{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:08:11Z","timestamp":1780445291533,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T00:00:00Z","timestamp":1669507200000},"content-version":"am","delay-in-days":391,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18H02607"],"award-info":[{"award-number":["JP18H02607"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K08259"],"award-info":[{"award-number":["JP18K08259"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19H05280"],"award-info":[{"award-number":["JP19H05280"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jdermsci.2021.09.007","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T08:09:35Z","timestamp":1632989375000},"page":"112-121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Loss of FAM83H promotes cell migration and invasion in cutaneous squamous cell carcinoma via impaired keratin distribution"],"prefix":"10.1016","volume":"104","author":[{"given":"Keiko","family":"Tokuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetsugu","family":"Hatakeyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Ujiie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruki","family":"Yanagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2021.09.007_bib1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cll.2017.06.003","article-title":"Cutaneous squamous cell carcinoma","volume":"37","author":"Parekh","year":"2017","journal-title":"Clin. Lab. Med."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jaad.2017.08.058","article-title":"Cutaneous squamous cell carcinoma: management of advanced and high-stage tumors","volume":"78","author":"Que","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fonc.2018.00079","article-title":"Novel therapeutic targets in cutaneous squamous cell carcinoma","volume":"8","author":"Yanagi","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib4","doi-asserted-by":"crossref","first-page":"6795","DOI":"10.1158\/0008-5472.CAN-18-1495","article-title":"Loss of TRIM29 alters keratin distribution to promote cell invasion in squamous cell carcinoma","volume":"78","author":"Yanagi","year":"2018","journal-title":"Cancer. Res."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib5","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ajhg.2007.09.020","article-title":"FAM83H mutations in families with autosomal-dominant hypocalcified amelogenesis imperfecta","volume":"82","author":"Kim","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib6","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1177\/0022034509349454","article-title":"Fam83h is associated with intracellular vesicles and ADHCAI","volume":"88","author":"Ding","year":"2009","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/1878-0261.12016","article-title":"FAM83 family oncogenes are broadly involved in human cancers: an integrative multi-omics approach","volume":"11","author":"Snijders","year":"2017","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib8","first-page":"4721","article-title":"A novel mechanism of keratin cytoskeleton organization through casein kinase I\u03b1 and FAM83H in colorectal cancer","volume":"126","author":"Kuga","year":"2013","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib9","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/1878-0261.12016","article-title":"FAM83 family oncogenes are broadly involved in human cancers: an integrative multi-omics approach","volume":"11","author":"Snijders","year":"2017","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib10","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/BF02621233","article-title":"Incomplete epidermal differentiation of A431 epidermoid carcinoma cells","volume":"22","author":"Rosdy","year":"1986","journal-title":"Vitro. Cell. Dev. Biol."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/1523-1747.ep12470554","article-title":"Effects of pemphigus antibody on the regeneration of cell\u2013cell contact in keratinocyte cultures grown in low to normal Ca++ concentration","volume":"89","author":"Kitajima","year":"1987","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib12","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1083\/jcb.106.3.761","article-title":"Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line","volume":"106","author":"Boukamp","year":"1988","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib13","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1158\/0008-5472.CAN-14-0872","article-title":"PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells","volume":"74","author":"Yanagi","year":"2014","journal-title":"Cancer. Res."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib14","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jdermsci.2017.08.004","article-title":"Drp1 regulates mitochondrial morphology and cell proliferation in cutaneous squamous cell carcinoma","volume":"88","author":"Kitamura","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib15","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jdermsci.2020.06.009","article-title":"Loss of dynamin-related protein 1 (Drp1) does not affect epidermal development or UVB-induced apoptosis but does accelerate UVB-induced carcinogenesis","volume":"99","author":"Yanagi","year":"2020","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib16","doi-asserted-by":"crossref","first-page":"5867","DOI":"10.1038\/s41388-020-01404-x","article-title":"Extramammary Paget's disease patient-derived xenografts harboring ERBB2 S310F mutation show sensitivity to HER2-targeted therapies","volume":"39","author":"Maeda","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.jdermsci.2021.09.007_bib17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/02656739609022508","article-title":"The potential role of HSP70 as an indicator of response to radiation and hyperthermia treatments for recurrent breast cancer","volume":"12","author":"Liu","year":"1996","journal-title":"Int. J. Hyperthermia"},{"key":"10.1016\/j.jdermsci.2021.09.007_bib18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1083\/jcb.201408079","article-title":"A role for disulfide bonding in keratin intermediate filament organization and dynamics in skin keratinocytes","volume":"209","author":"Feng","year":"2015","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib19","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/lary.24357","article-title":"Grade as a prognostic factor in oral squamous cell carcinoma: a population-based analysis of the data","volume":"124","author":"Thomas","year":"2014","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jdermsci.2021.09.007_bib20","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol. Cell. Proteomics."