{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:38:06Z","timestamp":1773286686994,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:00:00Z","timestamp":1411689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"funder":[{"name":"Sanofi K.K"}],"content-domain":{"domain":["jdcjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes and its Complications"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.jdiacomp.2014.09.012","type":"journal-article","created":{"date-parts":[[2014,9,28]],"date-time":"2014-09-28T15:19:36Z","timestamp":1411917576000},"page":"127-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effectiveness and safety of basal supported oral therapy with insulin glargine, in Japanese insulin-naive, type 2 diabetes patients, with or without microvascular complications: subanalysis of the observational, non-interventional, 24-week follow-up Add-on Lantus\u00ae to Oral Hypoglycemic Agents (ALOHA) study"],"prefix":"10.1016","volume":"29","author":[{"given":"Masato","family":"Odawara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kadowaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Naito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0180","first-page":"378","article-title":"Increased prevalence of microvascular complications in type 2 diabetes patients with the metabolic syndrome","volume":"8","author":"Abdul-Ghani","year":"2006","journal-title":"The Israel Medical Association Journal"},{"issue":"Suppl. 1","key":"10.1016\/j.jdiacomp.2014.09.012_bb0165","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.2337\/dc13-S011","article-title":"Standards of medical care in diabetes\u20142013","volume":"36","author":"American Diabetes Association","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0195","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2147\/vhrm.2006.2.1.59","article-title":"Insulin glargine in the treatment of type 1 and type 2 diabetes","volume":"2","author":"Barnett","year":"2006","journal-title":"Vascular Health and Risk Management"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0190","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1463-1326.2008.00980.x","article-title":"Insulin glargine provides greater improvements in glycaemic control vs. intensifying lifestyle management for people with type 2 diabetes treated with OADs and 7\u20138% A1c levels. The TULIP study","volume":"11","author":"Blickle","year":"2009","journal-title":"Diabetes, Obesity & Metabolism"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0055","doi-asserted-by":"crossref","first-page":"d4169","DOI":"10.1136\/bmj.d4169","article-title":"Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: Meta-analysis of randomised controlled trials","volume":"343","author":"Boussageon","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0105","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2337\/dc09-1471","article-title":"Effect of intensive compared with standard glycemia treatment strategies on mortality by baseline subgroup characteristics: The Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial","volume":"33","author":"Calles-Escandon","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0210","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2337\/dc08-0435","article-title":"Multifaceted determinants for achieving glycemic control: The International Diabetes Management Practice Study (IDMPS)","volume":"32","author":"Chan","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0230","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1210\/jc.2009-2828","article-title":"Determinants of severe hypoglycemia complicating type 2 diabetes: The Fremantle Diabetes Study","volume":"95","author":"Davis","year":"2010","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0050","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1056\/NEJMoa0808431","article-title":"Glucose control and vascular complications in veterans with type 2 diabetes","volume":"360","author":"Duckworth","year":"2009","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0160","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2337\/diaclin.26.2.77","article-title":"Microvascular and macrovascular complications of diabetes","volume":"26","author":"Fowler","year":"2008","journal-title":"Clinical Diabetes"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0095","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/j.1463-1326.2012.01613.x","article-title":"Factors influencing initial choice of insulin therapy in a large international non-interventional study of people with type 2 diabetes","volume":"14","author":"Freemantle","year":"2012","journal-title":"Diabetes, Obesity & Metabolism"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0010","doi-asserted-by":"crossref","first-page":"7S","DOI":"10.1016\/j.amjmed.2005.07.051","article-title":"The importance of tight glycemic control","volume":"118","author":"Gerich","year":"2005","journal-title":"The American Journal of Medicine"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0015","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1111\/j.1742-1241.2006.01175.x","article-title":"Diabetic microvascular complications: Can patients at risk be identified? A review","volume":"60","author":"Girach","year":"2006","journal-title":"International Journal of Clinical Practice"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0145","author":"Good Pharmacovigilance Practices"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0215","doi-asserted-by":"crossref","first-page":"d6898","DOI":"10.1136\/bmj.d6898","article-title":"Intensive glycaemic control for patients with type 2 diabetes: Systematic review with meta-analysis and trial sequential analysis of randomised clinical trials","volume":"343","author":"Hemmingsen","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0045","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1056\/NEJMoa0806470","article-title":"10-Year