{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:58:24Z","timestamp":1790827104696,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jdermsci.2026.08.005","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T14:45:22Z","timestamp":1787409922000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anterior gradient 2 is overexpressed in extramammary Paget's disease and involved in cell survival"],"prefix":"10.1016","author":[{"given":"Hitomi","family":"Matsunaga-Nakashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Sawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tselmeg Mijiddorj","family":"Myangat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayo","family":"Kashiwada-Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikko","family":"Kajihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azusa","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunari","family":"Makino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Masuguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamichi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nakahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jdermsci.2026.08.005_bib1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/jamaoncol.2021.7148","article-title":"Evidence-based clinical practice guidelines for extramammary paget disease","volume":"8","author":"Kibbi","year":"2022","journal-title":"JAMA Oncol."},{"issue":"2","key":"10.1016\/j.jdermsci.2026.08.005_bib2","first-page":"313","article-title":"Extramammary Paget's disease: treatment, prognostic factors and outcome in 76 patients","volume":"158","author":"Hatta","year":"2008","journal-title":"Br. J. Dermatol."},{"issue":"1","key":"10.1016\/j.jdermsci.2026.08.005_bib3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jdermsci.2015.03.014","article-title":"The role of sentinel lymph node biopsy in the management of invasive extramammary Paget's disease: multi-center","volume":"79","author":"Fujisawa","year":"2015","journal-title":"Retrosp. Study 151 Patients J. Dermatol. Sci."},{"issue":"6","key":"10.1016\/j.jdermsci.2026.08.005_bib4","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/1346-8138.13760","article-title":"Serum cytokeratin 19 fragment 21-1 is a useful tumor marker for the assessment of extramammary Paget's disease","volume":"44","author":"Kato","year":"2017","journal-title":"J. Dermatol."},{"issue":"11","key":"10.1016\/j.jdermsci.2026.08.005_bib5","first-page":"5249","article-title":"From development to cancer - an ever-increasing role of AGR2","volume":"11","author":"Jach","year":"2021","journal-title":"Am. J. Cancer Res."},{"issue":"6","key":"10.1016\/j.jdermsci.2026.08.005_bib6","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1158\/1078-0432.CCR-05-2057","article-title":"Prognostic relevance of AGR2 expression in breast cancer","volume":"12","author":"Fritzsche","year":"2006","journal-title":"Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.jdermsci.2026.08.005_bib7","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.bbrc.2019.05.154","article-title":"AGR2 is a target of canonical Wnt\/\u03b2-catenin signaling and is important for stemness maintenance in colorectal cancer stem cells","volume":"515","author":"Dahal Lamichane","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jdermsci.2026.08.005_bib8","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1186\/s12885-015-1658-2","article-title":"High expression of AGR2 in lung cancer is predictive of poor survival","volume":"15","author":"Alavi","year":"2015","journal-title":"BMC Cancer"},{"issue":"19","key":"10.1016\/j.jdermsci.2026.08.005_bib9","doi-asserted-by":"crossref","first-page":"7811","DOI":"10.1158\/0008-5472.CAN-08-1320","article-title":"Anterior gradient 2 is expressed and secreted during the development of pancreatic cancer and promotes cancer cell survival","volume":"68","author":"Ramachandran","year":"2008","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.jdermsci.2026.08.005_bib10","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/gcc.20188","article-title":"AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer","volume":"43","author":"Zhang","year":"2005","journal-title":"Genes. Chromosomes Cancer"},{"issue":"3","key":"10.1016\/j.jdermsci.2026.08.005_bib11","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.3892\/ol.2016.4160","article-title":"AGR2 is associated with gastric cancer progression and poor survival","volume":"11","author":"Zhang","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jdermsci.2026.08.005_bib12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.cca.2017.12.023","article-title":"AGR2 diagnostic value in nasopharyngeal carcinoma prognosis","volume":"484","author":"Li","year":"2018","journal-title":"Clin. Chim. Acta"},{"issue":"34","key":"10.1016\/j.jdermsci.2026.08.005_bib13","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.1038\/onc.2010.228","article-title":"The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancers","volume":"29","author":"Hrstka","year":"2010","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.jdermsci.2026.08.005_bib14","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.2353\/ajpath.2009.090246","article-title":"The metastasis-associated anterior gradient 2 protein is correlated with poor survival of breast cancer patients","volume":"175","author":"Barraclough","year":"2009","journal-title":"Am. J. Pathol."