{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:31:30Z","timestamp":1780083090211,"version":"3.54.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jdermsci.2022.08.005","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T10:37:26Z","timestamp":1660559846000},"page":"133-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Understanding the systemic burden of disease in hidradenitis suppurativa from plasma lipidomic analysis"],"prefix":"10.1016","volume":"107","author":[{"given":"Ellie","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sartaj Ahmad","family":"Mir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue Ting","family":"Ooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther W.L.","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeo","family":"Yi Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus R.","family":"Wenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne K.","family":"Bendt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha Suyien","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jdermsci.2022.08.005_bib1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1159\/000431175","article-title":"Hidradenitis suppurativa\/acne inversa: criteria for diagnosis, severity assessment, classification and disease evaluation","volume":"231","author":"Zouboulis","year":"2015","journal-title":"Dermatol. (Basel)"},{"issue":"6","key":"10.1016\/j.jdermsci.2022.08.005_bib2","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.jaad.2014.09.012","article-title":"Hidradenitis suppurativa is a systemic disease with substantial comorbidity burden: a chart-verified case-control analysis","volume":"71","author":"Shlyankevich","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2022.08.005_bib3","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.jaad.2008.06.020","article-title":"Prevalence and factors associated with hidradenitis suppurativa: results from two case-control studies","volume":"59","author":"Revuz","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jdermsci.2022.08.005_bib4","doi-asserted-by":"crossref","DOI":"10.1111\/jdv.17933","article-title":"Prevalence and perceptions towards hidradenitis suppurativa: a cross-sectional study in a non-dermatological outpatient population","author":"Han","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"1","key":"10.1016\/j.jdermsci.2022.08.005_bib5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4161\/derm.2.1.12490","article-title":"Comorbidities of hidradenitis suppurativa (acne inversa)","volume":"2","author":"Fimmel","year":"2010","journal-title":"Dermatoendocrinol"},{"issue":"1","key":"10.1016\/j.jdermsci.2022.08.005_bib6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jaad.2009.02.013","article-title":"Clinical characteristics of a series of 302 French patients with hidradenitis suppurativa, with an analysis of factors associated with disease severity","volume":"61","author":"Canoui-Poitrine","year":"2009","journal-title":"J. Am. Acad. Dermatol."},{"issue":"12","key":"10.1016\/j.jdermsci.2022.08.005_bib7","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1001\/jamadermatol.2014.1165","article-title":"Association of metabolic syndrome and hidradenitis suppurativa","volume":"150","author":"Miller","year":"2014","journal-title":"JAMA Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2022.08.005_bib8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000481836","article-title":"Hidradenitis suppurativa: an Asian perspective from a Singaporean institute","volume":"4","author":"Choi","year":"2018","journal-title":"Ski. Appendage Disord."},{"issue":"1","key":"10.1016\/j.jdermsci.2022.08.005_bib9","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jaad.2020.08.045","article-title":"Hidradenitis suppurativa in pediatric patients","volume":"86","author":"Choi","year":"2022","journal-title":"J. Am. Acad. Dermatol."},{"issue":"6","key":"10.1016\/j.jdermsci.2022.08.005_bib10","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jaad.2017.07.027","article-title":"Uncovering burden disparity: A comparative analysis of the impact of moderate-to-severe psoriasis and hidradenitis suppurativa","volume":"77","author":"Hamzavi","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"issue":"2","key":"10.1016\/j.jdermsci.2022.08.005_bib11","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jaad.2009.06.050","article-title":"Infliximab therapy for patients with moderate to severe hidradenitis suppurativa: a randomized, double-blind, placebo-controlled crossover trial","volume":"62","author":"Grant","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"issue":"22","key":"10.1016\/j.jdermsci.2022.08.005_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228436","article-title":"Cytokine pathways and investigational target therapies in hidradenitis suppurativa","volume":"21","author":"Del Duca","year":"2020","journal-title":"Int J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jdermsci.2022.08.005_bib13","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1111\/bjd.14371","article-title":"Gene expression profiling of skin and blood in hidradenitis suppurativa","volume":"174","author":"Blok","year":"2016","journal-title":"Br. J. Dermatol."