{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:37:09Z","timestamp":1792719429941,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jdcjournal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes and its Complications"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.jdiacomp.2016.07.020","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T17:23:50Z","timestamp":1469726630000},"page":"1555-1559","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Exenatide treatment increases serum irisin levels in patients with obesity and newly diagnosed type 2 diabetes"],"prefix":"10.1016","volume":"30","author":[{"given":"Jia","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.jdiacomp.2016.07.020_bb0005","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.2337\/dc13-S011","article-title":"Standards of medical care in diabetes\u20142013","volume":"36","author":"American Diabetes, A.","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0010","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1210\/en.2012-2029","article-title":"High-fat diet-mediated lipotoxicity and insulin resistance is related to impaired lipase expression in mouse skeletal muscle","volume":"154","author":"Badin","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0015","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"Bostrom","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0020","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.2337\/dc11-0291","article-title":"Effects of exenatide on measures of beta-cell function after 3years in metformin-treated patients with type 2 diabetes","volume":"34","author":"Bunck","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0025","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0140-6736(09)60659-0","article-title":"Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)","volume":"374","author":"Buse","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0030","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.diabres.2013.01.007","article-title":"Serum irisin levels in new-onset type 2 diabetes","volume":"100","author":"Choi","year":"2013","journal-title":"Diabetes Research and Clinical Practice"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0035","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0140-6736(03)15268-3","article-title":"Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies","volume":"363","author":"Consultation, W.H.O.E.","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0040","doi-asserted-by":"crossref","first-page":"951","DOI":"10.2337\/dc09-1521","article-title":"Effects of exenatide plus rosiglitazone on beta-cell function and insulin sensitivity in subjects with type 2 diabetes on metformin","volume":"33","author":"DeFronzo","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0045","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hep.21006","article-title":"Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in Ob\/Ob mice","volume":"43","author":"Ding","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0050","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/S0140-6736(06)69705-5","article-title":"The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes","volume":"368","author":"Drucker","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0055","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1210\/jc.2008-1940","article-title":"Racial and ethnic differences in mean plasma glucose, hemoglobin A1c, and 1,5-anhydroglucitol in over 2000 patients with type 2 diabetes","volume":"94","author":"Herman","year":"2009","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0060","doi-asserted-by":"crossref","first-page":"E2154","DOI":"10.1210\/jc.2014-1437","article-title":"Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation","volume":"99","author":"Huh","year":"2014","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0065","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1210\/en.2004-0478","article-title":"Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: Role of nuclear factor-kappaB and endoplasmic reticulum stress","volume":"145","author":"Kharroubi","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0070","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0092-8674(00)80546-2","article-title":"Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes","volume":"96","author":"Kulkarni","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0075","doi-asserted-by":"crossref","first-page":"e31394","DOI":"10.1371\/journal.pone.0031394","article-title":"Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL\/6J mice","volume":"7","author":"Lee","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0080","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1210\/me.2014-1353","article-title":"Irisin, a novel myokine, regulates glucose uptake in skeletal muscle cells via AMPK","volume":"29","author":"Lee","year":"2015","journal-title":"Molecular Endocrinology"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0085","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/apha.12421","article-title":"Metformin promotes irisin release from murine skeletal muscle independently of AMP-activated protein kinase activation","volume":"213","author":"Li","year":"2015","journal-title":"Acta Physiologica"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0090","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1210\/jc.2014-2544","article-title":"Elevated circulating levels of irisin and the effect of metformin treatment in women with polycystic ovary syndrome","volume":"100","author":"Li","year":"2015","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0095","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1074\/jbc.M209423200","article-title":"Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis","volume":"278","author":"Li","year":"2003","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0100","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/dmrr.2580","article-title":"GLP-1 receptor agonists: Effects on the progression of non-alcoholic fatty liver disease","volume":"31","author":"Liu","year":"2015","journal-title":"Diabetes\/Metabolism Research and Reviews"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0105","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.jdiacomp.2013.03.002","article-title":"Lower circulating irisin is associated with type 2 diabetes mellitus","volume":"27","author":"Liu","year":"2013","journal-title":"Journal of Diabetes and its Complications"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0110","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0115","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.metabol.2013.09.013","article-title":"Irisin in patients with nonalcoholic fatty liver disease","volume":"63","author":"Polyzos","year":"2014","journal-title":"Metabolism: Clinical and Experimental"},{"issue":"Suppl. 