{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:53:02Z","timestamp":1793141582661,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jdsjournal.com","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jdermsci.2025.01.002","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T08:04:10Z","timestamp":1736409850000},"page":"30-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Aberrant fumarate metabolism links interferon release in diffuse systemic sclerosis"],"prefix":"10.1016","volume":"117","author":[{"given":"Thomas","family":"Steadman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"O\u2019Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jdermsci.2025.01.002_bib1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/cei.13238","article-title":"The immunopathogenesis of fibrosis in systemic sclerosis","volume":"195","author":"Brown","year":"2019","journal-title":"Clin. Exp. Immunol."},{"issue":"8","key":"10.1016\/j.jdermsci.2025.01.002_bib2","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1136\/annrheumdis-2012-201958","article-title":"Toll-like receptor-mediated, enhanced production of profibrotic TIMP-1 in monocytes from patients with systemic sclerosis: role of serum factors","volume":"72","author":"Ciechomska","year":"2013","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.jdermsci.2025.01.002_bib3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13075-021-02437-7","article-title":"Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy?","volume":"23","author":"Kvacskay","year":"2021","journal-title":"Arthritis Res Ther."},{"issue":"4","key":"10.1016\/j.jdermsci.2025.01.002_bib4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00011-024-01853-0","article-title":"Tricarboxylic acid cycle metabolites: new players in macrophage","volume":"73","author":"Yang","year":"2024","journal-title":"Inflamm. Res"},{"issue":"7","key":"10.1016\/j.jdermsci.2025.01.002_bib5","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/PAS.0000000000000617","article-title":"Fumarate hydratase-deficient renal cell carcinoma is strongly correlated with fumarate hydratase mutation and hereditary leiomyomatosis and renal cell carcinoma syndrome","volume":"40","author":"Trpkov","year":"2016","journal-title":"Am. J. Surg. Pathol."},{"issue":"7952","key":"10.1016\/j.jdermsci.2025.01.002_bib6","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41586-023-05720-6","article-title":"Macrophage fumarate hydratase restrains mtRNA-mediated interferon production","volume":"615","author":"Hooftman","year":"2023","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.jdermsci.2025.01.002_bib7","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1136\/ard.2009.121400","article-title":"Type I interferon system activation and association with disease manifestations in systemic sclerosis","volume":"69","author":"Eloranta","year":"2010","journal-title":"Ann. Rheum. Dis."},{"issue":"2","key":"10.1016\/j.jdermsci.2025.01.002_bib8","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.molcel.2013.05.003","article-title":"The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling","volume":"51","author":"Sullivan","year":"2013","journal-title":"Mol. Cell"},{"issue":"7","key":"10.1016\/j.jdermsci.2025.01.002_bib9","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1083\/jcb.201702058","article-title":"Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals","volume":"216","author":"Quir\u00f3s","year":"2017","journal-title":"J. Cell Biol."},{"issue":"7952","key":"10.1016\/j.jdermsci.2025.01.002_bib10","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41586-023-05770-w","article-title":"Fumarate induces vesicular release of mtDNA to drive innate immunity","volume":"615","author":"Zecchini","year":"2023","journal-title":"Nature"},{"issue":"6472","key":"10.1016\/j.jdermsci.2025.01.002_bib11","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1126\/science.aav4011","article-title":"VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease","volume":"366","author":"Kim","year":"2019","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.jdermsci.2025.01.002_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/cells10082053","article-title":"The cell-permeable derivative of the immunoregulatory metabolite itaconate, 4-octyl itaconate, is anti-fibrotic in systemic sclerosis","volume":"10","author":"Henderson","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jdermsci.2025.01.002_bib13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3390\/v12020137","article-title":"SV40 large T antigen is not responsible for the loss of STING in 293T Cells but can inhibit cGAS-STING interferon induction","volume":"12","author":"Reus","year":"2020","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.jdermsci.2025.01.002_bib14","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/cr.2016.149","article-title":"Innate immune signaling and regulation in cancer immunotherapy","volume":"27","author":"Corrales","year":"2017","journal-title":"Cell Res"},{"key":"10.1016\/j.jdermsci.2025.01.002_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/art.42847","article-title":"Myeloablation followed by hematopoietic stem cell transplantation leads to long-term normalization of systemic sclerosis molecular signatures","author":"Wareing","year":"2024","journal-title":"Arthritis