{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:57:40Z","timestamp":1769551060013,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jaadinternational.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JAAD International"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.jdin.2023.11.009","type":"journal-article","created":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T06:35:39Z","timestamp":1703486139000},"page":"62-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["A topical BRAF inhibitor (LUT-014) for treatment of radiodermatitis among women with breast cancer"],"prefix":"10.1016","volume":"15","author":[{"given":"Sanford","family":"Katz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doug","family":"Ciuba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Ribas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noa","family":"Shelach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galit","family":"Zelinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Briana","family":"Barrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin W.","family":"Corn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdin.2023.11.009_bib1","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/S0140-6736(11)61629-2","article-title":"Effect of radiotherapy after breast conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomized trials","volume":"378","author":"Darby","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jdin.2023.11.009_bib2","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1001\/jamaoncol.2015.2590","article-title":"Differences in the acute toxic effects of breast radiotherapy by fractionation schedule: comparative analysis of physician-assessed and patient-reported outcomes in a large multicenter cohort","volume":"1","author":"Jagsi","year":"2015","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.jdin.2023.11.009_bib3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.radonc.2016.02.027","article-title":"Acute skin toxicity associated with a 1-week schedule of whole breast radiotherapy compared with a standard 3-week regimen delivered in the UK FAST-Forward trial","volume":"120","author":"Brunt","year":"2016","journal-title":"Radiother Oncol"},{"issue":"4","key":"10.1016\/j.jdin.2023.11.009_bib4","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3747\/co.v17i4.493","article-title":"Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature","volume":"17","author":"Salvo","year":"2010","journal-title":"Curr Oncol"},{"key":"10.1016\/j.jdin.2023.11.009_bib5","doi-asserted-by":"crossref","first-page":"e825","DOI":"10.1016\/j.clbc.2018.06.015","article-title":"Radiation-induced skin toxicity in breast cancer patients: a systematic review of randomized trials","volume":"18","author":"Yee","year":"2018","journal-title":"Clin Breast Cancer"},{"key":"10.1016\/j.jdin.2023.11.009_bib6","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1097\/01.NCC.0000305680.06143.39","article-title":"A case study to evaluate a new soft silicone dressing for patients with radiation skin reactions","volume":"31","author":"MacBride","year":"2008","journal-title":"Cancer Nurs"},{"key":"10.1016\/j.jdin.2023.11.009_bib7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/15569520600860009","article-title":"A double-blind vehicle controlled clinical study to evaluate the efficacy of MAS065D (Xclair), a hyaluronic acid-based formulation, in the management of radiation-induced dermatitis","volume":"25","author":"Primavera","year":"2006","journal-title":"Cutan Ocul Toxicol"},{"issue":"12","key":"10.1016\/j.jdin.2023.11.009_bib8","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1007\/s00520-012-1435-6","article-title":"Acute skin toxicity-related, out of pocket expenses in patients with breast cancer treated with external beam radiotherapy","volume":"20","author":"Schmur","year":"2012","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.jdin.2023.11.009_bib9","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s13187-013-0598-2","article-title":"Fears and misperceptions of radiation therapy: sources and impact on decision-making and anxiety","volume":"29","author":"Gillian","year":"2014","journal-title":"J Cancer Educ"},{"key":"10.1016\/j.jdin.2023.11.009_bib10","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1002\/cncr.31159","article-title":"The patient perspective on breast radiotherapy: initial fears and expectations versus reality","volume":"124","author":"Shaverdian","year":"2018","journal-title":"Cancer"},{"key":"10.1016\/j.jdin.2023.11.009_bib11","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1188\/20.ONF.654-670","article-title":"ONS guidelines for cancer-related radiodermatitis","volume":"47","author":"Gosselin","year":"2020","journal-title":"ONF"},{"key":"10.1016\/j.jdin.2023.11.009_bib12","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.prro.2021.05.005","article-title":"ASTRO Editorial: ONS guidelines for cancer treatment-related radiodermatitis","volume":"11","author":"Marquez","year":"2021","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.jdin.2023.11.009_bib13","doi-asserted-by":"crossref","first-page":"e172","DOI":"10.1016\/S1470-2045(23)00067-0","article-title":"Multinational association of supportive care in cancer (MASCC) clinical practice guidelines for the prevention and management of acute radiation dermatitis: international Delphi