{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T05:36:14Z","timestamp":1778132174306,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 106-2314-B-040 -004 -MY3"],"award-info":[{"award-number":["NSTC 106-2314-B-040 -004 -MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004699","name":"Chung Shan Medical University Hospital","doi-asserted-by":"publisher","award":["CSH-2024-C-020"],"award-info":[{"award-number":["CSH-2024-C-020"]}],"id":[{"id":"10.13039\/501100004699","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007632","name":"Changhua Christian Hospital","doi-asserted-by":"publisher","award":["CSMU-CCH-113-08"],"award-info":[{"award-number":["CSMU-CCH-113-08"]}],"id":[{"id":"10.13039\/501100007632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dental Sciences"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jds.2025.04.008","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T19:27:13Z","timestamp":1745004433000},"page":"1756-1763","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["GAS5 decreased the arecoline-induced myofibroblasts activity in buccal mucosal fibroblasts via acting as a competing endogenous RNA for miR-21"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4535-1176","authenticated-orcid":false,"given":"Chuan-Hang","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng-Yi","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Chun","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8159-6041","authenticated-orcid":false,"given":"Ming-Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Wen","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Chia","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-Chen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jds.2025.04.008_bib1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1600-0714.2007.00582.x","article-title":"Nomenclature and classification of potentially malignant disorders of the oral mucosa","volume":"36","author":"Warnakulasuriya","year":"2007","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jds.2025.04.008_bib2","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1600-0714.2005.00332.x","article-title":"Oral precancerous disorders associated with areca quid chewing, smoking, and alcohol drinking in southern Taiwan","volume":"34","author":"Chung","year":"2005","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jds.2025.04.008_bib3","doi-asserted-by":"crossref","first-page":"e265","DOI":"10.4317\/jced.51424","article-title":"Comparative study of the efficacy of herbal antioxdants oxitard and aloe vera in the treatment of oral submucous fibrosis","volume":"6","author":"Patil","year":"2014","journal-title":"J Clin Exp Dent"},{"key":"10.1016\/j.jds.2025.04.008_bib4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/jop.12463","article-title":"Evaluation of efficacy of Aloe vera in the treatment of oral submucous fibrosis-a clinical study","volume":"46","author":"Anuradha","year":"2017","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jds.2025.04.008_bib5","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.7314\/APJCP.2016.17.3.1255","article-title":"Clinical efficacy of a mouth exercising device adjunct to local ointment intra-lesional injections and surgical treatment for oral submucous fibrosis: a randomized controlled trial","volume":"17","author":"Patil","year":"2016","journal-title":"Asian Pac J Cancer Prev APJCP"},{"key":"10.1016\/j.jds.2025.04.008_bib6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10006-016-0580-3","article-title":"Immediate versus delayed aggressive physical therapy following buccal fat pad interposition in oral submucous fibrosis-a prospective study in central India","volume":"20","author":"Bande","year":"2016","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.jds.2025.04.008_bib7","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1600-0714.2005.00339.x","article-title":"Extracellular matrix remodeling in oral submucous fibrosis: its stage-specific modes revealed by immunohistochemistry and in situ hybridization","volume":"34","author":"Utsunomiya","year":"2005","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jds.2025.04.008_bib8","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.jds.2025.04.008_bib9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrcardio.2009.199","article-title":"Myocardial remodeling after infarction: the role of myofibroblasts","volume":"7","author":"van den Borne","year":"2010","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jds.2025.04.008_bib10","doi-asserted-by":"crossref","first-page":"9448","DOI":"10.1073\/pnas.1201840109","article-title":"Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis","volume":"109","author":"Kisseleva","year":"2012","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jds.2025.04.008_bib11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fphar.2014.00002","article-title":"Heterogeneity in fibroblast proliferation and survival in idiopathic pulmonary fibrosis","volume":"5","author":"Habiel","year":"2014","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jds.2025.04.008_bib12","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1600-0714.2010.00995.x","article-title":"Evaluation of myofibroblasts in oral submucous fibrosis: correlation with disease severity","volume":"40","author":"Angadi","year":"2011","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jds.2025.04.008_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051806","article-title":"Activation of TGF-\u03b2 pathway by areca nut constituents: a possible cause of oral submucous fibrosis","volume":"7","author":"Khan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jds.2025.04.008_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129252","article-title":"Role of areca nut induced TGF-\u03b2 and epithelial-mesenchymal interaction in the pathogenesis of oral submucous fibrosis","volume":"10","author":"Pant","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jds.2025.04.008_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/srep34314","article-title":"Role of areca nut induced JNK\/ATF2\/Jun axis in the activation of TGF-\u03b2 pathway in precancerous oral submucous fibrosis","volume":"6","author":"Pant","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jds.2025.04.008_bib16","doi-asserted-by":"crossref","first-page":"12384","DOI":"10.1074\/jbc.M208544200","article-title":"Myofibroblast differentiation by transforming growth factor-\u03b21 is dependent on cell adhesion and integrin signaling via focal adhesion kinase","volume":"278","author":"Thannickal","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jds.2025.04.008_bib17","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/jcmm.12219","article-title":"Arecoline-induced myofibroblast transdifferentiation from human buccal mucosal fibroblasts is mediated by