism","volume":"3","author":"Chen","year":"2012","journal-title":"Cell Death Dis."},{"issue":"5720","key":"10.1016\/j.jdermsci.2021.07.003_bib0210","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1126\/science.1107511","article-title":"A homolog of Drosophila grainy head is essential for epidermal integrity in mice","volume":"308","author":"Ting","year":"2005","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.jdermsci.2021.07.003_bib0215","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.prp.2016.11.020","article-title":"MicroRNA-194 regulates keratinocyte proliferation and differentiation by targeting Grainyhead-like 2 in psoriasis","volume":"213","author":"Yu","year":"2017","journal-title":"Pathol. Res. Pract."},{"issue":"1","key":"10.1016\/j.jdermsci.2021.07.003_bib0220","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bbrc.2016.01.157","article-title":"MiR-217 is down-regulated in psoriasis and promotes keratinocyte differentiation via targeting GRHL2","volume":"471","author":"Zhu","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jdermsci.2021.07.003_bib0225","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40169-015-0054-5","article-title":"Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites","volume":"4","author":"Swindell","year":"2015","journal-title":"Clin. Transl. Med."},{"issue":"4","key":"10.1016\/j.jdermsci.2021.07.003_bib0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006745","article-title":"GRHL3 binding and enhancers rearrange as epidermal keratinocytes transition between functional states","volume":"13","author":"Klein","year":"2017","journal-title":"PLoS Genet."},{"issue":"11","key":"10.1016\/j.jdermsci.2021.07.003_bib0235","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1038\/jid.2012.182","article-title":"Epigenetic regulation of gene expression in keratinocytes","volume":"132","author":"Botchkarev","year":"2012","journal-title":"J. Invest. Dermatol."},{"issue":"9","key":"10.1016\/j.jdermsci.2021.07.003_bib0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107467","article-title":"The crosstalk between IL-22 signaling and miR-197 in human keratinocytes","volume":"9","author":"Lerman","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.jdermsci.2021.07.003_bib0245","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/s41419-020-03028-1","article-title":"EZH2-dependent epigenetic modulation of histone H3 lysine-27 contributes to psoriasis by promoting keratinocyte proliferation","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis."},{"issue":"14","key":"10.1016\/j.jdermsci.2021.07.003_bib0250","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1101\/gad.1673508","article-title":"Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3","volume":"22","author":"Sen","year":"2008","journal-title":"Genes Dev."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181121001493?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181121001493?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:51:08Z","timestamp":1760331068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181121001493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S0923181121001493"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2021.07.003","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"H3K27Ac modification and gene expression in psoriasis","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2021.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V. on behalf of Japanese Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}