consensus-based recommendations","volume":"24","author":"Behroozian","year":"2023","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jdin.2023.11.009_bib14","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1158\/2159-8290.CD-20-1847","article-title":"Reducing skin toxicities from EGFR inhibitors with topical BRAF inhibitor therapy","volume":"11","author":"Lacouture","year":"2021","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jdin.2023.11.009_bib15","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1074-5521(99)80088-X","article-title":"Paradoxical activation of RAF by a novel RAF inhibitor","volume":"6","author":"Hall-Jackson","year":"1999","journal-title":"Chem Biol"},{"key":"10.1016\/j.jdin.2023.11.009_bib16","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature08902","article-title":"RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild type BRAF","volume":"464","author":"Poulikakos","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jdin.2023.11.009_bib17","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature08833","article-title":"RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth","volume":"464","author":"Hatzivassiliou","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jdin.2023.11.009_bib18","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1755-148X.2010.00685.x","article-title":"PLX4032, a selective BRAF (V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells","volume":"23","author":"Halaban","year":"2010","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jdin.2023.11.009_bib19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2147\/CMAR.S188655","article-title":"Radiation-induced skin reactions: mechanism and treatment","volume":"11","author":"Wei","year":"2018","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.jdin.2023.11.009_bib20","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.prro.2020.09.002","article-title":"Development of an illustrated scale for acute radiation dermatitis in breast cancer patients","volume":"11","author":"Shumway","year":"2021","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.jdin.2023.11.009_bib21","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1365-2230.1994.tb01167.x","article-title":"Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use","volume":"19","author":"Finlay","year":"1994","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jdin.2023.11.009_bib22","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.ijrobp.2016.01.038","article-title":"Avoiding severe toxicity from combined BRAF-inhibitor and radiation treatment: consensus guidelines from the Eastern Cooperative Oncology Group (ECOG)","volume":"95","author":"Anker","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jdin.2023.11.009_bib23","series-title":"Principles and Practice of Radiation Oncology","first-page":"2185","year":"2018"},{"key":"10.1016\/j.jdin.2023.11.009_bib24","article-title":"Predictive factors associated with radiation dermatitis in breast cancer","volume":"28","author":"Behroozian","year":"2021","journal-title":"Cancer Treat Res\u00a0Commun"},{"key":"10.1016\/j.jdin.2023.11.009_bib25","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3322\/caac.21405","article-title":"Obesity and adverse breast cancer risk and outcome: mechanistic insights and strategies for intervention","volume":"67","author":"Picon-Ruiz","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jdin.2023.11.009_bib26","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1200\/JCO.22.01873","article-title":"Mepitel film for the prevention of acute radiation dermatitis in breast cancer: a randomized multi-center open-label phase III trial","volume":"41","author":"Behroozian","year":"2022","journal-title":"J Clin Oncol"},{"issue":"7","key":"10.1016\/j.jdin.2023.11.009_bib27","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1001\/jamaoncol.2023.0444","article-title":"Bacterial decolonization for prevention of radiation dermatitis: a randomized clinical trial","volume":"9","author":"Kost","year":"2023","journal-title":"JAMA Oncol"},{"issue":"1","key":"10.1016\/j.jdin.2023.11.009_bib28","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1186\/s13063-021-05849-7","article-title":"Promoting inclusion in clinical trials-a rapid review of the literature and recommendations for action","volume":"22","author":"Bodicoat","year":"2021","journal-title":"Trials"}],"container-title":["JAAD International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666328723001803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666328723001803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T17:44:08Z","timestamp":1717436648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666328723001803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":28,"alternative-id":["S2666328723001803"],"URL":"https:\/\/doi.org\/10.1016\/j.jdin.2023.11.009","relation":{},"ISSN":["2666-3287"],"issn-type":[{"value":"2666-3287","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A topical BRAF inhibitor (LUT-014) for treatment of radiodermatitis among women with breast cancer","name":"articletitle","label":"Article Title"},{"value":"JAAD International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdin.2023.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the American Academy of Dermatology, Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}