{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T19:07:46Z","timestamp":1778526466711,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T00:00:00Z","timestamp":1677974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005866","name":"Far Eastern Memorial Hospital","doi-asserted-by":"publisher","award":["FEMH-2019-C-059"],"award-info":[{"award-number":["FEMH-2019-C-059"]}],"id":[{"id":"10.13039\/501100005866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005866","name":"Far Eastern Memorial Hospital","doi-asserted-by":"publisher","award":["FEMH-2020-C-055"],"award-info":[{"award-number":["FEMH-2020-C-055"]}],"id":[{"id":"10.13039\/501100005866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["111-2314-B-006-037-MY2"],"award-info":[{"award-number":["111-2314-B-006-037-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC 110-2314-B-006-059"],"award-info":[{"award-number":["NSTC 110-2314-B-006-059"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dental Sciences"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.jds.2023.03.005","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T20:20:26Z","timestamp":1679084426000},"page":"1288-1294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Significantly higher serum levels and positive rates of tumor biomarkers in patients with oral lichen planus"],"prefix":"10.1016","volume":"18","author":[{"given":"Yu-Hsueh","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6190-7162","authenticated-orcid":false,"given":"Chun-Pin","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jds.2023.03.005_bib1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1056\/NEJMcp1103641","article-title":"Lichen planus","volume":"366","author":"Le Cleach","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jds.2023.03.005_bib2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1001\/jamadermatol.2019.3797","article-title":"Global prevalence and incidence estimates of oral lichen planus: a systematic review and meta-analysis","volume":"156","author":"Li","year":"2020","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jds.2023.03.005_bib3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1600-0714.2010.00894.x","article-title":"A retrospective clinicopathological study of 550 patients with oral lichen planus in south-eastern Spain","volume":"39","author":"Bermejo-Fenoll","year":"2010","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jds.2023.03.005_bib4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1600-0714.2011.01054.x","article-title":"Factors predicting malignant transformation in oral potentially malignant disorders among patients accrued over a 10-year period in South East England","volume":"40","author":"Warnakulasuriya","year":"2011","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jds.2023.03.005_bib5","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/sj.ebd.6401349","article-title":"Malignant transformation rates in oral lichen planus","volume":"19","author":"Richards","year":"2018","journal-title":"Evid Base Dent"},{"key":"10.1016\/j.jds.2023.03.005_bib6","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jds.2021.01.005","article-title":"FoxP3(+)CD4(+), IFN-\u03b3(+)CD4(+), and IFN-\u03b3(+)CD8(+) cell levels in erosive and non-erosive types of oral lichen planus patients","volume":"16","author":"Sun","year":"2021","journal-title":"J Dent Sci"},{"key":"10.1016\/j.jds.2023.03.005_bib7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jfma.2017.12.009","article-title":"Hematinic deficiencies and anemia statuses in anti-gastric parietal cell antibody-positive or all autoantibodies-negative erosive oral lichen planus patients","volume":"117","author":"Chang","year":"2018","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jds.2023.03.005_bib8","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.molonc.2014.10.004","article-title":"Biomarker validation and testing","volume":"9","author":"Hayes","year":"2015","journal-title":"Mol Oncol"},{"key":"10.1016\/j.jds.2023.03.005_bib9","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1016\/S0022-5347(05)64998-1","article-title":"Strategies combining total and percent free prostate specific antigen for detecting prostate cancer: a prospective evaluation","volume":"167","author":"Gann","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.jds.2023.03.005_bib10","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/1471-2407-6-220","article-title":"CA 15-3 is predictive of response and disease recurrence following treatment in locally advanced breast cancer","volume":"6","author":"Al-azawi","year":"2006","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jds.2023.03.005_bib11","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1007\/s10350-004-6810-z","article-title":"Prediagnostic levels of carcinoembryonic antigen and CA 242 in colorectal cancer: a matched case-control study","volume":"46","author":"Palmqvist","year":"2003","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.jds.2023.03.005_bib12","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1600-0714.1998.tb01963.x","article-title":"Epithelial p53 gene expression and mutational analysis, combined with growth fraction assessment, in oral lichen planus","volume":"27","author":"Schifter","year":"1998","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jds.2023.03.005_bib13","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.tripleo.2004.10.018","article-title":"Higher