{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:38:04Z","timestamp":1793108284615,"version":"4.5.0"},"reference-count":108,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"am","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jdermsci.2021.11.003","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T15:33:15Z","timestamp":1639409595000},"page":"154-163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["The pathogeneses of pemphigus and pemphigoid diseases"],"prefix":"10.1016","volume":"104","author":[{"given":"Hideyuki","family":"Ujiie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yamagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Sawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Amagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Zillikens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2021.11.003_bib1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0092-8674(91)90360-B","article-title":"Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion","volume":"67","author":"Amagai","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.jdermsci.2021.11.003_bib2","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1056\/NEJMra061111","article-title":"Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome","volume":"355","author":"Stanley","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib3","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1172\/JCI114812","article-title":"Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome","volume":"86","author":"Diaz","year":"1990","journal-title":"J Clin. Investig."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib4","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1172\/JCI116368","article-title":"Human autoantibodies against the 230-kD bullous pemphigoid antigen (BPAG1) bind only to the intracellular domain of the hemidesmosome, whereas those against the 180-kD bullous pemphigoid antigen (BPAG2) bind along the plasma membrane of the hemidesmosome","volume":"91","author":"Ishiko","year":"1993","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib5","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/1523-1747.ep12292701","article-title":"Bullous pemphigoid and cicatricial pemphigoid autoantibodies react with ultrastructurally separable epitopes on the BP180 ectodomain: evidence that BP180 spans the lamina lucida","volume":"108","author":"B\u00e9dane","year":"1997","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib6","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/0092-8674(81)90115-X","article-title":"Characterization of bullous pemphigoid antigen: a unique basement membrane protein of stratified squamous epithelia","volume":"24","author":"Stanley","year":"1981","journal-title":"Cell"},{"key":"10.1016\/j.jdermsci.2021.11.003_bib7","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1172\/JCI113803","article-title":"Isolation of complementary DNA for bullous pemphigoid antigen by use of patients\u2019 autoantibodies","volume":"82","author":"Stanley","year":"1988","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0092-8674(95)90333-X","article-title":"Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration","volume":"81","author":"Guo","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.jdermsci.2021.11.003_bib9","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1056\/NEJM198404193101602","article-title":"Identification of the skin basement-membrane autoantigen in epidermolysis bullosa acquisita","volume":"310","author":"Woodley","year":"1984","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib10","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1172\/JCI113373","article-title":"Epidermolysis bullosa acquisita antigen is the globular carboxyl terminus of type VII procollagen","volume":"81","author":"Woodley","year":"1988","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib11","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nm1496","article-title":"Humanization of autoantigen","volume":"13","author":"Nishie","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.26","article-title":"Pemphigus","volume":"3","author":"Kasperkiewicz","year":"2017","journal-title":"Nat. Rev. Dis. Primer"},{"key":"10.1016\/j.jdermsci.2021.11.003_bib13","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.jaci.2020.02.013","article-title":"Autoimmune bullous skin diseases, pemphigus and pemphigoid","volume":"145","author":"Egami","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib14","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1172\/JCI5252","article-title":"Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris","volume":"103","author":"Mahoney","year":"1999","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib15","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0923-1811(99)00016-X","article-title":"Autoimmunity against desmosomal cadherins in pemphigus","volume":"20","author":"Amagai","year":"1999","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib16","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1046\/j.1468-3083.2002.00384.x","article-title":"Increased incidence of pemphigus vulgaris in southern Europeans living in Germany compared with native Germans","volume":"16","author":"Hahn-Ristic","year":"2002","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00403-014-1531-1","article-title":"Geographic variations in epidemiology of two autoimmune bullous diseases: pemphigus and bullous pemphigoid","volume":"307","author":"Alpsoy","year":"2015","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib18","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/1523-1747.ep12612836","article-title":"Comparative epidemiology of pemphigus in Tunisia and France: unusual incidence of pemphigus foliaceus in young Tunisian women","volume":"104","author":"Bastuji-Garin","year":"1995","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jaut.2008.08.003","article-title":"Advances in pemphigus and its endemic pemphigus foliaceus (Fogo Selvagem) phenotype: a paradigm of human autoimmunity","volume":"31","author":"Culton","year":"2008","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJM200007063430104","article-title":"The prevalence of antibodies against desmoglein 1 in endemic pemphigus foliaceus in Brazil. Cooperative Group on Fogo Selvagem Research","volume":"343","author":"Warren","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib21","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/jid.2014.430","article-title":"IgE anti-LJM11 sand fly salivary antigen may herald the onset of fogo