},{"issue":"7","key":"10.1016\/j.jdermsci.2026.08.005_bib15","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1002\/cam4.1530","article-title":"Downregulation of AGR2, p21, and cyclin D and alterations in p53 function were associated with tumor progression and chemotherapy resistance in epithelial ovarian carcinoma","volume":"7","author":"Alves","year":"2018","journal-title":"Cancer Med."},{"issue":"22","key":"10.1016\/j.jdermsci.2026.08.005_bib16","doi-asserted-by":"crossref","first-page":"7091","DOI":"10.1158\/0008-5472.CAN-11-1367","article-title":"AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D","volume":"71","author":"Dumartin","year":"2011","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.jdermsci.2026.08.005_bib17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12935-023-02879-w","article-title":"Anterior gradient 2 induces resistance to sorafenib via endoplasmic reticulum stress regulation in hepatocellular carcinoma","volume":"23","author":"Tsai","year":"2023","journal-title":"Cancer Cell. Int."},{"issue":"3","key":"10.1016\/j.jdermsci.2026.08.005_bib18","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jdermsci.2025.06.002","article-title":"Integrative genomic and transcriptomic profiling reveals dysregulation of FOXA1-AGR2 axis in penoscrotal extramammary Paget's disease","volume":"119","author":"Zhang","year":"2025","journal-title":"J. Dermatol. Sci."},{"issue":"2","key":"10.1016\/j.jdermsci.2026.08.005_bib19","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.ajpath.2011.10.030","article-title":"Increased accumulation of extracellular thrombospondin-2 due to low degradation activity stimulates type I collagen expression in scleroderma fibroblasts","volume":"180","author":"Kajihara","year":"2012","journal-title":"Am. J. Pathol."},{"issue":"10","key":"10.1016\/j.jdermsci.2026.08.005_bib20","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/modpathol.3800437","article-title":"Androgen receptors are frequently expressed in mammary and extramammary Paget's disease","volume":"18","author":"Liegl","year":"2005","journal-title":"Mod. Pathol."},{"issue":"9","key":"10.1016\/j.jdermsci.2026.08.005_bib21","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/1346-8138.16825","article-title":"Overexpression of heat shock protein 90 through the downregulation of miR-9-5p in extramammary Paget's disease","volume":"50","author":"Ohnuma","year":"2023","journal-title":"J. Dermatol."},{"issue":"5","key":"10.1016\/j.jdermsci.2026.08.005_bib22","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1007\/s13577-023-00951-1","article-title":"KS-EMPD-1: a novel cell line of primary extramammary Paget's disease","volume":"36","author":"Ito","year":"2023","journal-title":"Hum. Cell."},{"issue":"1","key":"10.1016\/j.jdermsci.2026.08.005_bib23","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/s41598-024-84566-y","article-title":"A multicenter study on TROP2 as a potential targeted therapy for extramammary Paget disease in Japan","volume":"15","author":"Ito","year":"2025","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.jdermsci.2026.08.005_bib24","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.3390\/ijms23126811","article-title":"Elevated Alpha 1(I) to Alpha 2(I) Collagen Ratio in Dermal Fibroblasts Possibly Contributes to Fibrosis in Systemic Sclerosis","volume":"23","author":"Sawamura","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jdermsci.2026.08.005_bib25","article-title":"Identification and validation of matrix metalloproteinase hub genes as potential biomarkers for Skin Cutaneous Melanoma","volume":"14","author":"Zhang","year":"2024","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.jdermsci.2026.08.005_bib26","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1038\/s41598-025-85887-2","article-title":"Comprehensive investigation of matrix metalloproteinases in skin cutaneous melanoma: diagnostic, prognostic, and therapeutic insights","volume":"15","author":"Wu","year":"2025","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jdermsci.2026.08.005_bib27","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1016\/j.jid.2016.11.020","article-title":"Research techniques made simple: analysis of collective cell migration using the wound healing assay","volume":"137","author":"Grada","year":"2017","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.jdermsci.2026.08.005_bib28","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/bjd.15303","article-title":"Inhibition of heat shock protein 90 exerts an antitumour effect in angiosarcoma: involvement of the vascular endothelial growth factor signalling pathway","volume":"177","author":"Yamada-Kanazawa","year":"2017","journal-title":"Br. J. Dermatol."