{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:43:03Z","timestamp":1787884983591,"version":"build-2784847793"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["KSVGH110-109"],"award-info":[{"award-number":["KSVGH110-109"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["KSVGH111-158"],"award-info":[{"award-number":["KSVGH111-158"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["107-2314-B-002-093-MY3"],"award-info":[{"award-number":["107-2314-B-002-093-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dental Sciences"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.jds.2023.02.013","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T09:43:49Z","timestamp":1678095829000},"page":"1280-1287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Action of econazole on Ca2+ levels and cytotoxicity in OC2 human oral cancer cells"],"prefix":"10.1016","volume":"18","author":[{"given":"Jue-Long","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Ren","family":"Jan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4853-1906","authenticated-orcid":false,"given":"Min-Huey","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jds.2023.02.013_bib1","first-page":"s165","article-title":"Optimizing topical antifungal therapy for superficial cutaneous fungal infections: focus on topical naftifine for cutaneous dermatophytosis","volume":"12","author":"James","year":"2013","journal-title":"J Drugs Dermatol JDD"},{"key":"10.1016\/j.jds.2023.02.013_bib2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/13880209.2014.914232","article-title":"Antifungal efficiency of miconazole and econazole and the interaction with transport protein: a comparative study","volume":"53","author":"Hu","year":"2015","journal-title":"Pharm Biol"},{"key":"10.1016\/j.jds.2023.02.013_bib3","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1021\/jo102459w","article-title":"Asymmetric chemoenzymatic synthesis of miconazole and econazole enantiomers. The importance of chirality in their biological evaluation","volume":"76","author":"Mangas-S\u00e1nchez","year":"2011","journal-title":"Org Chem"},{"key":"10.1016\/j.jds.2023.02.013_bib4","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/0006-2952(83)90045-X","article-title":"Effects of econazole nitrate on yeast cells and mitochondria","volume":"32","author":"Wilm","year":"1983","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jds.2023.02.013_bib5","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1139\/m82-166","article-title":"A comparison of the effects of several antifungal imidazole derivatives and polyenes on Candida albicans: an ultrastructural study by scanning electron microscopy","volume":"28","author":"Bastide","year":"1982","journal-title":"Can J Microbiol"},{"key":"10.1016\/j.jds.2023.02.013_bib6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/00362178585380611","article-title":"Suppression of ATP in Candida albicans by imidazole and derivative antifungal agents","volume":"23","author":"Odds","year":"1985","journal-title":"Sabouraudia"},{"key":"10.1016\/j.jds.2023.02.013_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/00362178285380171","article-title":"The \"hair root invasion test\", a semi-quantitative method for experimental evaluation of antimycotics in Guinea-pigs","volume":"20","author":"Petranyi","year":"1982","journal-title":"Sabouraudia"},{"key":"10.1016\/j.jds.2023.02.013_bib8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2165\/00003495-197816030-00001","article-title":"Econazole: a review of its antifungal activity and therapeutic efficacy","volume":"16","author":"Heel","year":"1978","journal-title":"Drugs"},{"key":"10.1016\/j.jds.2023.02.013_bib9","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1080\/10717544.2018.1461278","article-title":"Fabrication of a drug delivery system that enhances antifungal drug corneal penetration","volume":"25","author":"Li","year":"2018","journal-title":"Drug Deliv"},{"key":"10.1016\/j.jds.2023.02.013_bib10","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1191\/0960327105ht558oa","article-title":"Econazole induces increases in free intracellular Ca2+ concentrations in human osteosarcoma cells","volume":"24","author":"Chang","year":"2005","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.jds.2023.02.013_bib11","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1080\/10799890802517613","article-title":"Econazole-evoked [Ca2+]i rise and non-Ca2+-triggered cell death in rabbit corneal epithelial cells (SIRC)","volume":"28","author":"Chien","year":"2008","journal-title":"J Recept Signal Transduct Res"},{"key":"10.1016\/j.jds.2023.02.013_bib12","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.3748\/wjg.v12.i29.4694","article-title":"Effects of Ca2+ channel blockers on store-operated Ca2+ Channel currents of kupffer cells after hepatic ischemia\/reperfusion injury in rats","volume":"12","author":"Jiang","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jds.2023.02.013_bib13","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.4049\/jimmunol.170.9.4441","article-title":"A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes","volume":"170","author":"Ishikawa","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jds.2023.02.013_bib14","first-page":"331","article-title":"Imidazole antifungals miconazole and econazole induce apoptosis in mouse lymphoma and human T cell leukemia cells: regulation