Rheuma"},{"issue":"6","key":"10.1016\/j.jdermsci.2025.01.002_bib16","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.cmet.2016.10.008","article-title":"Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity","volume":"24","author":"Arts","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.jdermsci.2025.01.002_bib17","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1038\/srep05336","article-title":"Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis","volume":"4","author":"Gazdhar","year":"2014","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.jdermsci.2025.01.002_bib18","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1002\/art.41418","article-title":"Bioactive plasma mitochondrial DNA is associated with disease progression in scleroderma-associated interstitial lung disease","volume":"72","author":"Ryu","year":"2020","journal-title":"Arthritis Rheuma"},{"issue":"1","key":"10.1016\/j.jdermsci.2025.01.002_bib19","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1038\/s41467-022-34775-8","article-title":"Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis","volume":"13","author":"Paul","year":"2022","journal-title":"Nat. Commun."},{"issue":"7699","key":"10.1016\/j.jdermsci.2025.01.002_bib20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature25986","article-title":"Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1","volume":"556","author":"Mills","year":"2018","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.jdermsci.2025.01.002_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e23001","article-title":"4-Octyl itaconate inhibits poly(I:C)-induced interferon-\u03b2 secretion in mouse bone marrow-derived macrophages partially by activating Nrf2","volume":"9","author":"Yue","year":"2023","journal-title":"Heliyon"},{"issue":"11","key":"10.1016\/j.jdermsci.2025.01.002_bib22","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1093\/rheumatology\/kew251","article-title":"Low heme oxygenase-1 levels in patients with systemic sclerosis are associated with an altered Toll-like receptor response: another role for CXCL4?","volume":"55","author":"van Bon","year":"2016","journal-title":"Rheumatol. (Oxf. )"},{"issue":"9","key":"10.1016\/j.jdermsci.2025.01.002_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113040","article-title":"4-Octyl itaconate restricts STING activation by blocking its palmitoylation","volume":"42","author":"Su","year":"2023","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.jdermsci.2025.01.002_bib24","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1038\/s41467-024-48422-x","article-title":"Octyl itaconate enhances VSV\u039451 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways","volume":"15","author":"Kurmasheva","year":"2024","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.jdermsci.2025.01.002_bib25","doi-asserted-by":"crossref","first-page":"R128","DOI":"10.1186\/ar3066","article-title":"Characterization of monocyte\/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis","volume":"12","author":"Higashi-Kuwata","year":"2010","journal-title":"Arthritis Res Ther."},{"issue":"4","key":"10.1016\/j.jdermsci.2025.01.002_bib26","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2018.07.030","article-title":"Krebs cycle reimagined: the emerging roles of succinate and itaconate as signal transducers","volume":"174","author":"Murphy","year":"2018","journal-title":"Cell"},{"issue":"7444","key":"10.1016\/j.jdermsci.2025.01.002_bib27","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.jdermsci.2025.01.002_bib28","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1084\/jem.20160061","article-title":"GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis","volume":"213","author":"Littlewood-Evans","year":"2016","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.jdermsci.2025.01.002_bib29","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.coi.2022.01.004","article-title":"Emerging dimensions of cellular cGAS-STING signaling","volume":"74","author":"Guey","year":"2022","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.jdermsci.2025.01.002_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104883","article-title":"High serum C-X-C motif chemokine ligand 10 (CXCL10) levels may be associated with new onset interstitial lung disease in patients with systemic sclerosis: evidence from observational, clinical, transcriptomic and in vitro studies","volume":"98","author":"Al-Adwi","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jdermsci.2025.01.002_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2023.103097","article-title":"Non-classical circulating monocytes expressing high levels of microsomal prostaglandin E2 synthase-1 tag an aberrant IFN-response in systemic sclerosis","volume":"140","author":"Villanueva-Martin","year":"2023","journal-title":"J. Autoimmun."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181125000027?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181125000027?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T17:07:59Z","timestamp":1739466479000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181125000027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S0923181125000027"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2025.01.002","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aberrant fumarate metabolism links interferon release in diffuse systemic sclerosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2025.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2025 Published by Elsevier B.V. on behalf of Japanese Society for Investigative Dermatology. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}