{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:40:04Z","timestamp":1786992004502,"version":"build-2736575974"},"reference-count":19,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jdcjournal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes and its Complications"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.jdiacomp.2016.08.023","type":"journal-article","created":{"date-parts":[[2016,9,3]],"date-time":"2016-09-03T01:40:31Z","timestamp":1472866831000},"page":"213-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Elevated serum total bilirubin levels are negatively associated with major diabetic complications among Chinese senile diabetic patients"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7975-6702","authenticated-orcid":false,"given":"Miao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyu","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jdiacomp.2016.08.023_bb0005","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.2337\/db14-0228","article-title":"Bilirubin as a potential causal factor in type 2 diabetes risk: a Mendelian randomization study","volume":"64","author":"Abbasi","year":"2015","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.jdiacomp.2016.08.023_bb0010","doi-asserted-by":"crossref","first-page":"475","DOI":"10.7326\/M15-1563","article-title":"Diabetes Prevention at the Tipping Point: Aligning Clinical and Public Health Recommendations","volume":"163","author":"Ackermann","year":"2015","journal-title":"Annals of Internal Medicine"},{"issue":"1","key":"10.1016\/j.jdiacomp.2016.08.023_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diabetes.48.1.1","article-title":"Role of oxidative stress in diabetic complications: a new perspective on an old paradigm","volume":"48","author":"Baynes","year":"1999","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.jdiacomp.2016.08.023_bb0020","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.diabres.2015.07.001","article-title":"World Diabetes Congress Vancouver 2015: Public Health and Epidemiology Stream","volume":"109","author":"Boyko","year":"2015","journal-title":"Diabetes Research and Clinical Practice"},{"issue":"4","key":"10.1016\/j.jdiacomp.2016.08.023_bb0025","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jdiacomp.2016.01.019","article-title":"Does bilirubin protect against developing diabetes mellitus?","volume":"30","author":"Breimer","year":"2016","journal-title":"Journal of Diabetes and its Complications"},{"issue":"6","key":"10.1016\/j.jdiacomp.2016.08.023_bb0030","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","article-title":"The pathobiology of diabetic complications: a unifying mechanism","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.jdiacomp.2016.08.023_bb0035","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/dme.12338","article-title":"Physiological serum bilirubin concentrations are inversely associated with the prevalence of cardiovascular autonomic neuropathy in patients with Type 2 diabetes","volume":"31","author":"Chung","year":"2014","journal-title":"Diabetic Medicine"},{"issue":"1","key":"10.1016\/j.jdiacomp.2016.08.023_bb0040","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s10517-008-0019-4","article-title":"Primary biliary cirrhosis and coronary atherosclerosis: protective antioxidant effect of bilirubin","volume":"145","author":"Dudnik","year":"2008","journal-title":"Bulletin of Experimental Biology and Medicine"},{"issue":"4","key":"10.1016\/j.jdiacomp.2016.08.023_bb0045","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1620\/tjem.222.265","article-title":"Hyperbilirubinemia reduces the streptozotocin-induced pancreatic damage through attenuating the oxidative stress in the Gunn rat","volume":"222","author":"Fu","year":"2010","journal-title":"The Tohoku Journal of Experimental Medicine"},{"issue":"5","key":"10.1016\/j.jdiacomp.2016.08.023_bb0050","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.diabet.2015.05.003","article-title":"Low bilirubin levels are an independent risk factor for diabetic retinopathy and nephropathy in Japanese patients with type 2 diabetes","volume":"41","author":"Hamamoto","year":"2015","journal-title":"Diabetes & Metabolism"},{"key":"10.1016\/j.jdiacomp.2016.08.023_bb0055","doi-asserted-by":"crossref","DOI":"10.1111\/1753-0407.12440","article-title":"Secular trend of prevalence of type 2 diabetes in adults in China from 1995 to 2014: A meta-analysis","author":"Han","year":"2016","journal-title":"Journal of Diabetes"},{"issue":"3","key":"10.1016\/j.jdiacomp.2016.08.023_bb0060","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1161\/ATVBAHA.114.304929","article-title":"Circulating total bilirubin and risk of incident cardiovascular disease in the general population","volume":"35","author":"Kunutsor","year":"2015","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"8","key":"10.1016\/j.jdiacomp.2016.08.023_bb0065","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00392-014-0697-z","article-title":"Association of bilirubin with coronary artery calcification and cardiovascular events in the general population without known liver disease: the Heinz Nixdorf Recall study","volume":"103","author":"Mahabadi","year":"2014","journal-title":"Clinical Research in Cardiology"},{"issue":"2","key":"10.1016\/j.jdiacomp.2016.08.023_bb0070","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jdiacomp.2014.12.002","article-title":"Serum total bilirubin concentration is negatively associated with increasing severity of retinopathy in patients with type 2 diabetes mellitus","volume":"29","author":"Sekioka","year":"2015","journal-title":"Journal of Diabetes and its Complications"},{"issue":"4792","key":"10.1016\/j.jdiacomp.2016.08.023_bb0075","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.3029864","article-title":"Bilirubin is an antioxidant of possible physiological importance","volume":"235","author":"Stocker","year":"1987","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.jdiacomp.2016.08.023_bb0080","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/jdi.12134","article-title":"Association of serum bilirubin levels with development and progression of albuminuria, and decline in estimated glomerular filtration rate in patients with type 2 diabetes mellitus","volume":"5","author":"Toya","year":"2014","journal-title":"Journal of Diabetes Investigation"},{"key":"10.1016\/j.jdiacomp.2016.08.023_bb0085","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fphar.2012.00055","article-title":"The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases","volume":"3","author":"Vitek","year":"2012","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.jdiacomp.2016.08.023_bb0090","doi-asserted-by":"crossref","DOI":"10.1111\/jdi.12514","article-title":"Prevalence of type 2 diabetes mellitus among inland residents in China (2000-2014): A meta-analysis","author":"Yang","year":"2016","journal-title":"Journal of Diabetes Investigation"},{"issue":"3","key":"10.1016\/j.jdiacomp.2016.08.023_bb0095","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.diabres.2010.01.026","article-title":"Global healthcare expenditure on diabetes for 2010 and 2030","volume":"87","author":"Zhang","year":"2010","journal-title":"Diabetes Research and Clinical Practice"}],"container-title":["Journal of Diabetes and its Complications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872716304500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872716304500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T16:28:52Z","timestamp":1536424132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056872716304500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S1056872716304500"],"URL":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2016.08.023","relation":{},"ISSN":["1056-8727"],"issn-type":[{"value":"1056-8727","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevated serum total bilirubin levels are negatively associated with major diabetic complications among Chinese senile diabetic patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Diabetes and its Complications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2016.08.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}