{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:11:11Z","timestamp":1790673071469,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972919"],"award-info":[{"award-number":["81972919"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273513"],"award-info":[{"award-number":["82273513"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jdermsci.2022.11.005","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T12:08:45Z","timestamp":1671106125000},"page":"98-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Uncoupling melanogenesis from proliferation in epidermal melanocytes responding to stimulation with psoriasis-related proinflammatory cytokines"],"prefix":"10.1016","volume":"108","author":[{"given":"Yun-Zhu","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Kai","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Qi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Fei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tie-Chi","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2022.11.005_bib1","doi-asserted-by":"crossref","first-page":"16082","DOI":"10.1038\/nrdp.2016.82","article-title":"Psoriasis","volume":"2","author":"Greb","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"1","key":"10.1016\/j.jdermsci.2022.11.005_bib2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2174\/2589977513666210707114520","article-title":"IL-23\/Th17 axis: A potential therapeutic target of psoriasis","volume":"14","author":"Sharma","year":"2022","journal-title":"Curr. Drug Res. Rev."},{"issue":"1","key":"10.1016\/j.jdermsci.2022.11.005_bib3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.5114\/pdia.2013.33376","article-title":"Skin melanocytes: biology and development","volume":"30","author":"Cichorek","year":"2013","journal-title":"Post. Dermatol. Alergol."},{"issue":"3","key":"10.1016\/j.jdermsci.2022.11.005_bib4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.det.2007.04.001","article-title":"The melanocyte and the epidermal melanin unit: an expanded concept","volume":"25","author":"Nordlund","year":"2007","journal-title":"Dermatol. Clin."},{"key":"10.1016\/j.jdermsci.2022.11.005_bib5","first-page":"247","article-title":"Latest advances for the treatment of chronic plaque psoriasis with biologics and oral small molecules","volume":"15","author":"Bellinato","year":"2021","journal-title":"Biologics"},{"issue":"1","key":"10.1016\/j.jdermsci.2022.11.005_bib6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/bbrc.2000.2409","article-title":"In situ localization of agouti signal protein in murine skin using immunohistochemistry with an ASP-specific antibody","volume":"270","author":"Matsunaga","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.jdermsci.2022.11.005_bib7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/dbio.1997.8738","article-title":"Activation of the receptor tyrosine kinase Kit is required for the proliferation of melanoblasts in the mouse embryo","volume":"192","author":"Mackenzie","year":"1997","journal-title":"Dev. Biol."},{"issue":"20","key":"10.1016\/j.jdermsci.2022.11.005_bib8","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1097\/CM9.0000000000001689","article-title":"Pro-pigmentary action of 5-fluorouracil through the stimulated secretion of CXCL12 by dermal fibroblasts","volume":"134","author":"Liao","year":"2021","journal-title":"Chin. Med. J. (Engl. )"},{"issue":"6","key":"10.1016\/j.jdermsci.2022.11.005_bib9","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12372","article-title":"Induction of retinal-dependent calcium influx in human melanocytes by UVA or UVB radiation contributes to the stimulation of melanosome transfer","volume":"50","author":"Hu","year":"2017","journal-title":"Cell Prolif."},{"issue":"8","key":"10.1016\/j.jdermsci.2022.11.005_bib10","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/exd.13675","article-title":"Topical retinol attenuates stress-induced ageing signs in human skin ex vivo, through EGFR activation via EGF, but not ERK and AP-1 activation","volume":"28","author":"Romana-Souza","year":"2019","journal-title":"Exp. Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2022.11.005_bib11","doi-asserted-by":"crossref","first-page":"21192","DOI":"10.1038\/s41598-020-78292-4","article-title":"Human skin explant model for the investigation of topical therapeutics","volume":"10","author":"Neil","year":"2020","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.jdermsci.2022.11.005_bib12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/php.12848","article-title":"Signaling cascades activated by UVB in human melanocytes lead to the increased expression of melanocyte receptors, endothelin B receptor and c-KIT","volume":"94","author":"Terazawa","year":"2018","journal-title":"Photochem. Photobiol."},{"issue":"1","key":"10.1016\/j.jdermsci.2022.11.005_bib13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/jid.2008.184","article-title":"Imiquimod, a Toll-like receptor 7 agonist, inhibits melanogenesis and proliferation of human melanocytes","volume":"129","author":"Kang","year":"2009","journal-title":"J. Invest. Dermatol."},{"issue":"9","key":"10.1016\/j.jdermsci.2022.11.005_bib14","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.3390\/ijms19092667","article-title":"MC1R: Front and center in the bright side of dark eumelanin and DNA repair","volume":"19","author":"Swope","year":"2018","journal-title":"Int J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jdermsci.2022.11.005_bib15","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1073\/pnas.0806753106","article-title":"Microarray analysis sheds light on the dedifferentiating role of agouti signal protein in murine melanocytes via the Mc1r","volume":"106","author":"Le Pape","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.jdermsci.2022.11.005_bib16","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1038\/jid.2012.135","article-title":"Defining MC1R regulation in human melanocytes by its agonist \u03b1-melanocortin and antagonists agouti signaling protein and \u03b2-defensin 3","volume":"132","author":"Swope","year":"2012","journal-title":"J. Invest Dermatol."