{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:02:22Z","timestamp":1774688542147,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dental Sciences"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jds.2026.02.003","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:30:15Z","timestamp":1771475415000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["2-hydroxy ethylmethacrylate activates the extrinsic and intrinsic apoptotic processes through mitogen-activated protein kinase signaling pathways in cementoblasts - An in vitro study"],"prefix":"10.1016","author":[{"given":"Wei-Ju","family":"Lai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Ying","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6134-9659","authenticated-orcid":false,"given":"Chun Chuan","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jds.2026.02.003_bib1","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.jds.2023.01.033","article-title":"A registry-based study of tooth-colored restorative materials for decayed teeth in Taiwan","volume":"18","author":"Su","year":"2023","journal-title":"J Dent Sci"},{"key":"10.1016\/j.jds.2026.02.003_bib2","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1046\/j.1365-2842.2001.00802.x","article-title":"Water sorption and solubility of dental composites and identification of monomers released in an aqueous environment","volume":"28","author":"Ortengren","year":"2001","journal-title":"J Oral Rehabil"},{"key":"10.1016\/j.jds.2026.02.003_bib3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.dental.2009.08.014","article-title":"Eluted substances from unpolymerized and polymerized dental restorative materials and their Nernst partition coefficient","volume":"26","author":"Durner","year":"2010","journal-title":"Dent Mater"},{"key":"10.1016\/j.jds.2026.02.003_bib4","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.dental.2011.05.001","article-title":"How much do resin-based dental materials release? A meta-analytical approach","volume":"27","author":"Van Landuyt","year":"2011","journal-title":"Dent Mater"},{"key":"10.1016\/j.jds.2026.02.003_bib5","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.biomaterials.2004.03.021","article-title":"Stimulation of glutathione depletion, ROS production and cell cycle arrest of dental pulp cells and gingival epithelial cells by HEMA","volume":"26","author":"Chang","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.jds.2026.02.003_bib6","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s10856-011-4328-1","article-title":"Translationally controlled tumor protein against apoptosis from 2-hydroxyethyl methacrylate in human dental pulp cells","volume":"22","author":"Wanachottrakul","year":"2011","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.jds.2026.02.003_bib7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2591.2011.01942.x","article-title":"Overexpression of interleukin-6 and -8, cell growth inhibition and morphological changes in 2-hydroxyethyl methacrylate-treated human dental pulp mesenchymal stem cells","volume":"45","author":"Trubiani","year":"2012","journal-title":"Int Endod J"},{"key":"10.1016\/j.jds.2026.02.003_bib8","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.jfma.2020.11.022","article-title":"The effects of low-dose 2-hydroxyethyl methacrylate on apoptosis and survival in human dental pulp cells","volume":"120","author":"Chen","year":"2021","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jds.2026.02.003_bib9","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.1007\/s12035-023-03433-5","article-title":"A review on caspases: key regulators of biological activities and apoptosis","volume":"60","author":"Sahoo","year":"2023","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jds.2026.02.003_bib10","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s11010-023-04870-5","article-title":"How does caspases regulation play role in cell decisions? Apoptosis and beyond","volume":"479","author":"Ghorbani","year":"2024","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jds.2026.02.003_bib11","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.3390\/ijms21072346","article-title":"Understanding MAPK signaling pathways in apoptosis","volume":"21","author":"Yue","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jds.2026.02.003_bib12","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases","volume":"298","author":"Johnson","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jds.2026.02.003_bib13","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0099-2399(06)81361-0","article-title":"Histological evaluation of therapy using a calcium hydroxide dressing for teeth with incompletely formed apices and periapical lesions","volume":"19","author":"Leonardo","year":"1993","journal-title":"J Endod"},{"key":"10.1016\/j.jds.2026.02.003_bib14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1902\/jop.2000.71.1.63","article-title":"Employing a transgenic animal model to obtain cementoblasts in vitro","volume":"71","author":"D\u2019Errico","year":"2000","journal-title":"J Periodontol"},{"key":"10.1016\/j.jds.2026.02.003_bib15","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jds.2015.03.007","article-title":"Effects of nicotine on differentiation, prostaglandin E2 and nitric oxide production in cementoblasts","volume":"10","author":"Chen","year":"2015","journal-title":"J Dent Sci"},{"key":"10.1016\/j.jds.2026.02.003_bib16","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.3390\/cancers14225519","article-title":"CLEFMA induces the apoptosis of oral squamous carcinoma cells through the regulation of the p38\/HO-1 signaling pathway","volume":"14","author":"Chen","year":"2002","journal-title":"Cancers"},{"key":"10.1016\/j.jds.2026.02.003_bib17","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.jds.2024.11.006","article-title":"Sodium