{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:39:56Z","timestamp":1786991996421,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"am","delay-in-days":403,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H02757"],"award-info":[{"award-number":["JP22H02757"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H04986"],"award-info":[{"award-number":["JP22H04986"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jdermsci.2023.12.003","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T15:33:07Z","timestamp":1702308787000},"page":"10-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of skin barrier abnormalities and epidermal ceramide profiles among three \u03c9-O-acylceramide synthesis-deficient mouse strains"],"prefix":"10.1016","volume":"113","author":[{"given":"Yuta","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Sassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Kihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2023.12.003_bib1","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1600-0625.2008.00786.x","article-title":"The skin: an indispensable barrier","volume":"17","author":"Proksch","year":"2008","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.bbalip.2013.11.007","article-title":"Role of lipids in the formation and maintenance of the cutaneous permeability barrier","volume":"1841","author":"Feingold","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jdermsci.2023.12.003_bib3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.bbalip.2013.11.006","article-title":"The important role of stratum corneum lipids for the cutaneous barrier function","volume":"1841","author":"van Smeden","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jdermsci.2023.12.003_bib4","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.bbalip.2013.09.011","article-title":"Formation and functions of the corneocyte lipid envelope (CLE)","volume":"1841","author":"Elias","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jdermsci.2023.12.003_bib5","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1172\/JCI130675","article-title":"SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation","volume":"130","author":"Takeichi","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.plipres.2016.04.001","article-title":"Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides","volume":"63","author":"Kihara","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib7","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1194\/jlr.RA120000671","article-title":"Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC\/MS\/MS","volume":"61","author":"Kawana","year":"2020","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2022.100235","article-title":"Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases","volume":"63","author":"Suzuki","year":"2022","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib9","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/0005-2736(93)90126-K","article-title":"Covalently bound lipids in keratinizing epithelia","volume":"1150","author":"Chang","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jdermsci.2023.12.003_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112363","article-title":"Involvement of \u03c9-O-acylceramides and protein-bound ceramides in oral permeability barrier formation","volume":"42","author":"Sassa","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib11","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/1523-1747.ep12499809","article-title":"Comparison of lipids from epidermal and palatal stratum corneum","volume":"98","author":"Wertz","year":"1992","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib12","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.bbalip.2013.08.010","article-title":"The role of sphingolipid metabolism in cutaneous permeability barrier formation","volume":"1841","author":"Breiden","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jdermsci.2023.12.003_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jdermsci.2008.01.002","article-title":"Omega-O-acylceramide, a lipid essential for mammalian survival","volume":"51","author":"Uchida","year":"2008","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib14","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1111\/febs.15497","article-title":"Acylceramide is a key player in skin barrier function: insight into the molecular mechanisms of skin barrier formation and ichthyosis pathogenesis","volume":"288","author":"Akiyama","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib15","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2340\/00015555-3432","article-title":"Genetics of inherited ichthyoses and related diseases","volume":"100","author":"Fischer","year":"2020","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067317","article-title":"Cooperative synthesis of ultra long-chain fatty acid and ceramide during keratinocyte differentiation","volume":"8","author":"Mizutani","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jdermsci.2023.12.003_bib17","doi-asserted-by":"crossref","first-page":"18439","DOI":"10.1073\/pnas.1005572107","article-title":"ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis","volume":"107","author":"Ohno","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jdermsci.2023.12.003_bib18","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1128\/MCB.00192-13","article-title":"Impaired epidermal permeability barrier in mice lacking Elovl1, the gene responsible for very-long-chain fatty acid production","volume":"33","author":"Sassa","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib19","doi-asserted-by":"crossref","first-page":"7707","DOI":"10.1073\/pnas.1503491112","article-title":"Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation","volume":"112","author":"Ohno","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jdermsci.2023.12.003_bib20","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1073\/pnas.1917525117","article-title":"Skin permeability barrier formation by the ichthyosis-causative gene FATP4 through formation of the barrier lipid \u03c9-O-acylceramide","volume":"117","author":"Yamamoto","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jdermsci.2023.12.003_bib21","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/hmg\/ddr494","article-title":"Loss of ceramide synthase 3 causes lethal skin barrier disruption","volume":"21","author":"Jennemann","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib22","doi-asserted-by":"crossref","first-page":"14610","DOI":"10.1038\/ncomms14610","article-title":"PNPLA1 is a transacylase essential for the generation of the skin barrier lipid \u03c9-O-acylceramide","volume":"8","author":"Ohno","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib23","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.bbalip.2013.08.020","article-title":"The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier","volume":"1841","author":"Mu\u00f1oz-Garcia","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"15","key":"10.1016\/j.jdermsci.2023.12.003_bib24","doi-asserted-by":"crossref","first-page":"8402","DOI":"10.1073\/pnas.96.15.8402","article-title":"A novel function for transglutaminase 1: attachment of long-chain omega-hydroxyceramides to involucrin by ester bond formation","volume":"96","author":"Nemes","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jdermsci.2023.12.003_bib25","doi-asserted-by":"crossref","first-page":"14609","DOI":"10.1038\/ncomms14609","article-title":"PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis","volume":"8","author":"Hirabayashi","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib26","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jid.2019.07.689","article-title":"Severe skin permeability barrier dysfunction in knockout mice deficient in a fatty acid \u03c9-hydroxylase crucial to acylceramide production","volume":"140","author":"Miyamoto","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib27","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/hmg\/ddl480","article-title":"Loss of functional ELOVL4 depletes very long-chain fatty acids (\u2265C28) and the unique \u03c9-O-acylceramides in skin leading to neonatal death","volume":"16","author":"Vasireddy","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib28","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.braindev.2022.03.003","article-title":"Hypomyelinating spastic dyskinesia and ichthyosis caused by a homozygous splice site mutation leading to exon skipping in ELOVL1","volume":"44","author":"Takahashi","year":"2022","journal-title":"Brain Dev."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib29","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/jb\/mvs105","article-title":"Very long-chain fatty acids: elongation, physiology and related disorders","volume":"152","author":"Kihara","year":"2012","journal-title":"J. Biochem."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4062\/biomolther.2014.017","article-title":"Metabolism of very long-chain fatty acids: genes and pathophysiology","volume":"22","author":"Sassa","year":"2014","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib31","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1016\/j.febslet.2008.06.007","article-title":"Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis","volume":"582","author":"Ikeda","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jdermsci.2023.12.003_bib32","doi-asserted-by":"crossref","first-page":"15538","DOI":"10.1074\/jbc.M117.803171","article-title":"The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways","volume":"292","author":"Sawai","year":"2017","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181123002530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181123002530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:53:43Z","timestamp":1760331223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181123002530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S0923181123002530"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2023.12.003","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of skin barrier abnormalities and epidermal ceramide profiles among three \u03c9-O-acylceramide synthesis-deficient mouse strains","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2023.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}