},{"issue":"5","key":"10.1016\/j.jdermsci.2022.11.005_bib17","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1128\/AAC.01308-07","article-title":"Mouse beta-defensin-14, an antimicrobial ortholog of human beta-defensin-3","volume":"52","author":"Hinrichsen","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jdermsci.2022.11.005_bib18","first-page":"247","article-title":"Latest advances for the treatment of chronic plaque psoriasis with biologics and oral small molecules","volume":"15","author":"Bellinato","year":"2021","journal-title":"Biologics"},{"issue":"5","key":"10.1016\/j.jdermsci.2022.11.005_bib19","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1586\/1744666X.2014.894886","article-title":"The CXCL8\/IL-8 chemokine family and its receptors in inflammatory diseases","volume":"10","author":"Russo","year":"2014","journal-title":"Expert Rev. Clin. Immunol."},{"issue":"10","key":"10.1016\/j.jdermsci.2022.11.005_bib20","doi-asserted-by":"crossref","first-page":"8508","DOI":"10.1074\/jbc.M208231200","article-title":"Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2","volume":"278","author":"Heidemann","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.jdermsci.2022.11.005_bib21","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1189\/jlb.0408231","article-title":"The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice","volume":"84","author":"Bento","year":"2008","journal-title":"J. Leukoc. Biol."},{"issue":"11","key":"10.1016\/j.jdermsci.2022.11.005_bib22","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/labinvest.3700469","article-title":"Interaction between stem cell factor and endothelin-1: effects on melanogenesis in human skin xenografts","volume":"86","author":"Sriwiriyanont","year":"2006","journal-title":"Lab. Invest."},{"issue":"2","key":"10.1016\/j.jdermsci.2022.11.005_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jdermsci.2017.06.018","article-title":"Precise role of dermal fibroblasts on melanocyte pigmentation","volume":"88","author":"Wang","year":"2017","journal-title":"J. Dermatol. Sci."},{"issue":"4","key":"10.1016\/j.jdermsci.2022.11.005_bib24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/phpp.12650","article-title":"Epidermal barrier changes in patients with psoriasis: The role of phototherapy","volume":"37","author":"Montero-Vilchez","year":"2021","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"issue":"1","key":"10.1016\/j.jdermsci.2022.11.005_bib25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1517\/14712598.2016.1121986","article-title":"Secukinumab for treating plaque psoriasis","volume":"16","author":"Rothstein","year":"2016","journal-title":"Expert. Opin. Biol. Ther."},{"issue":"1","key":"10.1016\/j.jdermsci.2022.11.005_bib26","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/jid.2014.297","article-title":"Rationale for the development of speckled hyperpigmentation in the areas of psoriatic plaques after treatment with biologic agents","volume":"135","author":"Di Cesare","year":"2015","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2022.11.005_bib27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1684\/ejd.2015.2698","article-title":"Enhancement of mRNA expression of survivin and human beta-defensin-3 in lesions of psoriasis vulgaris","volume":"26","author":"Wang","year":"2016","journal-title":"Eur. J. Dermatol."},{"issue":"5","key":"10.1016\/j.jdermsci.2022.11.005_bib28","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/pcmr.12257","article-title":"MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation","volume":"27","author":"Garc\u00eda-Borr\u00f3n","year":"2014","journal-title":"Pigment Cell Melanoma Res"},{"issue":"5","key":"10.1016\/j.jdermsci.2022.11.005_bib29","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1755-148X.2009.00582.x","article-title":"Lamoreux, et al., Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway","volume":"22","author":"Hida","year":"2009","journal-title":"Pigment Cell Melanoma Res"},{"issue":"4","key":"10.1016\/j.jdermsci.2022.11.005_bib30","first-page":"66","article-title":"Imiquimod cream in low concentrations as new topical therapy for melasma","volume":"8","author":"Sharquite","year":"2019","journal-title":"Am. J. Dermatol. Venereol."},{"issue":"10","key":"10.1016\/j.jdermsci.2022.11.005_bib31","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1038\/sj.onc.1207317","article-title":"Expression of both TNF-alpha receptor subtypes is essential for optimal skin tumour development","volume":"23","author":"Arnott","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.jdermsci.2022.11.005_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2021.155432","article-title":"Tumor necrosis factor-alpha affects melanocyte survival and melanin synthesis via multiple pathways in vitiligo","volume":"140","author":"Singh","year":"2021","journal-title":"Cytokine"},{"issue":"4","key":"10.1016\/j.jdermsci.2022.11.005_bib33","first-page":"426","article-title":"Multi-center, double-blind, vehicle-controlled clinical trial of an alpha and beta defensin-containing anti-aging skin care regimen with clinical, histopathologic, immunohistochemical, photographic, and ultrasound evaluation","volume":"17","author":"Taub","year":"2018","journal-title":"J. Drugs Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2022.11.005_bib34","first-page":"597","article-title":"Evidence of involvement of CXC-chemokines in proliferation of cultivated human melanocytes","volume":"12","author":"Mockenhaupt","year":"2003","journal-title":"Int. J. Mol. Med."},{"issue":"16","key":"10.1016\/j.jdermsci.2022.11.005_bib35","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1517\/14656566.2015.1087508","article-title":"G, Advances in the treatment options for vitiligo: activated low-dose cytokines-based therapy","volume":"16","author":"Lotti","year":"2015","journal-title":"Expert Opin. Pharmacother."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181122002729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181122002729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:58:01Z","timestamp":1777582681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181122002729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S0923181122002729"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2022.11.005","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uncoupling melanogenesis from proliferation in epidermal melanocytes responding to stimulation with psoriasis-related proinflammatory cytokines","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2022.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}