selvagem in endemic Brazilian regions","volume":"135","author":"Qian","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib22","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1073\/pnas.88.11.5056","article-title":"Major histocompatibility complex haplotypes and class II genes in non-Jewish patients with pemphigus vulgaris","volume":"88","author":"Ahmed","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jdermsci.2021.11.003_bib23","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/bjd.17191","article-title":"Subtype-specific inherited predisposition to pemphigus in the Chinese population","volume":"180","author":"Zhang","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib24","doi-asserted-by":"crossref","first-page":"e212","DOI":"10.1111\/bjd.16022","article-title":"HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus","volume":"178","author":"de Sena Nogueira Maehara","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib25","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.4049\/jimmunol.159.4.2010","article-title":"Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins","volume":"159","author":"Ishii","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib26","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1001\/archdermatol.2009.9","article-title":"ELISA testing of anti-desmoglein 1 and 3 antibodies in the management of pemphigus","volume":"145","author":"Abasq","year":"2009","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib27","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jdermsci.2016.12.007","article-title":"Validation of chemiluminescent enzyme immunoassay in detection of autoantibodies in pemphigus and pemphigoid","volume":"85","author":"Fujio","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/bjd.17121","article-title":"Autoantibodies undetectable by chemiluminescent enzyme immunoassay require extended antigen-antibody reaction time for detection","volume":"180","author":"Mai","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib29","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jaad.2018.02.021","article-title":"Diagnosis and management of pemphigus: recommendations of an international panel of experts","volume":"82","author":"Murrell","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib30","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.jaad.2007.05.024","article-title":"Randomized controlled open-label trial of four treatment regimens for pemphigus vulgaris","volume":"57","author":"Chams-Davatchi","year":"2007","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib31","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/1346-8138.12486","article-title":"Japanese guidelines for the management of pemphigus","volume":"41","author":"Amagai","year":"2014","journal-title":"J. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib32","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1111\/jdv.16188","article-title":"Results of the guideline-based treatment for pemphigus: a single-centre experience with 84 cases","volume":"34","author":"Kakuta","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib33","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/bjd.17591","article-title":"Clinical and immunological features of pemphigus relapse","volume":"180","author":"Ujiie","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib34","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1016\/S0140-6736(17)30070-3","article-title":"First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (Ritux 3): a prospective, multicentre, parallel-group, open-label randomised trial","volume":"389","author":"Joly","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jdermsci.2021.11.003_bib35","doi-asserted-by":"crossref","first-page":"928","DOI":"10.2340\/00015555-2116","article-title":"Efficacy of rituximab for pemphigus: a systematic review and meta-analysis of different regimens","volume":"95","author":"Wang","year":"2015","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib36","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/1346-8138.14732","article-title":"Rituximab therapy for refractory autoimmune bullous diseases: a multicenter, open-label, single-arm, phase 1\/2 study on 10 Japanese patients","volume":"46","author":"Kurihara","year":"2019","journal-title":"J. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib37","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1111\/jdv.16561","article-title":"Long-term outcomes of rituximab therapy in pemphigus","volume":"34","author":"Shimanovich","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib38","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJM198205203062001","article-title":"Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease","volume":"306","author":"Anhalt","year":"1982","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib39","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1172\/JCI8748","article-title":"Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus","volume":"105","author":"Amagai","year":"2000","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib40","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/1521-4141(200203)32:3<627::AID-IMMU627>3.0.CO;2-1","article-title":"Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris","volume":"32","author":"Tsunoda","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib41","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.4049\/jimmunol.170.4.2170","article-title":"Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3","volume":"170","author":"Tsunoda","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib42","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1038\/sj.jid.5700450","article-title":"Synergistic pathogenic effects of combined mouse monoclonal anti-desmoglein 3 IgG antibodies on pemphigus vulgaris blister formation","volume":"126","author":"Kawasaki","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib43","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.4049\/jimmunol.181.2.1526","article-title":"Novel system evaluating in vivo pathogenicity of desmoglein 3-reactive T cell clones using murine pemphigus vulgaris","volume":"181","author":"Takahashi","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib44","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1172\/JCI57379","article-title":"Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice","volume":"121","author":"Takahashi","year":"2011","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib45","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.4049\/jimmunol.1401081","article-title":"Pathogenic