expressions of p53 and proliferating cell nuclear antigen (PCNA) in atrophic oral lichen planus and patients with areca quid chewing","volume":"99","author":"Lee","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.jds.2023.03.005_bib14","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/ijd.12279","article-title":"Immunohistochemical expression of Bcl-2 and Ki-67 in oral lichen planus and leukoplakia with different degrees of dysplasia","volume":"54","author":"Pigatti","year":"2015","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.jds.2023.03.005_bib15","first-page":"235","article-title":"Estimation of malignant transformation rate in cases of oral epithelial dysplasia and lichen planus using immunohistochemical expression of Ki-67, p53, BCL-2, and BAX markers","volume":"12","author":"Shailaja","year":"2015","journal-title":"Dent Res J"},{"key":"10.1016\/j.jds.2023.03.005_bib16","first-page":"4157","article-title":"Oral lichen planus and malignant transformation: the role of p16, Ki-67, Bub-3 and SOX4 in assessing precancerous potential","volume":"15","author":"Rosa","year":"2018","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jds.2023.03.005_bib17","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.cllc.2011.03.019","article-title":"Serum tumor markers CEA, CYFRA21-1, and CA-125 are associated with worse prognosis in advanced non-small-cell lung cancer (NSCLC)","volume":"12","author":"Cedr\u00e9s","year":"2011","journal-title":"Clin Lung Cancer"},{"key":"10.1016\/j.jds.2023.03.005_bib18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s10120-013-0259-5","article-title":"Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association","volume":"17","author":"Shimada","year":"2014","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.jds.2023.03.005_bib19","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/S0959-8049(02)00159-4","article-title":"SCC antigen in the serum as an independent prognostic factor in operable squamous cell carcinoma of the cervix","volume":"38","author":"Strauss","year":"2002","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jds.2023.03.005_bib20","doi-asserted-by":"crossref","first-page":"368","DOI":"10.5468\/ogs.2015.58.5.368","article-title":"The prognostic value of squamous cell carcinoma antigen for predicting tumor recurrence in cervical squamous cell carcinoma patients","volume":"58","author":"Ryu","year":"2015","journal-title":"Obstet Gynecol Sci"},{"key":"10.1016\/j.jds.2023.03.005_bib21","article-title":"Using SCC antigen and CRP levels as prognostic biomarkers in recurrent oral cavity squamous cell carcinoma","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jds.2023.03.005_bib22","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/S0278-2391(97)90071-9","article-title":"Combination assay for tumor markers in oral squamous cell carcinoma","volume":"55","author":"Kurokawa","year":"1997","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.jds.2023.03.005_bib23","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jfma.2020.12.013","article-title":"Serum levels and positive rates of tumor biomarkers in oral precancer patients","volume":"120","author":"Wu","year":"2021","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jds.2023.03.005_bib24","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.jds.2021.02.009","article-title":"Significantly higher serum tumor marker levels in patients with oral submucous fibrosis","volume":"16","author":"Wu","year":"2021","journal-title":"J Dent Sci"},{"key":"10.1016\/j.jds.2023.03.005_bib25","first-page":"3381","article-title":"Diagnostic values of serum tumor markers Cyfra21-1, SCCAg, ferritin, CEA, CA19-9, and AFP in oral\/oropharyngeal squamous cell carcinoma","volume":"9","author":"Yuan","year":"2016","journal-title":"OncoTargets Ther"},{"key":"10.1016\/j.jds.2023.03.005_bib26","doi-asserted-by":"crossref","first-page":"10195","DOI":"10.1007\/s13277-014-2317-y","article-title":"Clinical significance of serum ferritin in elderly patients with primary lung carcinoma","volume":"35","author":"Ji","year":"2014","journal-title":"Tumour Biol"},{"key":"10.1016\/j.jds.2023.03.005_bib27","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1245\/s10434-012-2392-5","article-title":"Risk stratification in oral cavity squamous cell carcinoma by preoperative CRP and SCC antigen levels","volume":"19","author":"Huang","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.jds.2023.03.005_bib28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0304-3835(00)00423-7","article-title":"Conventional tumor markers are prognostic indicators in patients with head and neck squamous cell carcinoma","volume":"155","author":"Kimura","year":"2000","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jds.2023.03.005_bib29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.4103\/2319-4170.132888","article-title":"Serum levels of ferritin, copper, and zinc in patients with oral cancer","volume":"37","author":"Baharvand","year":"2014","journal-title":"Biomed J"},{"key":"10.1016\/j.jds.2023.03.005_bib30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/jop.12600","article-title":"Squamous cell carcinoma antigen as a prognostic marker and its correlation with clinicopathological features in head and neck squamous cell carcinoma: systematic review and