{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:49:57Z","timestamp":1783637397109,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.jdermsci.2022.07.005","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T12:29:01Z","timestamp":1657715341000},"page":"58-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["The role of HMGB1 in inflammatory skin diseases"],"prefix":"10.1016","volume":"107","author":[{"given":"Takashi K.","family":"Satoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2022.07.005_bib1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrrheum.2011.222","article-title":"HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease","volume":"8","author":"Harris","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-immunol-030409-101323","article-title":"HMGB1 is a therapeutic target for sterile inflammation and infection","volume":"29","author":"Andersson","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib3","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2119\/molmed.2013.00164","article-title":"The role of HMGB1 in the pathogenesis of inflammatory and autoimmune diseases","volume":"20","author":"Magna","year":"2014","journal-title":"Mol. Med."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib4","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1073\/pnas.1316925111","article-title":"JAK\/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation","volume":"111","author":"Lu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.448262","article-title":"Cleavage of HMGB1 by proteolytic enzymes associated with inflammatory conditions","volume":"11","author":"Sowinska","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib6","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1084\/jem.20120189","article-title":"Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release","volume":"209","author":"Venereau","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.immuni.2008.05.013","article-title":"Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein","volume":"29","author":"Kazama","year":"2008","journal-title":"Immunity"},{"issue":"73ra20","key":"10.1016\/j.jdermsci.2022.07.005_bib8","article-title":"Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus","volume":"3","author":"Garcia-Romo","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib9","doi-asserted-by":"crossref","first-page":"L342","DOI":"10.1152\/ajplung.00151.2012","article-title":"HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4","volume":"304","author":"Tadie","year":"2013","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib10","doi-asserted-by":"crossref","first-page":"968","DOI":"10.4049\/jimmunol.2100593","article-title":"HMGB1-mediated neutrophil extracellular trap formation exacerbates intestinal ischemia\/reperfusion-induced acute lung injury","volume":"208","author":"Zhan","year":"2022","journal-title":"J. Immunol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib11","doi-asserted-by":"crossref","first-page":"4638","DOI":"10.1172\/JCI81660","article-title":"Platelet-derived HMGB1 is a critical mediator of thrombosis","volume":"125","author":"Vogel","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib12","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1038\/s41598-018-20479-x","article-title":"Deep vein thrombosis in mice is regulated by platelet HMGB1 through release of neutrophil-extracellular traps and DNA","volume":"8","author":"Dyer","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0300-9475.2005.01534.x","article-title":"RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages","volume":"61","author":"Kokkola","year":"2005","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1084\/jem.20141318","article-title":"MD-2 is required for disulfide HMGB1-dependent TLR4 signaling","volume":"212","author":"Yang","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib15","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1084\/jem.20111739","article-title":"HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4","volume":"209","author":"Schiraldi","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1084\/jem.20160217","article-title":"High mobility group box 1 orchestrates tissue regeneration via CXCR4","volume":"215","author":"Tirone","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib17","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/ni.2376","article-title":"Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1","volume":"13","author":"Chiba","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib18","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1084\/jem.20100643","article-title":"Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity","volume":"207","author":"Sakuishi","year":"2010","journal-title":"J. Exp. Med."},{"issue":"295081 (","key":"10.1016\/j.jdermsci.2022.07.005_bib19","article-title":"Enhanced HMGB1 expression may contribute to Th17 cells activation in rheumatoid arthritis","volume":"2012","author":"Shi","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib20","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1038\/jid.2011.139","article-title":"Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skin","volume":"131","author":"Bovenschen","year":"2011","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib21","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/jdv.13564","article-title":"High mobility group box 1 is increased in the sera of psoriatic patients with disease progression","volume":"30","author":"Bergmann","year":"2016","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib22","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00403-013-1330-0","article-title":"Increased HMGB1 serum levels and altered HMGB1 expression in patients with psoriasis vulgaris","volume":"305","author":"Chen","year":"2013","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4103\/ejdv.ejdv_10_17","article-title":"Role of high-mobility group box-1 as a marker of disease severity and diagnosis of metabolic syndrome in psoriatic patients","volume":"37","author":"Kamel","year":"2017","journal-title":"Egypt. J. Dermatol. Venerol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib24","first-page":"7","article-title":"Increased dermal expression of chromatin-associated protein HMGB1 and concomitant T-cell expression of the DNA RAGE in patients with psoriasis vulgaris","volume":"9","author":"Strohbuecker","year":"2019","journal-title":"Psoriasis (Auckl., N. Z.)"},{"key":"10.1016\/j.jdermsci.2022.07.005_bib25","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/1346-8138.13695","article-title":"Involvement of high mobility group box-1 in imiquimod-induced psoriasis-like mice model","volume":"44","author":"Chen","year":"2017","journal-title":"J. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib26","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/path.4848","article-title":"Proinflammatory effect of high-mobility group protein B1 on keratinocytes: an autocrine mechanism underlying psoriasis development","volume":"241","author":"Zhang","year":"2017","journal-title":"J. Pathol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib27","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1080\/15548627.2020.1725381","article-title":"Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin in\ufb02ammation","volume":"17","author":"Wang","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.jdermsci.2022.07.005_bib28","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/1346-8138.15467","article-title":"Increased level of high mobility group box 1 in the serum and skin in patients with generalized pustular psoriasis","volume":"47","author":"Watanabe","year":"2020","journal-title":"J. