{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:36:47Z","timestamp":1791549407087,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Medical Center Asan Institute for Life Sciences","doi-asserted-by":"publisher","award":["2023IP0019"],"award-info":[{"award-number":["2023IP0019"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00246165"],"award-info":[{"award-number":["RS-2023-00246165"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HP23C0072"],"award-info":[{"award-number":["HP23C0072"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jdsjournal.com","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jdermsci.2024.07.004","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T19:23:43Z","timestamp":1721676223000},"page":"121-129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Semaxanib, a VEGF inhibitor, suppresses melanogenesis by modulating CRTC3 independently of VEGF signaling"],"prefix":"10.1016","volume":"115","author":[{"given":"HyeJi","family":"Kwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Hyeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Min","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huonggiang","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchan","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Eun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngsup","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jdermsci.2024.07.004_bib1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/pcmr.12684","article-title":"Melasma, a photoaging disorder","volume":"31","author":"Passeron","year":"2018","journal-title":"Pigment Cell Melanoma Res."},{"issue":"14","key":"10.1016\/j.jdermsci.2024.07.004_bib2","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1101\/gad.14.14.1712","article-title":"Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage","volume":"14","author":"Goding","year":"2000","journal-title":"Genes Dev."},{"issue":"6","key":"10.1016\/j.jdermsci.2024.07.004_bib3","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/pcmr.12596","article-title":"Novel regulation of melanogenesis by adiponectin via the AMPK\/CRTC pathway","volume":"30","author":"Bang","year":"2017","journal-title":"Pigment Cell Melanoma Res."},{"issue":"4","key":"10.1016\/j.jdermsci.2024.07.004_bib4","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/exd.14260","article-title":"Skin pigmentation and its control: from ultraviolet radiation to stem cells","volume":"30","author":"Yardman-Frank","year":"2021","journal-title":"Exp. Dermatol."},{"issue":"3","key":"10.1016\/j.jdermsci.2024.07.004_bib5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrm3072","article-title":"CREB and the CRTC co-activators: sensors for hormonal and metabolic signals","volume":"12","author":"Altarejos","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7326","key":"10.1016\/j.jdermsci.2024.07.004_bib6","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/nature09564","article-title":"CRTC3 links catecholamine signalling to energy balance","volume":"468","author":"Song","year":"2010","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.jdermsci.2024.07.004_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109136","article-title":"Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK\/ERK pathways","volume":"35","author":"Ostojic","year":"2021","journal-title":"Cell Rep."},{"issue":"20","key":"10.1016\/j.jdermsci.2024.07.004_bib8","doi-asserted-by":"crossref","first-page":"9918","DOI":"10.7150\/thno.66378","article-title":"CRTC3, a sensor and key regulator for melanogenesis, as a tunable therapeutic target for pigmentary disorders","volume":"11","author":"Yoo","year":"2021","journal-title":"Theranostics"},{"issue":"11","key":"10.1016\/j.jdermsci.2024.07.004_bib9","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/j.celrep.2017.05.042","article-title":"A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin","volume":"19","author":"Mujahid","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.jdermsci.2024.07.004_bib10","article-title":"Therapeutic potential of rottlerin for skin hyperpigmentary disorders by inhibiting the transcriptional activity of CREB-regulated transcription coactivators","author":"Kim","year":"2019","journal-title":"J. Invest. Dermatol."},{"issue":"9","key":"10.1016\/j.jdermsci.2024.07.004_bib11","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.7150\/thno.41502","article-title":"JNK suppresses melanogenesis by interfering with CREB-regulated transcription coactivator 3-dependent MITF expression","volume":"10","author":"Kim","year":"2020","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.jdermsci.2024.07.004_bib12","first-page":"99","article-title":"SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1\/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types","volume":"59","author":"Fong","year":"1999","journal-title":"Cancer Res."},{"issue":"26","key":"10.1016\/j.jdermsci.2024.07.004_bib13","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1038\/sj.onc.1210159","article-title":"Semaxinib (SU5416) as a therapeutic agent targeting oncogenic Kit mutants resistant to imatinib mesylate","volume":"26","author":"Kosmider","year":"2007","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.jdermsci.2024.07.004_bib14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/01.coc.0000199882.53545.ac","article-title":"Phase I\/pilot study of SU5416 (semaxinib) in combination with irinotecan\/bolus 5-FU\/LV (IFL) in patients with metastatic colorectal cancer","volume":"29","author":"Lockhart","year":"2006","journal-title":"Am. J. Clin. Oncol."