{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T14:28:18Z","timestamp":1769264898869,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes and its Complications"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.jdiacomp.2020.107556","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T11:49:03Z","timestamp":1580730543000},"page":"107556","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Bioinformatics enrichment analysis of genes and pathways related to maternal type 1 diabetes associated with adverse fetal outcomes"],"prefix":"10.1016","volume":"34","author":[{"given":"Ravi","family":"Bhushan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Rani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akhtar","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawan K.","family":"Dubey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdiacomp.2020.107556_bb0005","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1210\/en.2011-1279","article-title":"Maternal diabetes compromises the organization of hypothalamic feeding circuits and impairs leptin sensitivity in offspring","volume":"152","author":"Steculorum","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0010","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.bbrc.2015.09.137","article-title":"Maternal diabetes triggers DNA damage and DNA damage response in neurulation stage embryos through oxidative stress","volume":"467","author":"Dong","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0015","article-title":"Role of adipokines and other inflammatory mediators in gestational diabetes mellitus and previous gestational diabetes mellitus","volume":"12","author":"Vrachnis","year":"2012","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0020","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1749-6632.2010.05670.x","article-title":"Perinatal mortality in diabetic pregnancy","volume":"1205","author":"Vitoratos","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0025","article-title":"Previous gestational diabetes mellitus and markers of cardiovascular risk","volume":"6","author":"Vrachnis","year":"2012","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0030","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6517313","article-title":"Peroxisome proliferator-activated receptor modulation during metabolic diseases and cancers: master and minions","volume":"2016","author":"Vitale","year":"2016","journal-title":"PPAR Res"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0035","article-title":"Impact of maternal diabetes on epigenetic modifications leading to diseases in the offspring","volume":"6","author":"Vrachnis","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0040","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1084\/jem.20081188","article-title":"Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia","volume":"205","author":"El-Osta","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0045","doi-asserted-by":"crossref","first-page":"724","DOI":"10.2337\/db07-1507","article-title":"In vitro hyperglycemia or a diabetic intrauterine environment reduces neonatal endothelial colony-forming cell numbers and function","volume":"57","author":"Ingram","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0050","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.placenta.2015.04.004","article-title":"Maternal diabetes induces changes in the umbilical cord gene expression","volume":"36","author":"Koskinen","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0055","doi-asserted-by":"crossref","first-page":"D760","DOI":"10.1093\/nar\/gkl887","article-title":"Mining tens of millions of expression profiles\u2014database and tools update","volume":"35","author":"Barrett","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0060","doi-asserted-by":"crossref","first-page":"W566","DOI":"10.1093\/nar\/gkv468","article-title":"ClustVis: a web tool for visualizing clustering of multivariate data using principal component analysis and heatmap","volume":"43","author":"Metsalu","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0065","doi-asserted-by":"crossref","first-page":"D808","DOI":"10.1093\/nar\/gks1094","article-title":"MeringCv and et al.STRING v9. 1: protein-protein interaction networks, with increased coverage and integration","volume":"41","author":"Franceschini","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0070","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/978-1-60761-987-1_18","article-title":"Cytoscape: software for visualization and analysis of biological networks","volume":"696","author":"Kohl","year":"2011","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0075","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0080","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1476-4598-13-76","article-title":"F-box protein complex FBXL19 regulates TGF\u03b21-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation","volume":"13","author":"Dong","year":"2014","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0085","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1016\/j.bbamcr.2013.07.005","article-title":"A new mechanism of RhoA ubiquitination and degradation: roles of SCF FBXL19 E3 ligase and Erk2","volume":"1833","author":"Wei","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0090","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1182\/blood-2015-06-649087","article-title":"EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression","volume":"126","author":"Renneville","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0095","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nature12652","article-title":"EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex","volume":"504","author":"Ohno","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0100","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ajhg.2012.05.003","article-title":"Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability","volume":"91","author":"Kleefstra","year":"2012","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0105","doi-asserted-by":"crossref","first-page":"31207","DOI":"10.1074\/jbc.M112.365601","article-title":"EHMT1 protein binds to nuclear