IgG antibodies against desmoglein 3 in pemphigus vulgaris are regulated by HLA-DRB1*04:02-restricted T cells","volume":"193","author":"Eming","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib46","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0140-6736(12)61140-4","article-title":"Pemphigoid diseases","volume":"381","author":"Schmidt","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jdermsci.2021.11.003_bib47","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3389\/fimmu.2019.00978","article-title":"Current clinical trials in pemphigus and pemphigoid","volume":"10","author":"Izumi","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107725","article-title":"Human eosinophils express the high affinity IgE receptor, Fc\u03b5RI, in bullous pemphigoid","volume":"9","author":"Messingham","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jdermsci.2021.11.003_bib49","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/1523-1747.ep12543517","article-title":"Localization of basement membrane components after dermal-epidermal junction separation","volume":"81","author":"Woodley","year":"1983","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib50","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1111\/jdv.15679","article-title":"Review of autoimmune blistering diseases: the pemphigoid diseases","volume":"33","author":"Daniel","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib51","doi-asserted-by":"crossref","first-page":"5742","DOI":"10.4049\/jimmunol.151.10.5742","article-title":"Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain","volume":"151","author":"Giudice","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib52","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/1523-1747.ep12337492","article-title":"Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies","volume":"109","author":"Zillikens","year":"1997","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib53","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/BF02505245","article-title":"The majority of bullous pemphigoid and herpes gestationis serum samples react with the NC16a domain of the 180-kDa bullous pemphigoid antigen","volume":"288","author":"Matsumura","year":"1996","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib54","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/1523-1747.ep12338088","article-title":"A highly sensitive enzyme-linked immunosorbent assay for the detection of circulating anti-BP180 autoantibodies in patients with bullous pemphigoid","volume":"109","author":"Zillikens","year":"1997","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib55","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0923-1811(02)00109-3","article-title":"BP180 ELISA using bacterial recombinant NC16a protein as a diagnostic and monitoring tool for bullous pemphigoid","volume":"30","author":"Kobayashi","year":"2002","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib56","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1001\/archderm.136.2.174","article-title":"Serum levels of autoantibodies to BP180 correlate with disease activity in patients with bullous pemphigoid","volume":"136","author":"Schmidt","year":"2000","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib57","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jdermsci.2004.10.007","article-title":"Correlation of clinical severity and ELISA indices for the NC16A domain of BP180 measured using BP180 ELISA kit in bullous pemphigoid","volume":"37","author":"Tsuji-Abe","year":"2005","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib58","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/j.1365-2133.2012.10820.x","article-title":"Epitope mapping of BP230 leading to a novel enzyme-linked immunosorbent assay for autoantibodies in bullous pemphigoid","volume":"166","author":"Bl\u00f6cker","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib59","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jdermsci.2005.11.002","article-title":"Enzyme-linked immunosorbent assay using bacterial recombinant proteins of human BP230 as a diagnostic tool for bullous pemphigoid","volume":"41","author":"Yoshida","year":"2006","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib60","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1046\/j.1523-1747.2002.19529.x","article-title":"Severity and phenotype of bullous pemphigoid relate to autoantibody profile against the NH2- and COOH-terminal regions of the BP180 ectodomain","volume":"119","author":"Hofmann","year":"2002","journal-title":"J. Investig.Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib61","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/j.1365-2133.2004.06245.x","article-title":"Development of a novel ELISA system for detection of anti-BP180 IgG and characterization of autoantibody profile in bullous pemphigoid patients","volume":"151","author":"Mariotti","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib62","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1016\/j.jid.2016.06.622","article-title":"Autoantibody profile differentiates between inflammatory and noninflammatory bullous pemphigoid","volume":"136","author":"Izumi","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib63","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2230.1989.tb00944.x","article-title":"Trauma-induced bullous pemphigoid","volume":"14","author":"Macfarlane","year":"1989","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib64","doi-asserted-by":"crossref","first-page":"8569","DOI":"10.1073\/pnas.93.16.8569","article-title":"A common major histocompatibility complex class II allele HLA-DQB1* 0301 is present in clinical variants of pemphigoid","volume":"93","author":"Delgado","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jdermsci.2021.11.003_bib65","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/j.1365-2133.2009.09300.x","article-title":"Incidence of bullous pemphigoid and pemphigus in Switzerland: a 2-year prospective study","volume":"161","author":"Marazza","year":"2009","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib66","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/jdv.12366","article-title":"Drug-induced pemphigoid: a review of the literature","volume":"28","author":"Stavropoulos","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib67","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.jaci.2018.03.014","article-title":"Regulatory T-cell dysfunction induces autoantibodies to bullous pemphigoid antigens in mice and human subjects","volume":"142","author":"Muramatsu","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib68","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/bjd.14601","article-title":"Bullous pemphigoid and dipeptidyl peptidase IV inhibitors: a case-noncase study in the French pharmacovigilance database","volume":"175","author":"B\u00e9n\u00e9","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib69","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/jcpt.12397","article-title":"Dipeptidyl peptidase-IV inhibitors induced bullous pemphigoid: a case report and analysis of cases reported in the European pharmacovigilance database","volume":"41","author":"Garc\u00eda","year":"2016","journal-title":"J. Clin. Pharm. Ther."