},{"issue":"12","key":"10.1016\/j.jdermsci.2024.07.004_bib15","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1038\/jid.2015.332","article-title":"Endothelial cells promote pigmentation through endothelin receptor B activation","volume":"135","author":"Regazzetti","year":"2015","journal-title":"J. Invest. Dermatol."},{"issue":"6","key":"10.1016\/j.jdermsci.2024.07.004_bib16","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/lsm.23345","article-title":"Dynamic optical coherence tomography of cutaneous blood vessels in melasma and vessel response to oral tranexamic acid","volume":"53","author":"Pomerantz","year":"2021","journal-title":"Lasers Surg. Med."},{"issue":"2","key":"10.1016\/j.jdermsci.2024.07.004_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2019.111798","article-title":"Activation of VEGF receptors in response to UVB promotes cell proliferation and melanogenesis of normal human melanocytes","volume":"387","author":"Zhu","year":"2020","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.jdermsci.2024.07.004_bib18","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1006\/bbrc.1993.1106","article-title":"Human melanoma cells but not normal melanocytes express vascular endothelial growth factor receptors","volume":"190","author":"Gitay-Goren","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.jdermsci.2024.07.004_bib19","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s004320050325","article-title":"Melanoma-associated expression of vascular endothelial growth factor and its receptors FLT-1 and KDR","volume":"125","author":"Graeven","year":"1999","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"8","key":"10.1016\/j.jdermsci.2024.07.004_bib20","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.0906-6705.2005.00345.x","article-title":"Modulation of vascular endothelial growth factor receptors in melanocytes","volume":"14","author":"Kim","year":"2005","journal-title":"Exp. Dermatol."},{"issue":"3","key":"10.1016\/j.jdermsci.2024.07.004_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1625","article-title":"Engineering small-molecule analogues of altiratinib via CREB-regulated transcription co-activator 3-target screening for the development of potent and safe topical therapeutics against skin hyperpigmentary diseases","volume":"14","author":"Lee","year":"2024","journal-title":"Clin. Transl. Med."},{"issue":"10","key":"10.1016\/j.jdermsci.2024.07.004_bib22","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1084\/jem.187.10.1565","article-title":"Murine cutaneous mastocytosis and epidermal melanocytosis induced by keratinocyte expression of transgenic stem cell factor","volume":"187","author":"Kunisada","year":"1998","journal-title":"J. Exp. Med."},{"issue":"9","key":"10.1016\/j.jdermsci.2024.07.004_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17091448","article-title":"Novel anti-melanogenesis properties of polydeoxyribonucleotide, a popular wound healing booster","volume":"17","author":"Noh","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.jdermsci.2024.07.004_bib24","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jaad.2017.01.036","article-title":"Postinflammatory hyperpigmentation: a comprehensive overview: treatment options and prevention","volume":"77","author":"Chaowattanapanit","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2024.07.004_bib25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1600-0781.1995.tb00156.x","article-title":"Topical W-7 inhibits ultraviolet radiation-induced melanogenesis in Skh:HR2 pigmented hairless mice","volume":"11","author":"Dowdy","year":"1995","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"issue":"4","key":"10.1016\/j.jdermsci.2024.07.004_bib26","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1021\/np50106a021","article-title":"Tyrosinase inhibitors from Anacardium occidentale fruits","volume":"57","author":"Kubo","year":"1994","journal-title":"J. Nat. Prod."},{"issue":"5","key":"10.1016\/j.jdermsci.2024.07.004_bib27","doi-asserted-by":"crossref","first-page":"8293","DOI":"10.3390\/ijms15058293","article-title":"Inhibitors of intracellular signaling pathways that lead to stimulated epidermal pigmentation: perspective of anti-pigmenting agents","volume":"15","author":"Imokawa","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jdermsci.2024.07.004_bib28","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/01.DER.0000438425.56740.8a","article-title":"Hydroquinone-induced depigmentation: case report and review of the literature","volume":"25","author":"Jow","year":"2014","journal-title":"Dermatitis"},{"issue":"2","key":"10.1016\/j.jdermsci.2024.07.004_bib29","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.det.2016.11.006","article-title":"Chemical-Induced Vitiligo","volume":"35","author":"Harris","year":"2017","journal-title":"Dermatol. Clin."},{"issue":"2","key":"10.1016\/j.jdermsci.2024.07.004_bib30","first-page":"765","article-title":"Arbutin: mechanism of its depigmenting action in human melanocyte culture","volume":"276","author":"Maeda","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jdermsci.2024.07.004_bib31","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1186\/s12906-015-0860-8","article-title":"Assessment of cytotoxicity exerted by leaf extracts from plants of the genus Rhododendron towards epidermal keratinocytes and intestine epithelial cells","volume":"15","author":"Rezk","year":"2015","journal-title":"BMC Complement. Alter. Med."