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib21","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1172\/JCI37762","article-title":"Toward unraveling the complexity of simple epithelial keratins in human disease","volume":"119","author":"Omary","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib22","doi-asserted-by":"crossref","first-page":"26557","DOI":"10.1038\/srep26557","article-title":"FAM83H and casein kinase I regulate the organization of the keratin cytoskeleton and formation of desmosomes","volume":"6","author":"Kuga","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib23","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1083\/jcb.201008095","article-title":"Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia","volume":"194","author":"Windoffer","year":"2011","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib24","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/onc.2010.456","article-title":"Keratins in health and cancer: more than mere epithelial cell markers","volume":"30","author":"Karantza","year":"2011","journal-title":"Oncogen"},{"key":"10.1016\/j.jdermsci.2021.09.007_bib25","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1073\/pnas.90.9.4261","article-title":"Expression of complete keratin filaments in mouse L cells augments cell migration and invasion","volume":"90","author":"Chu","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib26","first-page":"63","article-title":"Experimental coexpression of vimentin and keratin intermediate filaments in human melanoma cells augments motility","volume":"148","author":"Chu","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib27","first-page":"483","article-title":"Experimental co-expression of vimentin and keratin intermediate filaments in human breast cancer cells results in phenotypic interconversion and increased invasive behavior","volume":"150","author":"Hendrix","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib28","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1309\/CPUX-KWEH-7B26-YE19","article-title":"Cytokeratin 8 immunostaining pattern and E-cadherin expression distinguish lobular from ductal breast carcinoma","volume":"114","author":"Lehr","year":"2000","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib29","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/ncb1037","article-title":"Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells","volume":"5","author":"Beil","year":"2003","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib30","doi-asserted-by":"crossref","first-page":"8726","DOI":"10.1371\/journal.pone.0008726","article-title":"Impact of tumor cell cytoskeleton organization on invasiveness and migration: a microchannel-based approach","volume":"5","author":"Rolli","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jdermsci.2021.09.007_bib31","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1083\/jcb.132.3.381","article-title":"Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16","volume":"132","author":"Paladini","year":"1996","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib32","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1242\/jcs.03304","article-title":"Periplakin-dependent re-organisation of keratin cytoskeleton and loss of collective migration in keratin-8-downregulated epithelial sheets","volume":"119","author":"Long","year":"2006","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib33","doi-asserted-by":"crossref","first-page":"9497","DOI":"10.1038\/s41598-018-27918-9","article-title":"HIF stabilization inhibits renal epithelial cell migration and is associated with cytoskeletal alterations","volume":"8","author":"M\u00fcller","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib34","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bbrc.2015.01.086","article-title":"Integrin \u03b16\u03b24 and TRPV1 channel coordinately regulate directional keratinocyte migration","volume":"458","author":"Miyazaki","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib35","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.231241","article-title":"Real-time imaging of integrin \u03b24 dynamics using a reporter cell line generated by Crispr\/Cas9 genome editing","volume":"132","author":"Elaimy","year":"2019","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.jdermsci.2021.09.007_bib36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/cm.970190202","article-title":"Recent insights into the assembly, dynamics, and function of intermediate filament networks","volume":"19","author":"Skalli","year":"1991","journal-title":"Cell. Motil. Cytoskel."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181121002243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181121002243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:52:09Z","timestamp":1760331129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181121002243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S0923181121002243"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2021.09.007","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of FAM83H promotes cell migration and invasion in cutaneous squamous cell carcinoma via impaired keratin distribution","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2021.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}