{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T17:09:47Z","timestamp":1778432987186,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes and its Complications"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.jdiacomp.2014.02.008","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T18:30:48Z","timestamp":1393439448000},"page":"482-487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Prevalence and associations of diabetic retinopathy in a large cohort of prediabetic subjects: The Gutenberg Health Study"],"prefix":"10.1016","volume":"28","author":[{"given":"Julia","family":"Lamparter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Raum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Pfeiffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tunde","family":"Peto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"H\u00f6hn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Elflein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Wild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Mirshahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0065","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.amepre.2010.09.022","article-title":"Identifying adults at high risk for diabetes and cardiovascular disease using hemoglobin A1c National Health and Nutrition Examination Survey 2005\u20132006","volume":"40","author":"Ackermann","year":"2011","journal-title":"American Journal of Preventive Medicine"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0070","first-page":"S62","article-title":"Diagnosis and classification of diabetes mellitus","author":"ADA","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0230","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1440-1797.2007.00805.x","article-title":"Alterations in ocular surface and corneal thickness in relation to metabolic control in patients with chronic renal failure","volume":"12","author":"Akta\u015f","year":"2007","journal-title":"Nephrology (Carlton, Vic.)"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0075","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0161-6420(13)38012-9","article-title":"Grading diabetic retinopathy from stereoscopic color fundus photographs\u2013an extension of the modified Airlie House classification. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group","volume":"98","author":"Anonymous","year":"1991","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0080","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/ajcn\/68.4.899","article-title":"Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: executive summary. Expert panel on the identification, evaluation, and treatment of overweight in adults","volume":"68","author":"Anonymous","year":"1998","journal-title":"American Journal of Clinical Nutrition"},{"issue":"Pt 2","key":"10.1016\/j.jdiacomp.2014.02.008_bb0175","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/eye.1991.39","article-title":"Radiation retinopathy\u2013clinical, histopathological, ultrastructural and experimental correlations","volume":"5","author":"Archer","year":"1991","journal-title":"Eye (London, England)"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0165","doi-asserted-by":"crossref","DOI":"10.1111\/j.1755-3768.2012.02542.x","article-title":"Sex differences in risk factors for retinopathy in non-diabetic men and women: the Tromso Eye Study","author":"Bertelsen","year":"2013","journal-title":"Acta Ophthalmologica"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0245","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0008-4182(03)80109-6","article-title":"Effectiveness and safety of screening for diabetic retinopathy with two nonmydriatic digital images compared with the seven standard stereoscopic photographic fields","volume":"38","author":"Boucher","year":"2003","journal-title":"Canadian Journal of Ophthalmology"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0130","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.preteyeres.2007.12.001","article-title":"Diabetic retinopathy and systemic vascular complications","volume":"27","author":"Cheung","year":"2008","journal-title":"Progress in Retinal and Eye Research"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0105","first-page":"23","article-title":"Prevalence of diagnosed and undiagnosed diabetes and prediabetes in New Zealand: findings from the 2008\/09 Adult Nutrition Survey","volume":"126","author":"Coppell","year":"2013","journal-title":"New Zealand Medical Journal"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0155","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/sj.eye.6702085","article-title":"Five-year incidence and progression of vascular retinopathy in persons without diabetes: the Blue Mountains Eye Study","volume":"20","author":"Cugati","year":"2006","journal-title":"Eye (London, England)"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0085","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1001\/jama.286.2.180","article-title":"Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation","volume":"286","author":"D'Agostino","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0025","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/eurjhf\/hfr009","article-title":"Impact of diabetes mellitus on outcomes in patients with acute myocardial infarction and systolic heart failure","volume":"13","author":"Deedwania","year":"2011","journal-title":"European Journal of Heart Failure"},{"issue":"4","key":"10.1016\/j.jdiacomp.2014.02.008_bb0200","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1016\/j.ijcard.2013.05.038","article-title":"Prediabetes is not an independent risk factor for incident heart