3","key":"10.1016\/j.jdiacomp.2016.07.020_bb0120","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1463-1326.2012.01658.x","article-title":"Short-term intensified insulin treatment in type 2 diabetes: Long-term effects on beta-cell function","volume":"14","author":"Retnakaran","year":"2012","journal-title":"Diabetes, Obesity & Metabolism"},{"issue":"Suppl. 3","key":"10.1016\/j.jdiacomp.2016.07.020_bb0125","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/dom.12165","article-title":"Glucagon-like peptide-1: Modulator of beta-cell dysfunction and death","volume":"15","author":"Rondas","year":"2013","journal-title":"Diabetes, Obesity & Metabolism"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0130","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4161\/adip.27370","article-title":"The p38-PGC-1alpha-irisin-betatrophin axis: Exploring new pathways in insulin resistance","volume":"3","author":"Sanchis-Gomar","year":"2014","journal-title":"Adipocyte"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0135","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.peptides.2012.11.014","article-title":"Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity\u2014Correlation with body mass index","volume":"39","author":"Stengel","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0140","doi-asserted-by":"crossref","first-page":"157201","DOI":"10.1155\/2015\/157201","article-title":"Effects of glucagon-like peptide-1 receptor agonists on weight loss in patients with type 2 diabetes: A systematic review and network meta-analysis","volume":"2015","author":"Sun","year":"2015","journal-title":"Journal of Diabetes Research"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0145","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11302-012-9331-6","article-title":"High glucose and free fatty acids induce beta cell apoptosis via autocrine effects of ADP acting on the P2Y(13) receptor","volume":"9","author":"Tan","year":"2013","journal-title":"Purinergic Signalling"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0150","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3892\/etm.2012.601","article-title":"Protective effect of alpha-lipoic acid on islet cells co-cultured with 3T3L1 adipocytes","volume":"4","author":"Wang","year":"2012","journal-title":"Experimental and Therapeutic Medicine"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0155","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.peptides.2011.03.018","article-title":"Divergent effects of GLP-1 analogs exendin-4 and exendin-9 on the expression of myosin heavy chain isoforms in C2C12 myotubes","volume":"32","author":"Wang","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0160","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.atherosclerosis.2014.04.036","article-title":"Circulating irisin levels are positively associated with endothelium-dependent vasodilation in newly diagnosed type 2 diabetic patients without clinical angiopathy","volume":"235","author":"Xiang","year":"2014","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0165","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13098-015-0019-2","article-title":"Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance","volume":"7","author":"Xie","year":"2015","journal-title":"Diabetology & Metabolic Syndrome"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0170","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/joim.12293","article-title":"Comparison of the effects on glycaemic control and beta-cell function in newly diagnosed type 2 diabetes patients of treatment with exenatide, insulin or pioglitazone: A multicentre randomized parallel-group trial (the CONFIDENCE study)","volume":"277","author":"Xu","year":"2015","journal-title":"Journal of Internal Medicine"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0175","doi-asserted-by":"crossref","first-page":"e94235","DOI":"10.1371\/journal.pone.0094235","article-title":"Association of serum irisin with metabolic syndrome in obese Chinese adults","volume":"9","author":"Yan","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0180","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cmet.2006.10.001","article-title":"GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress","volume":"4","author":"Yusta","year":"2006","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0185","doi-asserted-by":"crossref","first-page":"514","DOI":"10.2337\/db13-1106","article-title":"Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling","volume":"63","author":"Zhang","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.jdiacomp.2016.07.020_bb0190","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.jhep.2013.04.030","article-title":"Irisin is inversely associated with intrahepatic triglyceride contents in obese adults","volume":"59","author":"Zhang","year":"2013","journal-title":"Journal of Hepatology"}],"container-title":["Journal of Diabetes and its Complications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872716302999?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872716302999?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T01:51:09Z","timestamp":1536544269000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056872716302999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S1056872716302999"],"URL":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2016.07.020","relation":{},"ISSN":["1056-8727"],"issn-type":[{"value":"1056-8727","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exenatide treatment increases serum irisin levels in patients with obesity and newly diagnosed type 2 diabetes","name":"articletitle","label":"Article Title"},{"value":"Journal of Diabetes and its Complications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2016.07.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}