},{"issue":"12","key":"10.1016\/j.jdermsci.2022.08.005_bib14","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1001\/jamadermatol.2014.1871","article-title":"Hidradenitis suppurativa: current progress and future questions","volume":"150","author":"Pascoe","year":"2014","journal-title":"JAMA Dermatol."},{"issue":"2","key":"10.1016\/j.jdermsci.2022.08.005_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrendo.2016.169","article-title":"Sphingolipids and phospholipids in insulin resistance and related metabolic disorders","volume":"13","author":"Meikle","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"issue":"2","key":"10.1016\/j.jdermsci.2022.08.005_bib16","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jaad.2017.03.016","article-title":"Gene expression of sphingolipid metabolism pathways is altered in hidradenitis suppurativa","volume":"77","author":"Dany","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"issue":"12","key":"10.1016\/j.jdermsci.2022.08.005_bib17","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1016\/j.jid.2020.04.011","article-title":"Lipidomics profiling of hidradenitis suppurativa skin lesions reveals lipoxygenase pathway dysregulation and accumulation of proinflammatory leukotriene B4","volume":"140","author":"Penno","year":"2020","journal-title":"J. Invest Dermatol."},{"issue":"11","key":"10.1016\/j.jdermsci.2022.08.005_bib18","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1194\/jlr.RA120000991","article-title":"Harmonized procedures lead to comparable quantification of total oxylipins across laboratories","volume":"61","author":"Mainka","year":"2020","journal-title":"J. Lipid Res"},{"issue":"9","key":"10.1016\/j.jdermsci.2022.08.005_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000870","article-title":"M, et al. High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies","volume":"18","author":"Beyene","year":"2020","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.jdermsci.2022.08.005_bib20","doi-asserted-by":"crossref","first-page":"11296","DOI":"10.1038\/s41598-018-29568-3","article-title":"Tear eicosanoids in healthy people and ocular surface disease","volume":"8","author":"Ambaw","year":"2018","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.jdermsci.2022.08.005_bib21","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.cpcardiol.2006.03.001","article-title":"Pathophysiology, diagnosis, and management of dyslipidemia","volume":"31","author":"Gau","year":"2006","journal-title":"Curr. Probl. Cardiol."},{"issue":"4","key":"10.1016\/j.jdermsci.2022.08.005_bib22","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2337\/dc16-1958","article-title":"Triglyceride and HDL-C Dyslipidemia and Risks of Coronary Heart Disease and Ischemic Stroke by Glycemic Dysregulation Status: The Strong Heart Study","volume":"40","author":"Lee","year":"2017","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.jdermsci.2022.08.005_bib23","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-2133.2006.07671.x","article-title":"Testosterone metabolism to 5alpha-dihydrotestosterone and synthesis of sebaceous lipids is regulated by the peroxisome proliferator-activated receptor ligand linoleic acid in human sebocytes","volume":"156","author":"Makrantonaki","year":"2007","journal-title":"Br. J. Dermatol."},{"issue":"2","key":"10.1016\/j.jdermsci.2022.08.005_bib24","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1365-2133.2011.10340.x","article-title":"Regulation of stearoyl-coenzyme A desaturase and fatty acid delta-6 desaturase-2 expression by linoleic acid and arachidonic acid in human sebocytes leads to enhancement of proinflammatory activity but does not affect lipogenesis","volume":"165","author":"Zouboulis","year":"2011","journal-title":"Br. J. Dermatol."