{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:39:00Z","timestamp":1790217540262,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes and its Complications"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jdiacomp.2024.108896","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T03:37:11Z","timestamp":1729568231000},"page":"108896","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of moderate-intensity aerobic training on cardiac structure and function in type 2 mellitus diabetic rats: Based on echocardiography and speckle tracking"],"prefix":"10.1016","volume":"38","author":[{"given":"Chunyan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengnan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiliang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdiacomp.2024.108896_bb0005","first-page":"225","article-title":"Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention","volume":"249","author":"Laakso","year":"2001","journal-title":"J Intern Med"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0010","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1161\/CIRCULATIONAHA.106.679597","article-title":"Diabetic cardiomyopathy revisited","volume":"115","author":"Boudina","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0015","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/HJH.0b013e3283331169","article-title":"Diabetes and incident heart failure in hypertensive and normotensive participants of the strong heart study","volume":"28","author":"De Simone","year":"2010","journal-title":"J Hypertens"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0020","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1136\/heartjnl-2014-307391","article-title":"Subclinical LV dysfunction and 10-year outcomes in type 2 diabetes mellitus","volume":"101","author":"Holland","year":"2015","journal-title":"Heart"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0025","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.115.003643","article-title":"Impact of improved glycemic control on cardiac function in type 2 diabetes mellitus","volume":"9","author":"Leung","year":"2016","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0030","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.ejheart.2006.03.001","article-title":"Type II diabetic mice exhibit contractile dysfunction but maintain cardiac output by favourable loading conditions","volume":"8","author":"Van Den Bergh","year":"2006","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0035","doi-asserted-by":"crossref","first-page":"339","DOI":"10.11152\/mu.2013.2066.183.qia","article-title":"Layer-specific myocardial strain analysis: investigation of regional deformation in a rabbit model of diabetes mellitus during different stages","volume":"18","author":"Qiao","year":"2016","journal-title":"Med Ultrason"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0040","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12933-019-0876-3","article-title":"Impact of acute hyperglycemia on layer-specific left ventricular strain in asymptomatic diabetic patients: an analysis based on two-dimensional speckle tracking echocardiography","volume":"18","author":"Bogdanovi\u0107","year":"2019","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0045","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.echo.2010.09.007","article-title":"Impaired myocardial radial function in asymptomatic patients with type 2 diabetes mellitus: a speckle-tracking imaging study","volume":"23","author":"Ernande","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0050","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jdiacomp.2017.07.022","volume":"32","author":"Stevanovic","year":"2018","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0055","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s12872-016-0395-z","article-title":"Silent diabetic cardiomyopathy in everyday practice: a clinical and echocardiographic study","volume":"16","author":"Loncarevic","year":"2016","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0060","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC guidelines on cardiovascular disease prevention in clinical practice","volume":"42","author":"Visseren","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0065","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.nut.2008.08.014","article-title":"Exercise training decreases proinflammatory profile in Zucker diabetic (type 2) fatty rats","volume":"25","author":"Teixeira De Lemos","year":"2009","journal-title":"Nutrition"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0070","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00421-022-04884-9","article-title":"Impact of continuous vs. interval training on oxygen extraction and cardiac function during exercise in type 2 diabetes mellitus","volume":"122","author":"Van Ryckeghem","year":"2022","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0075","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/s00125-020-05089-5","article-title":"Vascular improvements in individuals with type 2 diabetes following a 1 year randomised controlled exercise intervention, irrespective of changes in cardiorespiratory fitness","volume":"63","author":"Hetherington-Rauth","year":"2020","journal-title":"Diabetologia"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0080","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.3390\/nu15183950","article-title":"Moderate- and high-intensity endurance training alleviate diabetes-induced cardiac dysfunction in rats","volume":"15","author":"D\u2019Haese","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0085","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.metabol.2014.05.007","article-title":"A six-month exercise intervention in subclinical diabetic heart disease: effects on exercise capacity, autonomic and myocardial function","volume":"63","author":"Sacre","year":"2014","journal-title":"Metabolism"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0090","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s12576-019-00696-3","article-title":"Long-term moderate intensity exercise alleviates myocardial fibrosis in type 2 diabetic rats via inhibitions of oxidative stress and TGF-\u03b21\/Smad pathway","volume":"69","author":"Wang","year":"2019","journal-title":"J Physiol Sci"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0095","doi-asserted-by":"crossref","first-page":"H709","DOI":"10.1152\/ajpheart.00710.2011","article-title":"Geometrical models for cardiac MRI in rodents: comparison of quantification of left ventricular volumes and function by various geometrical models with a full-volume MRI data set in rodents","volume":"302","author":"Van De Weijer","year":"2012","journal-title":"Am J Physiol-Heart Circ Physiol"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0100","doi-asserted-by":"crossref","first-page":"H181","DOI":"10.1152\/ajpheart.00642.2003","article-title":"Long-term left ventricular echocardiographic follow-up of SHR and WKY rats: effects of hypertension and age","volume":"286","author":"Slama","year":"2004","journal-title":"Am J Physiol-Heart Circ Physiol"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr Off Publ Am Soc Echocardiogr"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0110","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.acvd.2017.01.014","article-title":"Layer-specific deformation of the left ventricle in uncomplicated patients with type 2 diabetes and arterial hypertension","volume":"111","author":"Tadic","year":"2018","journal-title":"Arch