{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:06:06Z","timestamp":1781766366743,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jdcjournal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes and its Complications"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.jdiacomp.2015.07.025","type":"journal-article","created":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T12:35:15Z","timestamp":1438432515000},"page":"1191-1197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Association of APOE polymorphisms with diabetes and cardiometabolic risk factors and the role of APOE genotypes in response to anti-diabetic therapy: results from the AIDHS\/SDS on a South Asian population"],"prefix":"10.1016","volume":"29","author":[{"given":"Bishwa","family":"Sapkota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gargi","family":"Priamvada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadley","family":"Finely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piers R.","family":"Blackett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher E.","family":"Aston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharambir K.","family":"Sanghera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3220","key":"10.1016\/j.jdiacomp.2015.07.025_bb0005","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1126\/science.124.3220.484-a","article-title":"Enzymatic deficiency in primaquine-sensitive erythrocytes","volume":"124","author":"Alving","year":"1956","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.jdiacomp.2015.07.025_bb0010","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1056\/NEJM199602293340906","article-title":"Metformin","volume":"334","author":"Bailey","year":"1996","journal-title":"New England Journal of Medicine"},{"issue":"11","key":"10.1016\/j.jdiacomp.2015.07.025_bb0015","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1001\/jama.298.11.1300","article-title":"Association of apolipoprotein E genotypes with lipid levels and coronary risk","volume":"298","author":"Bennet","year":"2007","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.jdiacomp.2015.07.025_bb0020","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.atherosclerosis.2008.06.007","article-title":"Relationship of the ApoE polymorphism to plasma lipid traits among South Asians, Chinese, and Europeans living in Canada","volume":"203","author":"Burman","year":"2009","journal-title":"Atherosclerosis"},{"issue":"6","key":"10.1016\/j.jdiacomp.2015.07.025_bb0025","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s00125-005-1751-1","article-title":"Long-term efficacy and tolerability of add-on pioglitazone therapy to failing monotherapy compared with addition of gliclazide or metformin in patients with type 2 diabetes","volume":"48","author":"Charbonnel","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.jdiacomp.2015.07.025_bb0030","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1475-2840-11-36","article-title":"Apolipoprotein E gene polymorphism: Effects on plasma lipids and risk of type 2 diabetes and coronary artery disease","volume":"11","author":"Chaudhary","year":"2012","journal-title":"Cardiovascular Diabetology"},{"issue":"16","key":"10.1016\/j.jdiacomp.2015.07.025_bb0035","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.jdiacomp.2015.07.025_bb0040","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1053\/meta.2001.24192","article-title":"Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30","volume":"50","author":"Glueck","year":"2001","journal-title":"Metabolism"},{"issue":"2","key":"10.1016\/j.jdiacomp.2015.07.025_bb0045","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diabres.2013.11.002","article-title":"Global estimates of diabetes prevalence for 2013 and projections for 2035","volume":"103","author":"Guariguata","year":"2014","journal-title":"Diabetes Research and Clinical Practice"},{"issue":"Suppl. 1","key":"10.1016\/j.jdiacomp.2015.07.025_bb0050","first-page":"S5","article-title":"Diagnosis and classification of diabetes mellitus","volume":"27","author":"Guidlines","year":"2004","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.jdiacomp.2015.07.025_bb0055","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2337\/diacare.27.1.141","article-title":"One-year glycemic control with a sulfonylurea plus pioglitazone versus a sulfonylurea plus metformin in patients with type 2 diabetes","volume":"27","author":"Hanefeld","year":"2004","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.jdiacomp.2015.07.025_bb0060","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2337\/dc07-1572","article-title":"Is glycemic control improving in U.S. adults?","volume":"31","author":"Hoerger","year":"2008","journal-title":"Diabetes Care"},{"issue":"4","key":"10.1016\/j.jdiacomp.2015.07.025_bb0065","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1073\/pnas.83.4.1125","article-title":"Expression of apolipoprotein E during nerve degeneration and regeneration","volume":"83","author":"Ignatius","year":"1986","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"10.1016\/j.jdiacomp.2015.07.025_bb0070","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1161\/01.ATV.0000201938.78044.75","article-title":"Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells","volume":"26","author":"Isoda","year":"2006","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"12","key":"10.1016\/j.jdiacomp.2015.07.025_bb0075","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.2337\/diacare.25.12.2244","article-title":"Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes","volume":"25","author":"Johnson","year":"2002","journal-title":"Diabetes Care"},{"issue":"4","key":"10.1016\/j.jdiacomp.2015.07.025_bb0080","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/ng0895-486","article-title":"APOE*4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism","volume":"10","author":"Kamboh","year":"1995","journal-title":"Nature Genetics"},{"issue":"4852","key":"10.1016\/j.jdiacomp.2015.07.025_bb0085","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology","volume":"240","author":"Mahley","year":"1988","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.jdiacomp.2015.07.025_bb0090","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0304-4157(83)90001-1","article-title":"Lipoprotein receptors and cholesterol