},{"issue":"9","key":"10.1016\/j.jdermsci.2026.08.005_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e05000","article-title":"Secretion of pro-oncogenic AGR2 protein in cancer","volume":"6","author":"Moidu","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.jdermsci.2026.08.005_bib30","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1186\/1471-2407-13-404","article-title":"Validation of four candidate pancreatic cancer serological biomarkers that improve the performance of CA19.9","volume":"13","author":"Makawita","year":"2013","journal-title":"BMC Cancer"},{"issue":"2","key":"10.1016\/j.jdermsci.2026.08.005_bib31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3233\/CBM-2012-0234","article-title":"Serum AGR2 as an early diagnostic and postoperative prognostic biomarker of human lung adenocarcinoma","volume":"10","author":"Chung","year":"2011","journal-title":"Cancer Biomark."},{"issue":"7","key":"10.1016\/j.jdermsci.2026.08.005_bib32","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/1346-8138.15392","article-title":"Combined serum carcinoembryonic antigen and cytokeratin 19 fragment levels provide a sensitive biomarker for lymph node metastasis in extramammary Paget's disease","volume":"47","author":"Kato","year":"2020","journal-title":"J. Dermatol."},{"issue":"3","key":"10.1016\/j.jdermsci.2026.08.005_bib33","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/bjd.17709","article-title":"Serum cell-free DNA levels are a useful marker for extramammary Paget disease","volume":"181","author":"Mijiddorj","year":"2019","journal-title":"Br. J. Dermatol."},{"issue":"3","key":"10.1016\/j.jdermsci.2026.08.005_bib34","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/bjd.17789","article-title":"Serum cytokeratin 19 fragment 21-1 and carcinoembryonic antigen combination assay as a biomarker of tumour progression and treatment response in extramammary Paget disease","volume":"181","author":"Nakamura","year":"2019","journal-title":"Br. J. Dermatol."},{"issue":"4","key":"10.1016\/j.jdermsci.2026.08.005_bib35","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1464-410X.2008.07575.x","article-title":"Penile and scrotal Paget's disease: 130 Chinese patients with long-term follow-up","volume":"102","author":"Wang","year":"2008","journal-title":"BJU Int."},{"issue":"6","key":"10.1016\/j.jdermsci.2026.08.005_bib36","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201810120","article-title":"Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation","volume":"11","author":"Maurel","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jdermsci.2026.08.005_bib37","doi-asserted-by":"crossref","first-page":"5231","DOI":"10.2147\/OTT.S252890","article-title":"FOXA1 promotes cell proliferation and suppresses apoptosis in HCC by directly regulating miR-212-3p\/FOXA1\/AGR2 signaling pathway","volume":"13","author":"Yuan","year":"2020","journal-title":"Onco. Targets Ther."},{"issue":"2","key":"10.1016\/j.jdermsci.2026.08.005_bib38","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.gendis.2015.01.003","article-title":"Current perspectives on FOXA1 regulation of androgen receptor signaling and prostate cancer","volume":"2","author":"Yang","year":"2015","journal-title":"Genes. Dis."},{"key":"10.1016\/j.jdermsci.2026.08.005_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154775","article-title":"Clinicopathological significance of androgen receptor expression in extramammary Paget disease: an analysis of 92 patients","volume":"249","author":"Kuramoto","year":"2023","journal-title":"Pathol. Res. Pract."},{"issue":"5","key":"10.1016\/j.jdermsci.2026.08.005_bib40","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1111\/j.1365-2133.2009.09603.x","article-title":"Androgen receptor and 5\u03b1-reductase immunohistochemical profiles in extramammary Paget disease","volume":"162","author":"Kasashima","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jdermsci.2026.08.005_bib41","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fonc.2018.00038","article-title":"Metastatic Extramammary Paget's Disease: Pathogenesis and Novel Therapeutic Approach","volume":"8","author":"Fukuda","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jdermsci.2026.08.005_bib42","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.canlet.2019.01.025","article-title":"Anterior Gradient-2 monoclonal antibody inhibits lung cancer growth and metastasis by upregulating p53 pathway and without exerting any toxicological effects: A preclinical study","volume":"449","author":"Negi","year":"2019","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.jdermsci.2026.08.005_bib43","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1080\/19336918.2019.1685928","article-title":"Paracrine signalling of AGR2 stimulates RhoA function in fibroblasts and modulates cell elongation and migration","volume":"13","author":"Mangukiya","year":"2019","journal-title":"Cell. Adh. Migr."}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181126001398?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181126001398?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:29:18Z","timestamp":1790825358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181126001398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":43,"alternative-id":["S0923181126001398"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2026.08.005","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anterior gradient 2 is overexpressed in extramammary Paget's disease and involved in cell survival","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2026.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}