{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T15:51:21Z","timestamp":1763221881385,"version":"3.45.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jdermsci.2025.09.004","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:21:01Z","timestamp":1758946861000},"page":"61-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regulation of melanogenesis via ubiquitin-proteasome system and autophagy by 3,3,5-trimethylcyclohexyl succinate dimethylamide and tranexamic acid"],"prefix":"10.1016","volume":"120","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanglan","family":"Zha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangying","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jdermsci.2025.09.004_bib1","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.3390\/ijms17071144","article-title":"Signaling pathways in melanogenesis","volume":"17","author":"D'Mello","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jdermsci.2025.09.004_bib2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ydbio.2018.04.016","article-title":"Wide coverage of the body surface by melanocyte-mediated skin pigmentation","volume":"449","author":"Tadokoro","year":"2019","journal-title":"Dev. Biol."},{"issue":"3","key":"10.1016\/j.jdermsci.2025.09.004_bib3","first-page":"1421","article-title":"Roles of inflammation factors in melanogenesis (Review)","volume":"21","author":"Fu","year":"2020","journal-title":"Mol. Med. Rep."},{"issue":"13","key":"10.1016\/j.jdermsci.2025.09.004_bib4","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.3390\/cells11132085","article-title":"The function of autophagy as a regulator of melanin homeostasis","volume":"11","author":"Lee","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jdermsci.2025.09.004_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115574","article-title":"Targeting tyrosinase in hyperpigmentation: current status, limitations and future promises","volume":"212","author":"Zolghadri","year":"2023","journal-title":"Biochem. Pharm."},{"issue":"2","key":"10.1016\/j.jdermsci.2025.09.004_bib6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jid.2022.08.040","article-title":"S-Palmitoylation of tyrosinase at Cysteine(500) regulates melanogenesis","volume":"143","author":"Niki","year":"2023","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2025.09.004_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-18629-3","article-title":"A systematic exploration reveals the potential of spermidine for hypopigmentation treatment through the stabilization of melanogenesis-associated proteins","volume":"12","author":"Brito","year":"2022","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jdermsci.2025.09.004_bib8","article-title":"Membrane-Associated ubiquitin ligase RING finger protein 152 orchestrates melanogenesis via tyrosinase ubiquitination","volume":"14","author":"Ueda","year":"2024","journal-title":"Membranes (Basel)"},{"issue":"7","key":"10.1016\/j.jdermsci.2025.09.004_bib9","doi-asserted-by":"crossref","first-page":"441","DOI":"10.14348\/molcells.2017.0115","article-title":"Crosstalk and interplay between the Ubiquitin-Proteasome system and autophagy","volume":"40","author":"Ji","year":"2017","journal-title":"Mol. Cells"},{"issue":"19","key":"10.1016\/j.jdermsci.2025.09.004_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/cells11192999","article-title":"Shining light on autophagy in skin pigmentation and pigmentary disorders","volume":"11","author":"Kovacs","year":"2022","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.jdermsci.2025.09.004_bib11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/pcmr.12838","article-title":"Autophagy induction can regulate skin pigmentation by causing melanosome degradation in keratinocytes and melanocytes","volume":"33","author":"Kim","year":"2020","journal-title":"Pigment Cell Melanoma Res."},{"issue":"2","key":"10.1016\/j.jdermsci.2025.09.004_bib12","first-page":"368","article-title":"The use of tranexamic acid in dermatology","volume":"62","author":"Ga\u0107ina","year":"2023","journal-title":"Acta Clin. Croat."},{"issue":"1","key":"10.1016\/j.jdermsci.2025.09.004_bib13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1755-148X.2009.00640.x","article-title":"Keratinocytes in culture accumulate phagocytosed melanosomes in the perinuclear area","volume":"23","author":"Ando","year":"2010","journal-title":"Pigment Cell Melanoma Res."