homeostasis","volume":"737","author":"Mahley","year":"1983","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.jdiacomp.2015.07.025_bb0095","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1744-8069-9-14","article-title":"Proteomic and functional annotation analysis of injured peripheral nerves reveals ApoE as a protein upregulated by injury that is modulated by metformin treatment","volume":"9","author":"Melemedjian","year":"2013","journal-title":"Molecular Pain"},{"issue":"9403","key":"10.1016\/j.jdiacomp.2015.07.025_bb0100","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0140-6736(03)15268-3","article-title":"Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies","volume":"363","author":"Panel","year":"2004","journal-title":"Lancet"},{"issue":"1\u20132","key":"10.1016\/j.jdiacomp.2015.07.025_bb0105","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mce.2008.10.002","article-title":"Genetic dissection of type 2 diabetes","volume":"297","author":"Ridderstrale","year":"2009","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"1","key":"10.1016\/j.jdiacomp.2015.07.025_bb0110","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1758-5996-5-6","article-title":"Metformin: An old but still the best treatment for type 2 diabetes","volume":"5","author":"Rojas","year":"2013","journal-title":"Diabetology and Metabolic Syndrome"},{"issue":"198","key":"10.1016\/j.jdiacomp.2015.07.025_bb0115","article-title":"Type 2 diabetes genetics: Beyond GWAS","volume":"3","author":"Sanghera","year":"2012","journal-title":"Journal of diabetes metabolism"},{"issue":"4","key":"10.1016\/j.jdiacomp.2015.07.025_bb0120","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.metabol.2009.07.043","article-title":"PPARG and ADIPOQ gene polymorphisms increase type 2 diabetes mellitus risk in Asian Indian Sikhs: Pro12Ala still remains as the strongest predictor","volume":"59","author":"Sanghera","year":"2010","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.jdiacomp.2015.07.025_bb0125","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0021-9150(96)05891-1","article-title":"Quantitative effects of the apolipoprotein E polymorphism in a biracial sample of 9-10-year-old girls","volume":"126","author":"Sanghera","year":"1996","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jdiacomp.2015.07.025_bb0130","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2350-9-59","article-title":"Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk","volume":"9","author":"Sanghera","year":"2008","journal-title":"BMC Medical Genetics"},{"issue":"3","key":"10.1016\/j.jdiacomp.2015.07.025_bb0135","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1161\/CIRCGENETICS.113.000412","article-title":"Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort","volume":"7","author":"Saxena","year":"2014","journal-title":"Circulation. Cardiovascular Genetics"},{"issue":"5","key":"10.1016\/j.jdiacomp.2015.07.025_bb0140","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.2337\/db12-1077","article-title":"Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India","volume":"62","author":"Saxena","year":"2013","journal-title":"Diabetes"},{"issue":"8 Pt 1","key":"10.1016\/j.jdiacomp.2015.07.025_bb0145","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1093\/clinchem\/41.8.1068","article-title":"Apolipoprotein E: An important gene and protein to follow in laboratory medicine","volume":"41","author":"Siest","year":"1995","journal-title":"Clinical Chemistry"},{"issue":"3","key":"10.1016\/j.jdiacomp.2015.07.025_bb0150","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/03014460600594513","article-title":"APOE distribution in world populations with new data from India and the UK","volume":"33","author":"Singh","year":"2006","journal-title":"Annals of Human Biology"},{"issue":"2","key":"10.1016\/j.jdiacomp.2015.07.025_bb0155","doi-asserted-by":"crossref","first-page":"137","DOI":"10.7326\/0003-4819-141-2-200407200-00013","article-title":"Meta-analysis: Apolipoprotein E genotypes and risk for coronary heart disease","volume":"141","author":"Song","year":"2004","journal-title":"Annals of Internal Medicine"},{"issue":"2","key":"10.1016\/j.jdiacomp.2015.07.025_bb0160","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s004390050811","article-title":"An ecological study of association between coronary heart disease mortality rates in men and the relative frequencies of common allelic variations in the gene coding for apolipoprotein E","volume":"103","author":"Stengard","year":"1998","journal-title":"Human Genetics"},{"issue":"5","key":"10.1016\/j.jdiacomp.2015.07.025_bb0165","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"10.1016\/j.jdiacomp.2015.07.025_bb0170","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1365-2796.2005.01531.x","article-title":"Metformin improves endothelial function in patients with metabolic syndrome","volume":"258","author":"Vitale","year":"2005","journal-title":"Journal of Internal Medicine"},{"issue":"4","key":"10.1016\/j.jdiacomp.2015.07.025_bb0175","doi-asserted-by":"crossref","first-page":"e95463","DOI":"10.1371\/journal.pone.0095463","article-title":"Apolipoprotein E gene polymorphism and risk for coronary heart disease in the Chinese population: A meta-analysis of 61 studies including 6634 cases and 6393 controls","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"}],"container-title":["Journal of Diabetes and its Complications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872715003256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872715003256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T19:36:31Z","timestamp":1599420991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056872715003256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S1056872715003256"],"URL":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2015.07.025","relation":{},"ISSN":["1056-8727"],"issn-type":[{"value":"1056-8727","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of APOE polymorphisms with diabetes and cardiometabolic risk factors and the role of APOE genotypes in response to anti-diabetic therapy: results from the AIDHS\/SDS on a South Asian population","name":"articletitle","label":"Article Title"},{"value":"Journal of Diabetes and its Complications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2015.07.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}