{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:46:32Z","timestamp":1791521192710,"version":"4.3.4"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M700287"],"award-info":[{"award-number":["2021M700287"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073015"],"award-info":[{"award-number":["82073015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303980"],"award-info":[{"award-number":["82303980"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jdermsci.2024.08.002","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T22:39:14Z","timestamp":1723934354000},"page":"41-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dermal fibroblasts retain site-specific transcriptomic identity in keloids"],"prefix":"10.1016","volume":"116","author":[{"given":"Pingping","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenxi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2024.08.002_bib1","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.jid.2023.03.1679","article-title":"A roadmap for a consensus human skin cell atlas and single-cell data standardization","volume":"143","author":"Almet","year":"2023","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib2","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/exd.14243","article-title":"Keloid disorder: fibroblast differentiation and gene expression profile in fibrotic skin diseases","volume":"30","author":"Macarak","year":"2021","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib3","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jid.2022.08.053","article-title":"Transcriptomic heterogeneity of skin across different anatomic sites","volume":"143","author":"Yan","year":"2023","journal-title":"J. Invest Dermatol."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cell.2021.12.008","article-title":"Limb development genes underlie variation in human fingerprint patterns","volume":"185","author":"Li","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jdermsci.2024.08.002_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcdb.2013.12.007","article-title":"Regionalisation of the skin","volume":"25\u201326","author":"Johansson","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature12783","article-title":"Distinct fibroblast lineages determine dermal architecture in skin development and repair","volume":"504","author":"Driskell","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jdermsci.2024.08.002_bib7","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1016\/j.cell.2021.06.024","article-title":"Fibroblasts: origins, definitions, and functions in health and disease","volume":"184","author":"Plikus","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jdermsci.2024.08.002_bib8","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/sj.jid.5700986","article-title":"A systems biology approach to anatomic diversity of skin","volume":"128","author":"Rinn","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib9","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/exd.13271","article-title":"Aberrant connective tissue differentiation towards cartilage and bone underlies human keloids in African Americans","volume":"26","author":"Fuentes-Duculan","year":"2017","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib10","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1111\/exd.14630","article-title":"Increased expression of bone\/cartilage-associated genes and core transcription factors in keloids by RNA sequencing","volume":"31","author":"Lin","year":"2022","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.matbio.2022.03.001","article-title":"Schwann cells contribute to keloid formation","volume":"108","author":"Direder","year":"2022","journal-title":"Matrix Biol."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib12","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jid.2021.06.010","article-title":"Single-cell RNA-sequencing reveals lineage-specific regulatory changes of fibroblasts and vascular endothelial cells in keloids","volume":"142","author":"Liu","year":"2022","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib13","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.jid.2022.01.017","article-title":"Integrated analysis of single-cell and spatial transcriptomics in keloids: highlights on fibrovascular interactions in keloid pathogenesis","volume":"142","author":"Shim","year":"2022","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1742-481X.2010.00698.x","article-title":"Keloid explant culture: a model for keloid fibroblasts isolation and cultivation based on the biological differences of its specific regions","volume":"7","author":"Tucci-Viegas","year":"2010","journal-title":"Int Wound J."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib15","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib16","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1002\/dvdy.24186","article-title":"The role of Zic genes in inner ear development in the mouse: Exploring mutant mouse phenotypes","volume":"243","author":"Chervenak","year":"2014","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib17","doi-asserted-by":"crossref","first-page":"37758","DOI":"10.1074\/jbc.M111.248039","article-title":"Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis","volume":"286","author":"Bernardo","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib18","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.matbio.2012.06.001","article-title":"Multiple enhancers associated with ACAN suggest highly redundant transcriptional regulation in cartilage","volume":"31","author":"Hu","year":"2012","journal-title":"Matrix Biol."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib19","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bone.2015.11.007","article-title":"CCN4\/WISP-1 positively regulates chondrogenesis by controlling TGF-\u03b23 function","volume":"83","author":"Yoshioka","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.jdermsci.2024.08.002_bib20","doi-asserted-by":"crossref","DOI":"10.1001\/archderm.137.11.1429","article-title":"Clinical genetics of familial keloids","volume":"137","author":"Marneros","year":"2001","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib21","article-title":"Cartilage-like composition of keloid scar extracellular matrix suggests fibroblast mis-differentiation in disease","volume":"4","author":"Barallobre-Barreiro","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib22","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1111\/j.1365-2443.2005.00902.x","article-title":"Gene expression in human keloids is altered from dermal to chondrocytic and osteogenic lineage","volume":"10","author":"Naitoh","year":"2005","journal-title":"Genes Cells"},{"key":"10.1016\/j.jdermsci.2024.08.002_bib23","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/stmcls\/sxad047","article-title":"ZIC1 dictates osteogenesis versus adipogenesis in human mesenchymal progenitor cells via a hedgehog dependent mechanism","volume":"41","author":"Thottappillil","year":"2023","journal-title":"Stem Cells"},{"key":"10.1016\/j.jdermsci.2024.08.002_bib24","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/wrr.12917","article-title":"Analysis of HOX gene expression and the effects of HOXA9 overexpression in fibroblasts derived from keloid lesions and normal skin","volume":"29","author":"Hahn","year":"2021","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.jdermsci.2024.08.002_bib25","article-title":"Aberrant expression in skin melanoma: a review","volume":"2012","author":"Pi\u00e9rard","year":"2012","journal-title":"J. Ski. Cancer"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181124001737?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181124001737?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T23:03:31Z","timestamp":1748732611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181124001737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S0923181124001737"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2024.08.002","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dermal fibroblasts retain site-specific transcriptomic identity in keloids","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2024.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V. on behalf of Japanese Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}