meta-analysis","volume":"47","author":"Travassos","year":"2018","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jds.2023.03.005_bib31","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.jds.2022.05.023","article-title":"Significantly lower mean serum vitamin B12 and folic acid levels and a significantly higher frequency of serum iron deficiency in younger than in older atrophic glossitis patients","volume":"17","author":"Wu","year":"2022","journal-title":"J Dent Sci"},{"key":"10.1016\/j.jds.2023.03.005_bib32","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.jds.2022.05.011","article-title":"Significantly higher frequencies of macrocytosis, anemia, serum vitamin B12 and folic acid deficiencies, and hyperhomocysteinemia in male than in female atrophic glossitis patients","volume":"17","author":"Wu","year":"2022","journal-title":"J Dent Sci"},{"key":"10.1016\/j.jds.2023.03.005_bib33","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.jfma.2018.07.016","article-title":"Significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in atrophic glossitis patients","volume":"117","author":"Chiang","year":"2018","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jds.2023.03.005_bib34","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0300-9785(86)80013-8","article-title":"Haematological abnormalities in oral lichen planus, candidiasis, leukoplakia and nonspecific stomatitis","volume":"15","author":"Challacombe","year":"1986","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.jds.2023.03.005_bib35","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jfma.2014.10.004","article-title":"Significant association of deficiencies of hemoglobin, iron, folic acid, and vitamin B12 and high homocysteine level with oral lichen planus","volume":"114","author":"Chen","year":"2015","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jds.2023.03.005_bib36","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/s12903-020-01229-w","article-title":"The profile of hematinic deficiencies in patients with oral lichen planus: a case-control study","volume":"20","author":"Bao","year":"2020","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.jds.2023.03.005_bib37","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1039\/C3MT00347G","article-title":"Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells","volume":"6","author":"Kell","year":"2014","journal-title":"Metallomics"},{"key":"10.1016\/j.jds.2023.03.005_bib38","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/bj3570241","article-title":"Ferritin and the response to oxidative stress","volume":"357","author":"Orino","year":"2001","journal-title":"Biochem J"},{"key":"10.1016\/j.jds.2023.03.005_bib39","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/jop.12767","article-title":"Clinical value of Naa10p and CEA levels in saliva and serum for diagnosis of oral squamous cell carcinoma","volume":"47","author":"Zheng","year":"2018","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jds.2023.03.005_bib40","doi-asserted-by":"crossref","first-page":"130","DOI":"10.34172\/joddd.2022.022","article-title":"Comparison of CEA and IgG serum levels in oral lichenoid lesions before and after treatment with topical corticosteroids","volume":"16","author":"Hosseinpour Sarmadi","year":"2022","journal-title":"J Dent Res Dent Clin Dent Prospects"},{"key":"10.1016\/j.jds.2023.03.005_bib41","first-page":"75","article-title":"Demonstration of cancinoembryonic antigen in oral lichen planus with epithelial dysplasia","volume":"13","author":"El Abany","year":"1988","journal-title":"Alexandria Dent J"},{"key":"10.1016\/j.jds.2023.03.005_bib42","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1034\/j.1600-0714.2001.300906.x","article-title":"Levamisole and\/or Chinese medicinal herbs can modulate the serum level of squamous cell carcinoma associated antigen in patients with erosive oral lichen planus","volume":"30","author":"Sun","year":"2001","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jds.2023.03.005_bib43","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4103\/ijd.IJD_658_19","article-title":"Elevation of serum SCCAII in cutaneous and oral lichen planus: missing link for hidden carcinogenic potential?","volume":"66","author":"Mikhael","year":"2021","journal-title":"Indian J Dermatol"},{"key":"10.1016\/j.jds.2023.03.005_bib44","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.21608\/edj.2020.25690.1071","article-title":"Evaluation of salivary versus serum squamous cell carcinoma antigen in oral lichen planus","volume":"66","author":"Abdelkawy","year":"2020","journal-title":"Egypt Dent J"}],"container-title":["Journal of Dental Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S199179022300065X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S199179022300065X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:07:50Z","timestamp":1778522870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S199179022300065X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S199179022300065X"],"URL":"https:\/\/doi.org\/10.1016\/j.jds.2023.03.005","relation":{},"ISSN":["1991-7902"],"issn-type":[{"value":"1991-7902","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Significantly higher serum levels and positive rates of tumor biomarkers in patients with oral lichen planus","name":"articletitle","label":"Article Title"},{"value":"Journal of Dental Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jds.2023.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}