{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:37:49Z","timestamp":1788435469767,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23AR077073-01A1"],"award-info":[{"award-number":["K23AR077073-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jaadinternational.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JAAD International"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jdin.2023.07.015","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T17:04:50Z","timestamp":1691859890000},"page":"74-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Clinical utility of peripheral blood laboratory testing in the diagnostic workup of prurigo nodularis: A\u00a0multicenter cohort study"],"prefix":"10.1016","volume":"13","author":[{"given":"Hannah L.","family":"Cornman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anusha","family":"Kambala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Parthasarathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriya V.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3736-1515","authenticated-orcid":false,"given":"Shawn G.","family":"Kwatra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jdin.2023.07.015_bib1","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1111\/ced.14722","article-title":"Clinical characteristics and disease burden in prurigo nodularis","volume":"46","author":"Aggarwal","year":"2021","journal-title":"Clin Exp Dermatol"},{"issue":"6","key":"10.1016\/j.jdin.2023.07.015_bib2","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.jaad.2020.04.182","article-title":"Prurigo nodularis: pathogenesis and management","volume":"83","author":"Williams","year":"2020","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.jdin.2023.07.015_bib3","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jaad.2021.05.036","article-title":"Health-related quality of life and economic burden of prurigo nodularis","volume":"86","author":"Whang","year":"2022","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"10.1016\/j.jdin.2023.07.015_bib4","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jaad.2018.04.047","article-title":"Ethnic differences and comorbidities of 909 prurigo nodularis patients","volume":"79","author":"Boozalis","year":"2018","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"10.1016\/j.jdin.2023.07.015_bib5","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.jaad.2019.03.083","article-title":"Association between prurigo nodularis and malignancy in middle-aged adults","volume":"81","author":"Larson","year":"2019","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.jdin.2023.07.015_bib6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3390\/medicines6030088","article-title":"Inpatient burden of prurigo nodularis in the United States","volume":"6","author":"Whang","year":"2019","journal-title":"Medicines"},{"issue":"2","key":"10.1016\/j.jdin.2023.07.015_bib7","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jid.2019.07.697","article-title":"Real-world prevalence of prurigo nodularis and burden of associated diseases","volume":"140","author":"Huang","year":"2020","journal-title":"J Invest Dermatol"},{"issue":"9","key":"10.1016\/j.jdin.2023.07.015_bib8","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1016\/j.jid.2021.02.749","article-title":"Prurigo nodularis is characterized by systemic and cutaneous T helper 22 immune polarization","volume":"141","author":"Belzberg","year":"2021","journal-title":"J Invest Dermatol"},{"issue":"10","key":"10.1016\/j.jdin.2023.07.015_bib9","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1016\/j.jid.2021.02.756","article-title":"A nationwide study of prurigo nodularis: disease burden and healthcare utilization in the United States","volume":"141","author":"Wongvibulsin","year":"2021","journal-title":"J Invest Dermatol"},{"issue":"3","key":"10.1016\/j.jdin.2023.07.015_bib10","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jaad.2021.02.030","article-title":"Real-world disease burden and comorbidities of pediatric prurigo nodularis","volume":"86","author":"Huang","year":"2022","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.jdin.2023.07.015_bib11","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jaad.2020.07.025","article-title":"Practical approaches for\u00a0diagnosis and management of prurigo nodularis: United States expert panel consensus","volume":"84","author":"Elmariah","year":"2021","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"10.1016\/j.jdin.2023.07.015_bib12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3390\/medicines6040097","article-title":"Diagnostic workup and evaluation of patients with prurigo nodularis","volume":"6","author":"Kwon","year":"2019","journal-title":"Medicines"},{"issue":"2","key":"10.1016\/j.jdin.2023.07.015_bib13","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jaad.2021.10.026","article-title":"Validation of international classification of diseases tenth revision code for prurigo nodularis","volume":"87","author":"Roh","year":"2022","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"10.1016\/j.jdin.2023.07.015_bib14","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jaad.2019.06.025","article-title":"The clinical utility of laboratory monitoring during isotretinoin therapy for acne and changes to monitoring practices over time","volume":"82","author":"Barbieri","year":"2020","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"10.1016\/j.jdin.2023.07.015_bib15","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jaad.2016.03.019","article-title":"Standardized laboratory monitoring with use of isotretinoin in acne","volume":"75","author":"Hansen","year":"2016","journal-title":"J Am Acad Dermatol"},{"issue":"8","key":"10.1016\/j.jdin.2023.07.015_bib16","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1001\/archderm.142.8.1016","article-title":"A population-based analysis of laboratory abnormalities during\u00a0isotretinoin therapy for acne vulgaris","volume":"142","author":"Zane","year":"2006","journal-title":"Arch Dermatol"},{"issue":"5","key":"10.1016\/j.jdin.2023.07.015_bib19","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1177\/00131640021970871","article-title":"Type