by Bcl-2 and potential role of calcium","volume":"3","author":"Sobecks","year":"1996","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jds.2023.02.013_bib15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3109\/08923979609052734","article-title":"Modulation of human T-lymphocyte plasma membrane Ca2+ permeability by imidazole antimycotics","volume":"18","author":"Hornstein","year":"1996","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"10.1016\/j.jds.2023.02.013_bib16","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","article-title":"Calcium signaling","volume":"131","author":"Clapham","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jds.2023.02.013_bib17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","article-title":"Calcium signaling: dynamics, homeostasis and remodelling","volume":"4","author":"Berridge","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jds.2023.02.013_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0143-4160(86)90026-6","article-title":"A model for receptor-regulated calcium entry","volume":"7","author":"Putney","year":"1986","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jds.2023.02.013_bib19","first-page":"310","article-title":"Paroxetine-induced Ca2+ movement and death in OC2 human oral cancer cells","volume":"54","author":"Fang","year":"2011","journal-title":"Chin J Physiol"},{"key":"10.1016\/j.jds.2023.02.013_bib20","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4077\/CJP.2014.BAC208","article-title":"Effect of fluoxetine on [Ca2\u207a]i and cell viability in OC2 human oral cancer cells","volume":"57","author":"Lin","year":"2014","journal-title":"Chin J Physiol"},{"key":"10.1016\/j.jds.2023.02.013_bib21","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jds.2023.02.013_bib22","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/S0021-9258(18)94218-3","article-title":"Use of manganese to discriminate between calcium influx and mobilization from internal stores in stimulated human neutrophils","volume":"264","author":"Merritt","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jds.2023.02.013_bib23","doi-asserted-by":"crossref","first-page":"H2692","DOI":"10.1152\/ajpheart.00260.2002","article-title":"Mg2+ blocks myogenic tone but not K+-induced constriction: role for SOCs in small arteries","volume":"283","author":"Zhang","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jds.2023.02.013_bib24","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/0166-2236(88)90195-6","article-title":"Calcium transport and buffering in neurons","volume":"11","author":"Blaustein","year":"1988","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.jds.2023.02.013_bib25","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1073\/pnas.87.7.2466","article-title":"Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2+-ATPase","volume":"87","author":"Thastrup","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jds.2023.02.013_bib26","doi-asserted-by":"crossref","first-page":"23856","DOI":"10.1016\/S0021-9258(18)54362-3","article-title":"The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. A role for Gp in receptor compartmentation","volume":"266","author":"Thompson","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jds.2023.02.013_bib27","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.bbagen.2011.10.004","article-title":"Analysis of IP3 receptors in and out of cells","volume":"1820","author":"Rossi","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jds.2023.02.013_bib28","first-page":"G587","article-title":"Extracellular ATP mediates Ca2+ signaling in cultured myenteric neurons via a PLC-dependent mechanism","volume":"270","author":"Kimball","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jds.2023.02.013_bib29","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1021\/bi00552a018","article-title":"New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures","volume":"19","author":"Tsien","year":"1980","journal-title":"Biochemist"},{"key":"10.1016\/j.jds.2023.02.013_bib30","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/jcb.20107","article-title":"Lysophospholipid receptor-dependent and independent calcium signaling","volume":"92","author":"Meyer","year":"2004","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jds.2023.02.013_bib31","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1440-1681.2005.04254.x","article-title":"Effects of econazole on Ca2+ levels and the growth of human prostate cancer PC3 cells","volume":"32","author":"Huang","year":"2005","journal-title":"Clin Exp Pharmacol Physiol"}],"container-title":["Journal of Dental Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1991790223000508?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1991790223000508?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T19:15:19Z","timestamp":1761851719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1991790223000508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S1991790223000508"],"URL":"https:\/\/doi.org\/10.1016\/j.jds.2023.02.013","relation":{},"ISSN":["1991-7902"],"issn-type":[{"value":"1991-7902","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Action of econazole on Ca2+ levels and cytotoxicity in OC2 human oral cancer cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Dental Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jds.2023.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}