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib70","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1001\/jamadermatol.2018.2352","article-title":"Association of bullous pemphigoid with dipeptidyl-peptidase 4 inhibitors in patients with diabetes: estimating the risk of the new agents and characterizing the patients","volume":"154","author":"Kridin","year":"2018","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib71","first-page":"1","article-title":"Dipeptidyl peptidase-4 inhibitors-associated bullous pemphigoid: a retrospective study of 168 pemphigoid and 9,304 diabetes mellitus cases","volume":"8","author":"Kawaguchi","year":"2018","journal-title":"J. Diabetes Investig."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib72","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1111\/bjd.16479","article-title":"Unique clinical and serological features of bullous pemphigoid associated with dipeptidyl peptidase-4 inhibitors","volume":"0","author":"Horikawa","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib73","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/bjd.16656","article-title":"Detection of anti-BP180 NC16A autoantibodies after the onset of dipeptidyl peptidase-IV inhibitor-associated bullous pemphigoid: a report of three patients","volume":"179","author":"Mai","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib74","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.jid.2017.11.023","article-title":"HLA-DQB1*03:01 as a biomarker for genetic susceptibility to bullous pemphigoid induced by DPP-4 inhibitors","volume":"138","author":"Ujiie","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib75","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3181\/00379727-136-35421","article-title":"Failure to transfer bullous pemphigoid with serum from patients","volume":"136","author":"Sams","year":"1971","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib76","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0738-081X(87)90056-3","article-title":"Animal models for bullous pemphigoid","volume":"5","author":"Anhalt","year":"1987","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib77","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1172\/JCI116856","article-title":"A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180","volume":"92","author":"Liu","year":"1993","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib78","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1172\/JCI11494","article-title":"Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid","volume":"108","author":"Chen","year":"2001","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib79","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1172\/JCI119639","article-title":"A major role for neutrophils in experimental bullous pemphigoid","volume":"100","author":"Liu","year":"1997","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib80","doi-asserted-by":"crossref","first-page":"914","DOI":"10.2353\/ajpath.2010.090744","article-title":"Blockade of autoantibody-initiated tissue damage by using recombinant fab antibody fragments against pathogenic autoantigen","volume":"176","author":"Wang","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib81","doi-asserted-by":"crossref","first-page":"7746","DOI":"10.4049\/jimmunol.1000667","article-title":"Human IgG1 monoclonal antibody against human collagen 17 noncollagenous 16A domain induces blisters via complement activation in experimental bullous pemphigoid model","volume":"185","author":"Li","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib82","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.4049\/jimmunol.0903101","article-title":"A novel active mouse model for bullous pemphigoid targeting humanized pathogenic antigen","volume":"184","author":"Ujiie","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib83","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.clim.2011.10.002","article-title":"Noncollagenous 16A domain of type XVII collagen-reactive CD4 + T cells play a pivotal role in the development of active disease in experimental bullous pemphigoid model","volume":"142","author":"Ujiie","year":"2012","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib84","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.4049\/jimmunol.1003402","article-title":"Antibodies to pathogenic epitopes on type XVII collagen cause skin fragility in a complement-dependent and -independent manner","volume":"188","author":"Natsuga","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib85","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.4049\/jimmunol.1400095","article-title":"Bullous pemphigoid autoantibodies directly induce blister formation without complement activation","volume":"193","author":"Ujiie","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib86","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01410","article-title":"Immune reaction to type XVII collagen induces intramolecular and intermolecular epitope spreading in experimental bullous pemphigoid models","volume":"10","author":"Ujiie","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib87","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.jid.2018.01.005","article-title":"Intravenous IgG reduces pathogenic autoantibodies, serum IL-6 levels, and disease severity in experimental bullous pemphigoid models","volume":"138","author":"Sasaoka","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib88","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jaut.2008.08.009","article-title":"Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model","volume":"31","author":"Liu","year":"2008","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib89","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.4049\/jimmunol.1100596","article-title":"Repetitive