{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:00:05Z","timestamp":1778810405741,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes and its Complications"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jdiacomp.2024.108879","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T18:34:37Z","timestamp":1728498877000},"page":"108879","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Endothelial dysfunction markers syndecan-1 and thrombomodulin are associated with higher albuminuria levels in type 2 diabetes with no history of clinical cardiovascular disease"],"prefix":"10.1016","volume":"38","author":[{"given":"Luis F.","family":"Ferreira-Divino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina G.","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"Rotbain Curovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver B.","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nete","family":"Tofte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Frimodt-M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tine W.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Mette","family":"Hvas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Rossing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdiacomp.2024.108879_bb0005","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.2215\/CJN.11491116","article-title":"Diabetic kidney disease: challenges, progress, and possibilities","volume":"12","author":"Alicic","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0010","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1001\/jama.286.4.421","article-title":"Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals","volume":"286","author":"Gerstein","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0015","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1681\/ASN.2012070718","article-title":"Kidney disease and increased mortality risk in type 2 diabetes","volume":"24","author":"Afkarian","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0020","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/01.CIR.0000133312.96477.48","article-title":"Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function, hypertension, and diabetes","volume":"110","author":"Klausen","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0025","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s00125-007-0616-1","article-title":"Estimated glomerular filtration rate, albuminuria and mortality in type 2 diabetes: the Casale Monferrato study","volume":"50","author":"Bruno","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0030","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1681\/ASN.2006050517","article-title":"Microalbuminuria as an early marker for cardiovascular disease","volume":"17","author":"de Zeeuw","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0035","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1161\/CIRCULATIONAHA.105.538132","article-title":"Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals: the Framingham Heart Study","volume":"112","author":"Arnl\u00f6v","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0040","first-page":"219","article-title":"Albuminuria reflects widespread vascular damage","volume":"32","author":"Deckert","year":"1989","journal-title":"The Steno hypothesis Diabetologia"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0045","doi-asserted-by":"crossref","unstructured":"De Pablo-Moreno JA, Serrano LJ, Revuelta L, S\u00e1nchez MJ, Liras A. The Vascular Endothelium and Coagulation: Homeostasis, Disease, and Treatment, with a Focus on the Von Willebrand Factor and Factors VIII and V. Int J Mol Sci. 2022;23(15).","DOI":"10.3390\/ijms23158283"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0050","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1161\/01.CIR.0000091257.27563.32","article-title":"Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I","volume":"108","author":"Creager","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0055","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1210\/jc.2008-2534","article-title":"Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications","volume":"94","author":"Goldberg","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0060","doi-asserted-by":"crossref","first-page":"108654","DOI":"10.1016\/j.jdiacomp.2023.108654","article-title":"Soluble urokinase plasminogen activator receptor, platelet aggregation, and carotid plaque thickness in diabetes: a cross-sectional analysis","volume":"38","author":"Rotbain Curovic","year":"2023","journal-title":"J Diabetes Complicat"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0065","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0070","doi-asserted-by":"crossref","first-page":"791309","DOI":"10.3389\/fmed.2021.791309","article-title":"Measuring the concentration of serum syndecan-1 to assess vascular endothelial glycocalyx injury during hemodialysis","volume":"8","author":"Kusuzawa","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0075","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/path.3964","article-title":"Endothelial glycocalyx dysfunction in disease: albuminuria and increased microvascular permeability","volume":"226","author":"Salmon","year":"2012","journal-title":"J Pathol"},{"issue":"8","key":"10.1016\/j.jdiacomp.2024.108879_bb0080","article-title":"Chronic kidney disease as oxidative stress- and inflammatory-mediated cardiovascular disease","volume":"9","author":"Podkowi\u0144ska","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0085","doi-asserted-by":"crossref","first-page":"898592","DOI":"10.3389\/fmed.2022.898592","article-title":"Endothelial glycocalyx degradation in critical illness and injury","volume":"9","author":"Patterson","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0090","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.diabres.2009.08.002","article-title":"Insulin increases shedding of syndecan-1 in the serum of patients with type 2 diabetes mellitus","volume":"86","author":"Wang","year":"2009","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0095","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.atherosclerosis.2014.03.016","article-title":"Damage of the endothelial glycocalyx in chronic kidney