{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:20:05Z","timestamp":1793650805723,"version":"4.5.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073471"],"award-info":[{"award-number":["82073471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jdermsci.2024.11.002","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T11:03:55Z","timestamp":1732273435000},"page":"8-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Upregulation of TLR2 in keratinocytes activates the MAPK pathway and plays a role in the pathogenesis of hidradenitis suppurativa"],"prefix":"10.1016","volume":"117","author":[{"given":"Haini","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongshuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoxi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jdermsci.2024.11.002_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/JD9.0000000000000204","article-title":"Prevalence of Acne Inversa (Hidradenitis Suppurativa) in China: a nationwide cross-sectional epidemiological study","volume":"05","author":"Zhong-Shuai","year":"2022","journal-title":"Int. J. Dermatol. Venereol."},{"issue":"10","key":"10.1016\/j.jdermsci.2024.11.002_bib2","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1111\/jdv.15071","article-title":"Prevalence and comorbidities associated with hidradenitis suppurativa in Korea: a nationwide population-based study","volume":"32","author":"Lee","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"5","key":"10.1016\/j.jdermsci.2024.11.002_bib3","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.clindermatol.2023.08.020","article-title":"Epidemiology of hidradenitis suppurativa","volume":"41","author":"Bukvi\u0107 Mokos","year":"2023","journal-title":"Clin. Dermatol."},{"issue":"9","key":"10.1016\/j.jdermsci.2024.11.002_bib4","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1111\/jdv.18163","article-title":"Unmet clinical needs and burden of disease in hidradenitis suppurativa: real-world experience from EU5 and US","volume":"36","author":"Ingram","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.jdermsci.2024.11.002_bib5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2147\/CCID.S111019","article-title":"Hidradenitis suppurativa: from pathogenesis to diagnosis and treatment","volume":"10","author":"Napolitano","year":"2017","journal-title":"Clin. Cosmet. Invest. Dermatol."},{"issue":"12","key":"10.1016\/j.jdermsci.2024.11.002_bib6","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1111\/1346-8138.14656","article-title":"Demographic and clinical features of hidradenitis suppurativa in Korea","volume":"45","author":"Yang","year":"2018","journal-title":"J. Dermatol."},{"issue":"3","key":"10.1016\/j.jdermsci.2024.11.002_bib7","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jaad.2014.04.001","article-title":"Hidradenitis suppurativa: a retrospective study of 846 Dutch patients to identify factors associated with disease severity","volume":"71","author":"Schrader","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"issue":"6007","key":"10.1016\/j.jdermsci.2024.11.002_bib8","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1126\/science.1196284","article-title":"Gamma-secretase gene mutations in familial acne inversa","volume":"330","author":"Wang","year":"2010","journal-title":"Sci. (N. Y., N. Y. )"},{"issue":"10","key":"10.1016\/j.jdermsci.2024.11.002_bib9","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1038\/jid.2012.162","article-title":"Mutations in the \u03b3-secretase genes NCSTN, PSENEN, and PSEN1 underlie rare forms of hidradenitis suppurativa (acne inversa)","volume":"132","author":"Pink","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jdermsci.2024.11.002_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.861241","article-title":"The genomic architecture of hidradenitis suppurativa-a systematic review","volume":"13","author":"Pace","year":"2022","journal-title":"Front. Genet."},{"issue":"3","key":"10.1016\/j.jdermsci.2024.11.002_bib11","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/bjd.14214","article-title":"Keratinocytes and neutrophils are important sources of proinflammatory molecules in hidradenitis suppurativa","volume":"174","author":"Lima","year":"2016","journal-title":"Br. J. Dermatol."},{"issue":"2","key":"10.1016\/j.jdermsci.2024.11.002_bib12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1365-2133.2008.08897.x","article-title":"Expression of toll-like receptor 2, NOD2 and dectin-1 and stimulatory effects of their ligands and histamine in normal human keratinocytes","volume":"160","author":"Kobayashi","year":"2009","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2024.11.002_bib13","first-page":"52","article-title":"Going, Toll-like receptors in skin inflammation and inflammatory diseases","volume":"20","author":"Kumar","year":"2021","journal-title":"EXCLI J."