},{"issue":"2","key":"10.1016\/j.jdermsci.2024.07.004_bib32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/14764172.2017.1368666","article-title":"Skin hyperpigmentation treatment using herbs: a review of clinical evidences","volume":"20","author":"Kanlayavattanakul","year":"2018","journal-title":"J. Cosmet. Laser Ther."},{"issue":"1","key":"10.1016\/j.jdermsci.2024.07.004_bib33","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/14756366.2016.1256882","article-title":"Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors","volume":"32","author":"Pillaiyar","year":"2017","journal-title":"J. Enzym. Inhib. Med. Chem."},{"issue":"3","key":"10.1016\/j.jdermsci.2024.07.004_bib34","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s40266-018-00633-w","article-title":"Pigmentation disorders in the elderly","volume":"36","author":"Armenta","year":"2019","journal-title":"Drugs Aging"},{"issue":"3","key":"10.1016\/j.jdermsci.2024.07.004_bib35","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jdermsci.2010.12.005","article-title":"Structural alterations of the cutaneous vasculature in aged and in photoaged human skin in vivo","volume":"61","author":"Kajiya","year":"2011","journal-title":"J. Dermatol. Sci."},{"issue":"19","key":"10.1016\/j.jdermsci.2024.07.004_bib36","doi-asserted-by":"crossref","first-page":"14617","DOI":"10.1074\/jbc.M109.085456","article-title":"AMP-activated protein kinase antagonizes pro-apoptotic extracellular signal-regulated kinase activation by inducing dual-specificity protein phosphatases in response to glucose deprivation in HCT116 carcinoma","volume":"285","author":"Kim","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.jdermsci.2024.07.004_bib37","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1097\/IAE.0b013e318240a558","article-title":"Inhibitory activity of ranibizumab, sorafenib, and pazopanib on light-induced overexpression of platelet-derived growth factor and vascular endothelial growth factor A and the vascular endothelial growth factor A receptors 1 and 2 and neuropilin 1 and 2","volume":"32","author":"Kernt","year":"2012","journal-title":"Retina"},{"issue":"1","key":"10.1016\/j.jdermsci.2024.07.004_bib38","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.biocel.2011.10.022","article-title":"Activation of VEGFR-2 signaling in response to moderate dose of ultraviolet B promotes survival of normal human keratinocytes","volume":"44","author":"Zhu","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.jdermsci.2024.07.004_bib39","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1600-0749.2003.00126.x","article-title":"Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders","volume":"17","author":"Imokawa","year":"2004","journal-title":"Pigment Cell Res."},{"issue":"1","key":"10.1016\/j.jdermsci.2024.07.004_bib40","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/1523-1747.ep12312500","article-title":"Endothelin-1 as a new melanogen: coordinated expression of its gene and the tyrosinase gene in UVB-exposed human epidermis","volume":"105","author":"Imokawa","year":"1995","journal-title":"J. Invest Dermatol."},{"issue":"24","key":"10.1016\/j.jdermsci.2024.07.004_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/cells11243949","article-title":"590 nm LED irradiation improved erythema through inhibiting angiogenesis of human microvascular endothelial cells and ameliorated pigmentation in melasma","volume":"11","author":"Dai","year":"2022","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.jdermsci.2024.07.004_bib42","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1755-148X.2010.00760.x","article-title":"Downregulation of SIK2 expression promotes the melanogenic program in mice","volume":"23","author":"Horike","year":"2010","journal-title":"Pigment Cell Melanoma Res."},{"issue":"10","key":"10.1016\/j.jdermsci.2024.07.004_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026148","article-title":"A potent inhibitor of SIK2, 3, 3\u2032, 7-trihydroxy-4\u2032-methoxyflavon (4\u2032-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells","volume":"6","author":"Kumagai","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jdermsci.2024.07.004_bib44","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jgr.2020.11.003","article-title":"Anti-melanogenic property of ginsenoside Rf from Panax ginseng via inhibition of CREB\/MITF pathway in melanocytes and ex vivo human skin","volume":"45","author":"Lee","year":"2021","journal-title":"J. Ginseng Res."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181124001506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181124001506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T15:00:24Z","timestamp":1737298824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181124001506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S0923181124001506"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2024.07.004","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Semaxanib, a VEGF inhibitor, suppresses melanogenesis by modulating CRTC3 independently of VEGF signaling","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2024.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}