follow-up of intensive glucose control in type 2 diabetes","volume":"359","author":"Holman","year":"2008","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0085","doi-asserted-by":"crossref","first-page":"e36361","DOI":"10.1371\/journal.pone.0036361","article-title":"An exploration of barriers to insulin initiation for physicians in Japan: Findings from the Diabetes Attitudes, Wishes and Needs (DAWN) JAPAN Study","volume":"7","author":"Ishii","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0220","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0140-6736(10)60576-4","article-title":"Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: An analysis of the ACCORD randomised trial","volume":"376","author":"Ismail-Beigi","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0130","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s13340-012-0087-6","article-title":"Baseline predictive factors for glycemic control in Japanese type 2 diabetes patients treated with insulin glargine plus oral antidiabetic drugs: ALOHA study subanalysis","volume":"4","author":"Kadowaki","year":"2013","journal-title":"Diabetology International"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0200","first-page":"445","article-title":"Efficacy and safety of insulin glargine in concurrent use with oral hypoglycemic agents for the treatment of type 2 diabetic patients","volume":"19","author":"Kawamori","year":"2003","journal-title":"Rinsho Iyaku"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0090","series-title":"International Diabetes Federation 2011 World Diabetes Congress","first-page":"P-1426","article-title":"Baseline and 1-year interim follow-up assessment of Japanese patients initiating insulin therapy enrolled in the CREDIT Study","author":"Kawamori","year":"2011"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0140","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1254\/fpj.140.81","article-title":"GPSP: Good post-marketing study practice","volume":"140","author":"Kumano","year":"2012","journal-title":"Nihon Yakurigaku Zasshi"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0235","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3349\/ymj.2010.51.3.367","article-title":"Risk factors for recurrent hypoglycemia in hospitalized diabetic patients admitted for severe hypoglycemia","volume":"51","author":"Lin","year":"2010","journal-title":"Yonsei Medical Journal"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0075","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1098-3597(09)60006-5","article-title":"Overcoming patient barriers to initiating insulin therapy in type 2 diabetes mellitus","volume":"8","author":"Marrero","year":"2007","journal-title":"Clinical Cornerstone"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0060","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2337\/dc08-9025","article-title":"Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes","volume":"32","author":"Nathan","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0020","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/dmrr.1012","article-title":"Diabetes in Japan: A review of disease burden and approaches to treatment","volume":"25","author":"Neville","year":"2009","journal-title":"Diabetes\/Metabolism Research and Reviews"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0240","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1758-5996-6-20","article-title":"Incidence and predictors of hypoglycemia in Japanese patients with type 2 diabetes treated by insulin glargine and oral antidiabetic drugs in real-life: ALOHA post-marketing surveillance study sub-analysis","volume":"6","author":"Odawara","year":"2014","journal-title":"Diabetology and Metabolic Syndrome"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0135","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1089\/dia.2011.0220","article-title":"Dosing of insulin glargine to achieve the treatment target in Japanese type 2 diabetes on a basal supported oral therapy regimen in real life: ALOHA Study subanalysis","volume":"14","author":"Odawara","year":"2012","journal-title":"Diabetes Technology & Therapeutics"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0115","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0168-8227(95)01064-K","article-title":"Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: A randomized prospective 6-year study","volume":"28","author":"Ohkubo","year":"1995","journal-title":"Diabetes Research and Clinical Practice"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0125","first-page":"458","article-title":"Safety and effectiveness of BOT (basal supported oral therapy) using insulin glargine in Japanese patients with type 2 diabetes\u2014results from postmarketing surveillance of insulin glargine (ALOHA study)","volume":"60","author":"Ohtani","year":"2011","journal-title":"Shinyaku to Rinsho (Journal of New Remedies & Clinics)"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0170","doi-asserted-by":"crossref","first-page":"428","DOI":"10.2337\/diacare.7.5.428","article-title":"Association of differing dietary, metabolic, and clinical risk factors with microvascular complications of diabetes: A prevalence study of 503 Mexican type II diabetic subjects. II","volume":"7","author":"Paisey","year":"1984","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0110","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1056\/NEJMoa0802987","article-title":"Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes","volume":"358","author":"Patel","year":"2008","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0080","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.2337\/diacare.28.11.2673","article-title":"Resistance to insulin therapy