immunization breaks tolerance to type XVII collagen and leads to bullous pemphigoid in mice","volume":"187","author":"Hirose","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib90","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.jaci.2018.04.006","article-title":"Regulatory T-cell deficiency leads to pathogenic bullous pemphigoid antigen 230 autoantibody and autoimmune bullous disease","volume":"142","author":"Haeberle","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib91","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.autrev.2019.06.007","article-title":"Epidermolysis bullosa acquisita: a comprehensive review","volume":"18","author":"Kridin","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib92","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.clindermatol.2011.03.011","article-title":"Epidermolysis bullosa acquisita","volume":"30","author":"Gupta","year":"2012","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib93","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/1744666X.2016.1221343","article-title":"Clinical features and diagnosis of epidermolysis bullosa acquisita","volume":"13","author":"Vorobyev","year":"2017","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib94","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3389\/fmed.2018.00362","article-title":"Epidermolysis bullosa acquisita: The 2019 update","volume":"6","author":"Koga","year":"2019","journal-title":"Front. Med."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib95","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/JID.2015.356","article-title":"Epidermolysis bullosa acquisita: from pathophysiology to novel therapeutic options","volume":"136","author":"Kasperkiewicz","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib96","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/exd.13335","article-title":"Signalling and targeted therapy of inflammatory cells in epidermolysis bullosa acquisita","volume":"26","author":"Ludwig","year":"2017","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib97","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.2174\/1381612821666150316122502","article-title":"Animal models to investigate pathomechanisms and evaluate novel treatments for autoimmune bullous dermatoses","volume":"21","author":"Iwata","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib98","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0625.1992.tb00065.x","article-title":"Molecular biology and pathology of type VII collagen","volume":"1","author":"Uitto","year":"1992","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib99","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/1346-8138.14222","article-title":"Epidermal aspects of type VII collagen: implications for dystrophic epidermolysis bullosa and epidermolysis bullosa acquisita","volume":"45","author":"Watanabe","year":"2018","journal-title":"J. Dermatol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib100","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1365-2133.2004.05933.x","article-title":"Epidermolysis bullosa acquisita sera react with distinct epitopes on the NC1 and NC2 domains of type VII collagen: study using immunoblotting of domain-specific recombinant proteins and postembedding immunoelectron microscopy","volume":"150","author":"Ishii","year":"2004","journal-title":"Br. J. Dermatol"},{"key":"10.1016\/j.jdermsci.2021.11.003_bib101","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s13023-018-0896-1","article-title":"Meta-analysis of the clinical and immunopathological characteristics and treatment outcomes in epidermolysis bullosa acquisita patients","volume":"13","author":"Iwata","year":"2018","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib102","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jaut.2009.11.003","article-title":"Pathogenicity of IgG subclass autoantibodies to type VII collagen: induction of dermal-epidermal separation","volume":"34","author":"Recke","year":"2010","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib103","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jaut.2012.04.002","article-title":"Enzymatic autoantibody glycan hydrolysis alleviates autoimmunity against type VII collagen","volume":"39","author":"Hirose","year":"2012","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib104","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1038\/ncomms3462","article-title":"Genome-wide mapping of gene-microbiota interactions in susceptibility to autoimmune skin blistering","volume":"4","author":"Srinivas","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib105","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.clim.2009.12.010","article-title":"T and B cells target identical regions of the non-collagenous domain 1 of type VII collagen in epidermolysis bullosa acquisita","volume":"135","author":"M\u00fcller","year":"2010","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib106","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083631","article-title":"Persistent autoantibody-production by intermediates between short-and long-lived plasma cells in inflamed lymph nodes of experimental epidermolysis bullosa acquisita","volume":"8","author":"Tiburzy","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jdermsci.2021.11.003_bib107","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3389\/fimmu.2017.00603","article-title":"Mechanisms of autoantibody-induced pathology","volume":"8","author":"Ludwig","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jdermsci.2021.11.003_bib108","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.jid.2016.12.021","article-title":"The leukotriene B4 and its receptor BLT1 act as critical drivers of neutrophil recruitment in murine bullous pemphigoid-like epidermolysis bullosa acquisita","volume":"137","author":"Sezin","year":"2017","journal-title":"J. Investig. Dermatol."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181121002887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181121002887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:52:28Z","timestamp":1760331148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181121002887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":108,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S0923181121002887"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2021.11.003","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The pathogeneses of pemphigus and pemphigoid diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2021.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}