butyrate activates the extrinsic and intrinsic apoptotic processes in murine cementoblasts","volume":"20","author":"Lo","year":"2025","journal-title":"J Dent Sci"},{"key":"10.1016\/j.jds.2026.02.003_bib18","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1002\/tox.23655","article-title":"Protective effect of wogonin on inflammatory responses in BisGMA-treated macrophages through the inhibition of MAPK and NF-kB pathways","volume":"37","author":"Yang","year":"2022","journal-title":"Environ Toxicol"},{"key":"10.1016\/j.jds.2026.02.003_bib19","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1046\/j.1365-2591.2002.00589.x","article-title":"Cytotoxicity of dentine-bonding agents on human pulp cells in vitro","volume":"35","author":"Huang","year":"2002","journal-title":"Int Endod J"},{"key":"10.1016\/j.jds.2026.02.003_bib20","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0099-2399(06)80141-X","article-title":"In vitro cytotoxicity and dentin permeability of HEMA","volume":"22","author":"Bouillaguet","year":"1996","journal-title":"J Endod"},{"key":"10.1016\/j.jds.2026.02.003_bib21","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1016\/j.biomaterials.2012.04.013","article-title":"The influence of glutathione on redox regulation by antioxidant proteins and apoptosis in macrophages exposed to 2-hydroxyethyl methacrylate (HEMA)","volume":"33","author":"Krifka","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jds.2026.02.003_bib22","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.biomaterials.2015.03.047","article-title":"Activation of the Nrf2-regulated antioxidant cell response inhibits HEMA-induced oxidative stress and supports cell viability","volume":"56","author":"Gallorini","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.jds.2026.02.003_bib23","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.dental.2012.04.031","article-title":"Synergistic interaction caused to human gingival fibroblasts from dental monomers","volume":"28","author":"Durner","year":"2012","journal-title":"Dent Mater"},{"key":"10.1016\/j.jds.2026.02.003_bib24","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3389\/fphys.2015.00275","article-title":"HEMA but not TEGDMA induces autophagy in human gingival fibroblasts","volume":"6","author":"Teti","year":"2015","journal-title":"Front Physiol"},{"key":"10.1016\/j.jds.2026.02.003_bib25","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.dental.2012.01.002","article-title":"Effects of resinous monomers on the odontogenic differentiation and mineralization potential of highly proliferative and clonogenic cultured apical papilla stem cells","volume":"28","author":"Bakopoulou","year":"2012","journal-title":"Dent Mater"},{"key":"10.1016\/j.jds.2026.02.003_bib26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jdent.2017.07.008","article-title":"In-vitro cytocompatibility of dental resin monomers on osteoblast-like cells","volume":"65","author":"Kraus","year":"2017","journal-title":"J Dent"},{"key":"10.1016\/j.jds.2026.02.003_bib27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1056-8719(97)00033-6","article-title":"Morphological and biochemical characterization and analysis of apoptosis","volume":"37","author":"Allen","year":"1997","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1016\/j.jds.2026.02.003_bib28","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.biomaterials.2010.11.031","article-title":"Activation of stress-regulated transcription factors by triethylene glycol dimethacrylate monomer","volume":"32","author":"Krifka","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.jds.2026.02.003_bib29","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.biomaterials.2011.10.026","article-title":"Function of MAPK and downstream transcription factors in monomer-induced apoptosis","volume":"33","author":"Krifka","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jds.2026.02.003_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082942","article-title":"BisGMA stimulates prostaglandin E2 production in macrophages via cyclooxygenase-2, cytosolic phospholipase A2, and mitogen-activated protein kinases family","volume":"8","author":"Kuan","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jds.2026.02.003_bib31","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.jds.2024.11.033","article-title":"Triethylene-glycol-dimethacrylate induces caspase-mediated apoptotic cell death in cementoblasts by the regulation of JNK and p38 pathways- an in vitro study","volume":"20","author":"Lai","year":"2025","journal-title":"J Dent Sci"}],"container-title":["Journal of Dental Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1991790226000310?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1991790226000310?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:30:23Z","timestamp":1774686623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1991790226000310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":31,"alternative-id":["S1991790226000310"],"URL":"https:\/\/doi.org\/10.1016\/j.jds.2026.02.003","relation":{},"ISSN":["1991-7902"],"issn-type":[{"value":"1991-7902","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"2-hydroxy ethylmethacrylate activates the extrinsic and intrinsic apoptotic processes through mitogen-activated protein kinase signaling pathways in cementoblasts - An in vitro study","name":"articletitle","label":"Article Title"},{"value":"Journal of Dental Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jds.2026.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Association for Dental Sciences of the Republic of China. Publishing services by Digital Commons.","name":"copyright","label":"Copyright"}]}}