I error rate comparisons of post hoc procedures for I j chi-square Tables","volume":"60","author":"MacDonald","year":"2000","journal-title":"Educ Psychol Meas"},{"issue":"1","key":"10.1016\/j.jdin.2023.07.015_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1053\/j.seminoncol.2005.11.002","article-title":"Hepatotoxicity of chemotherapy","volume":"33","author":"Floyd","year":"2006","journal-title":"Semin Oncol"},{"issue":"3","key":"10.1016\/j.jdin.2023.07.015_bib23","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0272-6386(83)80060-2","article-title":"Drug prescribing in renal failure: dosing guidelines for adults","volume":"3","author":"Bennett","year":"1983","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"10.1016\/j.jdin.2023.07.015_bib24","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1365-2133.1985.tb02357.x","article-title":"Nodular prurigo--a clinicopathological study of 46 patients","volume":"113","author":"Rowland Payne","year":"1985","journal-title":"Br J Dermatol"},{"issue":"1","key":"10.1016\/j.jdin.2023.07.015_bib25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1001\/jamapediatrics.2015.3065","article-title":"Association between atopic disease and anemia in US children","volume":"170","author":"Drury","year":"2016","journal-title":"JAMA Pediatr"},{"issue":"5","key":"10.1016\/j.jdin.2023.07.015_bib26","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jid.2021.10.011","article-title":"Cluster analysis of circulating plasma biomarkers in prurigo nodularis reveals a distinct systemic inflammatory signature in African Americans","volume":"142","author":"Sutaria","year":"2022","journal-title":"J Invest Dermatol"},{"issue":"7","key":"10.1016\/j.jdin.2023.07.015_bib27","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1001\/archderm.1993.01680280049009","article-title":"Mast cells, neutrophils, and eosinophils in prurigo nodularis","volume":"129","author":"Perez","year":"1993","journal-title":"Arch Dermatol"},{"issue":"8","key":"10.1016\/j.jdin.2023.07.015_bib28","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s004030000142","article-title":"Eosinophil cationic protein- and eosinophil-derived neurotoxin\/eosinophil protein X-immunoreactive eosinophils in prurigo nodularis","volume":"292","author":"Johansson","year":"2000","journal-title":"Arch Dermatol Res"},{"issue":"6","key":"10.1016\/j.jdin.2023.07.015_bib29","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1182\/blood.V99.6.2214","article-title":"Human eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuli","volume":"99","author":"Kobayashi","year":"2002","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.jdin.2023.07.015_bib30","first-page":"1443","article-title":"Clinical utility of the erythrocyte sedimentation rate","volume":"60","author":"Brigden","year":"1999","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.jdin.2023.07.015_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.1011142","article-title":"Circulating plasma IL-13 and periostin are dysregulated type 2 inflammatory biomarkers in prurigo nodularis: a cluster analysis","volume":"9","author":"Parthasarathy","year":"2022","journal-title":"Front Med"},{"issue":"5","key":"10.1016\/j.jdin.2023.07.015_bib32","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.jaad.2023.01.042","article-title":"The blood proteomic signature of prurigo nodularis reveals distinct inflammatory and neuropathic endotypes: a cluster analysis","volume":"88","author":"Parthasarathy","year":"2023","journal-title":"J Am Acad Dermatol"},{"issue":"12","key":"10.1016\/j.jdin.2023.07.015_bib33","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1111\/j.1365-4632.2009.04368.x","article-title":"Prurigo nodularis as the first manifestation of a chronic autoimmune cholestatic hepatitis","volume":"50","author":"Savoia","year":"2011","journal-title":"Int J Dermatol"},{"issue":"2","key":"10.1016\/j.jdin.2023.07.015_bib34","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jdermsci.2022.02.004","article-title":"Racial differences in dysregulation of the renin-angiotensin-aldosterone system in patients with prurigo nodularis","volume":"105","author":"Sutaria","year":"2022","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jdin.2023.07.015_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jid.2023.04.033","article-title":"A polygenic risk score for predicting racial and genetic susceptibility to prurigo nodularis","author":"Vasavda","year":"2023","journal-title":"J Invest Dermatol"},{"issue":"2","key":"10.1016\/j.jdin.2023.07.015_bib36","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1365-2230.2006.02310.x","article-title":"Nodular prurigo: metabolic diseases are a common association","volume":"32","author":"Winhoven","year":"2007","journal-title":"Clin Exp Dermatol"},{"issue":"6","key":"10.1016\/j.jdin.2023.07.015_bib37","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.anai.2014.09.010","article-title":"Prurigo nodularis and hashimoto thyroiditis","volume":"113","author":"Rishi","year":"2014","journal-title":"Ann Allergy Asthma Immunol"}],"container-title":["JAAD International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666328723001256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666328723001256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:01:07Z","timestamp":1762981267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666328723001256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":33,"alternative-id":["S2666328723001256"],"URL":"https:\/\/doi.org\/10.1016\/j.jdin.2023.07.015","relation":{},"ISSN":["2666-3287"],"issn-type":[{"value":"2666-3287","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical utility of peripheral blood laboratory testing in the diagnostic workup of prurigo nodularis: A\u00a0multicenter cohort study","name":"articletitle","label":"Article Title"},{"value":"JAAD International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdin.2023.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the American Academy of Dermatology, Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}