ZEB1","volume":"18","author":"Chang","year":"2014","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jds.2025.04.008_bib18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jfma.2015.05.009","article-title":"Elevation of twist expression by arecoline contributes to the pathogenesis of oral submucous fibrosis","volume":"115","author":"Lee","year":"2016","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jds.2025.04.008_bib19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature11233","article-title":"Landscape of transcription in human cells","volume":"489","author":"Djebali","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jds.2025.04.008_bib20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fgene.2012.00017","article-title":"A central role for long non-coding RNA in cancer","volume":"3","author":"Mitra","year":"2012","journal-title":"Front Genet"},{"key":"10.1016\/j.jds.2025.04.008_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9856538","article-title":"Identification of a novel lincRNA-p21miR-181b-PTEN signaling Cascade in liver fibrosis","volume":"2016","author":"Yu","year":"2016","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.jds.2025.04.008_bib22","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/hep.23922","article-title":"Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis","volume":"53","author":"Roderburg","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jds.2025.04.008_bib23","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.10444","article-title":"Long non-coding RNA-H19 antagonism protects against renal fibrosis","volume":"7","author":"Xie","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jds.2025.04.008_bib24","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1084\/jem.20100035","article-title":"miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis","volume":"207","author":"Liu","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.jds.2025.04.008_bib25","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1096\/fj.12-219493","article-title":"miR-145 regulates myofibroblast differentiation and lung fibrosis","volume":"27","author":"Yang","year":"2013","journal-title":"FASEB J"},{"key":"10.1016\/j.jds.2025.04.008_bib26","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1016\/j.ijcard.2012.07.021","article-title":"Myocardial and circulating levels of microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients","volume":"167","author":"Villar","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jds.2025.04.008_bib27","doi-asserted-by":"crossref","first-page":"28286","DOI":"10.1074\/jbc.M115.683813","article-title":"Long non-coding RNA growth arrest-specific transcript 5 (GAS5) inhibits liver fibrogenesis through a mechanism of competing endogenous RNA","volume":"290","author":"Yu","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jds.2025.04.008_bib28","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1136\/gutjnl-2011-300717","article-title":"MicroRNA-221\/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis","volume":"61","author":"Ogawa","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.jds.2025.04.008_bib29","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1007\/s13277-015-4111-x","article-title":"Long noncoding RNA GAS5 suppresses the migration and invasion of hepatocellular carcinoma cells via miR-21","volume":"37","author":"Hu","year":"2016","journal-title":"Tumour Biol"},{"key":"10.1016\/j.jds.2025.04.008_bib30","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/cdd.2013.110","article-title":"Negative regulation of lncRNA GAS5 by miR-21","volume":"20","author":"Zhang","year":"2013","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jds.2025.04.008_bib31","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.jfma.2020.10.019","article-title":"Arecoline enhances miR-21 to promote buccal mucosal fibroblasts activation","volume":"120","author":"Yang","year":"2021","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jds.2025.04.008_bib32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.oraloncology.2016.03.017","article-title":"microRNA-21 and microRNA-375 from oral cytology as biomarkers for oral tongue cancer detection","volume":"57","author":"He","year":"2016","journal-title":"Oral Oncol"},{"key":"10.1016\/j.jds.2025.04.008_bib33","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/jcmm.12219","article-title":"Arecoline-induced myofibroblast transdifferentiation from human buccal mucosal fibroblasts is mediated by ZEB1","volume":"18","author":"Chang","year":"2014","journal-title":"J Cell Mol"},{"key":"10.1016\/j.jds.2025.04.008_bib34","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1016\/j.jfma.2021.04.012","article-title":"Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor-\u03b2\/Smad2\/3 signaling inhibition","volume":"120","author":"Chen","year":"2021","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jds.2025.04.008_bib35","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1161\/CIRCRESAHA.115.305242","article-title":"Function and therapeutic potential of noncoding RNAs in cardiac fibrosis","volume":"118","author":"Creemers","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jds.2025.04.008_bib36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13073-016-0285-0","article-title":"Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins","volume":"8","author":"Zhou","year":"2016","journal-title":"Genome Med"},{"key":"10.1016\/j.jds.2025.04.008_bib37","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3109\/08977194.2011.595714","article-title":"TGF-\u03b2 signaling in fibrosis","volume":"29","author":"Biernacka","year":"2011","journal-title":"Growth Factors"},{"key":"10.1016\/j.jds.2025.04.008_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jds.2021.09.004","article-title":"miR-21 promotes the fibrotic properties in oral mucosa through targeting PDCD4","volume":"17","author":"Liao","year":"2022","journal-title":"J Dent Sci"}],"container-title":["Journal of Dental Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1991790225001217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1991790225001217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T02:12:19Z","timestamp":1750903939000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1991790225001217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S1991790225001217"],"URL":"https:\/\/doi.org\/10.1016\/j.jds.2025.04.008","relation":{},"ISSN":["1991-7902"],"issn-type":[{"value":"1991-7902","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GAS5 decreased the arecoline-induced myofibroblasts activity in buccal mucosal fibroblasts via acting as a competing endogenous RNA for miR-21","name":"articletitle","label":"Article Title"},{"value":"Journal of Dental Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jds.2025.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V\u00e9","name":"copyright","label":"Copyright"}]}}