},{"issue":"3\u20135","key":"10.1016\/j.jdermsci.2022.08.005_bib25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.plefa.2008.09.019","article-title":"Too much linoleic acid promotes inflammation-doesn\u2019t it?","volume":"79","author":"Fritsche","year":"2008","journal-title":"Prostaglandins Leukot. Ess. Fat. Acids"},{"issue":"5","key":"10.1016\/j.jdermsci.2022.08.005_bib26","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/jdv.12298","article-title":"Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions","volume":"28","author":"Zouboulis","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"9","key":"10.1016\/j.jdermsci.2022.08.005_bib27","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.2337\/dc21-0438","article-title":"Dietary Intake of Linoleic Acid, Its Concentrations, and the Risk of Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies","volume":"44","author":"Mousavi","year":"2021","journal-title":"Diabetes Care"},{"issue":"11","key":"10.1016\/j.jdermsci.2022.08.005_bib28","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1093\/jn\/134.11.2991","article-title":"Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women","volume":"134","author":"Zhao","year":"2004","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.jdermsci.2022.08.005_bib29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.chembiol.2018.10.008","article-title":"High-Throughput Plasma Lipidomics: Detailed Mapping of the Associations with Cardiometabolic Risk Factors","volume":"26","author":"Huynh","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.jdermsci.2022.08.005_bib30","article-title":"Large-scale lipidomics identifies associations between plasma sphingolipids and T2DM incidence","volume":"5","author":"Chew","year":"2019","journal-title":"JCI Insight"},{"issue":"2","key":"10.1016\/j.jdermsci.2022.08.005_bib31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00403-016-1709-9","article-title":"Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients","volume":"309","author":"My\u015bliwiec","year":"2017","journal-title":"Arch. Dermatol. Res"},{"issue":"1","key":"10.1016\/j.jdermsci.2022.08.005_bib32","doi-asserted-by":"crossref","first-page":"12033","DOI":"10.1038\/s41598-019-48381-0","article-title":"Arachidonic acid-derived hydroxyeicosatetraenoic acids are positively associated with colon polyps in adult males: a cross-sectional study","volume":"9","author":"Austin Pickens","year":"2019","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.jdermsci.2022.08.005_bib33","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/art.42000","article-title":"Clinical and Preclinical Evidence for Roles of Soluble Epoxide Hydrolase in Osteoarthritis Knee Pain","volume":"74","author":"Gowler","year":"2022","journal-title":"Arthritis Rheuma"},{"issue":"3","key":"10.1016\/j.jdermsci.2022.08.005_bib34","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/mnfr.201300405","article-title":"Impact of EPA ingestion on COX- and LOX-mediated eicosanoid synthesis in skin with and without a pro-inflammatory UVR challenge \u2013 Report of a randomised controlled study in humans","volume":"58","author":"Pilkington","year":"2014","journal-title":"Mol. Nutr. Food Res"},{"issue":"3","key":"10.1016\/j.jdermsci.2022.08.005_bib35","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1365-2125.2012.04374.x","article-title":"Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?","volume":"75","author":"Calder","year":"2013","journal-title":"Br. J. Clin. Pharm."},{"issue":"5","key":"10.1016\/j.jdermsci.2022.08.005_bib36","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1177\/1203475420929925","article-title":"The potential uses of omega-3 fatty acids in dermatology: a review","volume":"24","author":"Thomsen","year":"2020","journal-title":"J. Cutan. Med Surg."},{"key":"10.1016\/j.jdermsci.2022.08.005_bib37","first-page":"11","article-title":"Omega 3 fatty acid and skin diseases","author":"Sawada","year":"2021","journal-title":"Front. Immunol. [Internet]"},{"issue":"7","key":"10.1016\/j.jdermsci.2022.08.005_bib38","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.jid.2018.02.003","article-title":"Bioactive lipid mediator profiles in human psoriasis skin and blood","volume":"138","author":"Sorokin","year":"2018","journal-title":"J. Invest Dermatol."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181122001967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181122001967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:52:24Z","timestamp":1760331144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181122001967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0923181122001967"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2022.08.005","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Understanding the systemic burden of disease in hidradenitis suppurativa from plasma lipidomic analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2022.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}