},{"issue":"1","key":"10.1016\/j.jdermsci.2025.09.004_bib14","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1186\/s12951-022-01657-6","article-title":"Exosome-like nanovesicles derived from phellinus linteus inhibit Mical2 expression through cross-kingdom regulation and inhibit ultraviolet-induced skin aging","volume":"20","author":"Han","year":"2022","journal-title":"J. Nanobiotechnology"},{"issue":"1","key":"10.1016\/j.jdermsci.2025.09.004_bib15","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41392-023-01347-1","article-title":"Targeting p53 pathways: mechanisms, structures, and advances in therapy","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"issue":"4","key":"10.1016\/j.jdermsci.2025.09.004_bib16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41580-019-0199-y","article-title":"mTOR at the nexus of nutrition, growth, ageing and disease","volume":"21","author":"Liu","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.jdermsci.2025.09.004_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8090334","article-title":"The role of Ras-Associated protein 1 (Rap1) in cancer: bad actor or good player?","volume":"8","author":"Looi","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.jdermsci.2025.09.004_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1683414","article-title":"Tranexamic acid for adults with melasma: a systematic review and meta-analysis","volume":"2018","author":"Zhang","year":"2018","journal-title":"Biomed. Res. Int."},{"issue":"13","key":"10.1016\/j.jdermsci.2025.09.004_bib19","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000033420","article-title":"Mechanism of skin whitening through San-Bai decoction-induced tyrosinase inhibition and discovery of natural products targeting tyrosinase","volume":"102","author":"Li","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jdermsci.2025.09.004_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175231","article-title":"Pterostilbene inhibits melanogenesis, melanocyte dendricity and melanosome transport through cAMP\/PKA\/CREB pathway","volume":"932","author":"An","year":"2022","journal-title":"Eur. J. Pharm."},{"issue":"2","key":"10.1016\/j.jdermsci.2025.09.004_bib21","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/pcmr.12931","article-title":"Rab GTPases: key players in melanosome biogenesis, transport, and transfer","volume":"34","author":"Fukuda","year":"2021","journal-title":"Pigment Cell Melanoma Res."},{"issue":"14","key":"10.1016\/j.jdermsci.2025.09.004_bib22","doi-asserted-by":"crossref","first-page":"11289","DOI":"10.3390\/ijms241411289","article-title":"Melanin's journey from melanocytes to keratinocytes: uncovering the molecular mechanisms of melanin transfer and processing","volume":"24","author":"Bento-Lopes","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.jdermsci.2025.09.004_bib23","doi-asserted-by":"crossref","first-page":"a017046","DOI":"10.1101\/cshperspect.a017046","article-title":"Melanocytes and their diseases","volume":"4","author":"Yamaguchi","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"6","key":"10.1016\/j.jdermsci.2025.09.004_bib24","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1684\/ejd.2020.3930","article-title":"The role of autophagy in skin pigmentation","volume":"30","author":"Zhu","year":"2020","journal-title":"Eur. J. Dermatol."},{"issue":"10","key":"10.1016\/j.jdermsci.2025.09.004_bib25","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1038\/jid.2013.165","article-title":"Autophagy has a significant role in determining skin color by regulating melanosome degradation in keratinocytes","volume":"133","author":"Murase","year":"2013","journal-title":"J. Invest Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2025.09.004_bib26","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jdermsci.2017.05.019","article-title":"Tranexamic acid inhibits melanogenesis by activating the autophagy system in cultured melanoma cells","volume":"88","author":"Cho","year":"2017","journal-title":"J. Dermatol. Sci."},{"issue":"1","key":"10.1016\/j.jdermsci.2025.09.004_bib27","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12905-022-01850-7","article-title":"Role for autophagy-related markers Beclin-1 and LC3 in endometriosis","volume":"22","author":"Kong","year":"2022","journal-title":"BMC Women\u2019s Health"},{"issue":"2","key":"10.1016\/j.jdermsci.2025.09.004_bib28","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ceb.2009.11.014","article-title":"Mammalian autophagy: core molecular machinery and signaling regulation","volume":"22","author":"Yang","year":"2010","journal-title":"Curr. Opin. Cell Biol."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092318112500177X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092318112500177X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T15:46:38Z","timestamp":1763221598000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092318112500177X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S092318112500177X"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2025.09.004","relation":{},"ISSN":["0923-1811"],"issn-type":[{"type":"print","value":"0923-1811"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of melanogenesis via ubiquitin-proteasome system and autophagy by 3,3,5-trimethylcyclohexyl succinate dimethylamide and tranexamic acid","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2025.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V. on behalf of Japanese Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}