},{"issue":"10","key":"10.1016\/j.jdermsci.2024.11.002_bib14","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1111\/exd.14141","article-title":"A systematic review and critical appraisal of metagenomic and culture studies in hidradenitis suppurativa","volume":"30","author":"Williams","year":"2021","journal-title":"Exp. Dermatol."},{"issue":"7","key":"10.1016\/j.jdermsci.2024.11.002_bib15","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/exd.14531","article-title":"Mechanism of anti-inflammatory effects of rifampicin in an ex vivo culture system of hidradenitis suppurativa","volume":"31","author":"Haferland","year":"2022","journal-title":"Exp. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2024.11.002_bib16","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1136\/annrheumdis-2017-212401","article-title":"Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors","volume":"77","author":"Giannelou","year":"2018","journal-title":"Ann. Rheum. Dis."},{"issue":"43","key":"10.1016\/j.jdermsci.2024.11.002_bib17","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jdermsci.2024.11.002_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-1-4939-1050-2_3","article-title":"Tissue processing and hematoxylin and eosin staining","volume":"1180","author":"Feldman","year":"2014","journal-title":"Methods in molecular biology"},{"issue":"7","key":"10.1016\/j.jdermsci.2024.11.002_bib19","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot087163","article-title":"Measuring cell death by propidium iodide uptake and flow cytometry","volume":"2016","author":"Crowley","year":"2016","journal-title":"Cold Spring Harb. Protoc."},{"issue":"1","key":"10.1016\/j.jdermsci.2024.11.002_bib20","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jid.2018.07.020","article-title":"Nicastrin\/miR-30a-3p\/RAB31 axis regulates keratinocyte differentiation by impairing EGFR signaling in familial acne inversa","volume":"139","author":"He","year":"2019","journal-title":"J. Invest Dermatol."},{"key":"10.1016\/j.jdermsci.2024.11.002_bib21","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.3389\/fimmu.2018.02965","article-title":"Hidradenitis suppurativa: a systematic review integrating inflammatory pathways into a cohesive pathogenic model","volume":"9","author":"Vossen","year":"2018","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.jdermsci.2024.11.002_bib22","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/exd.14214","article-title":"What causes hidradenitis suppurativa ?-15 years after","volume":"29","author":"Zouboulis","year":"2020","journal-title":"Exp. Dermatol."},{"issue":"2","key":"10.1016\/j.jdermsci.2024.11.002_bib23","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1684\/ejd.2021.4005","article-title":"Hidradenitis suppurativa associated with a novel NCSTN mutation and concomitant Klippel-Trenaunay syndrome","volume":"31","author":"Lin","year":"2021","journal-title":"Eur. J. Dermatol."},{"issue":"3","key":"10.1016\/j.jdermsci.2024.11.002_bib24","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cell.2005.07.021","article-title":"Nicastrin: gatekeeper of the gamma-secretase complex","volume":"122","author":"Strooper","year":"2005","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.jdermsci.2024.11.002_bib25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s11684-019-0722-8","article-title":"Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like mouse model leads to a markedly increased IL-36a and Sprr2 expression","volume":"14","author":"Yang","year":"2020","journal-title":"Front. Med."},{"issue":"5","key":"10.1016\/j.jdermsci.2024.11.002_bib26","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.devcel.2004.09.014","article-title":"gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis","volume":"7","author":"Pan","year":"2004","journal-title":"Dev. Cell"},{"issue":"3","key":"10.1016\/j.jdermsci.2024.11.002_bib27","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/bjd.14223","article-title":"Nicastrin mutations in familial acne inversa impact keratinocyte proliferation and differentiation through the Notch and phosphoinositide 3-kinase\/AKT signalling pathways","volume":"174","author":"Xiao","year":"2016","journal-title":"Br. J. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2024.11.002_bib28","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/bjd.20642","article-title":"Large-scale serum analysis identifies unique systemic biomarkers in psoriasis and hidradenitis suppurativa","volume":"186","author":"Navrazhina","year":"2022","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2024.11.002_bib29","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3389\/fimmu.2020.00847","article-title":"Hidradenitis suppurativa as a potential subtype of autoinflammatory Keratinization Disease","volume":"11","author":"Nomura","year":"2020","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.jdermsci.2024.11.002_bib30","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/bjd.13668","article-title":"First nicastrin mutation in PASH (pyoderma gangrenosum, acne and suppurative hidradenitis) syndrome","volume":"173","author":"Duchatelet","year":"2015","journal-title":"Br. J. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2024.11.002_bib31","doi-asserted-by":"crossref","first-page":"e118","DOI":"10.1111\/ced.13906","article-title":"Nicastrin haploinsufficiency alters expression of type I interferon-stimulated genes: the relationship to familial hidradenitis suppurativa","volume":"44","author":"Cao","year":"2019","journal-title":"Clin. Exp. Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2024.11.002_bib32","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/jdv.15183","article-title":"Biofilm production and antibiotic susceptibility of Staphylococcus epidermidis strains from Hidradenitis Suppurativa lesions","volume":"33","author":"Ardon","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"2","key":"10.1016\/j.jdermsci.2024.11.002_bib33","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/exd.14234","article-title":"Mechanical forces and Hidradenitis Suppurativa","volume":"30","author":"Boer","year":"2021","journal-title":"Exp. Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2024.11.002_bib34","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/jcp.30923","article-title":"Keratinocyte TLR2 and TLR7 contribute to chronic itch through pruritic cytokines and chemokines in mice","volume":"238","author":"Wang","year":"2023","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.jdermsci.2024.11.002_bib35","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.jid.2018.10.021","article-title":"Phosphatidylglycerol inhibits toll-like receptor-mediated inflammation by danger-associated molecular patterns","volume":"139","author":"Choudhary","year":"2019","journal-title":"J. Invest. Dermatol."},{"issue":"23","key":"10.1016\/j.jdermsci.2024.11.002_bib36","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1016\/j.scib.2021.05.022","article-title":"A pig model carrying heterozygous point mutation of NCSTN simulates familial acne inversa and reveals dysregulated cholesterol biosynthesis via the Notch-pAMPK-HMGCR pathway","volume":"66","author":"Song","year":"2021","journal-title":"Sci. Bull."},{"issue":"3","key":"10.1016\/j.jdermsci.2024.11.002_bib37","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/bjd\/ljac107","article-title":"Adipokines as an important link between hidradenitis suppurativa and obesity: a narrative review","volume":"188","author":"Krajewski","year":"2023","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2024.11.002_bib38","article-title":"The important role of leptin in modulating the risk of dermatological diseases","volume":"11","author":"Su","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jdermsci.2024.11.002_bib39","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fpls.2016.00080","article-title":"MAPK cascades in guard cell signal transduction","volume":"7","author":"Lee","year":"2016","journal-title":"Front. Plant Sci."},{"issue":"9","key":"10.1016\/j.jdermsci.2024.11.002_bib40","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.1074\/jbc.M111.310375","article-title":"Notch signal suppresses Toll-like receptor-triggered inflammatory responses in macrophages by inhibiting extracellular signal-regulated kinase 1\/2-mediated nuclear factor \u03baB activation","volume":"287","author":"Zhang","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.jdermsci.2024.11.002_bib41","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/exd.12098","article-title":"Impaired Notch-MKP-1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology","volume":"22","author":"Melnik","year":"2013","journal-title":"Exp. Dermatol."},{"issue":"2","key":"10.1016\/j.jdermsci.2024.11.002_bib42","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-2133.2010.10034.x","article-title":"Hidradenitis suppurativa\/acne inversa: bilocated epithelial hyperplasia with very different sequelae","volume":"164","author":"von Laffert","year":"2011","journal-title":"Br. J. Dermatol."},{"issue":"6","key":"10.1016\/j.jdermsci.2024.11.002_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106896","article-title":"Mechanism underlying follicular hyperproliferation and oncogenesis in hidradenitis suppurativa","volume":"26","author":"Jin","year":"2023","journal-title":"iScience"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181124002214?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181124002214?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T05:11:02Z","timestamp":1762319462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181124002214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0923181124002214"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2024.11.002","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Upregulation of TLR2 in keratinocytes activates the MAPK pathway and plays a role in the pathogenesis of hidradenitis suppurativa","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2024.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}