factor-\u03baB p50 and represses gene expression","volume":"287","author":"Ea","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0110","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2016.06.003","article-title":"Histone methylation by the Kleefstra syndrome protein EHMT1 mediates homeostatic synaptic scaling","volume":"91","author":"Benevento","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004960","article-title":"TRIM32 senses and restricts influenza A virus by ubiquitination of PB1 polymerase","volume":"11","author":"Fu","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/srep13456","article-title":"TRIM32 modulates pluripotency entry and exit by directly regulating Oct4 stability","volume":"5","author":"Bahnassawy","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0125","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/hmg\/ddv049","article-title":"The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2","volume":"24","author":"Mokhonova","year":"2015","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0130","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1111\/ejn.12618","article-title":"The deletion of TRIM32 protects mice from anxiety- and depression-like behaviors under mild stress","volume":"40","author":"Ruan","year":"2014","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2015.00075","article-title":"The neural stem cell fate determinant TRIM32 regulates complex behavioral traits","volume":"9","author":"Hillje","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0140","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11010-016-2793-z","article-title":"Upregulated TRIM32 correlates with enhanced cell proliferation and poor prognosis in hepatocellular carcinoma","volume":"421","author":"Cui","year":"2016","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0145","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3390\/ijms17070999","article-title":"Pleiotropic actions of peroxisome proliferator-activated receptors (PPARs) in dysregulated metabolic homeostasis, inflammation and cancer: current evidence and future perspectives","volume":"17","author":"Lagan\u00e0","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0150","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ygeno.2014.03.003","article-title":"Transcriptome analysis of human primary endothelial cells (HUVEC) from umbilical cords of gestational diabetic mothers reveals candidate sites for an epigenetic modulation of specific gene expression","volume":"103","author":"Ambra","year":"2014","journal-title":"Genomics"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0155","doi-asserted-by":"crossref","first-page":"5351","DOI":"10.1007\/s11033-013-2635-y","article-title":"Transcriptome meta-analysis of peripheral lymphomononuclear cells indicates that gestational diabetes is closer to type 1 diabetes than to type 2 diabetes mellitus","volume":"40","author":"Collares","year":"2013","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0160","doi-asserted-by":"crossref","first-page":"209.e1","DOI":"10.1016\/j.ajog.2009.04.019","article-title":"Differential regulation of genes for fetoplacental lipid pathways in pregnancy with gestational and type 1 diabetes mellitus","volume":"201","author":"Radaelli","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0165","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1210\/jc.2017-02764","article-title":"Gestational weight gain in women with polycystic ovary syndrome: a controlled study","volume":"103","author":"Kent","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0170","doi-asserted-by":"crossref","DOI":"10.5812\/ijem.43695","article-title":"Evidence-based and patient-oriented inositol treatment in polycystic ovary syndrome: changing the perspective of the disease","volume":"15","author":"Lagan\u00e0","year":"2017","journal-title":"Int J Endocrinol Metab"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0175","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1007\/s12325-018-0810-1","article-title":"Polycystic ovary syndrome: implication for drug metabolism on assisted reproductive techniques-a literature review","volume":"35","author":"Reyes-Mu\u00f1oz","year":"2018","journal-title":"Adv Ther"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0180","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3109\/01443615.2013.841658","article-title":"Abnormal glucose tolerance later in life in women affected by glucose intolerance during pregnancy","volume":"34","author":"Corrado","year":"2014","journal-title":"J Obstet Gynaecol"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0185","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0020-7292(97)00084-2","article-title":"Gestational and pre-gestational diabetes: comparison of maternal and fetal characteristics and outcome","volume":"58","author":"El Mallah","year":"1997","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.jdiacomp.2020.107556_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdiacomp.2013.08.009","article-title":"Pre-gestational versus gestational diabetes: a population-based study on clinical and demographic differences","volume":"28","author":"Fong","year":"2014","journal-title":"J Diabetes Complicat"}],"container-title":["Journal of Diabetes and its Complications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872719308773?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872719308773?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:11:10Z","timestamp":1761005470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056872719308773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S1056872719308773"],"URL":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2020.107556","relation":{},"ISSN":["1056-8727"],"issn-type":[{"value":"1056-8727","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bioinformatics enrichment analysis of genes and pathways related to maternal type 1 diabetes associated with adverse fetal outcomes","name":"articletitle","label":"Article Title"},{"value":"Journal of Diabetes and its Complications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2020.107556","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107556"}}