disease","volume":"234","author":"Padberg","year":"2014","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0100","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1007\/s00125-006-0330-4","article-title":"Increased syndecan-1 in serum is related to early nephropathy in type 1 diabetes mellitus patients","volume":"49","author":"Svennevig","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0105","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1055\/a-1801-2055","article-title":"Circulating Thrombomodulin: release mechanisms, measurements, and levels in diseases and medical procedures","volume":"6","author":"Boron","year":"2022","journal-title":"TH Open"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0110","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00281-011-0282-8","article-title":"Thrombomodulin and its role in inflammation","volume":"34","author":"Conway","year":"2012","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0115","doi-asserted-by":"crossref","first-page":"698","DOI":"10.2215\/CJN.08160813","article-title":"Association of Kidney Function with changes in the endothelial surface layer","volume":"9","author":"Dane","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0120","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1464-5491.1995.tb00468.x","article-title":"Thrombomodulin levels in insulin-dependent diabetic patients with microalbuminuria","volume":"12","author":"Gruden","year":"1995","journal-title":"Diabet Med"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0125","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0009-8981(94)90036-1","article-title":"Elevated serum and urinary thrombomodulin levels in patients with non-insulin-dependent diabetes mellitus","volume":"225","author":"Shimano","year":"1994","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0130","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0959-440X(98)80100-0","article-title":"Three-dimensional structural studies on fragments of fibrinogen and fibrin","volume":"8","author":"Doolittle","year":"1998","journal-title":"Curr Opin Struct Biol"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0135","first-page":"457","article-title":"Coagulability of the blood in ischaemic heart-disease","volume":"273","author":"Mc","year":"1957","journal-title":"Lancet"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0140","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1007\/s00125-006-0288-2","article-title":"Diabetic nephropathy is associated with increased albumin and fibrinogen production in patients with type 2 diabetes","volume":"49","author":"Tessari","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0145","doi-asserted-by":"crossref","first-page":"5149825","DOI":"10.1155\/2016\/5149825","article-title":"Association between stable coronary artery disease and in vivo thrombin generation","volume":"2016","author":"Valente-Acosta","year":"2016","journal-title":"Cardiol Res Pract"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0150","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1161\/01.STR.0000124927.38723.f2","article-title":"Prothrombin fragment 1+2 is associated with carotid intima-media thickness in subjects free of clinical cardiovascular disease","volume":"35","author":"P\u00e1ramo","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0155","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1161\/01.STR.30.12.2547","article-title":"Markers of thrombin and platelet activity in patients with atrial fibrillation: correlation with stroke among 1531 participants in the stroke prevention in atrial fibrillation III study","volume":"30","author":"Feinberg","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0160","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.thromres.2019.12.018","article-title":"Thrombin generation, thrombin-antithrombin complex, and prothrombin fragment F1+2 as biomarkers for hypercoagulability in cancer patients","volume":"186","author":"Lundbech","year":"2020","journal-title":"Thromb Res"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0165","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1161\/01.CIR.0000129773.70647.94","article-title":"Soluble CD40 ligand, soluble P-selectin, interleukin-6, and tissue factor in diabetes mellitus: relationships to cardiovascular disease and risk factor intervention","volume":"109","author":"Lim","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0170","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12933-018-0763-3","article-title":"Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies","volume":"17","author":"Kaur","year":"2018","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0175","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/jth.13904","article-title":"Chronic kidney disease and bleeding risk in patients at high cardiovascular risk: a cohort study","volume":"16","author":"Ocak","year":"2018","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jdiacomp.2024.108879_bb0180","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1681\/ASN.2008030292","article-title":"First morning voids are more reliable than spot urine samples to assess microalbuminuria","volume":"20","author":"Witte","year":"2009","journal-title":"J Am Soc Nephrol"}],"container-title":["Journal of Diabetes and its Complications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872724002058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872724002058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T13:28:44Z","timestamp":1729776524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056872724002058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S1056872724002058"],"URL":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2024.108879","relation":{},"ISSN":["1056-8727"],"issn-type":[{"value":"1056-8727","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelial dysfunction markers syndecan-1 and thrombomodulin are associated with higher albuminuria levels in type 2 diabetes with no history of clinical cardiovascular disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Diabetes and its Complications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2024.108879","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024","name":"copyright","label":"Copyright"}],"article-number":"108879"}}