Cardiovasc Dis"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0115","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.echo.2009.10.004","article-title":"Circumferential and longitudinal strain in 3 myocardial layers in normal subjects and in patients with regional left ventricular dysfunction","volume":"23","author":"Leitman","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0120","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10396-020-01021-x","article-title":"Key factors of diastolic dysfunction and abnormal left ventricular relaxation in diabetic rats","volume":"47","author":"Kitpipatkun","year":"2020","journal-title":"J Med Ultrason"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0125","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1161\/CIRCULATIONAHA.109.869602","article-title":"Echocardiographic evaluation of diastolic function can be used to guide clinical care","volume":"120","author":"Little","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0130","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/S0002-9149(98)00134-9","article-title":"Left atrial mechanical adaptation to long-standing hemodynamic loads based on pressure\u2013volume relations","volume":"81","author":"Dernellis","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0135","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-00596-w","article-title":"Comparing left atrial indices by CMR in association with left ventricular diastolic dysfunction and adverse clinical outcomes","volume":"11","author":"Nguyen","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0140","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1007\/s00421-014-2989-4","article-title":"Left atrial functional changes following short-term exercise training","volume":"114","author":"Wright","year":"2014","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0145","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1249\/mss.0b013e318145b642","article-title":"Normalization of diastolic dysfunction in type 2 diabetics after exercise training","volume":"39","author":"Brassard","year":"2007","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0150","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1161\/01.RES.63.3.550","article-title":"Relation between transmural deformation and local myofiber direction in canine left ventricle","volume":"63","author":"Waldman","year":"1988","journal-title":"Circ Res"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-8227(02)00178-X","article-title":"Extracellular matrix maturation in the left ventricle of normal and diabetic swine","volume":"59","author":"Martinez","year":"2003","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0160","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1161\/01.RES.65.6.1657","article-title":"Alterations in collagen cross-linking impair myocardial contractility in the mouse heart","volume":"65","author":"Capasso","year":"1989","journal-title":"Circ Res"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0165","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s10554-023-02810-4","article-title":"Subclinical systolic dysfunction detected by 2D speckle tracking echocardiography in adults with diabetes mellitus: systematic review and meta-analysis of 6668 individuals with diabetes mellitus and 7218 controls","volume":"39","author":"Ghoreyshi-Hefzabad","year":"2023","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0170","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1093\/eurheartj\/ehn141","article-title":"Preserved left ventricular twist and circumferential deformation, but depressed longitudinal and radial deformation in patients with diastolic heart failure","volume":"29","author":"Wang","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0175","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1249\/MSS.0b013e31829ab43c","article-title":"Soccer training improves cardiac function in men with type 2 diabetes","volume":"45","author":"Schmidt","year":"2013","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0180","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s12576-019-00696-3","article-title":"Long-term moderate intensity exercise alleviates myocardial fibrosis in type 2 diabetic rats via inhibitions of oxidative stress and TGF-\u03b21\/Smad pathway","volume":"69","author":"Wang","year":"2019","journal-title":"J Physiol Sci"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0185","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.115.003651","article-title":"Exercise-induced left ventricular remodeling among competitive athletes: a phasic phenomenon","volume":"8","author":"Weiner","year":"2015","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0190","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1210\/me.2008-0265","article-title":"Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy","volume":"22","author":"Kim","year":"2008","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0195","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.cmet.2017.04.025","article-title":"Molecular mechanisms underlying cardiac adaptation to exercise","volume":"25","author":"Vega","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0200","doi-asserted-by":"crossref","first-page":"H124","DOI":"10.1152\/ajpheart.00108.2013","article-title":"Rat model of exercise-induced cardiac hypertrophy: hemodynamic characterization using left ventricular pressure-volume analysis","volume":"305","author":"Radovits","year":"2013","journal-title":"Am J Physiol-Heart Circ Physiol"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0205","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cardiores.2005.03.010","article-title":"Moderate vs. high exercise intensity: differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function","volume":"67","author":"Kemi","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0210","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s00125-015-3741-2","article-title":"High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes: a randomised controlled trial","volume":"59","author":"Cassidy","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0215","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jdiacomp.2024.108896_bb0220","doi-asserted-by":"crossref","first-page":"6504","DOI":"10.1111\/jcmm.14530","article-title":"Low-intensity aerobic exercise improves cardiac remodelling of adult spontaneously hypertensive rats","volume":"23","author":"Pagan","year":"2019","journal-title":"J Cell Mol Med"}],"container-title":["Journal of Diabetes and its Complications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872724002228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056872724002228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T11:15:05Z","timestamp":1742037305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056872724002228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S1056872724002228"],"URL":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2024.108896","relation":{},"ISSN":["1056-8727"],"issn-type":[{"value":"1056-8727","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of moderate-intensity aerobic training on cardiac structure and function in type 2 mellitus diabetic rats: Based on echocardiography and speckle tracking","name":"articletitle","label":"Article Title"},{"value":"Journal of Diabetes and its Complications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2024.108896","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108896"}}