{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:52:12Z","timestamp":1791528732183,"version":"4.3.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570475"],"award-info":[{"award-number":["82570475"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270242"],"award-info":[{"award-number":["82270242"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes and its Complications"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jdiacomp.2026.109411","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:13:30Z","timestamp":1789139610000},"page":"109411","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Significant decrease of serum extracellular vesicle neuropilin-1 in type 2 diabetes mellitus patients with endothelial dysfunction: a cross-sectional study"],"prefix":"10.1016","volume":"40","author":[{"given":"Zhengshuo","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieqiong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhechun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huina","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdiacomp.2026.109411_bb0005","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1161\/01.CIR.0000091257.27563.32","article-title":"Diabetes and vascular disease","volume":"108","author":"Creager","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0010","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-018-0763-3","article-title":"Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies","volume":"17","author":"Kaur","year":"2018","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0015","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.trsl.2012.01.009","article-title":"Biomarkers in diabetes: hemoglobin A1c, vascular and tissue markers","volume":"159","author":"Lyons","year":"2012","journal-title":"Transl Res"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0020","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1253\/circrep.CR-25-0042","article-title":"Improvement of cardiovascular prognostic value of endothelial function tests by repeated measurements","volume":"7","author":"Masaki","year":"2025","journal-title":"Circ Rep"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0025","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v4.27066","article-title":"Biological properties of extracellular vesicles and their physiological functions","volume":"4","author":"Yanez-Mo","year":"2015","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12400","article-title":"A beginner\u2019s guide to study extracellular vesicles in human blood plasma and serum","volume":"13","author":"Nieuwland","year":"2024","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0035","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1161\/CIRCRESAHA.117.309419","article-title":"Extracellular vesicles in metabolic syndrome","volume":"120","author":"Martinez","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0040","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.7150\/thno.65778","article-title":"Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications","volume":"12","author":"Liu","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0045","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12902-022-00982-z","article-title":"Elevated serum extracellular vesicle arginase 1 in type 2 diabetes mellitus: a cross-sectional study in middle-aged and elderly population","volume":"22","author":"Li","year":"2022","journal-title":"BMC Endocr Disord"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0050","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.cca.2021.08.010","article-title":"Increased concentrations of myeloperoxidase in serum and serum extracellular vesicles are associated with type 2 diabetes mellitus","volume":"522","author":"Peng","year":"2021","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0055","doi-asserted-by":"crossref","DOI":"10.1186\/s40001-023-01009-6","article-title":"Significant increase of serum extracellular vesicle-packaged growth differentiation factor 15 in type 2 diabetes mellitus: a cross-sectional study","volume":"28","author":"Zhao","year":"2023","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0060","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1039\/D2MO00257D","article-title":"Plasma extracellular vesicles microRNA-208b-3p and microRNA-143-3p as novel biomarkers for sudden cardiac death prediction in acute coronary syndrome","volume":"19","author":"Huang","year":"2023","journal-title":"Mol Omics"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0065","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12967-023-04820-1","article-title":"LIPCAR levels in plasma-derived extracellular vesicles is associated with left ventricle remodeling post-myocardial infarction","volume":"22","author":"Turkieh","year":"2024","journal-title":"J Transl Med"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0070","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1186\/s12967-024-05760-0","article-title":"Endothelial extracellular vesicles: their possible function and clinical significance in diabetic vascular complications","volume":"22","author":"Fang","year":"2024","journal-title":"J Transl Med"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0075","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.jacc.2005.02.047","article-title":"Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease","volume":"45","author":"Koga","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0080","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.atherosclerosis.2009.06.037","article-title":"Circulating level of microparticles and their correlation with arterial elasticity and endothelium-dependent dilation in patients with type 2 diabetes mellitus","volume":"208","author":"Feng","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0085","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/BST20230329","article-title":"Endothelial Neuropilin-1: a multifaced signal transducer with an emerging role in inflammation and atherosclerosis beyond angiogenesis","volume":"52","author":"Chikh","year":"2024","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0090","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.03720","article-title":"Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding","volume":"3","author":"Gelfand","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0095","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.isci.2018.12.005","article-title":"Neuropilin-1 controls endothelial homeostasis by regulating mitochondrial function and iron-dependent oxidative stress","volume":"11","author":"Issitt","year":"2019","journal-title":"iScience"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0100","doi-asserted-by":"crossref","first-page":"28074","DOI":"10.1074\/jbc.M804203200","article-title":"Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2","volume":"283","author":"Bae","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0105","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/ki.2008.603","article-title":"Advanced glycation end-products suppress neuropilin-1 expression in podocytes","volume":"75","author":"Bondeva","year":"2009","journal-title":"Kidney Int"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0110","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.2337\/dc26-S002","article-title":"2. Diagnosis and classification of diabetes: standards of care in diabetes-2026","volume":"49","author":"American Diabetes Association Professional Practice Committee for D","year":"2026","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0115","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1093\/eurheartj\/eht149","article-title":"Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I","volume":"34","author":"Paneni","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2024.132640","article-title":"Assessment of coronary endothelial dysfunction using contemporary coronary function testing","volume":"418","author":"de Jong","year":"2025","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0125","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.jacasi.2024.09.015","article-title":"Noninvasive assessment of vascular function: from physiological tests to biomarkers","volume":"4","author":"Higashi","year":"2024","journal-title":"JACC Asia"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0130","article-title":"A comprehensive review of clinical studies applying flow-mediated dilation","volume":"14","author":"Ahn","year":"2024","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0135","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1161\/CIRCULATIONAHA.112.093245","article-title":"The assessment of endothelial function","volume":"126","author":"Flammer","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0140","doi-asserted-by":"crossref","first-page":"13804","DOI":"10.3390\/ijms131113804","article-title":"Asymmetric dimethylarginine plasma levels and endothelial function in newly diagnosed type 2 diabetic patients","volume":"13","author":"Sciacqua","year":"2012","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0145","doi-asserted-by":"crossref","DOI":"10.1177\/0300060519893858","article-title":"Levels of soluble cell adhesion molecules in type 2 diabetes mellitus patients with macrovascular complications","volume":"48","author":"Hegazy","year":"2020","journal-title":"J Int Med Res"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0150","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00125-021-05380-z","article-title":"Hypoxia and hypoxia-inducible factors in diabetes and its complications","volume":"64","author":"Catrina","year":"2021","journal-title":"Diabetologia"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.665134","article-title":"Soluble neuropilin-1 response to hypoglycemia in type 2 diabetes: increased risk or protection in SARS-CoV-2 infection?","volume":"12","author":"Moin","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2024.1329633","article-title":"Cardiometabolic and immune response to exercise training in patients with metabolic syndrome: retrospective analysis of two randomized clinical trials","volume":"11","author":"Lechner","year":"2024","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jdiacomp.2026.109411_bb0165","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1111\/dom.16347","article-title":"Low levels of soluble neuropilin-1 were associated with depression in adults with newly diagnosed type 2 diabetes","volume":"27","author":"Melin","year":"2025","journal-title":"Diabetes Obes Metab"}],"container-title":["Journal of Diabetes and its Complications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105687272600156X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105687272600156X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:47:00Z","timestamp":1791528420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105687272600156X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S105687272600156X"],"URL":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2026.109411","relation":{},"ISSN":["1056-8727"],"issn-type":[{"value":"1056-8727","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Significant decrease of serum extracellular vesicle neuropilin-1 in type 2 diabetes mellitus patients with endothelial dysfunction: a cross-sectional study","name":"articletitle","label":"Article Title"},{"value":"Journal of Diabetes and its Complications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdiacomp.2026.109411","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109411"}}