{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:44:04Z","timestamp":1773287044086,"version":"3.50.1"},"reference-count":17,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jdcjournal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes and its Complications"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.jdiacomp.2015.08.004","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T01:19:23Z","timestamp":1439342363000},"page":"1277-1282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Naltrexone for treatment of impaired awareness of hypoglycemia in type 1 diabetes: A randomized clinical trial"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9909-6724","authenticated-orcid":false,"given":"Amir","family":"Moheet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Mangia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nolawit","family":"Tesfaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn E.","family":"Eberly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine","family":"Kubisiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth R.","family":"Seaquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdiacomp.2015.08.004_bb0040","first-page":"E852","article-title":"Opiate blockade enhances hypoglycemic counterregulation in normal and insulin-dependent diabetic subjects","volume":"260","author":"Caprio","year":"1991","journal-title":"The American Journal of Physiology"},{"key":"10.1016\/j.jdiacomp.2015.08.004_bb0055","doi-asserted-by":"crossref","first-page":"517","DOI":"10.2337\/diacare.18.4.517","article-title":"Reduced awareness of hypoglycemia in adults with IDDM \u2014 A prospective-study of hypoglycemic frequency and associated symptoms","volume":"18","author":"Clarke","year":"1995","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2015.08.004_bb0005","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.2337\/diabetes.54.12.3592","article-title":"Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes","volume":"54","author":"Cryer","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.jdiacomp.2015.08.004_bb0025","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.2337\/diab.43.12.1426","article-title":"Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM","volume":"43","author":"Dagogojack","year":"1994","journal-title":"Diabetes"},{"key":"10.1016\/j.jdiacomp.2015.08.004_bb0035","first-page":"E236","article-title":"Effect of opiate-receptor blockade on normoglycemic and hypoglycemic glucoregulation","volume":"250","author":"Eltayeb","year":"1986","journal-title":"The American Journal of Physiology"},{"key":"10.1016\/j.jdiacomp.2015.08.004_bb0015","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/BF00399801","article-title":"Long-term recovery from unawareness, deficient counterregulation and lack of cognitive dysfunction during hypoglycemia, following institution of rational, intensive insulin therapy in IDDM","volume":"37","author":"Fanelli","year":"1994","journal-title":"Diabetologia"},{"key":"10.1016\/j.jdiacomp.2015.08.004_bb0010","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1464-5491.2008.02413.x","article-title":"Prevalence of impaired awareness of hypoglycaemia in adults with type 1 diabetes","volume":"25","author":"Geddes","year":"2008","journal-title":"Diabetic Medicine"},{"key":"10.1016\/j.jdiacomp.2015.08.004_bb0075","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014A metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"Journal of Biomedical Informatics"},{"key":"10.1016\/j.jdiacomp.2015.08.004_bb0020","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.2337\/dc13-1004","article-title":"Restoration of self-awareness of hypoglycemia in adults with long-standing type 1 diabetes hyperinsulinemic-hypoglycemic clamp substudy results from the HypoCOMPaSS trial","volume":"36","author":"Leelarathna","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2015.08.004_bb0045","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1210\/jc.2009-0882","article-title":"Hypoglycemia-associated autonomic failure is prevented by opioid receptor blockade","volume":"94","author":"Leu","year":"2009","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.jdiacomp.2015.08.004_bb0070","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/(SICI)1522-2594(199906)41:6<1246::AID-MRM22>3.0.CO;2-N","article-title":"QUIPSS II with thin-slice TI1 periodic saturation: A method for improving accuracy of quantitative perfusion imaging using pulsed arterial spin labeling","volume":"41","author":"Luh","year":"1999","journal-title":"Magnetic Resonance in Medicine"},{"key":"10.1016\/j.jdiacomp.2015.08.004_bb0060","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1038\/jcbfm.2012.117","article-title":"Hypoglycemia-induced increases in thalamic cerebral blood flow are blunted in subjects with type 1 diabetes and hypoglycemia unawareness","volume":"32","author":"Mangia","year":"2012","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/j.jdiacomp.2015.08.004_bb0030","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1210\/jc.2011-2540","article-title":"The response to hypoglycemia: A role for the opioid system?","volume":"96","author":"McCrimmon","year":"2011","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.jdiacomp.2015.08.004_bb0085","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2337\/db10-0326","article-title":"Naloxone, but not valsartan, preserves responses to hypoglycemia after antecedent hypoglycemia role of metabolic reprogramming in counterregulatory failure","volume":"60","author":"Poplawski","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.jdiacomp.2015.08.004_bb0065","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.2337\/diab.42.12.1791","article-title":"Mechanism of awareness of hypoglycemia \u2014 Perception of neurogenic (predominantly cholinergic) rather than neuroglycopenic symptoms","volume":"42","author":"Towler","year":"1993","journal-title":"Diabetes"},{"key":"10.1016\/j.jdiacomp.2015.08.004_bb0050","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1210\/jc.2011-1723","article-title":"Opioid receptor blockade improves hypoglycemia-associated autonomic failure in type 1 diabetes mellitus","volume":"96","author":"Vele","year":"2011","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.jdiacomp.2015.08.004_bb0080","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0014-2999(96)00293-2","article-title":"Functional analysis of opioid receptor subtypes in the ventromedial hypothalamic nucleus of the rat","volume":"308","author":"Zhang","year":"1996","journal-title":"European Journal of Pharmacology"}],"container-title":["Journal of Diabetes and its Complications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872715003499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872715003499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T04:23:14Z","timestamp":1537417394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056872715003499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S1056872715003499"],"URL":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2015.08.004","relation":{},"ISSN":["1056-8727"],"issn-type":[{"value":"1056-8727","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Naltrexone for treatment of impaired awareness of hypoglycemia in type 1 diabetes: A randomized clinical trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Diabetes and its Complications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2015.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}