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib29","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2340\/00015555-2552","article-title":"The \u2018Alarmins\u2019 HMBG1 and IL-33 downregulate structural skin barrier proteins and impair epidermal growth","volume":"97","author":"Nygaard","year":"2017","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/pai.12481","article-title":"HMGB1 levels in children with atopic eczema\/dermatitis syndrome (AEDS)","volume":"27","author":"Cuppari","year":"2016","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib31","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.3892\/mmr.2017.6942","article-title":"Activation of the HMGB1\u2013TLR4\u2013NF\u2011\u03baB pathway may occur in patients with atopic eczema","volume":"16","author":"Wang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.intimp.2018.04.029","article-title":"Glycyrrhizin ameliorates atopic dermatitis-like symptoms through inhibition of HMGB1","volume":"60","author":"Wang","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib33","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/exd.12685","article-title":"Modulation of HMGB1 translocation and RAGE\/NF\u03baB cascade by quercetin treatment mitigates atopic dermatitis in NC\/Nga transgenic mice","volume":"24","author":"Karuppagounder","year":"2015","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib34","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2022343118","article-title":"HMGB1-mediated chromatin remodeling attenuates Il24 gene expression for the protection from allergic contact dermatitis","volume":"118","author":"Senda","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1642\u20131646","key":"10.1016\/j.jdermsci.2022.07.005_bib35","article-title":"HMGB1-RAGE-moesin axis may be indicted for acne vulgaris","volume":"21","author":"Salem","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib36","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.jid.2017.01.031","article-title":"The epidemiology of stevens-johnson syndrome and toxic epidermal necrolysis in the UK","volume":"137","author":"Frey","year":"2017","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib37","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1001\/archdermatol.2011.239","article-title":"High-mobility group box 1 protein (HMGB1) as a novel diagnostic tool for toxic epidermal necrolysis and Stevens-Johnson syndrome","volume":"147","author":"Nakajima","year":"2011","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib38","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/bjd.17610","article-title":"Serum and blister-fluid elevation and decreased epidermal content of high-mobility group box 1 protein in drug-induced Stevens-Johnson syndrome\/toxic epidermal necrolysis","volume":"181","author":"Carr","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib39","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1111\/bjd.15151","article-title":"Impact of high-mobility group box 1 on melanocytic survival and its involvement in the pathogenesis of vitiligo","volume":"176","author":"Kim","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib40","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1111\/ced.14782","article-title":"Blood high mobility group box 1 levels are not a suitable biomarker for disease activity or severity in nonsegmental vitiligo","volume":"46","author":"Park","year":"2021","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib41","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.jaad.2013.05.020","article-title":"Clinical significance of serum high-mobility group box 1 level in alopecia areata","volume":"69","author":"Lee","year":"2013","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib42","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.1038\/s41598-019-43242-2","article-title":"HMGB1 promotes hair growth via the modulation of prostaglandin metabolism","volume":"9","author":"Hwang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib43","doi-asserted-by":"crossref","first-page":"R174","DOI":"10.1186\/cc8152","article-title":"Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion","volume":"13","author":"Cohen","year":"2009","journal-title":"Crit. Care"},{"key":"10.1016\/j.jdermsci.2022.07.005_bib44","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.bcp.2004.03.048","article-title":"High mobility group box 1 protein, a cue for stem cell recruitment","volume":"68","author":"Palumbo","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib45","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/exd.12152","article-title":"Serum levels of high mobility group box 1 correlate with disease severity in recessive dystrophic epidermolysis bullosa","volume":"22","author":"Petrof","year":"2013","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib46","doi-asserted-by":"crossref","first-page":"6609","DOI":"10.1073\/pnas.1016753108","article-title":"PDGFRalpha-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia","volume":"108","author":"Tamai","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib47","doi-asserted-by":"crossref","first-page":"121","DOI":"10.5021\/ad.2017.29.1.121","article-title":"Increased Serum High Mobility Group Box 1 (HMGB1) concentration and the altered expression of HMGB1 and its receptor advanced glycation endproducts in pemphigus","volume":"29","author":"Li","year":"2017","journal-title":"Ann. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib48","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/exd.12422","article-title":"Increased serum HMGB1 levels in patients with Henoch-Sch\u00f6nlein purpura","volume":"23","author":"Chen","year":"2014","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib49","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.3389\/fimmu.2020.02032","article-title":"The anti-inflammatory effects of HMGB1 blockades in a mouse model of cutaneous vasculitis","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jdermsci.2022.07.005_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay8416","article-title":"Rebalancing expression of HMGB1 redox isoforms to counteract muscular dystrophy","volume":"13","author":"Careccia","year":"2021","journal-title":"Sci. Transl. Med."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181122001670?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181122001670?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:52:16Z","timestamp":1760331136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181122001670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S0923181122001670"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2022.07.005","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of HMGB1 in inflammatory skin diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2022.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}