among patients and providers: Results of the cross-national Diabetes Attitudes, Wishes, and Needs (DAWN) study","volume":"28","author":"Peyrot","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0175","first-page":"1152","article-title":"Prevalence of vascular complications and their risk factors in type 2 diabetes","volume":"47","author":"Ramachandran","year":"1999","journal-title":"The Journal of the Association of Physicians of India"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0065","doi-asserted-by":"crossref","first-page":"540","DOI":"10.4158\/EP.15.6.540","article-title":"Statement by an American Association of Clinical Endocrinologists\/American College of Endocrinology consensus panel on type 2 diabetes mellitus: An algorithm for glycemic control","volume":"15","author":"Rodbard","year":"2009","journal-title":"Endocrine Practice"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0025","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s00125-009-1360-5","article-title":"Relationship between glycated haemoglobin and microvascular complications: Is there a natural cut-off point for the diagnosis of diabetes?","volume":"52","author":"Sabanayagam","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0035","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2337\/db10-1198","article-title":"Glycated hemoglobin and the risk of kidney disease and retinopathy in adults with and without diabetes","volume":"60","author":"Selvin","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0005","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.diabres.2009.10.007","article-title":"Global estimates of the prevalence of diabetes for 2010 and 2030","volume":"87","author":"Shaw","year":"2010","journal-title":"Diabetes Research and Clinical Practice"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0120","first-page":"B21","article-title":"Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients","volume":"23","author":"Shichiri","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0185","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.2337\/diacare.26.9.2604","article-title":"Microvascular complications at time of diagnosis of type 2 diabetes are similar among diabetic patients detected by targeted screening and patients newly diagnosed in general practice: The Hoorn Screening Study","volume":"26","author":"Spijkerman","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0030","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/bmj.321.7258.405","article-title":"Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study","volume":"321","author":"Stratton","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0205","first-page":"41","article-title":"Effectiveness of basal-supported oral therapy (BOT) using insulin glargine in patients with poorly controlled type 2 diabetes","volume":"37","author":"Suzuki","year":"2012","journal-title":"The Tokai Journal of Experimental and Clinical Medicine"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0155","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.2040-1124.2010.00074.x","article-title":"Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus","volume":"1","author":"The Committee of the Japan Diabetes Society on the Diagnostic Criteria of Diabetes Mellitus","year":"2010","journal-title":"Journal of Diabetes Investigation"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0100","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1001\/archopht.116.7.874","article-title":"Early worsening of diabetic retinopathy in the Diabetes Control and Complications Trial","volume":"116","author":"The Diabetes Control and Complications Trial Research Group","year":"1998","journal-title":"Archives of Ophthalmology"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0070","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1753-0407.2011.00137.x","article-title":"First insulinization with basal insulin in patients with type 2 diabetes in a real-world setting in Asia","volume":"3","author":"Tsai","year":"2011","journal-title":"Journal of Diabetes"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0040","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0140-6736(98)07019-6","article-title":"Intensive blood\u2013glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)","volume":"352","author":"UK Prospective Diabetes Study (UKPDS) Group","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.jdiacomp.2014.09.012_bb0225","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1056\/NEJMoa1003795","article-title":"Severe hypoglycemia and risks of vascular events and death","volume":"363","author":"Zoungas","year":"2010","journal-title":"The New England Journal of Medicine"}],"container-title":["Journal of Diabetes and its Complications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872714002694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872714002694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T02:59:22Z","timestamp":1538189962000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056872714002694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S1056872714002694"],"URL":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2014.09.012","relation":{},"ISSN":["1056-8727"],"issn-type":[{"value":"1056-8727","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness and safety of basal supported oral therapy with insulin glargine, in Japanese insulin-naive, type 2 diabetes patients, with or without microvascular complications: subanalysis of the observational, non-interventional, 24-week follow-up Add-on Lantus\u00ae to Oral Hypoglycemic Agents (ALOHA) study","name":"articletitle","label":"Article Title"},{"value":"Journal of Diabetes and its Complications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2014.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}