{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T02:46:01Z","timestamp":1794365161484,"version":"4.9.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.jdermsci.2022.07.004","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T12:29:01Z","timestamp":1657715341000},"page":"75-81","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Risk factors for sepsis and effects of pretreatment with systemic steroid therapy for underlying condition in SJS\/TEN patients: Results of a nationwide cross-sectional survey in 489 Japanese patients"],"prefix":"10.1016","volume":"107","author":[{"given":"Yuma","family":"Sunaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsumi","family":"Hama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Ochiai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akatsuki","family":"Kokaze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Seon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Kurosawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Azukizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Asada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukie","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Aihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Mizukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Ohyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riichiro","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Hashizume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeko","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kabashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiko","family":"Tohyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Mieno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Ueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Sotozono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Niihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eishin","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Sueki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2022.07.004_bib1","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1001\/archpedi.1922.04120120077005","article-title":"A new eruptive fever associated with stomatitis and ophthalmia: report of two cases in children","volume":"24","author":"Stevens","year":"1992","journal-title":"Am. J. Dis. Child."},{"key":"10.1016\/j.jdermsci.2022.07.004_bib2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1365-2133.1956.tb12766.x","article-title":"Toxic epidermal necrolysis: an eruption resembling scalding of the skin","volume":"68","author":"Lyell","year":"1956","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.004_bib3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1001\/archderm.1993.01680220104023","article-title":"Clinical classification of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme","volume":"129","author":"Bastuji-Garin","year":"1993","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.004_bib4","first-page":"530","article-title":"Criteria for Stevens-Johnson syndrome (SJS)\/toxic epidermal necrolysis (TEN","volume":"10","author":"Sueki","year":"2016","journal-title":"). J. Environ. Dermatol. Cutan. Allergol."},{"key":"10.1016\/j.jdermsci.2022.07.004_bib5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jdermsci.2020.09.009","article-title":"The second nationwide epidemiological survey of Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"100","author":"Sunaga","year":"2020","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2022.07.004_bib6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.alit.2015.09.001","article-title":"Retrospective analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis in 87 Japanese patients--treatment and outcome","volume":"65","author":"Yamane","year":"2016","journal-title":"Allergol. Int."},{"key":"10.1016\/j.jdermsci.2022.07.004_bib7","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.burns.2013.03.011","article-title":"27 years of a single burn centre experience with Stevens-Johnson syndrome and toxic epidermal necrolysis: analysis of mortality risk for causative agents","volume":"39","author":"Weinand","year":"2013","journal-title":"Burns"},{"key":"10.1016\/j.jdermsci.2022.07.004_bib8","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jaad.2019.05.096","article-title":"Risk factors and diagnostic markers of bacteremia in Stevens-Johnson syndrome and toxic epidermal necrolysis: a cohort study of 176 patients","volume":"81","author":"Koh","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.004_bib9","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/sj.jid.5701033","article-title":"Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study","volume":"128","author":"Mockenhaupt","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.004_bib10","series-title":"The Nationwide Epidemiological Survey Manual for Investigating the Number of Patients and Clinico-epidemiological Features of Intractable Diseases","first-page":"1","author":"Nakamura","year":"2017"},{"key":"10.1016\/j.jdermsci.2022.07.004_bib11","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.burns.2019.10.008","article-title":"Retrospective study of 213 cases of Stevens-Johnson syndrome and toxic epidermal necrolysis from China","volume":"46","author":"Yang","year":"2020","journal-title":"Burns"},{"key":"10.1016\/j.jdermsci.2022.07.004_bib12","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1001\/archderm.1993.01680290135026","article-title":"Incidence of Stevens-Johnson syndrome and toxic epidermal necrolysis in patients with the acquired immunodeficiency syndrome in Germany","volume":"129","author":"Rzany","year":"1993","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.004_bib13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2165\/11593240-000000000-00000","article-title":"Incidence of toxic epidermal necrolysis and Stevens-Johnson Syndrome in an HIV cohort: an observational, retrospective case series study","volume":"13","author":"Mittmann N","year":"2012","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.004_bib14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1089\/aid.2011.0140","article-title":"A randomized case-control study of dynamic changes in peripheral blood Th17\/Treg cell balance and interleukin-17 levels in high active antiretroviral-Treated HIV type 1\/AIDS patients","volume":"28","author":"He","year":"2012","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"10.1016\/j.jdermsci.2022.07.004_bib15","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3390\/ijms20051142","article-title":"Context-dependent effect of glucocorticoids on the proliferation, differentiation, and apoptosis of regulatory T cells: a review of the empirical evidence and clinical applications","volume":"20","author":"Cari","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jdermsci.2022.07.004_bib16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1600-0404.2008.01090.x","article-title":"Glucocorticoids increase CD4CD25 cells percentage and Foxp3 expression in patients with multiple sclerosis","volume":"119","author":"Braitch","year":"2009","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.jdermsci.2022.07.004_bib17","doi-asserted-by":"crossref","first-page":"8071","DOI":"10.4049\/jimmunol.0804002","article-title":"Defective regulatory T cells in patinets with severe drug eruptions: timing of the dysfunction is associated with the pathological phenotype and outcome","volume":"182","author":"Takahashi","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2022.07.004_bib18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/1346-8138.14074","article-title":"Immune reconstitution inflammatory syndrome in non-HIV immunosuppressed patients","volume":"45","author":"Sueki","year":"2018","journal-title":"J. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.004_bib19","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000500945","article-title":"Severe cutaneous adverse reactions during tapering of high-dose systemic steroid therapy for autoimmune diseases: implications for non-HIV immune reconstitution inflammatory syndrome","volume":"11","author":"Sueki","year":"2019","journal-title":"Case. Rep. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.004_bib20","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1056\/NEJM199512143332404","article-title":"Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis","volume":"333","author":"Roujeau","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jdermsci.2022.07.004_bib21","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.jid.2019.12.025","article-title":"association of HLA-A*11:01with sulfonamide-related severe cutaneous adverse reactions in Japanese patients","volume":"140","author":"Nakamura","year":"2020","journal-title":"J. Invest. Dermatol."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181122001669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181122001669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:52:02Z","timestamp":1760331122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181122001669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S0923181122001669"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2022.07.004","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk factors for sepsis and effects of pretreatment with systemic steroid therapy for underlying condition in SJS\/TEN patients: Results of a nationwide cross-sectional survey in 489 Japanese patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2022.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}