failure, other cardiovascular events or mortality in older adults: findings from a population-based cohort study","volume":"168","author":"Deedwania","year":"2013","journal-title":"International Journal of Cardiology"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0215","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1167\/iovs.11-7208","article-title":"Are obesity and anthropometry risk factors for diabetic retinopathy? The diabetes management project","volume":"52","author":"Dirani","year":"2011","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0120","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1464-5491.2007.02043.x","article-title":"The prevalence of retinopathy in impaired glucose tolerance and recent-onset diabetes in the Diabetes Prevention Program","volume":"24","author":"Group DPPR","year":"2007","journal-title":"Diabetic Medicine"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0095","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0140-6736(11)60472-8","article-title":"HbA1c 5.7-6.4% and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): a longitudinal cohort study","volume":"378","author":"Heianza","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0060","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.ophtha.2012.10.031","article-title":"Distribution of intraocular pressure and its association with ocular features and cardiovascular risk factors: the Gutenberg Health Study","volume":"120","author":"Hoehn","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0150","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0002-9394(14)76496-7","article-title":"Ocular manifestations of insufficiency or thrombosis of the internal carotid artery","volume":"47","author":"Hollenhorst","year":"1959","journal-title":"American Journal of Ophthalmology"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0050","series-title":"International Diabetes Federation, Diabetes Atlas","author":"IDF","year":"2011"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0145","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/S0161-6420(89)32794-1","article-title":"Ocular manifestations of acquired immune deficiency syndrome","volume":"96","author":"Jabs","year":"1989","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0045","doi-asserted-by":"crossref","first-page":"164","DOI":"10.7326\/0003-4819-124-1_Part_2-199601011-00017","article-title":"Cost-effectiveness of detecting and treating diabetic retinopathy","volume":"124","author":"Javitt","year":"1996","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0210","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1001\/archophthalmol.2009.330","article-title":"Prevalence and risk factors of retinopathy in an Asian population without diabetes: the Singapore Malay Eye Study","volume":"128","author":"Jeganathan","year":"2010","journal-title":"Archives of Ophthalmology"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0195","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.ophtha.2012.08.029","article-title":"Risk of cardiovascular diseases is increased even with mild diabetic retinopathy: the Japan Diabetes Complications Study","volume":"120","author":"Kawasaki","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0160","first-page":"329","article-title":"The relation of systemic hypertension to changes in the retinal vasculature: the Beaver Dam Eye Study","volume":"95","author":"Klein","year":"1997","journal-title":"Transactions of the American Ophthalmological Society"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0235","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1001\/archopht.1996.01100130007001","article-title":"Structure and function of the corneal endothelium in diabetes mellitus type I and type II","volume":"114","author":"Larsson","year":"1996","journal-title":"Archives of Ophthalmology"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0205","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1001\/archopht.122.11.1631","article-title":"Risks of progression of retinopathy and vision loss related to tight blood pressure control in type 2 diabetes mellitus: UKPDS 69","volume":"122","author":"Matthews","year":"2004","journal-title":"Archives of Ophthalmology"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0240","first-page":"823","article-title":"Are seven standard photographic fields necessary for classification of diabetic retinopathy?","volume":"30","author":"Moss","year":"1989","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0140","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/(SICI)1096-9136(199706)14:6<449::AID-DIA367>3.0.CO;2-D","article-title":"Diabetic retinopathy assessed by fundus photography in Pima Indians with impaired glucose tolerance and NIDDM","volume":"14","author":"Nagi","year":"1997","journal-title":"Diabetic Medicine"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0015","doi-asserted-by":"crossref","first-page":"753","DOI":"10.2337\/dc07-9920","article-title":"Impaired fasting glucose and impaired glucose tolerance: implications for care","volume":"30","author":"Nathan","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0115","author":"NDEP"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0135","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.2337\/dc07-0732","article-title":"Retinal vascular changes in pre-diabetes and prehypertension: new findings and their research and clinical implications","volume":"30","author":"Nguyen","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0110","series-title":"National Diabetes Fact Sheet","article-title":"National estimates and general information on diabetes and prediabetes in the United States","author":"Prevention UDoHaHSCfDCa","year":"2011"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0170","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1159\/000073077","article-title":"Ocular involvement in leukemia\u2013a study of 288 cases","volume":"217","author":"Reddy","year":"2003","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0035","author":"Robinson"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0030","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/j.amjcard.2011.07.046","article-title":"A propensity-matched study of the association of diabetes mellitus with incident heart failure and mortality among community-dwelling older adults","volume":"108","author":"Roy","year":"2011","journal-title":"American Journal of Cardiology"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0225","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.ajo.2008.10.013","article-title":"Central corneal thickness and its associations with ocular and systemic factors: the Singapore Malay Eye Study","volume":"147","author":"Su","year":"2009","journal-title":"American Journal of Ophthalmology"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0220","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.ophtha.2007.08.021","article-title":"Diabetes, hyperglycemia, and central corneal thickness: the Singapore Malay Eye Study","volume":"115","author":"Su","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0020","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/S0140-6736(12)60283-9","article-title":"Prediabetes: a high-risk state for diabetes development","volume":"379","author":"Tabak","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0180","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.cardfail.2011.03.007","article-title":"Diabetic retinopathy is associated with impaired left ventricular relaxation","volume":"17","author":"Takeda","year":"2011","journal-title":"Journal of Cardiac Failure"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0090","series-title":"R: A language and environment for statistical computing","isbn-type":"print","author":"team R.","year":"2012","ISBN":"https:\/\/id.crossref.org\/isbn\/3900051070"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0010","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1056\/NEJM200105033441801","article-title":"Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance","volume":"344","author":"Tuomilehto","year":"2001","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0125","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1463-1326.2007.00759.x","article-title":"Retinopathy in subjects with impaired fasting glucose: the NANSY-Eye baseline report","volume":"10","author":"Tyrberg","year":"2008","journal-title":"Diabetes, Obesity & Metabolism"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0005","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1046\/j.1464-5491.2002.00835.x","article-title":"Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention","volume":"19","author":"Unwin","year":"2002","journal-title":"Diabetic Medicine"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0055","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1007\/s00103-012-1502-7","article-title":"The Gutenberg Health Study","volume":"55","author":"Wild","year":"2012","journal-title":"Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0100","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.ajo.2005.07.030","article-title":"Retinopathy in persons with impaired glucose metabolism: the Australian Diabetes Obesity and Lifestyle (AusDiab) study","volume":"140","author":"Wong","year":"2005","journal-title":"American Journal of Ophthalmology"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0190","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/S0140-6736(01)06253-5","article-title":"Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study","volume":"358","author":"Wong","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0185","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/jama.293.1.63","article-title":"Retinopathy and risk of congestive heart failure","volume":"293","author":"Wong","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0250","doi-asserted-by":"crossref","first-page":"556","DOI":"10.2337\/dc11-1909","article-title":"Global prevalence and major risk factors of diabetic retinopathy","volume":"35","author":"Yau","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2014.02.008_bb0040","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1001\/jama.2010.1111","article-title":"Prevalence of diabetic retinopathy in the United States, 2005\u20132008","volume":"304","author":"Zhang","year":"2010","journal-title":"JAMA"}],"container-title":["Journal of Diabetes and its Complications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872714000506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872714000506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:07:19Z","timestamp":1761005239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056872714000506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S1056872714000506"],"URL":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2014.02.008","relation":{},"ISSN":["1056-8727"],"issn-type":[{"value":"1056-8727","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence and associations of diabetic retinopathy in a large cohort of prediabetic subjects: The Gutenberg Health Study","name":"articletitle","label":"Article Title"},{"value":"Journal of Diabetes and its Complications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2014.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}